JP2023540228A5 - - Google Patents

Info

Publication number
JP2023540228A5
JP2023540228A5 JP2023513401A JP2023513401A JP2023540228A5 JP 2023540228 A5 JP2023540228 A5 JP 2023540228A5 JP 2023513401 A JP2023513401 A JP 2023513401A JP 2023513401 A JP2023513401 A JP 2023513401A JP 2023540228 A5 JP2023540228 A5 JP 2023540228A5
Authority
JP
Japan
Prior art keywords
group
optionally substituted
ring
substituted
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023513401A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023540228A (ja
JP7837952B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2021/114676 external-priority patent/WO2022042630A1/en
Publication of JP2023540228A publication Critical patent/JP2023540228A/ja
Publication of JP2023540228A5 publication Critical patent/JP2023540228A5/ja
Application granted granted Critical
Publication of JP7837952B2 publication Critical patent/JP7837952B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023513401A 2020-08-26 2021-08-26 ヘテロアリール基化合物、その製造方法および使用 Active JP7837952B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/111302 2020-08-26
CN2020111302 2020-08-26
CNPCT/CN2021/075781 2021-02-07
CN2021075781 2021-02-07
PCT/CN2021/114676 WO2022042630A1 (en) 2020-08-26 2021-08-26 Heteroaryl compounds, preparation methods and uses thereof

Publications (3)

Publication Number Publication Date
JP2023540228A JP2023540228A (ja) 2023-09-22
JP2023540228A5 true JP2023540228A5 (enExample) 2024-08-28
JP7837952B2 JP7837952B2 (ja) 2026-03-31

Family

ID=80354683

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023513401A Active JP7837952B2 (ja) 2020-08-26 2021-08-26 ヘテロアリール基化合物、その製造方法および使用

Country Status (5)

