JP2022519507A5 - - Google Patents
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- Publication number
- JP2022519507A5 JP2022519507A5 JP2021544294A JP2021544294A JP2022519507A5 JP 2022519507 A5 JP2022519507 A5 JP 2022519507A5 JP 2021544294 A JP2021544294 A JP 2021544294A JP 2021544294 A JP2021544294 A JP 2021544294A JP 2022519507 A5 JP2022519507 A5 JP 2022519507A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025034660A JP2025102784A (ja) | 2019-01-31 | 2025-03-05 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962799702P | 2019-01-31 | 2019-01-31 | |
| US62/799,702 | 2019-01-31 | ||
| PCT/US2020/016285 WO2020160514A1 (en) | 2019-01-31 | 2020-01-31 | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025034660A Division JP2025102784A (ja) | 2019-01-31 | 2025-03-05 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022519507A JP2022519507A (ja) | 2022-03-24 |
| JP2022519507A5 true JP2022519507A5 (https=) | 2023-02-06 |
| JPWO2020160514A5 JPWO2020160514A5 (https=) | 2023-02-06 |
| JP7646552B2 JP7646552B2 (ja) | 2025-03-17 |
Family
ID=71842366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021544294A Active JP7646552B2 (ja) | 2019-01-31 | 2020-01-31 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
| JP2025034660A Pending JP2025102784A (ja) | 2019-01-31 | 2025-03-05 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025034660A Pending JP2025102784A (ja) | 2019-01-31 | 2025-03-05 | 低減された非標的脱アミノ化を有する核酸塩基エディターおよび核酸塩基エディターの特徴づけのためのアッセイ |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3918078A4 (https=) |
| JP (2) | JP7646552B2 (https=) |
| KR (1) | KR20210121113A (https=) |
| CN (1) | CN114040977B (https=) |
| AU (1) | AU2020215730A1 (https=) |
| CA (1) | CA3127493A1 (https=) |
| WO (1) | WO2020160514A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN121555430A (zh) | 2018-05-11 | 2026-02-24 | 比姆医疗股份有限公司 | 使用可编程碱基编辑器系统取代病原性氨基酸的方法 |
| KR20210055733A (ko) | 2018-09-07 | 2021-05-17 | 빔 테라퓨틱스, 인크. | 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 |
| EP3850088A4 (en) | 2018-09-07 | 2023-07-19 | Beam Therapeutics, Inc. | Compositions and methods for improving base editing |
| WO2020168122A1 (en) | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| IL296024A (en) | 2020-03-04 | 2022-10-01 | Flagship Pioneering Innovations Vi Llc | Methods and compositions for modulating a genome |
| WO2021222318A1 (en) | 2020-04-28 | 2021-11-04 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
| CA3194019A1 (en) * | 2020-09-04 | 2022-03-10 | National University Corporation Kobe University | Miniaturized cytidine deaminase-containing complex for modifying double-stranded dna |
| AU2021347359A1 (en) | 2020-09-25 | 2023-05-18 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| CN116601293A (zh) * | 2020-12-07 | 2023-08-15 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| CN113308451B (zh) * | 2020-12-07 | 2023-07-25 | 中国科学院动物研究所 | 工程化的Cas效应蛋白及其使用方法 |
| CA3214494A1 (en) * | 2021-03-26 | 2022-09-29 | Beam Therapeutics Inc. | Adenosine deaminase variants and uses thereof |
| WO2022221699A1 (en) * | 2021-04-16 | 2022-10-20 | Beam Therapeutics, Inc. | Genetic modification of hepatocytes |
| WO2023283092A1 (en) * | 2021-07-06 | 2023-01-12 | Prime Medicine, Inc. | Compositions and methods for efficient genome editing |
| JP2024533311A (ja) | 2021-09-08 | 2024-09-12 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ゲノムを調節するための方法及び組成物 |
| CN117925585A (zh) * | 2022-04-07 | 2024-04-26 | 尧唐(上海)生物科技有限公司 | 腺苷脱氨酶、碱基编辑器融合蛋白、碱基编辑器系统及用途 |
| WO2025119307A1 (zh) * | 2023-12-06 | 2025-06-12 | 北京齐禾生科生物科技有限公司 | 优化的qbe碱基编辑系统及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150165054A1 (en) * | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| CA2971444A1 (en) * | 2014-12-20 | 2016-06-23 | Arc Bio, Llc | Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using crispr/cas system proteins |
| TWI813532B (zh) * | 2015-06-18 | 2023-09-01 | 美商博得學院股份有限公司 | 降低脱靶效應的ｃｒｉｓｐｒ酶突變 |
| WO2017048969A1 (en) * | 2015-09-17 | 2017-03-23 | The Regents Of The University Of California | Variant cas9 polypeptides comprising internal insertions |
| JP7109784B2 (ja) * | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
| WO2018119359A1 (en) * | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| CA3057192A1 (en) * | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| EP3625342B1 (en) * | 2017-05-18 | 2022-08-24 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| AU2018290843B2 (en) * | 2017-06-26 | 2025-04-24 | Massachusetts Institute Of Technology | CRISPR/Cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing |
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2020
- 2020-01-31 KR KR1020217026724A patent/KR20210121113A/ko active Pending
- 2020-01-31 JP JP2021544294A patent/JP7646552B2/ja active Active
- 2020-01-31 WO PCT/US2020/016285 patent/WO2020160514A1/en not_active Ceased
- 2020-01-31 CA CA3127493A patent/CA3127493A1/en active Pending
- 2020-01-31 EP EP20748889.1A patent/EP3918078A4/en active Pending
- 2020-01-31 AU AU2020215730A patent/AU2020215730A1/en active Pending
- 2020-01-31 CN CN202080026678.0A patent/CN114040977B/zh active Active
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2025
- 2025-03-05 JP JP2025034660A patent/JP2025102784A/ja active Pending