CN117836304A - 改进的寡核苷酸合成 - Google Patents

改进的寡核苷酸合成 Download PDF

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Publication number
CN117836304A
CN117836304A CN202280036841.0A CN202280036841A CN117836304A CN 117836304 A CN117836304 A CN 117836304A CN 202280036841 A CN202280036841 A CN 202280036841A CN 117836304 A CN117836304 A CN 117836304A
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CN
China
Prior art keywords
liquid composition
oligonucleotide
group
composition
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280036841.0A
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English (en)
Chinese (zh)
Inventor
R·艾森胡特
K·R·豪格
D·参孙
A·贝瑟尔曼
G·克卢森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bachem Holding AG
Original Assignee
Bachem Holding AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bachem Holding AG filed Critical Bachem Holding AG
Publication of CN117836304A publication Critical patent/CN117836304A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN202280036841.0A 2021-03-19 2022-03-18 改进的寡核苷酸合成 Pending CN117836304A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21163788.9 2021-03-19
EP21163788 2021-03-19
PCT/EP2022/057241 WO2022195111A1 (en) 2021-03-19 2022-03-18 Improved oligonucleotide synthesis

Publications (1)

Publication Number Publication Date
CN117836304A true CN117836304A (zh) 2024-04-05

Family

ID=75111538

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280036841.0A Pending CN117836304A (zh) 2021-03-19 2022-03-18 改进的寡核苷酸合成

Country Status (7)

Country Link
US (1) US20250179110A1 (https=)
EP (2) EP4161942B1 (https=)
JP (1) JP2024510483A (https=)
CN (1) CN117836304A (https=)
CA (1) CA3207897A1 (https=)
DK (1) DK4161942T3 (https=)
WO (1) WO2022195111A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20260001902A1 (en) 2022-09-19 2026-01-01 Bachem Holding Ag Improved oligonucleotide synthesis
WO2025229953A1 (ja) * 2024-04-30 2025-11-06 住友化学株式会社 オリゴヌクレオチドの製造方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003417A1 (en) * 1994-07-25 1996-02-08 Hybridon, Inc. Improved methods of detritylation for oligonucleotide synthesis
US20090131632A1 (en) * 2007-11-15 2009-05-21 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
CN103298823A (zh) * 2010-06-30 2013-09-11 集润德斯股份公司 一种使用n-硫代化合物用于寡核苷酸合成的新方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7202264B2 (en) 2003-01-31 2007-04-10 Isis Pharmaceuticals, Inc. Supports for oligomer synthesis
WO2009073809A2 (en) 2007-12-04 2009-06-11 Alnylam Pharmaceuticals, Inc. Carbohydrate conjugates as delivery agents for oligonucleotides
DK2711370T3 (en) 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
CN106795200B (zh) 2014-10-10 2020-06-19 豪夫迈·罗氏有限公司 Galnac亚磷酰胺、其核酸缀合物及其用途
WO2019075419A1 (en) 2017-10-13 2019-04-18 Dicerna Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION
SG11202008827XA (en) 2018-04-13 2020-10-29 Bristol Myers Squibb Co Novel phosphorous (v)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophoshorous (v) compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003417A1 (en) * 1994-07-25 1996-02-08 Hybridon, Inc. Improved methods of detritylation for oligonucleotide synthesis
US20090131632A1 (en) * 2007-11-15 2009-05-21 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
CN103298823A (zh) * 2010-06-30 2013-09-11 集润德斯股份公司 一种使用n-硫代化合物用于寡核苷酸合成的新方法

Also Published As

Publication number Publication date
EP4161942B1 (en) 2023-08-02
DK4161942T3 (da) 2023-10-23
US20250179110A1 (en) 2025-06-05
JP2024510483A (ja) 2024-03-07
CA3207897A1 (en) 2022-09-22
EP4161942A1 (en) 2023-04-12
EP4276104A2 (en) 2023-11-15
WO2022195111A1 (en) 2022-09-22
EP4276104A3 (en) 2024-05-22

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