RU2393155C2 - Триазолы, используемые в качестве ингибиторов протеинкиназ - Google Patents
Триазолы, используемые в качестве ингибиторов протеинкиназ Download PDFInfo
- Publication number
- RU2393155C2 RU2393155C2 RU2007118687/04A RU2007118687A RU2393155C2 RU 2393155 C2 RU2393155 C2 RU 2393155C2 RU 2007118687/04 A RU2007118687/04 A RU 2007118687/04A RU 2007118687 A RU2007118687 A RU 2007118687A RU 2393155 C2 RU2393155 C2 RU 2393155C2
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- RU
- Russia
- Prior art keywords
- group
- disease
- aliphatic group
- optionally substituted
- compound
- Prior art date
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- OYUDNKFIGXAIRZ-UHFFFAOYSA-N Nc1nc(Nc2ccc(C(CC3)CCC3N3CCOCC3)cc2)n[n]1-c1ccccn1 Chemical compound Nc1nc(Nc2ccc(C(CC3)CCC3N3CCOCC3)cc2)n[n]1-c1ccccn1 OYUDNKFIGXAIRZ-UHFFFAOYSA-N 0.000 description 2
- 0 CN(c1nc(Nc2ccc(C(*)(CC3)C*(*)CC*3*3CC*CC3)cc2)n[n]1*)I Chemical compound CN(c1nc(Nc2ccc(C(*)(CC3)C*(*)CC*3*3CC*CC3)cc2)n[n]1*)I 0.000 description 1
- OYUDNKFIGXAIRZ-KESTWPANSA-N Nc1nc(Nc2ccc([C@H](CC3)CC[C@@H]3N3CCOCC3)cc2)n[n]1-c1ccccn1 Chemical compound Nc1nc(Nc2ccc([C@H](CC3)CC[C@@H]3N3CCOCC3)cc2)n[n]1-c1ccccn1 OYUDNKFIGXAIRZ-KESTWPANSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/20—Antivirals for DNA viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62127004P | 2004-10-21 | 2004-10-21 | |
| US60/621,270 | 2004-10-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007118687A RU2007118687A (ru) | 2008-11-27 |
| RU2393155C2 true RU2393155C2 (ru) | 2010-06-27 |
Family
ID=35809788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007118687/04A RU2393155C2 (ru) | 2004-10-21 | 2005-10-21 | Триазолы, используемые в качестве ингибиторов протеинкиназ |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7645775B2 (enExample) |
| EP (1) | EP1811998B1 (enExample) |
| JP (1) | JP5085330B2 (enExample) |
| KR (1) | KR20070085407A (enExample) |
| CN (1) | CN101072556A (enExample) |
| AR (1) | AR054088A1 (enExample) |
| AT (1) | ATE485042T1 (enExample) |
| AU (1) | AU2005299816B2 (enExample) |
| BR (1) | BRPI0517435A (enExample) |
| CA (1) | CA2584752A1 (enExample) |
| CY (1) | CY1111197T1 (enExample) |
| DE (1) | DE602005024293D1 (enExample) |
| DK (1) | DK1811998T3 (enExample) |
| ES (1) | ES2352453T3 (enExample) |
| HR (1) | HRP20100715T1 (enExample) |
| IL (1) | IL182664A0 (enExample) |
| MX (1) | MX2007004841A (enExample) |
| NO (1) | NO20072567L (enExample) |
| NZ (1) | NZ555088A (enExample) |
| PL (1) | PL1811998T3 (enExample) |
| PT (1) | PT1811998E (enExample) |
| RU (1) | RU2393155C2 (enExample) |
| SI (1) | SI1811998T1 (enExample) |
| TW (1) | TW200630090A (enExample) |
| WO (1) | WO2006047256A1 (enExample) |
| ZA (1) | ZA200703950B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090103897A (ko) | 2006-12-28 | 2009-10-01 | 다이쇼 세이야꾸 가부시끼가이샤 | 피라졸로피리미딘 화합물 |
| PT2114955E (pt) | 2006-12-29 | 2013-04-18 | Rigel Pharmaceuticals Inc | Triazoles substituídos com arilo bicíclico em ponte ou heteroarilo bicíclico em ponte úteis como inibidores de axl |
| AU2007342007A1 (en) * | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| CA2710043C (en) | 2006-12-29 | 2016-02-09 | Rigel Pharmaceuticals, Inc. | Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| ES2607065T3 (es) | 2006-12-29 | 2017-03-29 | Rigel Pharmaceuticals, Inc. | Triazoles N3-heteroaril sustituidos y triazoles N5-heteroaril sustituidos útiles como inhibidores de axl |
| AU2016259396B2 (en) * | 2006-12-29 | 2018-11-08 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| AU2014200824B2 (en) * | 2006-12-29 | 2016-12-15 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| MX2010004177A (es) | 2007-10-18 | 2010-05-03 | Janssen Pharmaceutica Nv | 1,2,4-triazoles trisustituidos. |
| AU2009226988B2 (en) | 2008-03-19 | 2013-05-23 | Janssen Pharmaceutica Nv | Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators |
| ES2525132T3 (es) | 2008-05-09 | 2014-12-17 | Janssen Pharmaceutica, N.V. | Pirazoles trisustituidos como moduladores de los receptores de acetilcolina |
| EP2328888B1 (en) | 2008-07-09 | 2012-11-07 | Rigel Pharmaceuticals, Inc. | Bridged bicyclic heteroaryl substituted triazoles useful as axl inhibitors |
| WO2010083207A2 (en) | 2009-01-15 | 2010-07-22 | Rigel Pharmaceuticals, Inc. | Protein kinase c inhibitors and uses thereof |
| SG172997A1 (en) | 2009-01-16 | 2011-08-29 | Rigel Pharmaceuticals Inc | Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer |
| WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
| AR081034A1 (es) | 2010-05-11 | 2012-05-30 | Sanofi Aventis | Derivados de n-heteroaril tetrahidro-isoquinolina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades del sistema nervioso central |
| AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
| JP2013529198A (ja) | 2010-05-11 | 2013-07-18 | サノフイ | 置換されたｎ−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用 |
| TW201206939A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof |
| JP5766278B2 (ja) | 2010-05-11 | 2015-08-19 | サノフイ | 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用 |
| CN107142237B (zh) * | 2011-05-17 | 2021-03-02 | 深圳涌泰生物科技有限公司 | 培养基、细胞培养用试剂盒及细胞培养方法 |
| KR20150123918A (ko) * | 2013-03-05 | 2015-11-04 | 에프. 호프만-라 로슈 아게 | 항바이러스 화합물 |
| EP3302465A1 (en) | 2015-06-05 | 2018-04-11 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| KR20220042127A (ko) * | 2019-06-28 | 2022-04-04 | 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 | 피라졸로피리미딘 화합물, 그의 제조 방법 및 그의 응용 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2152392C1 (ru) * | 1994-07-12 | 2000-07-10 | Жансен Фармасетика Н.В. | Ацильные производные азолонов, способ их получения, фармацевтическая композиция на их основе и способ ее получения |
| RU2241708C2 (ru) * | 1997-02-19 | 2004-12-10 | Берлекс Лабораториз, Инк. | N-гетероциклические производные и их применение в качестве ингибиторов синтазы оксида азота |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| YU51803A (sh) * | 2000-12-22 | 2006-05-25 | Ortho Mc Neil Pharmaceutical Inc. | Supstituisani derivati triazol diamina kao inhibitori kinaza |
| DE10123586A1 (de) | 2001-05-08 | 2002-11-28 | Schering Ag | 3,5-Diamino-1,2,4-triazole als Kinase Inhibitoren |
| CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
| WO2005013982A1 (en) * | 2003-08-06 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
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2005
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- 2005-10-21 AU AU2005299816A patent/AU2005299816B2/en not_active Ceased
- 2005-10-21 DE DE602005024293T patent/DE602005024293D1/de not_active Expired - Lifetime
- 2005-10-21 ES ES05815914T patent/ES2352453T3/es not_active Expired - Lifetime
- 2005-10-21 KR KR1020077011405A patent/KR20070085407A/ko not_active Withdrawn
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- 2005-10-21 RU RU2007118687/04A patent/RU2393155C2/ru not_active IP Right Cessation
- 2005-10-21 ZA ZA200703950A patent/ZA200703950B/en unknown
- 2005-10-21 US US11/255,569 patent/US7645775B2/en not_active Expired - Fee Related
- 2005-10-21 DK DK05815914.6T patent/DK1811998T3/da active
- 2005-10-21 CA CA002584752A patent/CA2584752A1/en not_active Abandoned
- 2005-10-21 CN CNA2005800420882A patent/CN101072556A/zh active Pending
- 2005-10-21 WO PCT/US2005/037830 patent/WO2006047256A1/en not_active Ceased
- 2005-10-21 AT AT05815914T patent/ATE485042T1/de active
- 2005-10-21 PL PL05815914T patent/PL1811998T3/pl unknown
- 2005-10-21 SI SI200531181T patent/SI1811998T1/sl unknown
- 2005-10-21 AR ARP050104417A patent/AR054088A1/es not_active Application Discontinuation
- 2005-10-21 TW TW094137050A patent/TW200630090A/zh unknown
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2007
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2152392C1 (ru) * | 1994-07-12 | 2000-07-10 | Жансен Фармасетика Н.В. | