|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US4714681A
(en)
|
1981-07-01 |
1987-12-22 |
The Board Of Reagents, The University Of Texas System Cancer Center |
Quadroma cells and trioma cells and methods for the production of same
|
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
US5262319A
(en)
|
1985-04-19 |
1993-11-16 |
Oncogene Science, Inc. |
Method for obtaining bone marrow free of tumor cells using transforming growth factor β3
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5001225A
(en)
|
1986-12-08 |
1991-03-19 |
Georgetown University |
Monoclonal antibodies to a pan-malarial antigen
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5024947A
(en)
|
1987-07-24 |
1991-06-18 |
Cetus Corporation |
Serum free media for the growth on insect cells and expression of products thereby
|
|
US5266683A
(en)
|
1988-04-08 |
1993-11-30 |
Stryker Corporation |
Osteogenic proteins
|
|
US4925648A
(en)
|
1988-07-29 |
1990-05-15 |
Immunomedics, Inc. |
Detection and treatment of infectious and inflammatory lesions
|
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP0436597B1
(en)
|
1988-09-02 |
1997-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
ES2096590T3
(es)
|
1989-06-29 |
1997-03-16 |
Medarex Inc |
Reactivos biespecificos para la terapia del sida.
|
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
JPH03180192A
(ja)
*
|
1989-12-07 |
1991-08-06 |
Kirin Brewery Co Ltd |
遺伝子組換えによるヒトプロＴＧＦ―β１の製造
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
AU667460B2
(en)
|
1990-10-05 |
1996-03-28 |
Medarex, Inc. |
Targeted immunostimulation with bispecific reagents
|
|
EP0557300B1
(en)
|
1990-10-29 |
1997-11-19 |
Chiron Corporation |
Bispecific antibodies, method of production, and uses thereof
|
|
CA2405246A1
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with alterred binding properties
|
|
DE69209734T2
(de)
|
1991-01-30 |
1996-08-08 |
Ihara Chemical Ind Co |
Dithiocarbaminsäure salze, verfahren zur herstellung und verfahren zur herstellung von isothiocyanaten aus diesen salzen
|
|
DK0580737T3
(da)
|
1991-04-10 |
2004-11-01 |
Scripps Research Inst |
Heterodimere receptorbiblioteker ved anvendelse af phagemider
|
|
IE921342A1
(en)
|
1991-04-26 |
1992-11-04 |
Surface Active Ltd |
Novel antibodies, and methods for their use
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
JP3452946B2
(ja)
|
1992-02-19 |
2003-10-06 |
協和醗酵工業株式会社 |
抗ＴＧＦ−βマスキングプロテインモノクローナル抗体
|
|
EP1306095A3
(en)
|
1992-03-05 |
2003-06-25 |
Board Of Regents, The University Of Texas System |
Methods and compositions for targeting the vasculature of solid tumors
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
ES2149768T3
(es)
|
1992-03-25 |
2000-11-16 |
Immunogen Inc |
Conjugados de agentes enlazantes de celulas derivados de cc-1065.
