JP2008517923A5 - - Google Patents
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- Publication number
- JP2008517923A5 JP2008517923A5 JP2007538052A JP2007538052A JP2008517923A5 JP 2008517923 A5 JP2008517923 A5 JP 2008517923A5 JP 2007538052 A JP2007538052 A JP 2007538052A JP 2007538052 A JP2007538052 A JP 2007538052A JP 2008517923 A5 JP2008517923 A5 JP 2008517923A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- compound according
- optionally
- therapeutic agent
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001931 aliphatic group Chemical group 0.000 claims 34
- 150000001875 compounds Chemical class 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 229940124597 therapeutic agent Drugs 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- -1 1,2-methylenedioxy Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000006417 multiple sclerosis Diseases 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 208000020084 Bone disease Diseases 0.000 claims 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 230000001066 destructive effect Effects 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 239000011593 sulfur Substances 0.000 claims 3
- 208000019838 Blood disease Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 230000001028 anti-proliverative effect Effects 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000014951 hematologic disease Diseases 0.000 claims 2
- 208000018706 hematopoietic system disease Diseases 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000006164 6-membered heteroaryl group Chemical group 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 claims 1
- 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229940127225 asthma medication Drugs 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 230000000973 chemotherapeutic effect Effects 0.000 claims 1
- 239000012829 chemotherapy agent Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000002584 immunomodulator Effects 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62127004P | 2004-10-21 | 2004-10-21 | |
| US60/621,270 | 2004-10-21 | ||
| PCT/US2005/037830 WO2006047256A1 (en) | 2004-10-21 | 2005-10-21 | Triazoles useful as inhibitors of protein kinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008517923A JP2008517923A (ja) | 2008-05-29 |
| JP2008517923A5 true JP2008517923A5 (enExample) | 2008-11-20 |
| JP5085330B2 JP5085330B2 (ja) | 2012-11-28 |
Family
ID=35809788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538052A Expired - Fee Related JP5085330B2 (ja) | 2004-10-21 | 2005-10-21 | プロテインキナーゼの阻害剤として有用なトリアゾール |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7645775B2 (enExample) |
| EP (1) | EP1811998B1 (enExample) |
| JP (1) | JP5085330B2 (enExample) |
| KR (1) | KR20070085407A (enExample) |
| CN (1) | CN101072556A (enExample) |
| AR (1) | AR054088A1 (enExample) |
| AT (1) | ATE485042T1 (enExample) |
| AU (1) | AU2005299816B2 (enExample) |
| BR (1) | BRPI0517435A (enExample) |
| CA (1) | CA2584752A1 (enExample) |
| CY (1) | CY1111197T1 (enExample) |
| DE (1) | DE602005024293D1 (enExample) |
| DK (1) | DK1811998T3 (enExample) |
| ES (1) | ES2352453T3 (enExample) |
| HR (1) | HRP20100715T1 (enExample) |
| IL (1) | IL182664A0 (enExample) |
| MX (1) | MX2007004841A (enExample) |
| NO (1) | NO20072567L (enExample) |
| NZ (1) | NZ555088A (enExample) |
| PL (1) | PL1811998T3 (enExample) |
| PT (1) | PT1811998E (enExample) |
| RU (1) | RU2393155C2 (enExample) |
| SI (1) | SI1811998T1 (enExample) |
| TW (1) | TW200630090A (enExample) |
| WO (1) | WO2006047256A1 (enExample) |
| ZA (1) | ZA200703950B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090103897A (ko) | 2006-12-28 | 2009-10-01 | 다이쇼 세이야꾸 가부시끼가이샤 | 피라졸로피리미딘 화합물 |
| AU2016259396B2 (en) * | 2006-12-29 | 2018-11-08 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| AU2014200824B2 (en) * | 2006-12-29 | 2016-12-15 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| EP2079736B1 (en) * | 2006-12-29 | 2017-10-18 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as axl inhibitors |
| JP5567837B2 (ja) | 2006-12-29 | 2014-08-06 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｘｌインヒビターとして有用なＮ３−ヘテロアリール置換トリアゾールおよびＮ５−ヘテロアリール置換トリアゾール |
