JP2022520081A5 - - Google Patents
Info
- Publication number
- JP2022520081A5 JP2022520081A5 JP2021546894A JP2021546894A JP2022520081A5 JP 2022520081 A5 JP2022520081 A5 JP 2022520081A5 JP 2021546894 A JP2021546894 A JP 2021546894A JP 2021546894 A JP2021546894 A JP 2021546894A JP 2022520081 A5 JP2022520081 A5 JP 2022520081A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- tada
- protein according
- adenosine deaminase
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025093886A JP2025143279A (ja) | 2019-02-13 | 2025-06-05 | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
Applications Claiming Priority (33)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962805277P | 2019-02-13 | 2019-02-13 | |
| US201962805271P | 2019-02-13 | 2019-02-13 | |
| US201962805238P | 2019-02-13 | 2019-02-13 | |
| US62/805,238 | 2019-02-13 | ||
| US62/805,271 | 2019-02-13 | ||
| US62/805,277 | 2019-02-13 | ||
| US201962852228P | 2019-05-23 | 2019-05-23 | |
| US201962852224P | 2019-05-23 | 2019-05-23 | |
| US62/852,224 | 2019-05-23 | ||
| US62/852,228 | 2019-05-23 | ||
| US201962873140P | 2019-07-11 | 2019-07-11 | |
| US201962873144P | 2019-07-11 | 2019-07-11 | |
| US201962873138P | 2019-07-11 | 2019-07-11 | |
| US62/873,144 | 2019-07-11 | ||
| US62/873,140 | 2019-07-11 | ||
| US62/873,138 | 2019-07-11 | ||
| US201962876354P | 2019-07-19 | 2019-07-19 | |
| US62/876,354 | 2019-07-19 | ||
| US201962888867P | 2019-08-19 | 2019-08-19 | |
| US62/888,867 | 2019-08-19 | ||
| US201962912992P | 2019-10-09 | 2019-10-09 | |
| US62/912,992 | 2019-10-09 | ||
| US201962931722P | 2019-11-06 | 2019-11-06 | |
| US201962931747P | 2019-11-06 | 2019-11-06 | |
| US62/931,747 | 2019-11-06 | ||
| US62/931,722 | 2019-11-06 | ||
| US201962941523P | 2019-11-27 | 2019-11-27 | |
| US201962941569P | 2019-11-27 | 2019-11-27 | |
| US62/941,523 | 2019-11-27 | ||
| US62/941,569 | 2019-11-27 | ||
| US202062966526P | 2020-01-27 | 2020-01-27 | |
| US62/966,526 | 2020-01-27 | ||
| PCT/US2020/018192 WO2020168132A1 (en) | 2019-02-13 | 2020-02-13 | Adenosine deaminase base editors and methods of using same to modify a nucleobase in a target sequence |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025093886A Division JP2025143279A (ja) | 2019-02-13 | 2025-06-05 | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022520081A JP2022520081A (ja) | 2022-03-28 |
| JP2022520081A5 true JP2022520081A5 (https=) | 2023-02-17 |
| JP7693552B2 JP7693552B2 (ja) | 2025-06-17 |
Family
ID=72043868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021546894A Active JP7693552B2 (ja) | 2019-02-13 | 2020-02-13 | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
| JP2025093886A Pending JP2025143279A (ja) | 2019-02-13 | 2025-06-05 | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025093886A Pending JP2025143279A (ja) | 2019-02-13 | 2025-06-05 | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20220170027A1 (https=) |
| EP (1) | EP3924479A4 (https=) |
| JP (2) | JP7693552B2 (https=) |
| KR (1) | KR20210139265A (https=) |
| CN (1) | CN114072496A (https=) |
| AU (1) | AU2020221366A1 (https=) |
| CA (1) | CA3129158A1 (https=) |
| WO (1) | WO2020168132A1 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019178427A1 (en) | 2018-03-14 | 2019-09-19 | Arbor Biotechnologies, Inc. | Novel crispr dna targeting enzymes and systems |
