JP2025072507A5 - - Google Patents
Info
- Publication number
- JP2025072507A5 JP2025072507A5 JP2025017374A JP2025017374A JP2025072507A5 JP 2025072507 A5 JP2025072507 A5 JP 2025072507A5 JP 2025017374 A JP2025017374 A JP 2025017374A JP 2025017374 A JP2025017374 A JP 2025017374A JP 2025072507 A5 JP2025072507 A5 JP 2025072507A5
- Authority
- JP
- Japan
- Prior art keywords
- albumin binding
- amphiphilic
- lipid
- binding conjugate
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261620518P | 2012-04-05 | 2012-04-05 | |
| US61/620,518 | 2012-04-05 | ||
| JP2020099145A JP2020143165A (ja) | 2012-04-05 | 2020-06-08 | 免疫刺激組成物およびその使用方法 |
| JP2022165307A JP7631277B2 (ja) | 2012-04-05 | 2022-10-14 | 免疫刺激組成物およびその使用方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022165307A Division JP7631277B2 (ja) | 2012-04-05 | 2022-10-14 | 免疫刺激組成物およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025072507A JP2025072507A (ja) | 2025-05-09 |
| JP2025072507A5 true JP2025072507A5 (https=) | 2025-10-03 |
Family
ID=48083608
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504601A Active JP6375289B2 (ja) | 2012-04-05 | 2013-03-15 | 免疫刺激組成物およびその使用方法 |
| JP2017078218A Pending JP2017165739A (ja) | 2012-04-05 | 2017-04-11 | 免疫刺激組成物およびその使用方法 |
| JP2020099145A Pending JP2020143165A (ja) | 2012-04-05 | 2020-06-08 | 免疫刺激組成物およびその使用方法 |
| JP2022165307A Active JP7631277B2 (ja) | 2012-04-05 | 2022-10-14 | 免疫刺激組成物およびその使用方法 |
| JP2025017374A Pending JP2025072507A (ja) | 2012-04-05 | 2025-02-05 | 免疫刺激組成物およびその使用方法 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015504601A Active JP6375289B2 (ja) | 2012-04-05 | 2013-03-15 | 免疫刺激組成物およびその使用方法 |
| JP2017078218A Pending JP2017165739A (ja) | 2012-04-05 | 2017-04-11 | 免疫刺激組成物およびその使用方法 |
| JP2020099145A Pending JP2020143165A (ja) | 2012-04-05 | 2020-06-08 | 免疫刺激組成物およびその使用方法 |
| JP2022165307A Active JP7631277B2 (ja) | 2012-04-05 | 2022-10-14 | 免疫刺激組成物およびその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US9107904B2 (https=) |
| EP (2) | EP2833918B1 (https=) |
| JP (5) | JP6375289B2 (https=) |
| ES (1) | ES2731524T3 (https=) |
| WO (1) | WO2013151771A1 (https=) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2890501T3 (es) | 2009-03-02 | 2022-01-20 | Massachusetts Inst Technology | Métodos y productos para la creación de perfiles enzimáticos in vivo |
| WO2011091065A2 (en) | 2010-01-19 | 2011-07-28 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2013120302A (ru) | 2010-10-01 | 2014-11-20 | Модерна Терапьютикс, Инк. | Сконструированные нуклеиновые кислоты и способы их применения |
| EP2691101A2 (en) | 2011-03-31 | 2014-02-05 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| CN104114572A (zh) | 2011-12-16 | 2014-10-22 | 现代治疗公司 | 经修饰的核苷、核苷酸和核酸组合物 |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| JP6375289B2 (ja) * | 2012-04-05 | 2018-08-15 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫刺激組成物およびその使用方法 |
| US9844582B2 (en) | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
| WO2014081507A1 (en) | 2012-11-26 | 2014-05-30 | Moderna Therapeutics, Inc. | Terminally modified rna |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US20160058856A1 (en) * | 2013-04-05 | 2016-03-03 | Kyushu University, National University Corporation | Anti-tumor dna vaccine |