| CA2710230C (en) | 2006-12-29 | 2016-02-23 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic aryl and bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| CA2710043C (en) | 2006-12-29 | 2016-02-09 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| ES2424023T3 (es) | 2007-10-18 | 2013-09-26 | Janssen Pharmaceutica N.V. | 1,2,4-triazoles trisustituidos |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| CN102066343B (zh) | 2008-03-19 | 2013-12-04 | 詹森药业有限公司 | 作为烟碱乙酰胆碱受体调节剂的三取代1，2，4-三唑类 |
| EA018187B1 (ru) | 2008-05-09 | 2013-06-28 | Янссен Фармацевтика Нв | Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина |
| WO2010005879A1 (en) | 2008-07-09 | 2010-01-14 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| EP2387572B1 (en) * | 2009-01-15 | 2015-09-16 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| CN102281875B (zh) | 2009-01-16 | 2017-09-22 | 里格尔药品股份有限公司 | 预防、治疗或应对转移癌的使用axl抑制剂的组合疗法 |
| AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
| EP2569294B1 (en) | 2010-05-11 | 2015-03-11 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| TW201206444A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| TW201206910A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| TW201206889A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| CN107142237B (zh) * | 2011-05-17 | 2021-03-02 | 深圳涌泰生物科技有限公司 | 培养基、细胞培养用试剂盒及细胞培养方法 |
| MX2015011125A (es) * | 2013-03-05 | 2015-11-11 | Hoffmann La Roche | Compuestos antivirales. |
| AU2016270373A1 (en) | 2015-06-05 | 2018-01-04 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| KR20220042127A (ko) * | 2019-06-28 | 2022-04-04 | 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 | 피라졸로피리미딘 화합물, 그의 제조 방법 및 그의 응용 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637592A (en) * | 1994-07-12 | 1997-06-10 | Janssen Pharmaceutica N.V. | Acyl derivatives of azolones |
| PL335235A1 (en) * | 1997-02-19 | 2000-04-10 | Berlex Lab | N-heterocyclic derivatives as nos inhibitors |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| DE60120494T2 (de) * | 2000-12-22 | 2006-12-21 | Ortho-Mcneil Pharmaceutical, Inc. | Substituieten triazoldiamin derivaten und ihre verwendung als kinase inhibitoren |
| DE10123586A1 (de) * | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
| CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
| TW200514776A (en) * | 2003-08-06 | 2005-05-01 | Vertex Pharma | Aminotriazole compounds useful as inhibitors of protein kinases |
-
2005
- 2005-10-21 DE DE602005024293T patent/DE602005024293D1/de not_active Expired - Lifetime
- 2005-10-21 KR KR1020077011405A patent/KR20070085407A/ko not_active Withdrawn
- 2005-10-21 BR BRPI0517435-0A patent/BRPI0517435A/pt not_active IP Right Cessation
- 2005-10-21 MX MX2007004841A patent/MX2007004841A/es unknown
- 2005-10-21 US US11/255,569 patent/US7645775B2/en not_active Expired - Fee Related
- 2005-10-21 TW TW094137050A patent/TW200630090A/zh unknown
- 2005-10-21 AT AT05815914T patent/ATE485042T1/de active
- 2005-10-21 DK DK05815914.6T patent/DK1811998T3/da active
- 2005-10-21 NZ NZ555088A patent/NZ555088A/en not_active IP Right Cessation
- 2005-10-21 SI SI200531181T patent/SI1811998T1/sl unknown
- 2005-10-21 RU RU2007118687/04A patent/RU2393155C2/ru not_active IP Right Cessation
- 2005-10-21 HR HR20100715T patent/HRP20100715T1/hr unknown
- 2005-10-21 JP JP2007538052A patent/JP5085330B2/ja not_active Expired - Fee Related
- 2005-10-21 CA CA002584752A patent/CA2584752A1/en not_active Abandoned
- 2005-10-21 ES ES05815914T patent/ES2352453T3/es not_active Expired - Lifetime
- 2005-10-21 AU AU2005299816A patent/AU2005299816B2/en not_active Ceased
- 2005-10-21 WO PCT/US2005/037830 patent/WO2006047256A1/en not_active Ceased
- 2005-10-21 EP EP05815914A patent/EP1811998B1/en not_active Expired - Lifetime
- 2005-10-21 ZA ZA200703950A patent/ZA200703950B/en unknown
- 2005-10-21 CN CNA2005800420882A patent/CN101072556A/zh active Pending
- 2005-10-21 AR ARP050104417A patent/AR054088A1/es not_active Application Discontinuation
- 2005-10-21 PT PT05815914T patent/PT1811998E/pt unknown
- 2005-10-21 PL PL05815914T patent/PL1811998T3/pl unknown
-
2007
- 2007-04-19 IL IL182664A patent/IL182664A0/en unknown
- 2007-05-21 NO NO20072567A patent/NO20072567L/no not_active Application Discontinuation
-
2011
- 2011-01-04 CY CY20111100005T patent/CY1111197T1/el unknown
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