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
AU5587094A
(en)
|
1992-10-26 |
1994-05-24 |
Kirin Brewery Company, Limited |
Method for producing large latent transforming growth factor-beta complexes and large latency associated peptide
|
|
US5951983A
(en)
|
1993-03-05 |
1999-09-14 |
Universite Catholique De Louvain |
Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies
|
|
US5994618A
(en)
|
1997-02-05 |
1999-11-30 |
Johns Hopkins University School Of Medicine |
Growth differentiation factor-8 transgenic mice
|
|
DK0690873T3
(da)
|
1993-03-19 |
2003-09-29 |
Univ Johns Hopkins Med |
Vækstdifferentieringsfaktor-8
|
|
US7393682B1
(en)
*
|
1993-03-19 |
2008-07-01 |
The Johns Hopkins University School Of Medicine |
Polynucleotides encoding promyostatin polypeptides
|
|
US6465239B1
(en)
|
1993-03-19 |
2002-10-15 |
The John Hopkins University School Of Medicine |
Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
|
|
DE69434520T3
(de)
|
1993-07-30 |
2009-10-15 |
Affymax, Inc., Palo Alto |
Biotinylierung von proteinen
|
|
EP0733070A1
(en)
|
1993-12-08 |
1996-09-25 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
PT1231268E
(pt)
|
1994-01-31 |
2005-11-30 |
Univ Boston |
Bancos de anticorpos policlonais
|
|
US5972335A
(en)
|
1994-03-29 |
1999-10-26 |
The Victoria University Of Manchester |
Wound healing
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
US5541087A
(en)
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
|
US5786464C1
(en)
|
1994-09-19 |
2012-04-24 |
Gen Hospital Corp |
Overexpression of mammalian and viral proteins
|
|
US5919652A
(en)
|
1994-11-09 |
1999-07-06 |
The Regents Of The University Of California |
Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof
|
|
US5616561A
(en)
|
1995-03-31 |
1997-04-01 |
Regents Of The University Of California |
TGF-β antagonists as mitigators of radiation-induced tissue damage
|
|
CA2219361C
(en)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
US5967979A
(en)
|
1995-11-14 |
1999-10-19 |
Verg, Inc. |
Method and apparatus for photogrammetric assessment of biological tissue
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
KR20000064752A
(ko)
|
1996-03-22 |
2000-11-06 |
더 제네랄 호스피탈 코포레이션 |
중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
|
|
US6114148C1
(en)
|
1996-09-20 |
2012-05-01 |
Gen Hospital Corp |
High level expression of proteins
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
US6348584B1
(en)
|
1996-10-17 |
2002-02-19 |
John Edward Hodgson |
Fibronectin binding protein compounds
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
EP1958962A3
(en)
|
1997-06-12 |
2013-05-01 |
Novartis International Pharmaceutical Ltd. |
Artificial antibody polypeptides
|
|
DE69841139D1
(de)
|
1997-07-14 |
2009-10-22 |
Univ Liege |
Mutationen im myostatingen steigern muskelmasse in säugetieren
|
|
US6656475B1
(en)
*
|
1997-08-01 |
2003-12-02 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
|
|
US6891082B2
(en)
*
|
1997-08-01 |
2005-05-10 |
The Johns Hopkins University School Of Medicine |
Transgenic non-human animals expressing a truncated activintype II receptor
|
|
CA2304208A1
(en)
|
1997-09-19 |
1999-03-25 |
Dana-Farber Cancer Institute, Inc. |
Intrabody-mediated control of immune reactions
|
|
ES2330062T3
(es)
|
1998-05-06 |
2009-12-03 |
Metamorphix, Inc. |
Procedimientos para tratar la diabetes por inhibicion de gdf-8.
|
|
JP3762222B2
(ja)
|
1998-10-07 |
2006-04-05 |
ストライカー・コーポレーション |
改変型ＴＧＦ−βスーパーファミリータンパク質
|
|
AU772694B2
(en)
|
1999-01-21 |
2004-05-06 |
Metamorphix International, Inc. |
Growth differentiation factor inhibitors and uses therefor
|
|
GB2344886B
(en)
|
1999-03-10 |
2000-11-01 |
Medical Res Council |
Selection of intracellular immunoglobulins
|
|
EP1181041A2
(en)
|
1999-04-30 |
2002-02-27 |
Curis, Inc. |
Morphogen-induced enhancement of fertility
|
|
US6492497B1
(en)
|
1999-04-30 |
2002-12-10 |
Cambridge Antibody Technology Limited |
Specific binding members for TGFbeta1
|
|
US6784999B1
(en)
|
1999-05-17 |
2004-08-31 |
The Florida International University Board Of Trustees |
Surface plasmon resonance detection with high angular resolution and fast response time
|
|
US7056512B1
(en)
|
1999-07-20 |
2006-06-06 |
Pharmexa A/S |
Method for down-regulating GDF-8 activity
|
|
US7358056B1
(en)
|
1999-08-30 |
2008-04-15 |
Signal Pharmaceuticals |
Methods for modulating signal transduction mediated by TGF-β and related proteins
|
|
IT1317922B1
(it)
|
2000-10-24 |
2003-07-15 |
S I S S A Scuola Internaz Supe |
Metodo per identificare in vivo epitopi intracellulari.
