CN114072496A - 腺苷脱氨酶碱基编辑器及使用其修饰靶标序列中的核碱基的方法 - Google Patents

腺苷脱氨酶碱基编辑器及使用其修饰靶标序列中的核碱基的方法 Download PDF

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CN114072496A
CN114072496A CN202080028658.7A CN202080028658A CN114072496A CN 114072496 A CN114072496 A CN 114072496A CN 202080028658 A CN202080028658 A CN 202080028658A CN 114072496 A CN114072496 A CN 114072496A
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fusion protein
tada
adenosine deaminase
domain
cas9
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N·戈代尔利
M·帕克
I·斯雷梅克
Y·于
B·蔡澈
J·M·格尔克
N·彼得罗相
A·梅萨纳
Y·阿拉泰恩
F·葛瑞格尔
G·伦格
S·贝尔科维奇
D·A·玻恩
S-J·李
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Bim Medical Co ltd
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    • C12N9/14—Hydrolases (3)
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04005—Cytidine deaminase (3.5.4.5)

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CN202080028658.7A 2019-02-13 2020-02-13 腺苷脱氨酶碱基编辑器及使用其修饰靶标序列中的核碱基的方法 Pending CN114072496A (zh)

Applications Claiming Priority (33)

Application Number Priority Date Filing Date Title
US201962805271P 2019-02-13 2019-02-13
US201962805238P 2019-02-13 2019-02-13
US201962805277P 2019-02-13 2019-02-13
US62/805,277 2019-02-13
US62/805,238 2019-02-13
US62/805,271 2019-02-13
US201962852224P 2019-05-23 2019-05-23
US201962852228P 2019-05-23 2019-05-23
US62/852,228 2019-05-23
US62/852,224 2019-05-23
US201962873140P 2019-07-11 2019-07-11
US201962873144P 2019-07-11 2019-07-11
US201962873138P 2019-07-11 2019-07-11
US62/873,138 2019-07-11
US62/873,140 2019-07-11
US62/873,144 2019-07-11
US201962876354P 2019-07-19 2019-07-19
US62/876,354 2019-07-19
US201962888867P 2019-08-19 2019-08-19
US62/888,867 2019-08-19
US201962912992P 2019-10-09 2019-10-09
US62/912,992 2019-10-09
US201962931747P 2019-11-06 2019-11-06
US201962931722P 2019-11-06 2019-11-06
US62/931,722 2019-11-06
US62/931,747 2019-11-06
US201962941523P 2019-11-27 2019-11-27
US201962941569P 2019-11-27 2019-11-27
US62/941,569 2019-11-27
US62/941,523 2019-11-27
US202062966526P 2020-01-27 2020-01-27
US62/966,526 2020-01-27
PCT/US2020/018192 WO2020168132A1 (en) 2019-02-13 2020-02-13 Adenosine deaminase base editors and methods of using same to modify a nucleobase in a target sequence

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US (3) US20220170027A1 (https=)
EP (1) EP3924479A4 (https=)
JP (2) JP7693552B2 (https=)
KR (1) KR20210139265A (https=)
CN (1) CN114072496A (https=)
AU (1) AU2020221366A1 (https=)
CA (1) CA3129158A1 (https=)
WO (1) WO2020168132A1 (https=)

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WO2024230760A1 (zh) * 2023-05-09 2024-11-14 北京齐禾生科生物科技有限公司 一种可作用于dna的腺苷脱氨酶及其应用
WO2025149051A1 (zh) * 2024-01-10 2025-07-17 上海数因信科智能科技有限公司 腺嘌呤脱氨酶、包含其的碱基编辑器融合蛋白和碱基编辑器系统及其应用
WO2025152584A1 (zh) * 2024-01-15 2025-07-24 上海贝斯昂科生物科技有限公司 基因编辑组合物及其用途
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