| JP6847660B2 (ja) | 2013-06-07 | 2021-03-24 | マサチューセッツ インスティテュート オブ テクノロジー | リガンドをコードする合成バイオマーカーのアフィニティベースの検出 |
| CN105579582A (zh) | 2013-07-25 | 2016-05-11 | 埃克西奎雷股份有限公司 | 用于预防和治疗用途的作为免疫刺激剂的基于球形核酸的构建体 |
| WO2015023797A1 (en) | 2013-08-13 | 2015-02-19 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
| JP6527516B2 (ja) | 2013-12-03 | 2019-06-05 | ノースウェスタン ユニバーシティ | リポソーム粒子、前述のものを作製する方法及びその使用 |
| US20170175121A1 (en) * | 2014-04-03 | 2017-06-22 | Exicure, Inc. | Self assembling nucleic acid nanostructures |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| US20170224777A1 (en) | 2014-08-12 | 2017-08-10 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and a cancer vaccine |
| WO2016028940A1 (en) | 2014-08-19 | 2016-02-25 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| CA2963931A1 (en) | 2014-10-06 | 2016-04-14 | Exicure, Inc. | Anti-tnf compounds |
| GB201418004D0 (en) * | 2014-10-10 | 2014-11-26 | Isis Innovation | Polymer adjuvant |
| CN104288758B (zh) * | 2014-10-22 | 2018-04-03 | 中国科学院生物物理研究所 | 聚乙二醇化磷脂为载体的胶束多肽疫苗 |
| KR20170078843A (ko) | 2014-11-21 | 2017-07-07 | 노오쓰웨스턴 유니버시티 | 구형 핵산 나노입자 접합체의 서열 특이적 세포 흡수 |
| WO2016085986A1 (en) | 2014-11-24 | 2016-06-02 | Northwestern University | High density lipoprptein nanoparticles for inflammation |
| WO2016112963A1 (en) * | 2015-01-13 | 2016-07-21 | Riboxx Gmbh | Delivery of biomolecules into cells |
| WO2016115320A1 (en) * | 2015-01-14 | 2016-07-21 | Exicure, Inc. | Nucleic acid nanostructructures with core motifs |
| WO2018179172A1 (ja) * | 2017-03-29 | 2018-10-04 | 塩野義製薬株式会社 | 免疫賦活活性を有する核酸誘導体 |
| US10940201B2 (en) | 2015-09-30 | 2021-03-09 | Shionogi & Co., Ltd. | Nucleic acid derivative having immunostimulatory activity |
| KR102230325B1 (ko) | 2015-09-30 | 2021-03-19 | 시오노기 앤드 컴파니, 리미티드 | 면역 부활 활성을 갖는 핵산 유도체 |
| EP3364949A4 (en) | 2015-10-22 | 2019-07-31 | ModernaTX, Inc. | CANCER VACCINES |
| WO2017132555A1 (en) * | 2016-01-29 | 2017-08-03 | Vedantra Pharmaceuticals, Inc. | Alk polypeptides and methods of use thereof |
| US10888603B2 (en) | 2016-02-12 | 2021-01-12 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating cancer cells expressing tumor-associated integrins |
| WO2017155981A1 (en) | 2016-03-07 | 2017-09-14 | Massachusetts Institute Of Technology | Protein-chaperoned t-cell vaccines |
| WO2017173427A1 (en) * | 2016-04-01 | 2017-10-05 | Vycellix Inc | Novel rna construct and methods of use thereof for enhancing the therapeutic effects of cytotoxic cells and stem cells |
| WO2017177115A1 (en) * | 2016-04-08 | 2017-10-12 | Massachusetts Institute Of Technology | Methods to specifically profile protease activity at lymph nodes |
| WO2017192874A1 (en) | 2016-05-04 | 2017-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Albumin-binding immunomodulatory compositions and methods of use thereof |
| US11428689B2 (en) | 2016-05-05 | 2022-08-30 | Massachusetts Institute Of Technology | Methods and uses for remotely triggered protease activity measurements |
| WO2018013924A1 (en) | 2016-07-15 | 2018-01-18 | Massachusetts Institute Of Technology | Synthetic nanoparticles for delivery of immunomodulatory compounds |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| CA2954115C (en) * | 2016-10-16 | 2022-04-12 | Neil Gordon | Ultra-sensitive bioanalyte quantification from self-assembled quadruplex tags |