Country Link
US (1) US20230357233A1 (enExample)
EP (1) EP4204412A4 (enExample)
JP (1) JP7837952B2 (enExample)
CN (1) CN115968286A (enExample)
WO (1) WO2022042630A1 (enExample)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114615981B (zh) 2019-08-29 2024-04-12 米拉蒂治疗股份有限公司 Kras g12d抑制剂
WO2021085653A1 (en) 2019-10-31 2021-05-06 Taiho Pharmaceutical Co., Ltd. 4-aminobut-2-enamide derivatives and salts thereof
EP4067343A4 (en) 2019-11-29 2024-01-03 Taiho Pharmaceutical Co., Ltd. NEW PHENOLIC COMPOUND OR SALT THEREOF
WO2021215544A1 (en) 2020-04-24 2021-10-28 Taiho Pharmaceutical Co., Ltd. Kras g12d protein inhibitors
US12702658B2 (en) 2020-04-24 2026-08-11 Taiho Pharmaceutical Co., Ltd. Anticancer combination therapy with N-(1-acryloyl-azetidin-3-yl)-2-((1H-indazol-3-yl)amino)methyl)-1H-imidazole-5-carboxamide inhibitor of KRAS-G12C
EP4182313A4 (en) * 2020-07-16 2024-10-09 Mirati Therapeutics, Inc. KRAS-G12D INHIBITORS
WO2022109487A1 (en) 2020-11-23 2022-05-27 Merck Sharp & Dohme Corp. Spirocyclic-substituted 6,7-dihydro-pyrano[2,3-d]pyrimidine inhibitors of kras g12c mutant
WO2022170999A1 (zh) * 2021-02-09 2022-08-18 南京明德新药研发有限公司 吡啶[4,3-d]嘧啶类化合物
WO2022194066A1 (zh) * 2021-03-15 2022-09-22 贝达药业股份有限公司 Kras g12d抑制剂及其在医药上的应用
CN115109078A (zh) * 2021-03-22 2022-09-27 苏州泽璟生物制药股份有限公司 嘧啶并吡啶类抑制剂及其制备方法和应用
CN115141215B (zh) * 2021-03-30 2023-09-15 上海德琪医药科技有限公司 Kras g12d蛋白抑制剂和其用途
CN116157400B (zh) * 2021-03-30 2024-10-22 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途
WO2022217042A1 (en) * 2021-04-09 2022-10-13 Ikena Oncology, Inc. Naphthyl-substituted quinoline-4(1h)-ones and related compounds and their use in treating medical conditions
CN117715915A (zh) * 2021-04-09 2024-03-15 杭州英创医药科技有限公司 作为kras g12d抑制剂的杂环化合物
CN115197245A (zh) * 2021-04-09 2022-10-18 上海拓界生物医药科技有限公司 一种Kras抑制剂及其制备方法
CN116157401B (zh) * 2021-04-28 2025-06-20 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途
EP4332105A4 (en) * 2021-04-30 2025-05-28 Genfleet Therapeutics (Shanghai) Inc. PYRIDINO- OR PYRIMIDO-CYCLIC COMPOUND, ITS PREPARATION PROCESS AND ITS MEDICAL USE
IL308195A (en) 2021-05-05 2024-01-01 Revolution Medicines Inc RAS inhibitors for cancer treatment
PE20240088A1 (es) 2021-05-05 2024-01-16 Revolution Medicines Inc Inhibidores de ras
WO2022235866A1 (en) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Covalent ras inhibitors and uses thereof
WO2022236578A1 (en) * 2021-05-10 2022-11-17 Nikang Therapeutics, Inc. Exocyclic amino quinazoline derivatives as kras inhibitors
US20240300980A1 (en) * 2021-05-22 2024-09-12 Shanghai Kechow Pharma, Inc. Heterocyclic compounds as kras inhibitor, and preparation therefor and use thereof in treatment
BR112023024906A2 (pt) * 2021-05-28 2024-02-15 Redx Pharma Plc Compostos
CN115466272A (zh) * 2021-06-11 2022-12-13 博瑞生物医药(苏州)股份有限公司 一种嘧啶并杂环化合物,包含其的药物组合物及其用途
WO2022262686A1 (en) * 2021-06-13 2022-12-22 Jingrui Biopharma Co., Ltd. Kras g12d inhibitors
CA3221608A1 (en) * 2021-06-14 2022-12-22 Kumquat Biosciences Inc. Fused heteroaryl compounds useful as anticancer agents
WO2022266206A1 (en) 2021-06-16 2022-12-22 Erasca, Inc. Kras inhibitor conjugates
AU2022304939A1 (en) * 2021-06-30 2024-02-08 Shanghai Allist Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound, and preparation method therefor, intermediate thereof, and application thereof
CN117157292A (zh) * 2021-07-16 2023-12-01 苏州赞荣医药科技有限公司 Kras g12d抑制剂和其用途
WO2023284881A1 (en) * 2021-07-16 2023-01-19 Silexon Ai Technology Co., Ltd. Heterocyclic compounds useful as kras g12d inhibitors