|
|
US20030104402A1
(en)
|
2001-01-23 |
2003-06-05 |
University Of Rochester |
Methods of producing or identifying intrabodies in eukaryotic cells
|
|
DE10108240B4
(de)
|
2001-02-21 |
2018-06-28 |
Leica Microsystems Cms Gmbh |
Verfahren zur Abbildung und Vermessung mikroskopischer dreidimensionaler Strukturen
|
|
US20040047891A1
(en)
|
2001-02-26 |
2004-03-11 |
Sabina Glozman |
Systems devices and methods for intrabody targeted delivery and reloading of therapeutic agents
|
|
GB0108165D0
(en)
|
2001-03-31 |
2001-05-23 |
Univ Manchester |
Intracellular analysis
|
|
CA2453662A1
(en)
|
2001-07-19 |
2003-01-30 |
Stefan Ewert |
Modification of human variable domains
|
|
AU2002355477B2
(en)
|
2001-08-03 |
2008-09-25 |
Medical Research Council |
Method of identifying a consensus sequence for intracellular antibodies
|
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
|
US7241444B2
(en)
|
2002-01-18 |
2007-07-10 |
Pierre Fabre Medicament |
Anti-IGF-IR antibodies and uses thereof
|
|
GB0201611D0
(en)
|
2002-01-24 |
2002-03-13 |
Grosveld Frank |
Transgenic animal
|
|
GB0226723D0
(en)
|
2002-11-15 |
2002-12-24 |
Medical Res Council |
Antibodies for in vitro use
|
|
GB0226727D0
(en)
|
2002-11-15 |
2002-12-24 |
Medical Res Council |
Intrabodies
|
|
AU2003219277A1
(en)
|
2002-03-14 |
2003-09-29 |
Medical Research Council |
Intracellular antibodies
|
|
SI2332989T1
(sl)
|
2002-05-22 |
2015-06-30 |
Esbatech, An Alcon Biomedical Research Unit Llc |
Imunoglobulinski bralni okvirji, ki kaĺ˝ejo izboljĺ ano stabilnost v intraceliäśnem okolju, in postopki za njihovo identifikacijo
|
|
EP2192129A1
(en)
|
2002-09-16 |
2010-06-02 |
Johns Hopkins University |
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
|
|
AR047392A1
(es)
|
2002-10-22 |
2006-01-18 |
Wyeth Corp |
Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
|
|
US20040223966A1
(en)
|
2002-10-25 |
2004-11-11 |
Wolfman Neil M. |
ActRIIB fusion polypeptides and uses therefor
|
|
JP2006521088A
(ja)
|
2002-11-15 |
2006-09-21 |
メディカル リサーチ カウンシル |
抗活性化ｒａｓ抗体
|
|
GB0226729D0
(en)
|
2002-11-15 |
2002-12-24 |
Medical Res Council |
Intracellular antibodies
|
|
EP1482309A1
(en)
|
2003-05-07 |
2004-12-01 |
Institut Curie |
Means for detecting protein conformation and applications thereof
|
|
BRPI0410927A
(pt)
|
2003-06-02 |
2006-06-27 |
Wyeth Corp |
métodos terapêuticos e profiláticos para distúrbios neuromusculares
|
|
WO2005010049A2
(en)
|
2003-07-09 |
2005-02-03 |
Eli Lilly And Company |
Tgf-beta1 ligands
|
|
WO2005016254A2
(en)
*
|
2003-07-16 |
2005-02-24 |
