CN114040977B - 非靶脱氨反应减低的核碱基编辑器和用于定性核碱基编辑器的测定 - Google Patents

非靶脱氨反应减低的核碱基编辑器和用于定性核碱基编辑器的测定 Download PDF

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CN114040977B
CN114040977B CN202080026678.0A CN202080026678A CN114040977B CN 114040977 B CN114040977 B CN 114040977B CN 202080026678 A CN202080026678 A CN 202080026678A CN 114040977 B CN114040977 B CN 114040977B
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cas9
amino acid
deaminase
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fusion protein
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CN114040977A (zh
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I·斯雷梅克
J·M·格尔克
N·戈代尔利
Y·于
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Bim Medical Co ltd
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04005—Cytidine deaminase (3.5.4.5)

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CN202080026678.0A 2019-01-31 2020-01-31 非靶脱氨反应减低的核碱基编辑器和用于定性核碱基编辑器的测定 Active CN114040977B (zh)

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US201962799702P 2019-01-31 2019-01-31
US62/799,702 2019-01-31
PCT/US2020/016285 WO2020160514A1 (en) 2019-01-31 2020-01-31 Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors

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CN114040977A CN114040977A (zh) 2022-02-11
CN114040977B true CN114040977B (zh) 2024-09-03

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EP (1) EP3918078A4 (https=)
JP (2) JP7646552B2 (https=)
KR (1) KR20210121113A (https=)
CN (1) CN114040977B (https=)
AU (1) AU2020215730A1 (https=)
CA (1) CA3127493A1 (https=)
WO (1) WO2020160514A1 (https=)

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CN121555430A (zh) 2018-05-11 2026-02-24 比姆医疗股份有限公司 使用可编程碱基编辑器系统取代病原性氨基酸的方法
KR20210055733A (ko) 2018-09-07 2021-05-17 빔 테라퓨틱스, 인크. 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법
EP3850088A4 (en) 2018-09-07 2023-07-19 Beam Therapeutics, Inc. Compositions and methods for improving base editing
WO2020168122A1 (en) 2019-02-13 2020-08-20 Beam Therapeutics Inc. Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence
EP4034138A4 (en) 2019-09-27 2024-07-31 Beam Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
IL296024A (en) 2020-03-04 2022-10-01 Flagship Pioneering Innovations Vi Llc Methods and compositions for modulating a genome
WO2021222318A1 (en) 2020-04-28 2021-11-04 The Broad Institute, Inc. Targeted base editing of the ush2a gene
CA3194019A1 (en) * 2020-09-04 2022-03-10 National University Corporation Kobe University Miniaturized cytidine deaminase-containing complex for modifying double-stranded dna
AU2021347359A1 (en) 2020-09-25 2023-05-18 Beam Therapeutics Inc. Fratricide resistant modified immune cells and methods of using the same
CN116601293A (zh) * 2020-12-07 2023-08-15 中国科学院动物研究所 工程化的Cas效应蛋白及其使用方法
CN113308451B (zh) * 2020-12-07 2023-07-25 中国科学院动物研究所 工程化的Cas效应蛋白及其使用方法
CA3214494A1 (en) * 2021-03-26 2022-09-29 Beam Therapeutics Inc. Adenosine deaminase variants and uses thereof
WO2022221699A1 (en) * 2021-04-16 2022-10-20 Beam Therapeutics, Inc. Genetic modification of hepatocytes
WO2023283092A1 (en) * 2021-07-06 2023-01-12 Prime Medicine, Inc. Compositions and methods for efficient genome editing
JP2024533311A (ja) 2021-09-08 2024-09-12 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー ゲノムを調節するための方法及び組成物
CN117925585A (zh) * 2022-04-07 2024-04-26 尧唐(上海)生物科技有限公司 腺苷脱氨酶、碱基编辑器融合蛋白、碱基编辑器系统及用途
WO2025119307A1 (zh) * 2023-12-06 2025-06-12 北京齐禾生科生物科技有限公司 优化的qbe碱基编辑系统及其应用

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CN108290933A (zh) * 2015-06-18 2018-07-17 布罗德研究所有限公司 降低脱靶效应的crispr酶突变
CN108699116A (zh) * 2015-10-23 2018-10-23 哈佛大学的校长及成员们 用于基因编辑的演化的cas9蛋白

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EP3918078A1 (en) 2021-12-08
WO2020160514A1 (en) 2020-08-06
EP3918078A4 (en) 2022-12-14
CA3127493A1 (en) 2020-08-06
JP2025102784A (ja) 2025-07-08
JP7646552B2 (ja) 2025-03-17
CN114040977A (zh) 2022-02-11
KR20210121113A (ko) 2021-10-07
JP2022519507A (ja) 2022-03-24
AU2020215730A1 (en) 2021-07-29
US20220098572A1 (en) 2022-03-31

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