| AU2019265019B2 (en) | 2018-05-11 | 2025-11-06 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| WO2019222555A1 (en) | 2018-05-16 | 2019-11-21 | Arbor Biotechnologies, Inc. | Novel crispr-associated systems and components |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| AU2020215730A1 (en) | 2019-01-31 | 2021-07-29 | Beam Therapeutics Inc. | Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors |
| JP7693552B2 (ja) * | 2019-02-13 | 2025-06-17 | ビーム セラピューティクス インク． | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
| CA3128755C (en) | 2019-02-13 | 2024-06-04 | Beam Therapeutics Inc. | Compositions and methods for treating hemoglobinopathies |
| CN120174005A (zh) | 2019-02-13 | 2025-06-20 | 比姆医疗股份有限公司 | 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞 |
| CA3145913A1 (en) | 2019-07-29 | 2021-02-04 | James Everett Dahlman | Nanomaterials containing constrained lipids and uses thereof |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| IL294318A (en) | 2020-01-09 | 2022-08-01 | Guide Therapeutics Llc | Nanomaterials |
| WO2021163587A1 (en) * | 2020-02-13 | 2021-08-19 | Beam Therapeutics Inc. | Compositions and methods for engraftment of base edited cells |
| CN121380024A (zh) * | 2020-03-31 | 2026-01-23 | 阿伯生物技术公司 | 包含Cas12i2变体多肽的组合物及其用途 |
| CN116134141A (zh) * | 2020-09-04 | 2023-05-16 | 国立大学法人神户大学 | 包含小型化胞苷脱氨酶的双链dna修饰用复合体 |
| CA3196831A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| WO2022119294A1 (ko) * | 2020-12-01 | 2022-06-09 | 한양대학교 산학협력단 | 사이토신 교정 활성이 제거된 아데닌 염기교정 유전자가위 및 이의 용도 |
| US20240018550A1 (en) * | 2020-12-01 | 2024-01-18 | Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University) | Adenine base editor having increased thymine-cytosine sequence-specific cytosine editing activity, and use thereof |
| CN116761888A (zh) | 2021-01-20 | 2023-09-15 | 比姆医疗股份有限公司 | 纳米材料 |
| EP4281080A4 (en) | 2021-01-20 | 2025-09-24 | Beam Therapeutics Inc | NANOMATERIALS COMPRISING A BIODEGRADABLE ELEMENT |
| CN115704015B (zh) * | 2021-08-12 | 2025-08-12 | 清华大学 | 基于腺嘌呤和胞嘧啶双碱基编辑器的靶向诱变系统 |
| CN115772512B (zh) * | 2021-09-07 | 2025-12-23 | 华东师范大学 | 腺嘌呤脱氨酶、包含其的腺嘌呤碱基编辑器及其应用 |
| EP4409000A1 (en) | 2021-09-28 | 2024-08-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Base editing approaches for the treatment of beta-hemoglobinopathies |
| CN119286831A (zh) * | 2021-10-21 | 2025-01-10 | 复旦大学 | 碱基编辑器及其构建方法与应用 |
| WO2023099591A1 (en) | 2021-12-01 | 2023-06-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for increasing fetal hemoglobin content by editing the +55-kb region of the erythroid-specific bcl11a enhancer |
| WO2023121970A1 (en) | 2021-12-20 | 2023-06-29 | Beam Therapeutics Inc. | Ionizable amine and ester lipids and lipid nanoparticles |
| EP4452942A1 (en) | 2021-12-20 | 2024-10-30 | Beam Therapeutics Inc. | Nanomaterials comprising disulfides |
| JP2025500824A (ja) | 2021-12-20 | 2025-01-15 | ビーム セラピューティクス インク． | 四価脂質化合物を含むナノ材料 |
| CA3241488A1 (en) | 2021-12-20 | 2023-06-29 | Beam Therapeutics Inc. | Ionizable amine lipids and lipid nanoparticles |
| EP4452925A1 (en) | 2021-12-20 | 2024-10-30 | Beam Therapeutics Inc. | Nanomaterial comprising diamines |
| WO2023144104A1 (en) | 2022-01-25 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Base editing approaches for the treatment of βeta-thalassemia |
