KR20210139265A - 표적 서열에서 핵염기를 변형하기 위한 아데노신 데아미나제 염기 편집기 및 이의 사용 방법 - Google Patents

표적 서열에서 핵염기를 변형하기 위한 아데노신 데아미나제 염기 편집기 및 이의 사용 방법 Download PDF

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KR20210139265A
KR20210139265A KR1020217029282A KR20217029282A KR20210139265A KR 20210139265 A KR20210139265 A KR 20210139265A KR 1020217029282 A KR1020217029282 A KR 1020217029282A KR 20217029282 A KR20217029282 A KR 20217029282A KR 20210139265 A KR20210139265 A KR 20210139265A
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cas9
fusion protein
domain
tada
adenosine deaminase
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니콜 가우델리
마이클 페커
이안 슬레이메이커
이 유
베른트 제츠체
제이슨 마이클 게르케
나탈리 페트로시안
엔젤리카 메사나
이본 아라틴
프랑신 그레고아르
제네시스 룽
샤우나 베르코비치
데이비드 에이. 본
승주 이
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빔 테라퓨틱스, 인크.
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
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    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04005—Cytidine deaminase (3.5.4.5)

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KR1020217029282A 2019-02-13 2020-02-13 표적 서열에서 핵염기를 변형하기 위한 아데노신 데아미나제 염기 편집기 및 이의 사용 방법 Pending KR20210139265A (ko)

Applications Claiming Priority (33)

Application Number Priority Date Filing Date Title
US201962805271P 2019-02-13 2019-02-13
US201962805238P 2019-02-13 2019-02-13
US201962805277P 2019-02-13 2019-02-13
US62/805,277 2019-02-13
US62/805,238 2019-02-13
US62/805,271 2019-02-13
US201962852224P 2019-05-23 2019-05-23
US201962852228P 2019-05-23 2019-05-23
US62/852,228 2019-05-23
US62/852,224 2019-05-23
US201962873140P 2019-07-11 2019-07-11
US201962873144P 2019-07-11 2019-07-11
US201962873138P 2019-07-11 2019-07-11
US62/873,138 2019-07-11
US62/873,140 2019-07-11
US62/873,144 2019-07-11
US201962876354P 2019-07-19 2019-07-19
US62/876,354 2019-07-19
US201962888867P 2019-08-19 2019-08-19
US62/888,867 2019-08-19
US201962912992P 2019-10-09 2019-10-09
US62/912,992 2019-10-09
US201962931747P 2019-11-06 2019-11-06
US201962931722P 2019-11-06 2019-11-06
US62/931,722 2019-11-06
US62/931,747 2019-11-06
US201962941523P 2019-11-27 2019-11-27
US201962941569P 2019-11-27 2019-11-27
US62/941,569 2019-11-27
US62/941,523 2019-11-27
US202062966526P 2020-01-27 2020-01-27
US62/966,526 2020-01-27
PCT/US2020/018192 WO2020168132A1 (en) 2019-02-13 2020-02-13 Adenosine deaminase base editors and methods of using same to modify a nucleobase in a target sequence

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KR20210139265A true KR20210139265A (ko) 2021-11-22

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US (3) US20220170027A1 (https=)
EP (1) EP3924479A4 (https=)
JP (2) JP7693552B2 (https=)
KR (1) KR20210139265A (https=)
CN (1) CN114072496A (https=)
AU (1) AU2020221366A1 (https=)
CA (1) CA3129158A1 (https=)
WO (1) WO2020168132A1 (https=)

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US20210130805A1 (en) 2021-05-06
JP2022520081A (ja) 2022-03-28
WO2020168132A1 (en) 2020-08-20
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CA3129158A1 (en) 2020-08-20
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