CN115968286A - 杂芳基化合物，其制备方法和用途 - Google Patents

杂芳基化合物，其制备方法和用途 Download PDF

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Publication number
CN115968286A
CN115968286A CN202180051529.4A CN202180051529A CN115968286A CN 115968286 A CN115968286 A CN 115968286A CN 202180051529 A CN202180051529 A CN 202180051529A CN 115968286 A CN115968286 A CN 115968286A
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Chinese (zh)
Inventor
代星
杨红
黄贤海
牛浩涛
韩自省
王振武
张强
刘艳琴
江岳恒
陶良山
翁吉芳
史喆
王耀林
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Yifang Biological Co ltd
Yifang Biotechnology Shanghai Co ltd
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Yifang Biological Co ltd
Yifang Biotechnology Shanghai Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180051529.4A 2020-08-26 2021-08-26 杂芳基化合物，其制备方法和用途 Pending CN115968286A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/111302 2020-08-26
CN2020111302 2020-08-26
CN2021075781 2021-02-07
CNPCT/CN2021/075781 2021-02-07
PCT/CN2021/114676 WO2022042630A1 (en) 2020-08-26 2021-08-26 Heteroaryl compounds, preparation methods and uses thereof

Publications (1)

Publication Number Publication Date
CN115968286A true CN115968286A (zh) 2023-04-14

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US (1) US20230357233A1 (enExample)
EP (1) EP4204412A4 (enExample)
JP (1) JP7837952B2 (enExample)
CN (1) CN115968286A (enExample)
WO (1) WO2022042630A1 (enExample)

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CN116157401A (zh) * 2021-04-28 2023-05-23 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途
CN116848112A (zh) * 2021-02-09 2023-10-03 南京明德新药研发有限公司 吡啶[4，3-d]嘧啶类化合物
CN117642407A (zh) * 2021-06-30 2024-03-01 上海艾力斯医药科技股份有限公司 一种含氮杂环化合物、其制备方法、中间体及应用
CN117659051A (zh) * 2021-03-30 2024-03-08 上海德琪医药科技有限公司 Kras g12d蛋白抑制剂和其用途
CN117683052A (zh) * 2023-12-07 2024-03-12 上海相辉医药科技有限公司 一种kras g12d抑制剂mrtx1133的制备方法
WO2025002302A1 (zh) * 2023-06-28 2025-01-02 广东东阳光药业股份有限公司 嘧啶并吡啶化合物、其药物组合物及其用途
WO2025077663A1 (zh) * 2023-10-08 2025-04-17 成都海博为药业有限公司 一种稠环化合物及应用
WO2025124415A1 (en) * 2023-12-15 2025-06-19 Nikang Therapeutics Inc. TETRACYCLIC DERIVATIVES AS K-Ras G12D INHIBITORS

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CN116157400B (zh) * 2021-03-30 2024-10-22 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途
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CN117222650A (zh) * 2021-04-30 2023-12-12 劲方医药科技(上海)有限公司 吡啶或嘧啶并环类化合物，其制法与医药上的用途
KR20240017811A (ko) 2021-05-05 2024-02-08 레볼루션 메디슨즈, 인크. 암의 치료를 위한 ras 억제제
JP2024516450A (ja) 2021-05-05 2024-04-15 レボリューション メディシンズ インコーポレイテッド 共有結合性ｒａｓ阻害剤及びその使用
TW202309052A (zh) 2021-05-05 2023-03-01 美商銳新醫藥公司 Ｒａｓ抑制劑
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WO2023284537A1 (en) * 2021-07-16 2023-01-19 Shanghai Zion Pharma Co. Limited Kras g12d inhibitors and uses thereof
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CN116669740A (zh) * 2021-08-16 2023-08-29 华润医药研究院（深圳）有限公司 嘧啶并吡啶类化合物及其制备方法和医药用途
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CN116284055B (zh) * 2021-09-10 2025-09-23 润佳（苏州）医药科技有限公司 一种kras抑制剂及其用途
WO2023061294A1 (zh) * 2021-10-13 2023-04-20 再鼎医药(上海)有限公司 含氮杂环类衍生物调节剂、其制备方法及应用
WO2023061463A1 (zh) * 2021-10-15 2023-04-20 广东东阳光药业有限公司 新的嘧啶并吡啶化合物、其药物组合物及其用途
WO2023072188A1 (zh) * 2021-10-29 2023-05-04 贝达药业股份有限公司 Kras g12d抑制剂及其在医药上的应用
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CN116217591A (zh) * 2021-12-02 2023-06-06 思路迪生物医药(上海)有限公司 一类作为kras g12d突变抑制剂的吡啶并嘧啶类衍生物
CN117940436A (zh) * 2021-12-02 2024-04-26 上海和誉生物医药科技有限公司 一种7-(萘-1-基)吡啶并[4,3-d]嘧啶衍生物及其制备和应用
CN116253748A (zh) * 2021-12-09 2023-06-13 苏州浦合医药科技有限公司 取代的双环杂芳基化合物作为kras g12d抑制剂
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CN118556063A (zh) * 2022-01-21 2024-08-27 上海湃隆生物科技有限公司 杂环类化合物、药物组合物及其应用
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CN116848112A (zh) * 2021-02-09 2023-10-03 南京明德新药研发有限公司 吡啶[4，3-d]嘧啶类化合物
CN117659051A (zh) * 2021-03-30 2024-03-08 上海德琪医药科技有限公司 Kras g12d蛋白抑制剂和其用途
CN116157401A (zh) * 2021-04-28 2023-05-23 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途
CN116157401B (zh) * 2021-04-28 2025-06-20 浙江海正药业股份有限公司 杂环类衍生物及其制备方法和用途
CN117642407A (zh) * 2021-06-30 2024-03-01 上海艾力斯医药科技股份有限公司 一种含氮杂环化合物、其制备方法、中间体及应用
WO2025002302A1 (zh) * 2023-06-28 2025-01-02 广东东阳光药业股份有限公司 嘧啶并吡啶化合物、其药物组合物及其用途
WO2025077663A1 (zh) * 2023-10-08 2025-04-17 成都海博为药业有限公司 一种稠环化合物及应用
CN117683052A (zh) * 2023-12-07 2024-03-12 上海相辉医药科技有限公司 一种kras g12d抑制剂mrtx1133的制备方法
WO2025124415A1 (en) * 2023-12-15 2025-06-19 Nikang Therapeutics Inc. TETRACYCLIC DERIVATIVES AS K-Ras G12D INHIBITORS

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