| WO2023169454A1 (zh) * | 2022-03-08 | 2023-09-14 | 中国科学院遗传与发育生物学研究所 | 腺嘌呤脱氨酶及其在碱基编辑中的用途 |
| CN114634923B (zh) * | 2022-04-07 | 2024-02-23 | 尧唐(上海)生物科技有限公司 | 腺苷脱氨酶、碱基编辑器融合蛋白、碱基编辑器系统及用途 |
| JP2025515503A (ja) | 2022-04-28 | 2025-05-15 | ザ ブロード インスティテュート，インコーポレーテッド | 塩基エディタをコードするａａｖベクターおよびその使用 |
| CN114686456B (zh) * | 2022-05-10 | 2023-02-17 | 中山大学 | 基于双分子脱氨酶互补的碱基编辑系统及其应用 |
| US20250223326A1 (en) | 2022-05-10 | 2025-07-10 | Institut National de la Santé et de la Recherche Médicale | Syncitin-1 fusion proteins and uses thereof for cargo delivery into target cells |
| US20250241956A1 (en) | 2022-05-10 | 2025-07-31 | Institut National de la Santé et de la Recherche Médicale | Base editing approaches for correcting the cd39 (cag>tag) mutation in patients suffering from beta-thalassemia |
| KR20250037788A (ko) * | 2022-06-15 | 2025-03-18 | 빔 테라퓨틱스, 인크. | 보체 활성화를 감소시키기 위한 조성물 및 방법 |
| WO2024006774A2 (en) * | 2022-06-27 | 2024-01-04 | Beam Therapeutics Inc. | Compositions and methods for non-genotoxic cell conditioning |
| CA3260437A1 (en) | 2022-07-20 | 2024-01-25 | Beam Therapeutics Inc. | NANOMATERIALS INCLUDING TRIOLS |
| WO2024018056A1 (en) | 2022-07-22 | 2024-01-25 | Institut National de la Santé et de la Recherche Médicale | Base editing approaches for correcting the ivs2-1 (g>a) mutation in patients suffering from βeta-thalassemia |
| WO2024086596A1 (en) * | 2022-10-18 | 2024-04-25 | 4M Genomics Inc. | Polypeptide fusions or conjugates for gene editing |
| JP2026506554A (ja) | 2023-02-06 | 2026-02-25 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 多重塩基編集による遺伝子改変造血幹細胞の濃縮 |
| WO2024229240A2 (en) * | 2023-05-03 | 2024-11-07 | Beam Therapeutics Inc. | Compositions and methods for treating stargardt disease |
| WO2024230760A1 (zh) * | 2023-05-09 | 2024-11-14 | 北京齐禾生科生物科技有限公司 | 一种可作用于dna的腺苷脱氨酶及其应用 |
| WO2024240223A1 (en) | 2023-05-24 | 2024-11-28 | Accuredit Therapeutics (Suzhou) Co., Ltd. | Deaminases and variants thereof for use in base editing |
| WO2025038821A1 (en) * | 2023-08-16 | 2025-02-20 | Chroma Medicine, Inc. | Methods and compositions for multiplex epigenetic editing |
| WO2025059520A1 (en) * | 2023-09-15 | 2025-03-20 | Beam Therapeutics Inc. | Compositions and methods for base editing a phenylalanine hydroxylase polynucleotide |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| CN120290534A (zh) * | 2024-01-10 | 2025-07-11 | 上海数因信科智能科技有限公司 | 腺嘌呤脱氨酶、包含其的碱基编辑器融合蛋白和碱基编辑器系统及其应用 |
| CN117568313B (zh) * | 2024-01-15 | 2024-04-26 | 上海贝斯昂科生物科技有限公司 | 基因编辑组合物及其用途 |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025202473A1 (en) * | 2024-03-28 | 2025-10-02 | Revvity Discovery Limited | A nucleic acid deaminase, a base editor and uses thereof |
| US20250332260A1 (en) | 2024-04-10 | 2025-10-30 | Garuda Therapeutics, Inc. | Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations |
| WO2025228273A1 (zh) * | 2024-04-28 | 2025-11-06 | 广州瑞风生物科技有限公司 | 脱氨酶、单碱基编辑器及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| JP2018522249A (ja) * | 2015-04-24 | 2018-08-09 | エディタス・メディシン、インコーポレイテッド | Ｃａｓ９分子／ガイドｒｎａ分子複合体の評価 |
| US11008555B2 (en) * | 2015-09-17 | 2021-05-18 | The Regents Of The University Of California | Variant Cas9 polypeptides comprising internal insertions |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| EP3538561A4 (en) * | 2016-11-11 | 2020-10-21 | The Regents of The University of California | RNA-GUIDED VARIANT POLYPEPTIDES AND THEIR METHODS OF USE |