| WO2018187515A1 (en) | 2017-04-04 | 2018-10-11 | Avidea Technologies, Inc. | Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response |
| CA3059358A1 (en) | 2017-04-07 | 2018-10-11 | Massachusetts Institute Of Technology | Methods to spatially profile protease activity in tissue and sections |
| NL2018803B1 (en) * | 2017-04-27 | 2018-11-05 | Academisch Ziekenhuis Leiden Handelend Onder De Naam Leids Univ Medisch Centrum/ H O D N Lumc | Adjuvant compounds |
| US11696954B2 (en) | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| JP2020526558A (ja) | 2017-07-13 | 2020-08-31 | ノースウェスタン ユニバーシティ | オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法 |
| US11077199B2 (en) | 2017-08-09 | 2021-08-03 | Massachusetts Institute Of Technology | Albumin binding peptide conjugates and methods thereof |
| US20190046649A1 (en) * | 2017-08-09 | 2019-02-14 | University Of Maryland, Baltimore County | Delivery device and use thereof for loading cell plasma membranes |
| WO2019060425A1 (en) * | 2017-09-19 | 2019-03-28 | Massachusetts Institute Of Technology | COMPOSITIONS FOR CHIMERIC ANTIGENIC RECEPTOR T CELL THERAPY AND USES THEREOF |
| MX2020004600A (es) * | 2017-11-02 | 2020-10-05 | Janssen Biopharma Inc | Constructos de oligonucleotidos y usos de estos. |
| KR20200099556A (ko) | 2017-12-15 | 2020-08-24 | 바이엘 애니멀 헬스 게엠베하 | 면역자극성 조성물 |
| BR112020017645A2 (pt) | 2018-03-02 | 2020-12-29 | Elicio Therapeutics Inc. | Compostos que incluem uma sequência kras mutante e um lipídio e usos dos mesmos |
| US11054428B2 (en) | 2018-03-05 | 2021-07-06 | Massachusetts Institute Of Technology | Inhalable nanosensors with volatile reporters and uses thereof |
| WO2019217459A1 (en) | 2018-05-07 | 2019-11-14 | Alnylam Pharmaceuticals, Inc. | Extrahepatic delivery |
| WO2020055503A1 (en) | 2018-09-14 | 2020-03-19 | Massachusetts Institute Of Technology | Nanoparticle vaccine adjuvant and methods of use thereof |
| EP3856921B1 (en) | 2018-09-25 | 2026-04-29 | Massachusetts Institute Of Technology | Lung protease nanosensors and uses thereof |
| EP3856763A1 (en) | 2018-09-28 | 2021-08-04 | Massachusetts Institute of Technology | Collagen-localized immunomodulatory molecules and methods thereof |
| CN113056258A (zh) * | 2018-10-18 | 2021-06-29 | 德国癌症研究中心 | 吸入用干燥药物组合物 |
| WO2020150560A1 (en) | 2019-01-17 | 2020-07-23 | Massachusetts Institute Of Technology | Sensors for detecting and imaging of cancer metastasis |
| WO2020154032A1 (en) | 2019-01-23 | 2020-07-30 | Massachusetts Institute Of Technology | Combination immunotherapy dosing regimen for immune checkpoint blockade |
| US11504425B2 (en) | 2019-02-26 | 2022-11-22 | Wayne State University | Amphiphilic oligodeoxynucleotide conjugates as adjuvant enhancers |
| EP3941511A2 (en) | 2019-03-20 | 2022-01-26 | Massachusetts Institute of Technology | Uses of amphiphiles in immune cell therapy and compositions therefor |
| JP7584410B2 (ja) * | 2019-06-03 | 2024-11-15 | 塩野義製薬株式会社 | 二分岐脂質結合オリゴヌクレオチドの製造方法及び中間体 |
| JP2022538974A (ja) | 2019-06-26 | 2022-09-07 | マサチューセッツ インスチテュート オブ テクノロジー | 免疫調節融合タンパク質－金属水酸化物錯体およびその方法 |
| CN110483706B (zh) * | 2019-07-11 | 2021-10-12 | 江苏大学 | 一种基于寡核苷酸双亲性温敏性嵌段聚合物双功能荧光探针的制备方法及应用 |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| US20210340524A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof |
| US12433954B2 (en) | 2020-05-01 | 2025-10-07 | Massachusetts Institute Of Technology | Methods of activating anti-CD19 chimeric antigen receptor (CAR) T cells using amphiphilic ligand conjugates comprising CAR-targeting protein sequence motifs |
| AU2021294342A1 (en) * | 2020-06-26 | 2023-02-23 | Elicio Therapeutics, Inc. | Compositions and methods for inducing an immune response against coronavirus |
| CN116507344A (zh) * | 2020-06-26 | 2023-07-28 | 伊莱西奥治疗有限公司 | 用于诱导针对冠状病毒的免疫应答的组合物和方法 |
| PH12023550922A1 (en) * | 2020-10-07 | 2023-11-20 | Council Queensland Inst Medical Res | Herpesvirus polyepitope vaccines |
| US20240423972A1 (en) | 2021-02-01 | 2024-12-26 | Yale University | Chemotherapeutic bioadhesive particles with immunostimulatory molecules for cancer treatment |
| US20240299450A1 (en) * | 2021-03-10 | 2024-09-12 | Elicio Therapeutics, Inc. | Uses of amphiphiles in immune cell therapy and compositions therefor |
| WO2023114570A1 (en) | 2021-12-19 | 2023-06-22 | Massachusetts Institute Of Technology | Compositions and methods for long-lasting germinal center responses to a priming immunization |
| US20230414763A1 (en) | 2022-03-04 | 2023-12-28 | Massachusetts Institute Of Technology | Transmucosal amphiphile-protein conjugate vaccine |
| CN115590974A (zh) * | 2022-05-27 | 2023-01-13 | 苏州大学（Cn） | 功能化靶向制剂及其制备方法、应用 |
| WO2024226775A2 (en) * | 2023-04-26 | 2024-10-31 | Elicio Therapeutics, Inc. | Compositions containing polynucleotide and polypeptide amphiphiles and methods of use thereof |
| CN118557712A (zh) * | 2024-05-15 | 2024-08-30 | 苏州大学 | 靶向型免疫耐受性疫苗及其制备方法与用途 |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| JP3022967B2 (ja) | 1985-03-15 | 2000-03-21 | アンチバイラルズ インコーポレイテッド | 立体規則性ポリヌクレオチド結合ポリマー |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5256641A (en) | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
| FR2670787B1 (fr) | 1990-12-18 | 1995-06-23 | Pasteur Institut | Lipopeptides inducteurs des lymphocytes t cytotoxiques et utilisation comme vaccins. |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| US5786571A (en) | 1997-05-09 | 1998-07-28 | Lexmark International, Inc. | Wrapped temperature sensing assembly |
| AU2001268427B2 (en) * | 2000-06-16 | 2007-03-29 | Glaxosmithkline Intellectual Property Limited | Antibodies that immunospecifically bind to blys |
| US7563618B2 (en) * | 2001-03-23 | 2009-07-21 | Geron Corporation | Oligonucleotide conjugates |
| EP1474432A1 (en) * | 2002-02-04 | 2004-11-10 | Biomira Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
| CA2536139A1 (en) | 2003-09-25 | 2005-04-07 | Coley Pharmaceutical Group, Inc. | Nucleic acid-lipophilic conjugates |
| GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
| US8124128B2 (en) | 2005-11-08 | 2012-02-28 | Industrial Technology Research Institute | Amphiphilic block copolymers and nano particles comprising the same |
| US20070154398A1 (en) | 2005-12-30 | 2007-07-05 | Industrial Technology Research Institute | Block copolymers and nano micelles comprising the same |
| US20100144846A1 (en) | 2006-10-26 | 2010-06-10 | Coley Pharmaceutical Gmbh | Oligoribonucleotides and uses thereof |
| TWM320264U (en) | 2006-12-08 | 2007-10-01 | P Two Ind Inc | Multi-band frequency-selective filter |
