|
GB9600384D0
(en)
|
1996-01-09 |
1996-03-13 |
Nyfotek As |
Dna glycosylases
|
|
US6886207B1
(en)
|
1999-06-14 |
2005-05-03 |
The Procter & Gamble Company |
Toothbrush
|
|
EP1235914A2
(en)
|
1999-11-24 |
2002-09-04 |
Joseph Rosenecker |
Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
|
|
US20040003420A1
(en)
|
2000-11-10 |
2004-01-01 |
Ralf Kuhn |
Modified recombinase
|
|
US20050222030A1
(en)
|
2001-02-21 |
2005-10-06 |
Anthony Allison |
Modified annexin proteins and methods for preventing thrombosis
|
|
WO2002068676A2
(en)
|
2001-02-27 |
2002-09-06 |
University Of Rochester |
METHODS AND COMPOSITIONS FOR MODIFYING APOLIPOPROTEIN B mRNA EDITING
|
|
AU2002330714A1
(en)
|
2001-05-30 |
2003-01-02 |
Biomedical Center |
In silico screening for phenotype-associated expressed sequences
|
|
US7300829B2
(en)
|
2003-06-02 |
2007-11-27 |
Applied Materials, Inc. |
Low temperature process for TFT fabrication
|
|
WO2010132092A2
(en)
|
2009-05-12 |
2010-11-18 |
The Scripps Research Institute |
Cytidine deaminase fusions and related methods
|
|
US20110104787A1
(en)
|
2009-11-05 |
2011-05-05 |
President And Fellows Of Harvard College |
Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences
|
|
EP2513296A4
(en)
|
2009-12-18 |
2013-05-22 |
Univ Leland Stanford Junior |
USE OF CYTIDINE DAMINASE ASSOCIATED ACTIVITIES TO PROMOTE DEMETHYLATION AND CELL REPROGRAMMEIRING
|
|
KR102096534B1
(ko)
|
2011-09-28 |
2020-04-03 |
에라 바이오테크, 에스.에이. |
분할된 인테인 및 그의 이용
|
|
CN103088008B
(zh)
|
2011-10-31 |
2014-08-20 |
中国科学院微生物研究所 |
胞苷脱氨酶及其编码基因和它们的应用
|
|
US20150017136A1
(en)
|
2013-07-15 |
2015-01-15 |
Cellectis |
Methods for engineering allogeneic and highly active t cell for immunotherapy
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
WO2013188037A2
(en)
|
2012-06-11 |
2013-12-19 |
Agilent Technologies, Inc |
Method of adaptor-dimer subtraction using a crispr cas6 protein
|
|
EP3431497B1
(en)
|
2012-06-27 |
2022-07-27 |
The Trustees of Princeton University |
Split inteins, conjugates and uses thereof
|
|
PL3360964T3
(pl)
|
2012-12-06 |
2020-03-31 |
Sigma-Aldrich Co. Llc |
Modyfikacja i regulacja genomu oparta na crispr
|
|
WO2014093655A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
US20140273230A1
(en)
|
2013-03-15 |
2014-09-18 |
Sigma-Aldrich Co., Llc |
Crispr-based genome modification and regulation
|
|
FI2997141T3
(fi)
|
2013-05-13 |
2022-12-15 |
|
CD19-spesifinen kimeerinen antigeenireseptori ja sen käyttöjä
|
|
WO2014186686A2
(en)
|
2013-05-17 |
2014-11-20 |
Two Blades Foundation |
Targeted mutagenesis and genome engineering in plants using rna-guided cas nucleases
|
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
|
EP3666892A1
(en)
|
2013-07-10 |
2020-06-17 |
President and Fellows of Harvard College |
Orthogonal cas9 proteins for rna-guided gene regulation and editing
|
|
WO2015021426A1
(en)
|
2013-08-09 |
2015-02-12 |
Sage Labs, Inc. |
A crispr/cas system-based novel fusion protein and its application in genome editing
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
EP3835419A1
(en)
|
2013-12-12 |
2021-06-16 |
The Regents of The University of California |
Methods and compositions for modifying a single stranded target nucleic acid
|
|
JP6793547B2
(ja)
*
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
|
|
ES2918501T3
(es)
|
2013-12-19 |
2022-07-18 |
Novartis Ag |
Receptores de antígenos quiméricos de mesotelina humana y usos de los mismos
|
|
WO2015092024A2
(en)
|
2013-12-20 |
2015-06-25 |
Cellectis |