EP4378478A4 (en) 2021-07-27 2025-11-12 Toray Industries MEDICINE FOR THE TREATMENT AND/OR PREVENTION OF CANCER
CN116143806A (zh) * 2021-08-08 2023-05-23 上海凌达生物医药有限公司 一类含氮杂环类化合物、制备方法和用途
JP2024532735A (ja) * 2021-08-10 2024-09-10 アムジエン・インコーポレーテツド 複素環式化合物及び使用方法
WO2023020347A1 (zh) * 2021-08-16 2023-02-23 华润医药研究院(深圳)有限公司 嘧啶并吡啶类化合物及其制备方法和医药用途
WO2023020523A1 (en) * 2021-08-18 2023-02-23 Jacobio Pharmaceuticals Co., Ltd. Bicyclic derivatives and use thereof
WO2023020519A1 (en) * 2021-08-18 2023-02-23 Jacobio Pharmaceuticals Co., Ltd. 1, 4-oxazepane derivatives and uses thereof
WO2023020521A1 (en) * 2021-08-18 2023-02-23 Jacobio Pharmaceuticals Co., Ltd. Pyridine fused pyrimidine derivatives and use thereof
CN116284055B (zh) * 2021-09-10 2025-09-23 润佳(苏州)医药科技有限公司 一种kras抑制剂及其用途
WO2023061294A1 (zh) * 2021-10-13 2023-04-20 再鼎医药(上海)有限公司 含氮杂环类衍生物调节剂、其制备方法及应用
EP4417606A4 (en) * 2021-10-15 2025-10-22 Sunshine Lake Pharma Co Ltd NOVEL PYRIMIDOPYRIDINE COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
WO2023072188A1 (zh) * 2021-10-29 2023-05-04 贝达药业股份有限公司 Kras g12d抑制剂及其在医药上的应用
KR20240114793A (ko) 2021-11-05 2024-07-24 프론티어 메디슨즈 코포레이션 Kras g12c 억제제
CN116217591A (zh) * 2021-12-02 2023-06-06 思路迪生物医药(上海)有限公司 一类作为kras g12d突变抑制剂的吡啶并嘧啶类衍生物
CN117940436A (zh) * 2021-12-02 2024-04-26 上海和誉生物医药科技有限公司 一种7-(萘-1-基)吡啶并[4,3-d]嘧啶衍生物及其制备和应用
WO2023103523A1 (zh) * 2021-12-09 2023-06-15 苏州浦合医药科技有限公司 取代的双环杂芳基化合物作为kras g12d抑制剂
CA3243183A1 (en) * 2021-12-21 2023-06-29 Bridgene Biosciences, Inc. RAS ONCOPROTEIN INHIBITORS
WO2023134465A1 (zh) * 2022-01-11 2023-07-20 上海艾力斯医药科技股份有限公司 一种含氮杂环化合物、其制备方法、中间体及应用
WO2023138583A1 (zh) * 2022-01-21 2023-07-27 上海湃隆生物科技有限公司 杂环类化合物、药物组合物及其应用
CN118679170A (zh) * 2022-01-28 2024-09-20 上海艾力斯医药科技股份有限公司 一种含氮杂环化合物、其制备方法及应用
CA3243798A1 (en) 2022-02-09 2023-08-17 Quanta Therapeutics, Inc. Kras Modulators and Their Uses
CN117659049A (zh) * 2022-08-23 2024-03-08 苏州泽璟生物制药股份有限公司 取代桥环类抑制剂及其制备方法和应用
WO2023179629A1 (zh) * 2022-03-22 2023-09-28 苏州泽璟生物制药股份有限公司 取代桥环类抑制剂及其制备方法和应用
JP2025510656A (ja) * 2022-03-24 2025-04-15 ベイジーン スウィッツァーランド ゲーエムベーハー 複素環式化合物、その組成物、及びそれらを用いた治療方法
CN114573438A (zh) * 2022-03-31 2022-06-03 上海应用技术大学 一种单氟氯/溴代丙酮类化合物及其制备方法
CN116891488B (zh) * 2022-04-11 2025-12-12 成都海博为药业有限公司 稠环化合物、包含其的药物组合物及应用
WO2023198078A1 (zh) * 2022-04-11 2023-10-19 杭州英创医药科技有限公司 作为kras g12d抑制剂的多环化合物
WO2023198191A1 (zh) * 2022-04-15 2023-10-19 杭州多域生物技术有限公司 一种六元并六元化合物、制备方法、药物组合物和应用
WO2023230190A1 (en) 2022-05-25 2023-11-30 Quanta Therapeutics, Inc. Pyrimidine based modulators and uses thereof
CN117642408B (zh) * 2022-06-24 2026-06-23 暨南大学 含硒杂环类化合物及其药用组合物和应用
CN117327102B (zh) * 2022-06-30 2026-04-28 重庆华森英诺生物科技有限公司 Kras抑制剂、其制备方法及应用
WO2024008178A1 (zh) * 2022-07-08 2024-01-11 贝达药业股份有限公司 Kras g12d抑制剂及其在医药上的应用
CN116969977B (zh) * 2022-07-13 2026-05-01 重庆华森英诺生物科技有限公司 Pan-kras抑制剂
TW202409051A (zh) 2022-07-27 2024-03-01 大陸商江蘇恆瑞醫藥股份有限公司 稠環類化合物、其製備方法及其在醫藥上的應用
AU2023320565A1 (en) 2022-08-05 2025-01-23 Kumquat Biosciences Inc. Heterocyclic compounds and uses thereof
US20260137687A1 (en) * 2022-08-24 2026-05-21 The Regents Of The University Of California GTPase INHIBITORS AND USES THEREOF
CN120018863A (zh) * 2022-08-24 2025-05-16 珃诺生物医药科技(杭州)有限公司 用于调节kras(g12d)的方法和组合物
WO2024045066A1 (en) * 2022-08-31 2024-03-07 Nikang Therapeutics, Inc. Alkylidene carbamate as kras inhibitors
WO2024051721A1 (en) * 2022-09-07 2024-03-14 Nikang Therapeutics, Inc. Tetracyclic derivatives as kras inhibitors
WO2024054926A1 (en) * 2022-09-07 2024-03-14 Bristol-Myers Squibb Company Kras g12d inhibitors
