GR900100368A - Μέ?οδος για τον διαχωρισμό των ρακεμικών μορφών 4-αρυλο-2-οξο-πυρρολιδινο-3-καρβονικών εστέρων. - Google Patents

Μέ?οδος για τον διαχωρισμό των ρακεμικών μορφών 4-αρυλο-2-οξο-πυρρολιδινο-3-καρβονικών εστέρων.

Info

Publication number
GR900100368A
GR900100368A GR900100368A GR900100368A GR900100368A GR 900100368 A GR900100368 A GR 900100368A GR 900100368 A GR900100368 A GR 900100368A GR 900100368 A GR900100368 A GR 900100368A GR 900100368 A GR900100368 A GR 900100368A
Authority
GR
Greece
Prior art keywords
oxo
esteres
arylo
pyrrolidin
carbonic
Prior art date
Application number
GR900100368A
Other languages
English (en)
Inventor
Kurt Hamp
Karl Dr Petzoldt
Ralph Dr Schmiechen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of GR900100368A publication Critical patent/GR900100368A/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Περιγράφεται μία ενζυματική μέθοδος για τον διαχωρισμό ρακεμικών μορφών 4-αρυλο-2-οξο-πυρρολιδινο-3-καρβονικών εστέρων του γενικού χημικού τύπου Ι ω
GR900100368A 1989-06-28 1990-05-16 Μέ?οδος για τον διαχωρισμό των ρακεμικών μορφών 4-αρυλο-2-οξο-πυρρολιδινο-3-καρβονικών εστέρων. GR900100368A (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3921593A DE3921593A1 (de) 1989-06-28 1989-06-28 Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester

Publications (1)

Publication Number Publication Date
GR900100368A true GR900100368A (el) 1991-11-15

Family

ID=6384062

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100368A GR900100368A (el) 1989-06-28 1990-05-16 Μέ?οδος για τον διαχωρισμό των ρακεμικών μορφών 4-αρυλο-2-οξο-πυρρολιδινο-3-καρβονικών εστέρων.

Country Status (11)

Country Link
US (1) US5539111A (el)
EP (1) EP0437555B1 (el)
AT (1) ATE127159T1 (el)
CA (1) CA2026862A1 (el)
DD (1) DD295358A5 (el)
DE (2) DE3921593A1 (el)
DK (1) DK0437555T3 (el)
ES (1) ES2076369T3 (el)
GR (1) GR900100368A (el)
IE (1) IE902338A1 (el)
WO (1) WO1991000362A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003517266A (ja) * 1998-02-17 2003-05-27 ジー・ディー・サール・アンド・カンパニー ラクタムの酵素分割方法
CN1604776A (zh) 2001-10-16 2005-04-06 记忆药物公司 作为用于治疗神经病综合症的pde－4抑制剂的4－(4－烷氧基－3－羟基苯基)－2－吡咯烷酮衍生物
SG169900A1 (en) * 2003-04-16 2011-04-29 Memory Pharm Corp 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
RU2379292C2 (ru) * 2003-04-18 2010-01-20 Мемори Фармасьютиклз Корпорейшн Производные пиразола в качестве ингибиторов фосфодиэстеразы 4
US7148362B2 (en) * 2003-09-18 2006-12-12 Hoffmann-La Roche Inc. Process for the preparation of enantiopure pyrrolidin-2-one derivatives
CN101166733A (zh) * 2004-10-15 2008-04-23 记忆药物公司 作为磷酸二酯酶4抑制剂的吡唑衍生物
WO2006044955A1 (en) * 2004-10-20 2006-04-27 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008645A1 (de) * 1978-08-01 1980-03-19 Schering Aktiengesellschaft Alkoxyphenylpyrrolidone, Verfahren zu ihrer Herstellung und Arzneimittel auf Basis dieser Verbindungen
EP0197474A2 (en) * 1985-04-01 1986-10-15 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing optically active indoline-2-carboxylic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2413935A1 (de) * 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
JPS5931693A (ja) * 1982-08-13 1984-02-20 Kanegafuchi Chem Ind Co Ltd 光学活性オキサゾリジノン誘導体の製造方法
US4732853A (en) * 1984-11-21 1988-03-22 President And Fellows Of Harvard College Method of making chiral epoxy alcohols
US5180671A (en) * 1986-04-16 1993-01-19 Sumitomo Chemical Company, Limited Method for producing optically active cyclopropane carboxylic acid
US4879421A (en) * 1988-08-15 1989-11-07 General Electric Company Method for preparing optically active binaphthol and spiroibiindanol
EP0529483B1 (de) * 1991-08-22 1996-02-28 Lonza Ag Verfahren zur Herstellung von optisch aktiven 4-Amino-3-hydroxycarbonsäuren

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008645A1 (de) * 1978-08-01 1980-03-19 Schering Aktiengesellschaft Alkoxyphenylpyrrolidone, Verfahren zu ihrer Herstellung und Arzneimittel auf Basis dieser Verbindungen
EP0197474A2 (en) * 1985-04-01 1986-10-15 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing optically active indoline-2-carboxylic acid

Also Published As

Publication number Publication date
IE902338L (en) 1990-12-30
EP0437555A1 (de) 1991-07-24
WO1991000362A1 (de) 1991-01-10
DE59009580D1 (de) 1995-10-05
ATE127159T1 (de) 1995-09-15
DK0437555T3 (da) 1995-12-27
CA2026862A1 (en) 1990-12-29
ES2076369T3 (es) 1995-11-01
DD295358A5 (de) 1991-10-31
US5539111A (en) 1996-07-23
EP0437555B1 (de) 1995-08-30
IE902338A1 (en) 1991-01-16
DE3921593A1 (de) 1991-01-10

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