Method of engineering multi-input signal sensitive t cell for immunotherapy
|
|
EP3115457B1
(en)
|
2014-03-05 |
2019-10-02 |
National University Corporation Kobe University |
Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
|
|
US20170335281A1
(en)
|
2014-03-15 |
2017-11-23 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor
|
|
KR20170032406A
(ko)
|
2014-07-15 |
2017-03-22 |
주노 쎄러퓨티크스 인코퍼레이티드 |
입양 세포 치료를 위한 조작된 세포
|
|
US10544201B2
(en)
|
2014-07-31 |
2020-01-28 |
Cellectis |
ROR1 specific multi-chain chimeric antigen receptor
|
|
EP3186375A4
(en)
|
2014-08-28 |
2019-03-13 |
North Carolina State University |
Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING
|
|
BR112017007765B1
(pt)
|
2014-10-14 |
2023-10-03 |
Halozyme, Inc |
Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo
|
|
WO2016061368A1
(en)
|
2014-10-15 |
2016-04-21 |
The Children's Hospital Of Philadelphia |
Compositions and methods for treating b-lymphoid malignancies
|
|
US10258697B2
(en)
|
2014-10-29 |
2019-04-16 |
Massachusetts Eye And Ear Infirmary |
Efficient delivery of therapeutic molecules in vitro and in vivo
|
|
PT3216867T
(pt)
|
2014-11-04 |
2020-07-16 |
Univ Kobe Nat Univ Corp |
Método para modificar a sequência de genoma para introduzir mutação específica a sequência de adn alvo por reação de remoção de bases, e complexo molecular nele utilizado
|
|
MA40921A
(fr)
|
2014-11-05 |
2017-09-12 |
Abbvie Stemcentrx Llc |
Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation
|
|
WO2016075612A1
(en)
|
2014-11-12 |
2016-05-19 |
Rinat Neuroscience Corp. |
Inhibitory chimeric antigen receptors
|
|
HRP20191873T1
(hr)
|
2014-12-12 |
2020-01-24 |
Bluebird Bio, Inc. |
Kimerni antigenski receptori
|
|
WO2016100955A2
(en)
|
2014-12-20 |
2016-06-23 |
Identifygenomics, Llc |
Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins
|
|
EP3250689B1
(en)
*
|
2015-01-28 |
2020-11-04 |
The Regents of The University of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
MA41613A
(fr)
|
2015-02-23 |
2018-01-02 |
Abbvie Stemcentrx Llc |
Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs
|
|
JP2018522249A
(ja)
|
2015-04-24 |
2018-08-09 |
エディタス・メディシン、インコーポレイテッド |
Ｃａｓ９分子／ガイドｒｎａ分子複合体の評価
|
|
US20180291372A1
(en)
|
2015-05-14 |
2018-10-11 |
Massachusetts Institute Of Technology |
Self-targeting genome editing system
|
|
WO2016196388A1
(en)
|
2015-05-29 |
2016-12-08 |
Juno Therapeutics, Inc. |
Composition and methods for regulating inhibitory interactions in genetically engineered cells
|
|
EP3331582A4
(en)
|
2015-05-29 |
2019-08-07 |
Agenovir Corporation |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF TRANSPLANTATION CELLS
|
|
WO2016196655A1
(en)
*
|
2015-06-03 |
2016-12-08 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
|
TWI906646B
(zh)
*
|
2015-06-18 |
2025-12-01 |
美商博得學院股份有限公司 |
降低脫靶效應的ｃｒｉｓｐｒ酶突變
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
JP7044373B2
(ja)
|
2015-07-15 |
2022-03-30 |
ラトガース，ザ ステート ユニバーシティ オブ ニュージャージー |
ヌクレアーゼ非依存的な標的化遺伝子編集プラットフォームおよびその用途
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
AU2016323985B2
(en)
|
2015-09-17 |
2022-12-15 |
Novartis Ag |
CAR T cell therapies with enhanced efficacy
|
|
US11008555B2
(en)
*
|
2015-09-17 |
2021-05-18 |
The Regents Of The University Of California |
Variant Cas9 polypeptides comprising internal insertions
|
|
IL310721B2
(en)
|
2015-10-23 |
2025-11-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
BR112018008442A2
(pt)
|
2015-11-05 |
2018-11-06 |
Juno Therapeutics Inc |