| ES2552471T3 (es) * | 2007-02-07 | 2015-11-30 | The Regents Of The University Of California | Conjugados de agonistas de TLR sintéticos y usos de los mismos |
| EP2136788B1 (en) | 2007-03-30 | 2011-10-26 | Bind Biosciences, Inc. | Cancer cell targeting using nanoparticles |
| US20120087949A1 (en) | 2008-12-19 | 2012-04-12 | University Of Florida Research Foundation, Inc. | Oligonucleotide micelles |
| AU2010243285B2 (en) * | 2009-04-30 | 2013-06-06 | Coley Pharmaceutical Group, Inc. | Pneumococcal vaccine and uses thereof |
| ES2731343T3 (es) * | 2009-05-19 | 2019-11-15 | Univ Miami | Composiciones, kits y métodos para presentación de antígenos in vitro, evaluación de eficacia de vacunas y evaluación de la inmunotoxicidad de productos biológicos y fármacos |
| TWI397428B (zh) | 2009-12-29 | 2013-06-01 | 財團法人工業技術研究院 | 標的第四介白素受體之傳輸系統 |
| AU2011227714B2 (en) * | 2010-03-19 | 2014-09-04 | Takeda Pharmaceutical Company Limited | TFPI inhibitors and methods of use |
| EP2575868A1 (en) * | 2010-06-07 | 2013-04-10 | Pfizer Vaccines LLC | Ige ch3 peptide vaccine |
| ES2791716T3 (es) | 2010-12-14 | 2020-11-05 | Univ Maryland | Células T que expresan al receptor de antígeno quimérico antietiqueta universal y métodos para el tratamiento del cáncer |
| EP4427814A3 (en) * | 2011-05-25 | 2024-11-20 | Camurus AB | Controlled release peptide formulations |
| US9714419B2 (en) * | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
| CA2849705A1 (en) * | 2011-09-23 | 2013-03-28 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Modified albumin-binding domains and uses thereof to improve pharmacokinetics |
| JP6375289B2 (ja) * | 2012-04-05 | 2018-08-15 | マサチューセッツ インスティテュート オブ テクノロジー | 免疫刺激組成物およびその使用方法 |
| CN104507537A (zh) | 2012-07-13 | 2015-04-08 | 宾夕法尼亚大学董事会 | 用于调节car t细胞的组合物和方法 |
| EP2908853B1 (en) * | 2012-10-21 | 2018-12-05 | University Of Rochester | Thy1 (cd90) as a therapy to control adipose tissue accumulation |
| KR102109188B1 (ko) * | 2013-04-01 | 2020-05-11 | 삼성전자주식회사 | 양이온성 지질을 포함하는 온도민감성 리포좀 및 그의 용도 |
| WO2014204762A1 (en) | 2013-06-19 | 2014-12-24 | Massachusetts Institute Of Technology | In vivo targeting of cells with ligand-conjugated particles |
| KR102339240B1 (ko) | 2013-10-15 | 2021-12-15 | 더 스크립스 리서치 인스티튜트 | 펩타이드 키메라 항원 수용체 t 세포 스위치 및 이의 용도 |
| JP6413404B2 (ja) | 2014-07-07 | 2018-10-31 | カシオ計算機株式会社 | 電子機器、位置推定方法及びプログラム |
| MX386433B (es) | 2014-08-14 | 2025-03-18 | L E A F Holdings Group Llc | Fármaco de afinidad encapsulado en liposoma. |
| MX389823B (es) | 2014-10-27 | 2025-03-20 | Fred Hutchinson Cancer Center | Composiciones y metodos para reforzar la eficacia de inmunoterapia celular adoptiva. |
| CN107708741A (zh) | 2015-06-12 | 2018-02-16 | 免疫医疗公司 | 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法 |
| US10881612B2 (en) | 2015-08-21 | 2021-01-05 | The Methodist Hospital | Cationic liposomes for cancer immunotherapy |
| IL260957B2 (en) | 2016-02-09 | 2023-11-01 | Bracco Suisse Sa | Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof |
| US20170224797A1 (en) | 2016-02-10 | 2017-08-10 | Xeme Biopharma Inc. | Cancer Therapy Using a Vaccine in Combination with a Cell-Based Immunotherapeutic Agent |
| CN109069539A (zh) | 2016-02-18 | 2018-12-21 | 恩立夫克治疗有限责任公司 | 用于癌症治疗的联合免疫疗法和细胞因子控制疗法 |
