CN112020496A - 作为rho激酶抑制剂的苯并吡唑类化合物 - Google Patents

作为rho激酶抑制剂的苯并吡唑类化合物 Download PDF

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Publication number
CN112020496A
CN112020496A CN201980026510.7A CN201980026510A CN112020496A CN 112020496 A CN112020496 A CN 112020496A CN 201980026510 A CN201980026510 A CN 201980026510A CN 112020496 A CN112020496 A CN 112020496A
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compound
reaction
isomer
pharmaceutically acceptable
acceptable salt
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CN112020496B (zh
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吴凌云
尹军
王才林
肖哲明
黎健
陈曙辉
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Medshine Discovery Inc
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Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

公开了一类作为RHO激酶抑制剂的苯并吡唑类化合物，其药物组合物以及它们在制备RHO抑制药物中的应用，具体公开了式I‑1所示化合物、其药学上可接受的盐或异构体。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN201980026510.7A 2018-04-18 2019-04-18 作为rho激酶抑制剂的苯并吡唑类化合物 Active CN112020496B (zh)

Applications Claiming Priority (5)

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CN201810349362 2018-04-18
CN201810349362X 2018-04-18
CN201811221303 2018-10-19
CN2018112213030 2018-10-19
PCT/CN2019/083210 WO2019201297A1 (zh) 2018-04-18 2019-04-18 作为rho激酶抑制剂的苯并吡唑类化合物

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CN112020496A true CN112020496A (zh) 2020-12-01
CN112020496B CN112020496B (zh) 2023-04-28

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US (1) US11345678B2 (zh)
EP (1) EP3782987A4 (zh)
JP (1) JP7187575B2 (zh)
CN (1) CN112020496B (zh)
WO (1) WO2019201297A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021038419A1 (en) * 2019-08-23 2021-03-04 Insilico Medicine Ip Limited Kinase inhibitors and methods of synthesis and treatment
WO2021073592A1 (zh) * 2019-10-18 2021-04-22 南京明德新药研发有限公司 作为rho激酶抑制剂的苯并吡唑类化合物的盐型、晶型及其制备方法
CN116438175A (zh) * 2020-11-11 2023-07-14 南京明德新药研发有限公司 苯并脲环衍生物及其制备方法和应用
CN113214172A (zh) * 2021-04-25 2021-08-06 西南大学 氟康唑中间体还原胺化产物的制备方法
CN114181139B (zh) * 2021-12-27 2023-12-08 四川仁安药业有限责任公司 一种5-卤代烟酸的合成方法

Citations (1)

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WO2005074643A2 (en) * 2004-01-30 2005-08-18 Smithkline Beecham Corporation Benzamide compounds useful as rock inhibitors

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CR9465A (es) 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
EP1979353A2 (en) 2006-01-19 2008-10-15 OSI Pharmaceuticals, Inc. Fused heterobicyclic kinase inhibitors
WO2008054599A2 (en) 2006-09-27 2008-05-08 Surface Logix, Inc. Rho kinase inhibitors
KR20100032886A (ko) * 2007-06-08 2010-03-26 아보트 러보러터리즈 키나제 억제제로서의 5-헤테로아릴 치환된 인다졸
CN101903349B (zh) * 2007-08-27 2014-01-08 Abbvie德国有限责任两合公司 4-(4-吡啶基)-苯甲酰胺及其作为rock活性调节剂的应用
AU2010222848A1 (en) 2009-03-09 2011-10-20 Surface Logix, Inc. Rho kinase inhibitors
DK2987487T3 (da) * 2009-08-10 2020-12-07 Samumed Llc Indazolinhibitorer af wnt-signalvejen og terapeutiske anvendelser deraf
WO2011050245A1 (en) 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
WO2012135697A2 (en) 2011-03-30 2012-10-04 H. Lee Moffitt Cancer Center & Research Institute Inc. Novel rho kinase inhibitors and methods of use
US9815820B2 (en) 2012-10-05 2017-11-14 Kadmon Corporation, Llc Rho kinase inhibitors
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
ES2838573T3 (es) 2014-08-21 2021-07-02 Bristol Myers Squibb Co Derivados de benzamida ligados como inhibidores potentes de ROCK
AU2017351216C1 (en) * 2016-10-24 2021-10-14 Translational Drug Development, Llc Amide compounds as kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005074643A2 (en) * 2004-01-30 2005-08-18 Smithkline Beecham Corporation Benzamide compounds useful as rock inhibitors

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JP2021522201A (ja) 2021-08-30
EP3782987A1 (en) 2021-02-24
JP7187575B2 (ja) 2022-12-12
CN112020496B (zh) 2023-04-28
EP3782987A4 (en) 2021-05-19
US11345678B2 (en) 2022-05-31
WO2019201297A1 (zh) 2019-10-24
US20210371393A1 (en) 2021-12-02

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