| WO2018213726A1 (en) * | 2017-05-18 | 2018-11-22 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| US10392616B2 (en) * | 2017-06-30 | 2019-08-27 | Arbor Biotechnologies, Inc. | CRISPR RNA targeting enzymes and systems and uses thereof |
| US11946040B2 (en) * | 2019-02-04 | 2024-04-02 | The General Hospital Corporation | Adenine DNA base editor variants with reduced off-target RNA editing |
| CA3128755C (en) * | 2019-02-13 | 2024-06-04 | Beam Therapeutics Inc. | Compositions and methods for treating hemoglobinopathies |
| KR20210126680A (ko) * | 2019-02-13 | 2021-10-20 | 빔 테라퓨틱스, 인크. | 알파-1 항트립신 결핍증을 치료하기 위한 조성물 및 방법 |
| JP7693552B2 (ja) * | 2019-02-13 | 2025-06-17 | ビーム セラピューティクス インク． | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
| AU2020279751A1 (en) * | 2019-05-21 | 2021-12-02 | Beam Therapeutics Inc. | Methods of editing a single nucleotide polymorphism using programmable base editor systems |
-
2020
- 2020-02-13 JP JP2021546894A patent/JP7693552B2/ja active Active
- 2020-02-13 AU AU2020221366A patent/AU2020221366A1/en active Pending
- 2020-02-13 CN CN202080028658.7A patent/CN114072496A/zh active Pending
- 2020-02-13 WO PCT/US2020/018192 patent/WO2020168132A1/en not_active Ceased
- 2020-02-13 EP EP20755422.1A patent/EP3924479A4/en active Pending
- 2020-02-13 US US17/430,669 patent/US20220170027A1/en active Pending
- 2020-02-13 CA CA3129158A patent/CA3129158A1/en active Pending
- 2020-02-13 KR KR1020217029282A patent/KR20210139265A/ko active Pending
- 2020-12-18 US US17/127,630 patent/US11155803B2/en active Active
-
2023
- 2023-10-13 US US18/486,913 patent/US20240132867A1/en active Pending
-
2025
- 2025-06-05 JP JP2025093886A patent/JP2025143279A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022520081A5 (https=) | ||
| JP2022519882A5 (https=) | ||
| JP2025170240A5 (https=) | ||
| JP2022546608A5 (https=) | ||
| JP2022519507A5 (https=) | ||
| JP2022533673A5 (https=) | ||
| Tanaka et al. | Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain | |
| JP2025102784A5 (https=) | ||
| CA2222279A1 (en) | Hypoxia inducible factor-1 and method of use | |
| Karn et al. | Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns. | |
| JP2025087691A5 (https=) | ||
| AU764571B2 (en) | 5' ESTs and encoded human proteins | |
| Sogawa et al. | Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat. | |
| JP2022519761A5 (https=) | ||
| IE66307B1 (en) | Recombinant human endothelial cell growth factor | |
| EA003086B1 (ru) | ПОЛИПЕПТИДЫ LAG-3V1, LAG-3V2 И LAG-3V3 И КОДИРУЮЩИЕ ИХ кДНК | |
| IE61773B1 (en) | Novel lymphokine related peptides | |
| JP2021536250A5 (https=) | ||
| Angulo et al. | Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein | |
| Saito et al. | Cloning of a full-length cDNA encoding bovine thymus poly (ADP-ribose) synthetase: evolutionarily conserved segments and their potential functions | |
| Takasawa et al. | Novel gene activated in rat insulinomas | |
| JP2005245469A (ja) | 腫瘍サプレッサ遺伝子、並びに癌の検出、腫瘍進行のモニタおよび癌処置のための方法 | |
| JP2021522825A5 (https=) | ||
| JP2022542294A5 (https=) | ||
| Pilz et al. | Mapping of the human homologs of the murine paired-box-containing genes |