DK4161942T3 - Forbedret oligonukleotidsyntese der undertrykker depurinering - Google Patents

Forbedret oligonukleotidsyntese der undertrykker depurinering Download PDF

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Publication number
DK4161942T3
DK4161942T3 DK22711569.8T DK22711569T DK4161942T3 DK 4161942 T3 DK4161942 T3 DK 4161942T3 DK 22711569 T DK22711569 T DK 22711569T DK 4161942 T3 DK4161942 T3 DK 4161942T3
Authority
DK
Denmark
Prior art keywords
depurination
suppresses
oligonucleotide synthesis
enhanced oligonucleotide
enhanced
Prior art date
Application number
DK22711569.8T
Other languages
Danish (da)
English (en)
Inventor
Ralf Eisenhuth
Daniel Samson
Arne Berthelmann
Karl Rüdiger Haug
Guido Creusen
Original Assignee
Bachem Holding Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bachem Holding Ag filed Critical Bachem Holding Ag
Application granted granted Critical
Publication of DK4161942T3 publication Critical patent/DK4161942T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
DK22711569.8T 2021-03-19 2022-03-18 Forbedret oligonukleotidsyntese der undertrykker depurinering DK4161942T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP21163788 2021-03-19
PCT/EP2022/057241 WO2022195111A1 (en) 2021-03-19 2022-03-18 Improved oligonucleotide synthesis

Publications (1)

Publication Number Publication Date
DK4161942T3 true DK4161942T3 (da) 2023-10-23

Family

ID=75111538

Family Applications (1)

Application Number Title Priority Date Filing Date
DK22711569.8T DK4161942T3 (da) 2021-03-19 2022-03-18 Forbedret oligonukleotidsyntese der undertrykker depurinering

Country Status (7)

Country Link
US (1) US20250179110A1 (https=)
EP (2) EP4161942B1 (https=)
JP (1) JP2024510483A (https=)
CN (1) CN117836304A (https=)
CA (1) CA3207897A1 (https=)
DK (1) DK4161942T3 (https=)
WO (1) WO2022195111A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20260001902A1 (en) 2022-09-19 2026-01-01 Bachem Holding Ag Improved oligonucleotide synthesis
WO2025229953A1 (ja) * 2024-04-30 2025-11-06 住友化学株式会社 オリゴヌクレオチドの製造方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003417A1 (en) * 1994-07-25 1996-02-08 Hybridon, Inc. Improved methods of detritylation for oligonucleotide synthesis
US7202264B2 (en) 2003-01-31 2007-04-10 Isis Pharmaceuticals, Inc. Supports for oligomer synthesis
US8299206B2 (en) 2007-11-15 2012-10-30 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
WO2009073809A2 (en) 2007-12-04 2009-06-11 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
US8710210B2 (en) * 2010-06-30 2014-04-29 Girindus America, Inc. Method of using N-thio compounds for oligonucleotide synthesis
DK2711370T3 (en) 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
CN106795200B (zh) 2014-10-10 2020-06-19 豪夫迈·罗氏有限公司 Galnac亚磷酰胺、其核酸缀合物及其用途
WO2019075419A1 (en) 2017-10-13 2019-04-18 Dicerna Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION
SG11202008827XA (en) 2018-04-13 2020-10-29 Bristol Myers Squibb Co Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds

Also Published As

Publication number Publication date
EP4161942B1 (en) 2023-08-02
US20250179110A1 (en) 2025-06-05
JP2024510483A (ja) 2024-03-07
CN117836304A (zh) 2024-04-05
CA3207897A1 (en) 2022-09-22
EP4161942A1 (en) 2023-04-12
EP4276104A2 (en) 2023-11-15
WO2022195111A1 (en) 2022-09-22
EP4276104A3 (en) 2024-05-22

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