JP2023542705A5 - - Google Patents
Info
- Publication number
- JP2023542705A5 JP2023542705A5 JP2023519028A JP2023519028A JP2023542705A5 JP 2023542705 A5 JP2023542705 A5 JP 2023542705A5 JP 2023519028 A JP2023519028 A JP 2023519028A JP 2023519028 A JP2023519028 A JP 2023519028A JP 2023542705 A5 JP2023542705 A5 JP 2023542705A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- domain
- cytidine deaminase
- fusion protein
- sequence ids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063083662P | 2020-09-25 | 2020-09-25 | |
| US63/083,662 | 2020-09-25 | ||
| US202163164893P | 2021-03-23 | 2021-03-23 | |
| US63/164,893 | 2021-03-23 | ||
| US202163230580P | 2021-08-06 | 2021-08-06 | |
| US63/230,580 | 2021-08-06 | ||
| PCT/US2021/052088 WO2022067122A1 (en) | 2020-09-25 | 2021-09-24 | Zinc finger fusion proteins for nucleobase editing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023542705A JP2023542705A (ja) | 2023-10-11 |
| JP2023542705A5 true JP2023542705A5 (https=) | 2024-10-07 |
Family
ID=78500694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023519028A Pending JP2023542705A (ja) | 2020-09-25 | 2021-09-24 | 核酸塩基編集のためのジンクフィンガー融合タンパク質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240043829A1 (https=) |
| EP (1) | EP4217479A1 (https=) |
| JP (1) | JP2023542705A (https=) |
| KR (1) | KR20230074519A (https=) |
| CN (1) | CN116261594A (https=) |
| AU (1) | AU2021350099A1 (https=) |
| CA (1) | CA3196599A1 (https=) |
| IL (1) | IL301393A (https=) |
| WO (1) | WO2022067122A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022072393A1 (en) * | 2020-09-29 | 2022-04-07 | University Of Washington | Use of a double-stranded dna cytosine deaminase for mapping dna-protein interactions |
| JP2026501648A (ja) * | 2022-12-30 | 2026-01-16 | 北京大学 | 塩基エディターシステムおよびその使用方法 |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| DE69534629D1 (de) | 1994-01-18 | 2005-12-29 | Scripps Research Inst | Derivate von zinkfingerproteinen und methoden |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| USRE39229E1 (en) | 1994-08-20 | 2006-08-08 | Gendaq Limited | Binding proteins for recognition of DNA |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| AU2001263155A1 (en) | 2000-05-16 | 2001-11-26 | Massachusetts Institute Of Technology | Methods and compositions for interaction trap assays |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| JP2005500061A (ja) | 2001-08-20 | 2005-01-06 | ザ スクリップス リサーチ インスティテュート | Ｃｎｎについての亜鉛フィンガー結合ドメイン |
| CA2607104A1 (en) * | 2005-05-05 | 2006-11-16 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Sequence enabled reassembly (seer) - a novel method for visualizing specific dna sequences |
| ES2582091T3 (es) | 2005-10-18 | 2016-09-09 | Precision Biosciences | Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas |
| US9394531B2 (en) | 2008-05-28 | 2016-07-19 | Sangamo Biosciences, Inc. | Compositions for linking DNA-binding domains and cleavage domains |
| US8586526B2 (en) | 2010-05-17 | 2013-11-19 | Sangamo Biosciences, Inc. | DNA-binding proteins and uses thereof |
| ES2751916T3 (es) | 2010-02-08 | 2020-04-02 | Sangamo Therapeutics Inc | Semidominios de escisión genomanipulados |