receptores quiméricos contendo domínios induto-res de traf e composições e métodos relacionados
|
|
US11020429B2
(en)
|
2015-11-05 |
2021-06-01 |
Juno Therapeutics, Inc. |
Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
|
|
PT3408292T
(pt)
|
2016-01-29 |
2023-07-19 |
Univ Princeton |
Inteínas divididas com excecional atividade de splicing
|
|
EP3443002A4
(en)
|
2016-04-14 |
2019-12-04 |
Bluebird Bio, Inc. |
SYSTEMS FOR RECOVERED CHIMERIC ANTIGEN RECEPTORS
|
|
KR102546839B1
(ko)
|
2016-08-03 |
2023-06-23 |
워싱턴 유니버시티 |
키메라 항원 수용체를 이용한 t 세포 악성종양의 치료를 위한 car-t 세포의 유전자 편집
|
|
CN110214183A
(zh)
|
2016-08-03 |
2019-09-06 |
哈佛大学的校长及成员们 |
腺苷核碱基编辑器及其用途
|
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
KR102622411B1
(ko)
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
SG10201913505WA
(en)
*
|
2016-10-17 |
2020-02-27 |
Univ Nanyang Tech |
Truncated crispr-cas proteins for dna targeting
|
|
WO2018085690A1
(en)
|
2016-11-04 |
2018-05-11 |
Bluebird Bio, Inc. |
Anti-bcma car t cell compositions
|
|
EP3538561A4
(en)
|
2016-11-11 |
2020-10-21 |
The Regents of The University of California |
RNA-GUIDED VARIANT POLYPEPTIDES AND THEIR METHODS OF USE
|
|
US11192929B2
(en)
*
|
2016-12-08 |
2021-12-07 |
Regents Of The University Of Minnesota |
Site-specific DNA base editing using modified APOBEC enzymes
|
|
SG10202106058WA
(en)
|
2016-12-08 |
2021-07-29 |
Intellia Therapeutics Inc |
Modified guide rnas
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
KR20230125856A
(ko)
|
2016-12-23 |
2023-08-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
Pcsk9의 유전자 편집
|
|
EP3565608A4
(en)
|
2017-01-05 |
2020-12-16 |
Rutgers, The State University of New Jersey |
TARGETED GENE EDITING PLATFORM INDEPENDENT OF BICATENARY DNA BREAKAGE AND ITS USES
|
|
WO2018152197A1
(en)
|
2017-02-15 |
2018-08-23 |
Massachusetts Institute Of Technology |
Dna writers, molecular recorders and uses thereof
|
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
KR20240116572A
(ko)
*
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
US11591589B2
(en)
|
2017-04-21 |
2023-02-28 |
The General Hospital Corporation |
Variants of Cpf1 (Cas12a) with altered PAM specificity
|
|
WO2018213726A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
EP3630849A4
(en)
|
2017-05-25 |
2021-01-13 |
The General Hospital Corporation |
BIPARTITE BASIC EDITOR (BBE) AND TYPE II-C-CAS9 ZINC FINGER EDITOR ARCHITECTURES
|
|
KR102761791B1
(ko)
|
2017-06-26 |
2025-02-05 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법
|
|
WO2019005886A1
(en)
|
2017-06-26 |
2019-01-03 |
The Broad Institute, Inc. |
CRISPR / CAS-CYTIDINE DEAMINASE COMPOSITIONS, SYSTEMS AND METHODS FOR TARGETED EDITING OF NUCLEIC ACIDS
|
|
US10392616B2
(en)
|
2017-06-30 |
2019-08-27 |
Arbor Biotechnologies, Inc. |
CRISPR RNA targeting enzymes and systems and uses thereof
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
CA3073448A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
CN109957569B
(zh)
|
2017-12-22 |
2022-10-25 |
苏州齐禾生科生物科技有限公司 |
基于cpf1蛋白的碱基编辑系统和方法
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
CA3108281A1
(en)
|
2018-08-03 |
2020-02-06 |
Beam Therapeutics Inc. |
Multi-effector nucleobase editors and methods of using same to modify a nucleic acid target sequence
|
|
EP3841203A4
(en)
|
2018-08-23 |
2022-11-02 |
The Broad Institute Inc. |
CAS9 VARIANTS WITH NON-CANONICAL PAM SPECIFICITIES AND THEIR USES
|
|
EP3847254A4
(en)
|
2018-09-07 |
2022-08-10 |
Beam Therapeutics Inc. |
COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM
|
|
EP3887521A1
(en)
|
2018-11-29 |
2021-10-06 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
AU2020215730A1
(en)
|
2019-01-31 |
2021-07-29 |
Beam Therapeutics Inc. |
Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors
|
|
WO2020160517A1
(en)
|
2019-01-31 |
2020-08-06 |
Beam Therapeutics Inc. |
Nucleobase editors having reduced off-target deamination and methods of using same to modify a nucleobase target sequence
|
|
US11946040B2
(en)
|
2019-02-04 |
2024-04-02 |
The General Hospital Corporation |
Adenine DNA base editor variants with reduced off-target RNA editing
|
|
CN120174005A
(zh)
|
2019-02-13 |
2025-06-20 |
比姆医疗股份有限公司 |
具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
|
|
US20220098593A1
(en)
|
2019-02-13 |
2022-03-31 |
Beam Therapeutics Inc. |
Splice acceptor site disruption of a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
|
|
WO2020168088A1
(en)
|
2019-02-13 |
2020-08-20 |
Beam Therapeutics Inc. |
Compositions and methods for treating glycogen storage disease type 1a
|
|
CA3128755C
(en)
|
2019-02-13 |
2024-06-04 |
Beam Therapeutics Inc. |
Compositions and methods for treating hemoglobinopathies
|
|
US20230140953A1
(en)
|
2019-02-13 |
2023-05-11 |
Beam Therapeutics Inc. |
Methods of editing a disease-associated gene using adenosine deaminase base editors, including for the treatment of genetic disease
|
|
JP7693552B2
(ja)
|
2019-02-13 |
2025-06-17 |
ビーム セラピューティクス インク． |
アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法
|
|
KR20210126680A
(ko)
|
2019-02-13 |
2021-10-20 |
빔 테라퓨틱스, 인크. |
알파-1 항트립신 결핍증을 치료하기 위한 조성물 및 방법
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
KR102258713B1
(ko)
|
2019-07-31 |
2021-05-31 |
한양대학교 산학협력단 |
사이토신 염기교정용 조성물 및 이의 용도
|
|
AU2020344547A1
(en)
|
2019-09-09 |
2022-03-24 |
Beam Therapeutics Inc. |
Novel nucleobase editors and methods of using same
|
|
AU2020466994A1
(en)
|
2019-09-17 |
2022-04-21 |
Rutgers, The State University Of New Jersey |
Highly efficient DNA base editors mediated by RNA-aptamer recruitment for targeted genome modification and uses thereof
|
|
EP4051788A4
(en)
|
2019-10-30 |
2023-12-06 |
Pairwise Plants Services, Inc. |
TYPE V CRISPR CAS BASE EDITORS AND METHODS OF USE THEREOF
|
|
US20230086199A1
(en)
|
2019-11-26 |
2023-03-23 |
The Broad Institute, Inc. |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
|
EP4100032B1
(en)
|
2020-02-05 |
2025-10-15 |
The Broad Institute, Inc. |
Gene editing methods for treating spinal muscular atrophy
|
|
EP4100519A2
(en)
|
2020-02-05 |
2022-12-14 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
|
JP2023517890A
(ja)
|
2020-03-04 |
2023-04-27 |
スージョウ チー バイオデザイン バイオテクノロジー カンパニー リミテッド |
改善されたシトシン塩基編集システム
|
|
JP2023518395A
(ja)
|
2020-03-19 |
2023-05-01 |
インテリア セラピューティクス，インコーポレイテッド |
指向性ゲノム編集のための方法及び組成物
|
|
EP4132951A4
(en)
|
2020-04-09 |
2025-06-11 |
Verve Therapeutics, Inc. |
CHEMICALLY MODIFIED GENE EDITING GUIDE RNAS WITH CAS12B
|
|
WO2022008935A1
(en)
|
2020-07-10 |
2022-01-13 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
|
US20240247242A1
(en)
|
2020-07-15 |
2024-07-25 |
LifeEDIT Therapeutics, Inc. |
Uracil stabilizing proteins and active fragments and variants thereof and methods of use
|
|
JP2023540797A
(ja)
|
2020-09-11 |
2023-09-26 |
メタゲノミ，インコーポレイテッド |
塩基編集酵素
|
|
MX2023002848A
(es)
|
2020-09-11 |
2023-03-22 |
Lifeedit Therapeutics Inc |
Enzimas modificadoras del acido desoxirribonucleico (adn) y fragmentos activos y sus variantes y metodos de uso.
