AR054088A1 - Triazoles como inhibidores de proteinquinasas. composiciones farmaceuticas - Google Patents
Triazoles como inhibidores de proteinquinasas. composiciones farmaceuticasInfo
- Publication number
- AR054088A1 AR054088A1 ARP050104417A ARP050104417A AR054088A1 AR 054088 A1 AR054088 A1 AR 054088A1 AR P050104417 A ARP050104417 A AR P050104417A AR P050104417 A ARP050104417 A AR P050104417A AR 054088 A1 AR054088 A1 AR 054088A1
- Authority
- AR
- Argentina
- Prior art keywords
- aliphatic
- optionally substituted
- hydrogen
- haloaliphatic
- halogen
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 26
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- -1 triazole compound Chemical class 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 239000001301 oxygen Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000010931 gold Substances 0.000 abstract 1
- 229910052737 gold Inorganic materials 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 239000003909 protein kinase inhibitor Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62127004P | 2004-10-21 | 2004-10-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054088A1 true AR054088A1 (es) | 2007-06-06 |
Family
ID=35809788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104417A AR054088A1 (es) | 2004-10-21 | 2005-10-21 | Triazoles como inhibidores de proteinquinasas. composiciones farmaceuticas |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7645775B2 (enExample) |
| EP (1) | EP1811998B1 (enExample) |
| JP (1) | JP5085330B2 (enExample) |
| KR (1) | KR20070085407A (enExample) |
| CN (1) | CN101072556A (enExample) |
| AR (1) | AR054088A1 (enExample) |
| AT (1) | ATE485042T1 (enExample) |
| AU (1) | AU2005299816B2 (enExample) |
| BR (1) | BRPI0517435A (enExample) |
| CA (1) | CA2584752A1 (enExample) |
| CY (1) | CY1111197T1 (enExample) |
| DE (1) | DE602005024293D1 (enExample) |
| DK (1) | DK1811998T3 (enExample) |
| ES (1) | ES2352453T3 (enExample) |
| HR (1) | HRP20100715T1 (enExample) |
| IL (1) | IL182664A0 (enExample) |
| MX (1) | MX2007004841A (enExample) |
| NO (1) | NO20072567L (enExample) |
| NZ (1) | NZ555088A (enExample) |
| PL (1) | PL1811998T3 (enExample) |
| PT (1) | PT1811998E (enExample) |
| RU (1) | RU2393155C2 (enExample) |
| SI (1) | SI1811998T1 (enExample) |
| TW (1) | TW200630090A (enExample) |
| WO (1) | WO2006047256A1 (enExample) |
| ZA (1) | ZA200703950B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090103897A (ko) | 2006-12-28 | 2009-10-01 | 다이쇼 세이야꾸 가부시끼가이샤 | 피라졸로피리미딘 화합물 |
| PT2114955E (pt) | 2006-12-29 | 2013-04-18 | Rigel Pharmaceuticals Inc | Triazoles substituídos com arilo bicíclico em ponte ou heteroarilo bicíclico em ponte úteis como inibidores de axl |
| AU2007342007A1 (en) * | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| CA2710043C (en) | 2006-12-29 | 2016-02-09 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| ES2607065T3 (es) | 2006-12-29 | 2017-03-29 | Rigel Pharmaceuticals, Inc. | Triazoles N3-heteroaril sustituidos y triazoles N5-heteroaril sustituidos útiles como inhibidores de axl |
| AU2016259396B2 (en) * | 2006-12-29 | 2018-11-08 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| AU2014200824B2 (en) * | 2006-12-29 | 2016-12-15 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| MX2010004177A (es) | 2007-10-18 | 2010-05-03 | Janssen Pharmaceutica Nv | 1,2,4-triazoles trisustituidos. |
| AU2009226988B2 (en) | 2008-03-19 | 2013-05-23 | Janssen Pharmaceutica Nv | Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators |
| ES2525132T3 (es) | 2008-05-09 | 2014-12-17 | Janssen Pharmaceutica, N.V. | Pirazoles trisustituidos como moduladores de los receptores de acetilcolina |
| EP2328888B1 (en) | 2008-07-09 | 2012-11-07 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| WO2010083207A2 (en) | 2009-01-15 | 2010-07-22 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| SG172997A1 (en) | 2009-01-16 | 2011-08-29 | Rigel Pharmaceuticals Inc | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| AR081034A1 (es) | 2010-05-11 | 2012-05-30 | Sanofi Aventis | Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central |
| AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
