DK0437555T3 - Fremgangsmåde til racematadskillelse af 4-aryl-2-oxo-pyrrolidin-3-carboxylsyreestere - Google Patents

Fremgangsmåde til racematadskillelse af 4-aryl-2-oxo-pyrrolidin-3-carboxylsyreestere

Info

Publication number
DK0437555T3
DK0437555T3 DK90909039.1T DK90909039T DK0437555T3 DK 0437555 T3 DK0437555 T3 DK 0437555T3 DK 90909039 T DK90909039 T DK 90909039T DK 0437555 T3 DK0437555 T3 DK 0437555T3
Authority
DK
Denmark
Prior art keywords
oxo
pyrrolidine
aryl
carboxylic acid
acid esters
Prior art date
Application number
DK90909039.1T
Other languages
English (en)
Inventor
Karl Petzoldt
Ralph Schmiechen
Kurt Hamp
Matthias Gottwald
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0437555T3 publication Critical patent/DK0437555T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK90909039.1T 1989-06-28 1990-06-14 Fremgangsmåde til racematadskillelse af 4-aryl-2-oxo-pyrrolidin-3-carboxylsyreestere DK0437555T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3921593A DE3921593A1 (de) 1989-06-28 1989-06-28 Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-ester

Publications (1)

Publication Number Publication Date
DK0437555T3 true DK0437555T3 (da) 1995-12-27

Family

ID=6384062

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90909039.1T DK0437555T3 (da) 1989-06-28 1990-06-14 Fremgangsmåde til racematadskillelse af 4-aryl-2-oxo-pyrrolidin-3-carboxylsyreestere

Country Status (11)

Country Link
US (1) US5539111A (da)
EP (1) EP0437555B1 (da)
AT (1) ATE127159T1 (da)
CA (1) CA2026862A1 (da)
DD (1) DD295358A5 (da)
DE (2) DE3921593A1 (da)
DK (1) DK0437555T3 (da)
ES (1) ES2076369T3 (da)
GR (1) GR900100368A (da)
IE (1) IE902338A1 (da)
WO (1) WO1991000362A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1054996T3 (da) * 1998-02-17 2004-05-24 Searle & Co Fremgangsmåde til den enzymatiske adskillelse af lactamer
KR100951218B1 (ko) 2001-10-16 2010-04-05 메모리 파마슈티칼스 코포레이션 신경계 증후군의 치료를 위한 ｐｄｅ-4 억제제로서의4-(4-알콕시-3-히드록시페닐)-2-피롤리돈 유도체
CN1805929A (zh) * 2003-04-16 2006-07-19 记忆药物公司 磷酸二酯酶4抑制剂
AU2004232973A1 (en) * 2003-04-18 2004-11-04 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
US7148362B2 (en) 2003-09-18 2006-12-12 Hoffmann-La Roche Inc. Process for the preparation of enantiopure pyrrolidin-2-one derivatives
US7432266B2 (en) * 2004-10-15 2008-10-07 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US7585882B2 (en) * 2004-10-20 2009-09-08 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2413935A1 (de) * 1974-03-20 1975-10-16 Schering Ag 4-(polyalkoxy-phenyl)-2-pyrrolidone
DE2834114A1 (de) * 1978-08-01 1980-02-14 Schering Ag Polyalkoxyphenylpyrrolidone iii, verfahren zu ihrer herstellung und ihre verwendung
JPS5931693A (ja) * 1982-08-13 1984-02-20 Kanegafuchi Chem Ind Co Ltd 光学活性オキサゾリジノン誘導体の製造方法
US4732853A (en) * 1984-11-21 1988-03-22 President And Fellows Of Harvard College Method of making chiral epoxy alcohols
DE3680132D1 (de) * 1985-04-01 1991-08-14 Kanegafuchi Chemical Ind Verfahren zur herstellung von optisch aktiver indolin-2-carbonsaeure.
US5180671A (en) * 1986-04-16 1993-01-19 Sumitomo Chemical Company, Limited Method for producing optically active cyclopropane carboxylic acid
US4879421A (en) * 1988-08-15 1989-11-07 General Electric Company Method for preparing optically active binaphthol and spiroibiindanol
EP0529483B1 (de) * 1991-08-22 1996-02-28 Lonza Ag Verfahren zur Herstellung von optisch aktiven 4-Amino-3-hydroxycarbonsäuren

Also Published As

Publication number Publication date
ATE127159T1 (de) 1995-09-15
US5539111A (en) 1996-07-23
EP0437555A1 (de) 1991-07-24
EP0437555B1 (de) 1995-08-30
GR900100368A (el) 1991-11-15
IE902338L (en) 1990-12-30
IE902338A1 (en) 1991-01-16
DE59009580D1 (de) 1995-10-05
DE3921593A1 (de) 1991-01-10
DD295358A5 (de) 1991-10-31
CA2026862A1 (en) 1990-12-29
WO1991000362A1 (de) 1991-01-10
ES2076369T3 (es) 1995-11-01

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