|
|
IT202000028688A1
(it)
|
2020-11-27 |
2022-05-27 |
Consiglio Nazionale Ricerche |
Varianti della citidina deaminasi per l’editazione di basi
|
|
CA3207144A1
(en)
|
2021-01-05 |
2022-07-14 |
Horizon Discovery Limited |
Method for producing genetically modified cells
|
|
JP2024502348A
(ja)
|
2021-01-05 |
2024-01-18 |
ホライズン・ディスカバリー・リミテッド |
Ｔｒａｃｒ不含 Ｖ型Ｃａｓシステム用のガイドＲＮＡデザインおよび複合体
|
|
WO2022150372A1
(en)
|
2021-01-05 |
2022-07-14 |
Horizon Discovery Ltd. |
Guide rna designs and complexes for type v cas systems
|
|
CA3208612A1
(en)
|
2021-02-19 |
2022-08-25 |
Beam Therapeutics Inc. |
Recombinant rabies viruses for gene therapy
|
|
EP4313118A4
(en)
|
2021-03-26 |
2025-06-18 |
Beam Therapeutics Inc. |
ADENOSINE DEAMINASE VARIANTS AND THEIR USES
|
|
US20240327859A1
(en)
|
2021-07-02 |
2024-10-03 |
University Of Maryland, College Park |
Cytidine deaminases and methods of genome editing using the same
|
|
CA3225808A1
(en)
|
2021-07-16 |
2023-01-19 |
David R. Liu |
Context-specific adenine base editors and uses thereof
|
|
US20240352439A1
(en)
|
2021-09-03 |
2024-10-24 |
The University Of Chicago |
Polypeptides and methods for modifying nucleic acids
|
|
IL311607A
(en)
|
2021-09-22 |
2024-05-01 |
Verve Therapeutics Inc |
PCSK9 or ANGPTL3 gene editing and preparations and methods for using them to treat the disease
|
|
US20230105319A1
(en)
|
2021-09-24 |
2023-04-06 |
Crispr Therapeutics Ag |
PRODRUG INCORPORATED sgRNA SYNTHESIS
|
|
WO2023125814A1
(zh)
|
2021-12-29 |
2023-07-06 |
华东师范大学 |
腺嘌呤脱氨酶及其应用
|
|
CN119013310A
(zh)
|
2022-02-17 |
2024-11-22 |
正序(上海)生物科技有限公司 |
具有改善的编辑精确度的突变的胞嘧啶脱氨酶
|
|
CN114634923B
(zh)
|
2022-04-07 |
2024-02-23 |
尧唐(上海)生物科技有限公司 |
腺苷脱氨酶、碱基编辑器融合蛋白、碱基编辑器系统及用途
|
|
EP4532704A2
(en)
|
2022-05-26 |
2025-04-09 |
UCB Biopharma SRL |
Novel nucleic acid-editing proteins
|
|
EP4540378A1
(en)
|
2022-06-20 |
2025-04-23 |
CRISPR Therapeutics AG |
Base editing proteins and uses thereof
|
|
AU2023288909A1
(en)
|
2022-06-23 |
2025-01-09 |
Basf Agricultural Solutions Us Llc |
Diversifying base editing
|
|
WO2024040083A1
(en)
|
2022-08-16 |
2024-02-22 |
The Broad Institute, Inc. |
Evolved cytosine deaminases and methods of editing dna using same
|
|
KR20250075667A
(ko)
|
2022-09-23 |
2025-05-28 |
기초과학연구원 |
신규한 아데닌 탈아미노효소 변이체 및 이를 사용한 염기 교정 방법
|
|
EP4594486A2
(en)
|
2022-09-26 |
2025-08-06 |
Beam Therapeutics Inc. |
Synthetic polypeptides and uses thereof
|
|
WO2024179426A2
(en)
|
2023-02-28 |
2024-09-06 |
Accuredit Therapeutics (Suzhou) Co., Ltd. |
Deaminases for use in base editing
|
|
EP4688814A1
(en)
|
2023-04-27 |
2026-02-11 |
University of Massachusetts |
Cas-embedded cytidine deaminase ribonucleoprotein complexes having improved base editing specificity and efficiency
|
|
CN121079412A
(zh)
|
2023-04-28 |
2025-12-05 |
比姆医疗股份有限公司 |
经修饰的指导rna
|
|
AU2024303631A1
(en)
|
2023-06-15 |
2025-12-11 |
Beam Therapeutics Inc. |
Methods and compositions for treating alpha-1 antitrypsin deficiency
|
|
CN117965505A
(zh)
|
2023-06-28 |
2024-05-03 |
微光基因(苏州)有限公司 |
工程化的腺苷脱氨酶及碱基编辑器
|