| JP2013529198A (ja) | 2010-05-11 | 2013-07-18 | サノフイ | 置換されたｎ−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用 |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| JP5766278B2 (ja) | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| CN107142237B (zh) * | 2011-05-17 | 2021-03-02 | 深圳涌泰生物科技有限公司 | 培养基、细胞培养用试剂盒及细胞培养方法 |
| KR20150123918A (ko) * | 2013-03-05 | 2015-11-04 | 에프. 호프만-라 로슈 아게 | 항바이러스 화합물 |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| KR20220042127A (ko) * | 2019-06-28 | 2022-04-04 | 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 | 피라졸로피리미딘 화합물, 그의 제조 방법 및 그의 응용 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637592A (en) * | 1994-07-12 | 1997-06-10 | Janssen Pharmaceutica N.V. | Acyl derivatives of azolones |
| DK0968206T3 (da) * | 1997-02-19 | 2007-03-26 | Berlex Inc | N-heterocykliske derivater som NOS-inhibitorer |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| YU51803A (sh) * | 2000-12-22 | 2006-05-25 | Ortho Mc Neil Pharmaceutical Inc. | Supstituisani derivati triazol diamina kao inhibitori kinaza |
| DE10123586A1 (de) | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
| CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
| WO2005013982A1 (en) * | 2003-08-06 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
-
2005
- 2005-10-21 NZ NZ555088A patent/NZ555088A/en not_active IP Right Cessation
- 2005-10-21 EP EP05815914A patent/EP1811998B1/en not_active Expired - Lifetime
- 2005-10-21 AU AU2005299816A patent/AU2005299816B2/en not_active Ceased
- 2005-10-21 DE DE602005024293T patent/DE602005024293D1/de not_active Expired - Lifetime
- 2005-10-21 ES ES05815914T patent/ES2352453T3/es not_active Expired - Lifetime
- 2005-10-21 KR KR1020077011405A patent/KR20070085407A/ko not_active Withdrawn
- 2005-10-21 HR HR20100715T patent/HRP20100715T1/hr unknown
- 2005-10-21 BR BRPI0517435-0A patent/BRPI0517435A/pt not_active IP Right Cessation
- 2005-10-21 MX MX2007004841A patent/MX2007004841A/es unknown
- 2005-10-21 RU RU2007118687/04A patent/RU2393155C2/ru not_active IP Right Cessation
- 2005-10-21 ZA ZA200703950A patent/ZA200703950B/en unknown
- 2005-10-21 US US11/255,569 patent/US7645775B2/en not_active Expired - Fee Related
- 2005-10-21 DK DK05815914.6T patent/DK1811998T3/da active
- 2005-10-21 CA CA002584752A patent/CA2584752A1/en not_active Abandoned
- 2005-10-21 CN CNA2005800420882A patent/CN101072556A/zh active Pending
- 2005-10-21 WO PCT/US2005/037830 patent/WO2006047256A1/en not_active Ceased
- 2005-10-21 AT AT05815914T patent/ATE485042T1/de active
- 2005-10-21 PL PL05815914T patent/PL1811998T3/pl unknown
- 2005-10-21 SI SI200531181T patent/SI1811998T1/sl unknown
- 2005-10-21 AR ARP050104417A patent/AR054088A1/es not_active Application Discontinuation
- 2005-10-21 TW TW094137050A patent/TW200630090A/zh unknown
- 2005-10-21 JP JP2007538052A patent/JP5085330B2/ja not_active Expired - Fee Related
- 2005-10-21 PT PT05815914T patent/PT1811998E/pt unknown
-
2007
- 2007-04-19 IL IL182664A patent/IL182664A0/en unknown
- 2007-05-21 NO NO20072567A patent/NO20072567L/no not_active Application Discontinuation
-
2011
- 2011-01-04 CY CY20111100005T patent/CY1111197T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005299816B2 (en) | 2011-09-01 |
| NO20072567L (no) | 2007-07-17 |
| IL182664A0 (en) | 2007-09-20 |
| RU2393155C2 (ru) | 2010-06-27 |
| ES2352453T3 (es) | 2011-02-18 |
| AU2005299816A1 (en) | 2006-05-04 |
| HRP20100715T1 (hr) | 2011-02-28 |
| CY1111197T1 (el) | 2015-06-11 |
| SI1811998T1 (sl) | 2011-01-31 |
| ATE485042T1 (de) | 2010-11-15 |
| TW200630090A (en) | 2006-09-01 |
| NZ555088A (en) | 2009-08-28 |
| BRPI0517435A (pt) | 2008-10-07 |
| JP2008517923A (ja) | 2008-05-29 |
| MX2007004841A (es) | 2007-05-21 |
| US7645775B2 (en) | 2010-01-12 |
| KR20070085407A (ko) | 2007-08-27 |
| CN101072556A (zh) | 2007-11-14 |
| PT1811998E (pt) | 2010-12-23 |
| WO2006047256A1 (en) | 2006-05-04 |
| EP1811998A1 (en) | 2007-08-01 |
| DE602005024293D1 (de) | 2010-12-02 |
| US20070270410A1 (en) | 2007-11-22 |
| EP1811998B1 (en) | 2010-10-20 |
| RU2007118687A (ru) | 2008-11-27 |
| DK1811998T3 (da) | 2011-02-14 |
| CA2584752A1 (en) | 2006-05-04 |
| PL1811998T3 (pl) | 2011-05-31 |
| JP5085330B2 (ja) | 2012-11-28 |
| ZA200703950B (en) | 2008-07-30 |
| AU2005299816A2 (en) | 2006-05-04 |
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