AU2023338980A1 (en) * 2022-09-09 2025-04-03 Ranok Therapeutics (Hangzhou) Co. Ltd. 4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-naphthalene-pyrido[4,3-d]pyrimidine derivatives as inhibitors of the kras(g12d) mutant oncoproteine for the treatment of cancer
TW202426463A (zh) * 2022-09-09 2024-07-01 大陸商上海翰森生物醫藥科技有限公司 含嘧啶多環類生物抑制劑、其製備方法和應用
WO2024061333A1 (zh) * 2022-09-21 2024-03-28 甘李药业股份有限公司 一种kras突变蛋白抑制剂、及其制备方法和应用
CN117800976A (zh) * 2022-09-30 2024-04-02 上海凌达生物医药有限公司 一类含氮杂环类化合物、制备方法和用途
CN117886833A (zh) * 2022-10-13 2024-04-16 广东东阳光药业股份有限公司 一种嘧啶并吡啶化合物、其药物组合物及其用途
US20260216179A1 (en) * 2022-10-31 2026-07-30 Beta Pharma, Inc. 1,5-naphthyridine derivatives as kras oncoprotein inhibitors
AU2023377064A1 (en) 2022-11-09 2025-05-22 Revolution Medicines, Inc. Compounds, complexes, and methods for their preparation and of their use
WO2024234360A1 (en) * 2023-05-18 2024-11-21 Nikang Therapeutics , Inc. Tetracyclic derivatives as kras inhibitors
EP4680609A1 (en) 2023-03-15 2026-01-21 Quanta Therapeutics, Inc. Kras modulators and uses thereof
WO2024215862A2 (en) * 2023-04-12 2024-10-17 Board Of Regents, The University Of Texas System Heterocyclic compounds as nras inhibitors
KR20250170697A (ko) * 2023-04-14 2025-12-05 선샤인 레이크 파르마 컴퍼니 리미티드 Kras 억제제 화합물, 이의 약학 조성물 및 이의 용도
JP2026523985A (ja) * 2023-06-28 2026-07-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッド ピリミドピリジン化合物、その医薬組成物及びその使用
WO2025006967A1 (en) 2023-06-30 2025-01-02 Bristol-Myers Squibb Company Kras inhibitors
CN122122158A (zh) * 2023-08-08 2026-05-29 瑟拉斯有限公司 用于治疗癌症和其他适应症的稠合吡啶
TW202523324A (zh) * 2023-10-08 2025-06-16 大陸商成都海博為藥業有限公司 一種稠環化合物及應用
KR20260110993A (ko) 2023-10-09 2026-07-14 인사이트 코포레이션 Kras g12d 억제제 및 egfr 억제제를 포함하는 암 치료용 조합
US20250114346A1 (en) 2023-10-09 2025-04-10 Incyte Corporation Combination therapy using a kras g12d inhibitor and pd-1 inhibitor or pd-l1 inhibitor
KR20260096846A (ko) 2023-10-20 2026-06-24 머크 샤프 앤드 돔 엘엘씨 Kras 단백질의 소분자 억제제
TW202535880A (zh) 2023-10-30 2025-09-16 大陸商江蘇恆瑞醫藥股份有限公司 稠合雜芳基類化合物、其製備方法及其在醫藥上的應用
CN117683052A (zh) * 2023-12-07 2024-03-12 上海相辉医药科技有限公司 一种kras g12d抑制剂mrtx1133的制备方法
WO2025123318A1 (en) * 2023-12-15 2025-06-19 Shanghai Blueray Biopharma Co., Ltd. TETRACYCLIC DERIVATIVES AS K-Ras G12D INHIBITORS
US20260137674A1 (en) 2024-10-23 2026-05-21 Incyte Corporation Combination therapy using a kras g12d inhibitor, and a nucleoside analog, and/or a microtubule inhibitor
WO2026090333A1 (en) 2024-10-23 2026-04-30 Incyte Corporation Combination using a kras g12d inhibitor and chemotherapy combinations as well as their use in the treatment of cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060477A (en) * 1995-06-07 2000-05-09 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
KR101464384B1 (ko) * 2005-11-22 2014-11-21 쿠도스 파마슈티칼스 리미티드 mTOR 억제제로서 피리도피리미딘, 피라조피리미딘 및피리미도피리미딘 유도체
JP2019529484A (ja) * 2016-09-29 2019-10-17 アラクセス ファーマ エルエルシー Kras g12c変異体タンパク質の阻害剤
JP7369719B2 (ja) * 2018-06-12 2023-10-26 アムジエン・インコーポレーテツド KRas G12C阻害剤及びそれを使用する方法
JP7516029B2 (ja) * 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Kras g12c阻害剤化合物の重要な中間体の改良合成法
EP3887373A1 (en) * 2018-11-29 2021-10-06 Araxes Pharma LLC Compounds and methods of use thereof for treatment of cancer
WO2020146613A1 (en) * 2019-01-10 2020-07-16 Mirati Therapeutics, Inc. Kras g12c inhibitors
CN114615981B (zh) * 2019-08-29 2024-04-12 米拉蒂治疗股份有限公司 Kras g12d抑制剂
AU2021298154A1 (en) * 2020-06-25 2023-02-23 Tolremo Therapeutics Ag Combination of a CBP/p300 bromodomain inhibitor and a KRAS inhibitor for the treatment of cancer