| HRP20200254T1 (hr) | 2010-05-03 | 2020-05-29 | Sangamo Therapeutics, Inc. | Pripravci za povezivanje modula cink fingera |
| CN106459894B (zh) | 2014-03-18 | 2020-02-18 | 桑格摩生物科学股份有限公司 | 用于调控锌指蛋白表达的方法和组合物 |
| KR102455249B1 (ko) | 2016-08-24 | 2022-10-17 | 상가모 테라퓨틱스, 인코포레이티드 | 가공된 표적 특이적 뉴클레아제 |
| EP3630849A4 (en) * | 2017-05-25 | 2021-01-13 | The General Hospital Corporation | BIPARTITE BASIC EDITOR (BBE) AND TYPE II-C-CAS9 ZINC FINGER EDITOR ARCHITECTURES |
| AU2019326408A1 (en) * | 2018-08-23 | 2021-03-11 | Sangamo Therapeutics, Inc. | Engineered target specific base editors |
| US20250011748A1 (en) * | 2020-01-28 | 2025-01-09 | The Broad Institute, Inc. | Base editors, compositions, and methods for modifying the mitochondrial genome |
| BR112023005073A2 (pt) * | 2020-09-18 | 2023-10-31 | Inst Basic Science | Desaminase direcionada e edição de base usando a mesma |
| JP2024502630A (ja) * | 2021-01-12 | 2024-01-22 | マーチ セラピューティクス， インコーポレイテッド | コンテキスト依存性二本鎖ｄｎａ特異的デアミナーゼ及びその使用 |
-
2021
- 2021-09-24 CN CN202180066106.XA patent/CN116261594A/zh active Pending
- 2021-09-24 AU AU2021350099A patent/AU2021350099A1/en not_active Abandoned
- 2021-09-24 IL IL301393A patent/IL301393A/en unknown
- 2021-09-24 JP JP2023519028A patent/JP2023542705A/ja active Pending
- 2021-09-24 US US18/246,574 patent/US20240043829A1/en active Pending
- 2021-09-24 KR KR1020237013407A patent/KR20230074519A/ko active Pending
- 2021-09-24 EP EP21802040.2A patent/EP4217479A1/en active Pending
- 2021-09-24 WO PCT/US2021/052088 patent/WO2022067122A1/en not_active Ceased
- 2021-09-24 CA CA3196599A patent/CA3196599A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023542705A5 (https=) | ||
| JP7216877B2 (ja) | 新規なＣＲＩＳＰＲ／Ｃａｓ１２ｆ酵素およびシステム | |
| CN103224947B (zh) | 一种基因打靶系统 | |
| US11634463B2 (en) | Methods and compositions for treating hemophilia | |
| JP2022519507A5 (https=) | ||
| JP2023510352A5 (https=) | ||
| Wu et al. | Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4 | |
| EP3071592B1 (en) | Artificial dna-binding proteins and uses thereof | |
| JP2025102784A5 (https=) | ||
| KR20190005801A (ko) | 표적 특이적 crispr 변이체 | |
| US20250154505A1 (en) | Effector proteins and methods of use | |
| JP2022166155A (ja) | 肝臓において目的のタンパク質を発現するためのプラットフォーム | |
| KR20180101442A (ko) | Dna-결합 도메인 및 절단 도메인을 연결시키기 위한 조성물 | |
| WO2022092317A1 (ja) | エンジニアリングされたＣａｓ１２ｆタンパク質 | |
| WO2019127087A1 (zh) | 基因组编辑系统和方法 | |
| WO2012136476A1 (en) | Method of activating a target gene in a cell | |
| JP2024073630A (ja) | 新規転写アクチベーター | |
| US20250179454A1 (en) | Fusion proteins and uses thereof for precision editing | |
| CN118599013A (zh) | 一种具有胞嘧啶脱氨功能的融合蛋白及其应用 | |
| KR102617424B1 (ko) | 동물 세포에서 표적 ｄｎａ의 메틸화 감소와 표적 유전자의 발현 증가를 위한 조성물, 키트, 및 이를 이용한 방법 | |
| KR20200125191A (ko) | 표적 특이적 crispr 변이체 | |
| WO2025102267A9 (en) | TREATMENT OF β‐HEMOGLOBINOPATHIES BY GENE EDITING | |
| KR20190037167A (ko) | 혈액응고인자 viii 유전자 역위 보정능의 유전자 가위 시스템으로 구성된 혈우병 치료용 조성물 | |
| CN119709700A (zh) | 一种靶向范围更广的Cas12f核酸酶及其衍生基因编辑工具 | |
| AU2024302819A1 (en) | Zinc finger protein, zinc finger nuclease, vector, and genome editing method using said substances |