JP2024510483A - 改善されたオリゴヌクレオチド合成 - Google Patents

改善されたオリゴヌクレオチド合成 Download PDF

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Publication number
JP2024510483A
JP2024510483A JP2023556964A JP2023556964A JP2024510483A JP 2024510483 A JP2024510483 A JP 2024510483A JP 2023556964 A JP2023556964 A JP 2023556964A JP 2023556964 A JP2023556964 A JP 2023556964A JP 2024510483 A JP2024510483 A JP 2024510483A
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JP
Japan
Prior art keywords
group
liquid composition
oligonucleotide
moiety
composition
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Pending
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JP2023556964A
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English (en)
Japanese (ja)
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JP2024510483A5 (https=
Inventor
ラルフ・アイゼンフート
カール・リュディガー・ハウグ
ダニエル・ザムゾン
アーネ・ベルテルマン
ギード・クロセイン
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バッヘン・ホールディング・アクチエンゲゼルシャフト
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Publication of JP2024510483A publication Critical patent/JP2024510483A/ja
Publication of JP2024510483A5 publication Critical patent/JP2024510483A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
JP2023556964A 2021-03-19 2022-03-18 改善されたオリゴヌクレオチド合成 Pending JP2024510483A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21163788.9 2021-03-19
EP21163788 2021-03-19
PCT/EP2022/057241 WO2022195111A1 (en) 2021-03-19 2022-03-18 Improved oligonucleotide synthesis

Publications (2)

Publication Number Publication Date
JP2024510483A true JP2024510483A (ja) 2024-03-07
JP2024510483A5 JP2024510483A5 (https=) 2025-03-25

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ID=75111538

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023556964A Pending JP2024510483A (ja) 2021-03-19 2022-03-18 改善されたオリゴヌクレオチド合成

Country Status (7)

Country Link
US (1) US20250179110A1 (https=)
EP (2) EP4161942B1 (https=)
JP (1) JP2024510483A (https=)
CN (1) CN117836304A (https=)
CA (1) CA3207897A1 (https=)
DK (1) DK4161942T3 (https=)
WO (1) WO2022195111A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025229953A1 (ja) * 2024-04-30 2025-11-06 住友化学株式会社 オリゴヌクレオチドの製造方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20260001902A1 (en) 2022-09-19 2026-01-01 Bachem Holding Ag Improved oligonucleotide synthesis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003417A1 (en) * 1994-07-25 1996-02-08 Hybridon, Inc. Improved methods of detritylation for oligonucleotide synthesis
US7202264B2 (en) 2003-01-31 2007-04-10 Isis Pharmaceuticals, Inc. Supports for oligomer synthesis
US8299206B2 (en) 2007-11-15 2012-10-30 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
WO2009073809A2 (en) 2007-12-04 2009-06-11 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
US8710210B2 (en) * 2010-06-30 2014-04-29 Girindus America, Inc. Method of using N-thio compounds for oligonucleotide synthesis
DK2711370T3 (en) 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
CN106795200B (zh) 2014-10-10 2020-06-19 豪夫迈·罗氏有限公司 Galnac亚磷酰胺、其核酸缀合物及其用途
WO2019075419A1 (en) 2017-10-13 2019-04-18 Dicerna Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION
SG11202008827XA (en) 2018-04-13 2020-10-29 Bristol Myers Squibb Co Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025229953A1 (ja) * 2024-04-30 2025-11-06 住友化学株式会社 オリゴヌクレオチドの製造方法

Also Published As

Publication number Publication date
EP4161942B1 (en) 2023-08-02
DK4161942T3 (da) 2023-10-23
US20250179110A1 (en) 2025-06-05
CN117836304A (zh) 2024-04-05
CA3207897A1 (en) 2022-09-22
EP4161942A1 (en) 2023-04-12
EP4276104A2 (en) 2023-11-15
WO2022195111A1 (en) 2022-09-22
EP4276104A3 (en) 2024-05-22

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