The Ohio State University Research Foundation |
Methods and reagents for treating inflammation and fibrosis
|
|
WO2005013915A2
(en)
|
2003-08-08 |
2005-02-17 |
The Regents Of The University Of California |
Novel indications for transforming growth factor-beta regulators
|
|
JP4653660B2
(ja)
*
|
2003-09-04 |
2011-03-16 |
独立行政法人理化学研究所 |
ＴＧＦ−β活性化制御領域の切断面を認識する抗体
|
|
EP1677735B1
(en)
|
2003-10-17 |
2014-07-23 |
Joslin Diabetes Center, Inc. |
Methods and compositions for modulating adipocyte function
|
|
KR100500610B1
(ko)
|
2003-10-29 |
2005-07-11 |
한국전기연구원 |
형광 현미경 및 이를 사용한 관측 방법
|
|
CA2550933A1
(en)
|
2003-12-22 |
2005-07-14 |
Amgen Inc. |
Methods for identifying functional antibodies
|
|
CA2551877A1
(en)
|
2003-12-31 |
2005-07-21 |
Schering-Plough Ltd. |
Neutralizing epitope-based growth enhancing vaccine
|
|
EP1729793B1
(en)
|
2004-03-02 |
2015-07-22 |
Acceleron Pharma Inc. |
Alk7 and myostatin inhibitors for muscle wasting disorders
|
|
ATE557042T1
(de)
|
2004-03-23 |
2012-05-15 |
Lilly Co Eli |
Anti-myostatin-antikörper
|
|
AU2005247508A1
(en)
|
2004-05-27 |
2005-12-08 |
Acceleron Pharma Inc. |
Cerberus/coco derivatives and uses thereof
|
|
AU2005272646A1
(en)
|
2004-08-12 |
2006-02-23 |
Wyeth |
Combination therapy for diabetes, obesity, and cardiovascular diseases using GDF-8 inhibitors
|
|
JP4974892B2
(ja)
|
2004-09-15 |
2012-07-11 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
臍帯血由来のｔ調節性細胞の単離および増殖の方法
|
|
EA011879B1
(ru)
|
2004-09-24 |
2009-06-30 |
Эмджин Инк. |
МОЛЕКУЛЫ С МОДИФИЦИРОВАННЫМ Fc ФРАГМЕНТОМ
|
|
US20080118487A1
(en)
|
2004-09-30 |
2008-05-22 |
Orico Limited |
Myostatin Isoform
|
|
US20060121042A1
(en)
|
2004-10-27 |
2006-06-08 |
Medimmune, Inc. |
Modulation of antibody specificity by tailoring the affinity to cognate antigens
|
|
JP2008526201A
(ja)
|
2004-12-30 |
2008-07-24 |
シェーリング−プラウ・リミテッド |
中和エピトープベースの成長増強ワクチン
|
|
NZ538097A
(en)
|
2005-02-07 |
2006-07-28 |
Ovita Ltd |
Method and compositions for improving wound healing
|
|
WO2006086469A2
(en)
|
2005-02-08 |
2006-08-17 |
Genzyme Corporation |
Antibodies to tgfbeta
|
|
WO2006106599A1
(ja)
|
2005-03-01 |
2006-10-12 |
Kyoto University |
細胞外ドメインシェディングの異常亢進に起因する疾患の予防及び／又は治療のための医薬
|
|
WO2006103639A2
(en)
*
|
2005-03-31 |
2006-10-05 |
Case Western Reserve University |
Methods and reagents for identifying/isolating t regulatory (treg) cells and for treating individuals
|
|
ATE505489T1
(de)
|
2005-04-22 |
2011-04-15 |
Lilly Co Eli |
Tgf-beta-1-spezifische antikörper
|
|
NL1031674C2
(nl)
|
2005-04-25 |
2007-04-26 |
Pfizer |
Antilichamen tegen myostatine.