| US20180028634A1 (en) | 2016-07-29 | 2018-02-01 | Lan Bo Chen | Method for prolonging and enhancing anti-tumor vaccine response |
| US10766968B2 (en) | 2017-08-23 | 2020-09-08 | Brown University | Methods and compositions relating to anti-CHI3L1 antibody reagents to treat cancer |
| WO2019060425A1 (en) | 2017-09-19 | 2019-03-28 | Massachusetts Institute Of Technology | COMPOSITIONS FOR CHIMERIC ANTIGENIC RECEPTOR T CELL THERAPY AND USES THEREOF |
| EP3941511A2 (en) | 2019-03-20 | 2022-01-26 | Massachusetts Institute of Technology | Uses of amphiphiles in immune cell therapy and compositions therefor |
| WO2023224715A1 (en) | 2022-05-19 | 2023-11-23 | Massachusetts Institute Of Technology | Car cells targeting an inserted ligand |
-
2013
- 2013-03-15 JP JP2015504601A patent/JP6375289B2/ja active Active
- 2013-03-15 WO PCT/US2013/032600 patent/WO2013151771A1/en not_active Ceased
- 2013-03-15 EP EP13715498.5A patent/EP2833918B1/en active Active
- 2013-03-15 US US13/844,075 patent/US9107904B2/en active Active
- 2013-03-15 ES ES13715498T patent/ES2731524T3/es active Active
- 2013-03-15 EP EP19160590.6A patent/EP3563872A1/en active Pending
-
2015
- 2015-07-02 US US14/790,432 patent/US10029016B2/en active Active
-
2017
- 2017-04-11 JP JP2017078218A patent/JP2017165739A/ja active Pending
-
2018
- 2018-07-19 US US16/040,181 patent/US10953105B2/en active Active
-
2020
- 2020-06-08 JP JP2020099145A patent/JP2020143165A/ja active Pending
-
2021
- 2021-03-05 US US17/193,999 patent/US12303566B2/en active Active
-
2022
- 2022-10-14 JP JP2022165307A patent/JP7631277B2/ja active Active
-
2025
- 2025-01-17 US US19/031,093 patent/US20250195674A1/en not_active Abandoned
- 2025-02-05 JP JP2025017374A patent/JP2025072507A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2025072507A5 (https=) | ||
| Moura et al. | Functionalized branched polymers: promising immunomodulatory tools for the treatment of cancer and immune disorders | |
| JP6367554B2 (ja) | アジュバント化合成ナノキャリアの投与量選択 | |
| JP5769624B2 (ja) | ワクチン | |
| US9056095B2 (en) | Immunogenic composition | |
| US8323696B2 (en) | Nanoparticles for immunotherapy | |
| WO2008056654A1 (fr) | Dérivé polymère d'un antagoniste métabolique d'acide nucléique | |
| JP2020535128A5 (https=) | ||
| JPWO2021019102A5 (https=) | ||
| JP2017521045A5 (https=) | ||
| JPH10501568A (ja) | 抗ウイルス性デンドリマー | |
| CN105188764B (zh) | Dna嵌入剂的细胞递送 | |
| JP2010529214A (ja) | カチオン性基及び疎水性基により官能基化したポリグルタミン酸及びその応用、特にはその治療への応用 | |
| CA2297101A1 (en) | Receptor specific transepithelial transport of therapeutics | |
| WO2000047186A1 (en) | Polynucleotide compositions for intramuscular and intradermal administration | |
| FR2814958A1 (fr) | Composition vaccinale | |
| JP2003531930A (ja) | 両親媒性大環状誘導体およびそれらの類似体 | |
| JP2015172065A (ja) | 多価アジュバントディスプレイ | |
| US20070160622A1 (en) | Method for assembling a polymer-biologic delivery composition | |
| US20240075132A1 (en) | Immunity-inducing agent and pharmaceutical composition containing same | |
| KR20240054288A (ko) | 면역원성 증강용 조성물 | |
| CN112707943A (zh) | 结合5′-末端缀合物和中性/阳离子混合脂材包载的小干扰rna及其修饰方法 | |
| Yu et al. | Saccharide modified pharmaceutical nanocarriers for targeted drug and gene delivery | |
| Rai et al. | Functionalisation of dendrimers | |
| Dobhal et al. | Chitosan-Based nanoparticulate systems: Implication towards therapeutics application |