JP2024510483A5 - - Google Patents

Info

Publication number
JP2024510483A5
JP2024510483A5 JP2023556964A JP2023556964A JP2024510483A5 JP 2024510483 A5 JP2024510483 A5 JP 2024510483A5 JP 2023556964 A JP2023556964 A JP 2023556964A JP 2023556964 A JP2023556964 A JP 2023556964A JP 2024510483 A5 JP2024510483 A5 JP 2024510483A5
Authority
JP
Japan
Prior art keywords
group
phosphorus
composition
building block
methoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023556964A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024510483A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2022/057241 external-priority patent/WO2022195111A1/en
Publication of JP2024510483A publication Critical patent/JP2024510483A/ja
Publication of JP2024510483A5 publication Critical patent/JP2024510483A5/ja
Pending legal-status Critical Current

Links

JP2023556964A 2021-03-19 2022-03-18 改善されたオリゴヌクレオチド合成 Pending JP2024510483A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21163788.9 2021-03-19
EP21163788 2021-03-19
PCT/EP2022/057241 WO2022195111A1 (en) 2021-03-19 2022-03-18 Improved oligonucleotide synthesis

Publications (2)

Publication Number Publication Date
JP2024510483A JP2024510483A (ja) 2024-03-07
JP2024510483A5 true JP2024510483A5 (https=) 2025-03-25

Family

ID=75111538

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023556964A Pending JP2024510483A (ja) 2021-03-19 2022-03-18 改善されたオリゴヌクレオチド合成

Country Status (7)

Country Link
US (1) US20250179110A1 (https=)
EP (2) EP4161942B1 (https=)
JP (1) JP2024510483A (https=)
CN (1) CN117836304A (https=)
CA (1) CA3207897A1 (https=)
DK (1) DK4161942T3 (https=)
WO (1) WO2022195111A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20260001902A1 (en) 2022-09-19 2026-01-01 Bachem Holding Ag Improved oligonucleotide synthesis
WO2025229953A1 (ja) * 2024-04-30 2025-11-06 住友化学株式会社 オリゴヌクレオチドの製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003417A1 (en) * 1994-07-25 1996-02-08 Hybridon, Inc. Improved methods of detritylation for oligonucleotide synthesis
US7202264B2 (en) 2003-01-31 2007-04-10 Isis Pharmaceuticals, Inc. Supports for oligomer synthesis
US8299206B2 (en) 2007-11-15 2012-10-30 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
WO2009073809A2 (en) 2007-12-04 2009-06-11 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
US8710210B2 (en) * 2010-06-30 2014-04-29 Girindus America, Inc. Method of using N-thio compounds for oligonucleotide synthesis
DK2711370T3 (en) 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
CN106795200B (zh) 2014-10-10 2020-06-19 豪夫迈·罗氏有限公司 Galnac亚磷酰胺、其核酸缀合物及其用途
WO2019075419A1 (en) 2017-10-13 2019-04-18 Dicerna Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION
SG11202008827XA (en) 2018-04-13 2020-10-29 Bristol Myers Squibb Co Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds

Similar Documents

Publication Publication Date Title
JP7803520B2 (ja) オリゴヌクレオチド合成用セグメントおよびその製造方法、ならびにそれを用いたオリゴヌクレオチドの合成方法
JP2024510483A5 (https=)
EP0035255B1 (en) Process for removing trityl blocking groups from 5'-o trityl nucleosides and oligonucleotides
KR102375480B1 (ko) 인 보호기 및 이의 제조 방법 및 용도
JP2022531876A5 (https=)
US6593088B1 (en) Reversible photocoupling nucleic acid and phosphoroamidite
EP1404696B1 (en) Activators for oligonucleotide synthesis
JP2000204076A (ja) アリ―ルピリジンの製造方法
CN115003682A (zh) 核酸寡聚物的制造方法
Huang et al. Synthesis of sulfonate-linked DNA
CA2421489A1 (en) Synthons for oligonucleotide synthesis
CN113993876A (zh) 使用改进的氧化方案制备寡核苷酸的方法
Lago et al. Solid phase synthesis of a 1, 3, 5-trisubstituted pyridinium salt library
JP2023514503A5 (https=)
JP3113311B2 (ja) 触媒組成物及び重合方法、ヘキサキスホスフィン及びヘキサハロ化合物
CN115335387A (zh) 核酸寡聚物的制造方法
US6239220B1 (en) Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
EP0064796A2 (en) Phosphorylating agent and process for the phosphorylation of organic hydroxyl compounds
JP5956108B2 (ja) 1,3,5−トリメチルヘキサヒドロ−1,3,5−トリアジンを含有しないn−メチルイミダゾールのキャッピング剤を用いたオリゴヌクレオチドまたはホスホロチオ酸オリゴヌクレオチドの合成
JP4797156B2 (ja) リボヌクレオシドの2’水酸基の脱保護方法
US20110201799A1 (en) Synthesis of oligonucleotides
JP2005518451A (ja) ホスフィチル化化合物を製造する方法
JP4570057B2 (ja) アリールピリジン誘導体の製造法
JP2003261569A (ja) 配位子を有する複素環化合物及びその製造方法、及びこの複素環化合物を用いる金属元素の固定化膜
JP4381055B2 (ja) アリルアミン類の製造方法