|
|
ES2534760T3
(es)
|
2005-08-19 |
2015-04-28 |
Wyeth Llc |
Anticuerpos antagonistas contra GDF-8 y sus usos en el tratamiento de ELA y otros trastornos asociados con GDF-8
|
|
BRPI0616923A2
(pt)
*
|
2005-10-06 |
2011-07-05 |
Lilly Co Eli |
anticorpos monoclonais, seus usos e composição farmacêutica
|
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
|
EP1948675B1
(en)
|
2005-10-25 |
2014-07-30 |
The Johns Hopkins University |
Methods and compositions for the treatment of marfan syndrome and associated disorders
|
|
EP2389947A1
(en)
|
2006-03-23 |
2011-11-30 |
Novartis AG |
Anti-tumor cell antigen antibody therapeutics
|
|
CA2661836A1
(en)
|
2006-09-05 |
2008-03-13 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
|
JP2008102117A
(ja)
|
2006-09-21 |
2008-05-01 |
Fujifilm Corp |
表面プラズモン増強蛍光センサおよび蛍光検出方法
|
|
DK2083863T3
(da)
|
2006-10-03 |
2015-06-22 |
Genzyme Corp |
Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi
|
|
WO2009018438A1
(en)
|
2007-07-31 |
2009-02-05 |
Cornell Research Foundation, Inc. |
Protein discovery using intracellular ribosome display
|
|
KR100988471B1
(ko)
|
2007-07-06 |
2010-10-18 |
전자부품연구원 |
실시간 세포 분석 장치 및 이를 이용한 세포의 대사 측정방법
|
|
US20100266577A1
(en)
|
2007-07-25 |
2010-10-21 |
Felipe Samaniego |
Method of Cancer Treatment with Antagonists of FAS Inhibitors
|
|
EP3178496A1
(en)
|
2007-08-24 |
2017-06-14 |
Keio University |
Fstl1 suppressor for use in the treatment of tumours
|
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
|
WO2009114702A2
(en)
|
2008-03-14 |
2009-09-17 |
Humanzyme Limited |
Recombinant production of authentic human proteins using human cell expression systems
|
|
GB0809592D0
(en)
|
2008-05-27 |
2008-07-02 |
Imp Innovations Ltd |
Biomaterials
|
|
EP2143735A1
(en)
|
2008-07-10 |
2010-01-13 |
Institut Pasteur |
Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
|
|
US20100009424A1
(en)
|
2008-07-14 |
2010-01-14 |
Natasha Forde |
Sonoporation systems and methods
|
|
AR074777A1
(es)
|
2008-12-19 |
2011-02-09 |
Glaxo Group Ltd |
Proteinas de union a antigeno
|
|
US8669085B2
(en)
|
2009-02-05 |
2014-03-11 |
Ut-Battelle, Llc |
Transformation of gram positive bacteria by sonoporation
|
|
BRPI1010587A2
(pt)
|
2009-06-08 |
2019-04-09 |
Acceleron Pharma Inc. |
métodos para aumentar adipócitos termogênicos
|
|
US8399624B1
(en)
|
2009-06-25 |
2013-03-19 |
Esbatech, An Alcon Biomedical Research Unit Llc |
Acceptor framework for CDR grafting
|
|
US8815779B2
(en)
|
2009-09-16 |
2014-08-26 |
SwitchGear Genomics, Inc. |
Transcription biomarkers of biological responses and methods
|
|
EP3818988A1
(en)
|
2009-11-03 |
2021-05-12 |
Acceleron Pharma Inc. |
Methods for treating fatty liver disease
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
JP6267425B2
(ja)
|
2009-11-17 |
2018-01-24 |
アクセルロン ファーマ， インコーポレイテッド |
筋ジストロフィー治療のためのユートロフィン誘導に関するａｃｔｒｉｉｂタンパク質およびその改変体およびその使用
|
|
US8637637B2
(en)
|
2010-01-12 |
2014-01-28 |
Bill Nai-Chau Sun |
Fc fusion proteins of human growth hormone
|
|
WO2011102483A1
(ja)
|
2010-02-19 |
2011-08-25 |
独立行政法人理化学研究所 |
ヒトTGF-βのLAPに結合する抗体
|
|
JO3340B1
(ar)
|