Similar Documents

Publication Publication Date Title
JP2023531269A5 (enExample)
JP4896717B2 (ja) N−メチル−置換ベンゾアミダゾール
JP2022130631A5 (enExample)
AU2014222641B2 (en) Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of Hepatitis B
JP5576485B2 (ja) 新生物疾患又は自己免疫疾患を処置するためのプロドラッグとしてのフラザノベンゾイミダゾール
JP2020533288A5 (enExample)
JP2021519783A5 (enExample)
JP2022505835A5 (enExample)
JP2014517017A5 (ja) 化合物、その医薬組成物、及び癌治療用の阻害薬としてのその使用
JP2005504789A5 (enExample)
RU2010101611A (ru) Полициклические производные гуанина и способы их применения
JP2018511631A5 (enExample)
RU2011124304A (ru) Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
JP2007511504A5 (enExample)
JP2025502377A5 (enExample)
RU2010113358A (ru) Гуанидинсодержащие соединения, применимые в качестве антагонистов мускариновых рецепторов
AU2019372121A1 (en) Heterocyclic compounds as BET inhibitors
JP2020500869A5 (enExample)
JP2008517923A5 (enExample)
CA2565852C (en) 3- or 4-monosubstituted phenol and thiophenol derivatives useful as h3 ligands
JP2010527984A5 (enExample)
JP2014520108A5 (enExample)
JP2022533939A5 (enExample)
JP2025517106A5 (enExample)
JP2006509842A5 (enExample)