2010-05-26 |
2019-03-13 |
Regeneron Pharma |
مضادات حيوية لـعامل تمايز النمو 8 البشري
|
|
UY33421A
(es)
|
2010-06-03 |
2011-12-30 |
Glaxo Wellcome House |
Proteinas de union al antígeno humanizados
|
|
EP2407487A1
(en)
|
2010-07-14 |
2012-01-18 |
F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. |
Multispecific modular antibody
|
|
US8999343B2
(en)
|
2010-08-16 |
2015-04-07 |
Amgen Inc. |
Antibodies that bind myostatin, compositions and methods
|
|
CN103501815B
(zh)
|
2010-10-08 |
2016-09-28 |
希望之城公司 |
针对中间位的单克隆抗体框架结合界面、中间位投递系统及其使用方法
|
|
EP2703485B1
(en)
|
2011-03-30 |
2018-12-26 |
National University Corporation University Of Toyama |
Method for selecting plasma cells and plasmablasts, and method for producing target antigen-specific antibody
|
|
SG195253A1
(en)
*
|
2011-06-03 |
2013-12-30 |
Xoma Technology Ltd |
Antibodies specific for tgf-beta
|
|
US9505763B2
(en)
|
2011-07-25 |
2016-11-29 |
Vanderbilt University |
Cancer treatment using BMP inhibitor
|
|
CN103890246A
(zh)
|
2011-08-18 |
2014-06-25 |
亲和生物科学公司 |
可溶性多肽
|
|
WO2013033420A1
(en)
|
2011-08-30 |
2013-03-07 |
Whitehead Institute For Biomedical Research |
Methods of downregulating translocated oncogene expression using bromodomain inhibitors
|
|
KR102056932B1
(ko)
|
2011-10-10 |
2019-12-17 |
시티 오브 호프 |
메디토프와 메디토프-결합 항체 및 이들의 용도
|
|
AU2012339722B2
(en)
|
2011-11-14 |
2017-09-14 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and/or Activin A
|
|
LT2794658T
(lt)
|
2011-12-19 |
2017-05-10 |
Synimmune Gmbh |
Bispecifinė antikūno molekulė
|
|
EP2861617A1
(en)
|
2012-06-15 |
2015-04-22 |
Pfizer Inc. |
Improved antagonist antibodies against gdf-8 and uses therefor
|
|
EP3165535B1
(en)
|
2012-08-22 |
2019-05-15 |
Mogam Biotechnology Research Institute |
Screening and engineering method of super-stable immunoglobulin variable domains and their uses
|
|
TWI633117B
(zh)
|
2012-09-13 |
2018-08-21 |
必治妥美雅史谷比公司 |
結合至肌肉生長抑制素（ｍｙｏｓｔａｔｉｎ）以纖維連接蛋白爲主之支架結構域蛋白質
|
|
US20150284455A1
(en)
|
2012-11-06 |
2015-10-08 |
Scholar Rock, Inc. |
Compositions and methods for modulating cell signaling
|
|
US20150328249A1
(en)
|
2012-12-11 |
2015-11-19 |
Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center |
Modulation of myofiber repair by anti-myostatin strategies and/or ppar gamma ligands, alone or in combination with stem cells, for the therapy of critical limb ischemia and other ischemic processes affecting the skeletal muscle
|
|
RU2714733C2
(ru)
|
2013-03-15 |
2020-02-19 |
Мемориал Слоан-Кеттеринг Кэнсер Сентер |
Технологии мультимеризации
|
|
HRP20251426T1
(hr)
|
2013-05-06 |
2026-01-02 |
Scholar Rock, Inc. |
Sastavi i postupci za modulaciju faktora rasta
|
|
WO2015015003A1
(en)
|
2013-08-01 |
2015-02-05 |
Université Catholique de Louvain |
Anti-garp protein and uses thereof
|
|
EP2832747A1
(en)
|
2013-08-01 |
2015-02-04 |
Université Catholique de Louvain |
Anti-GARP protein and uses thereof
|
|
US20170073406A1
(en)
|
2014-05-06 |
2017-03-16 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
|
HK1243940A1
(zh)
|
2014-11-06 |
2018-07-27 |
Scholar Rock, Inc. |
抗原肌肉生长抑制素/潜在肌肉生长抑制素的抗体及其用途
|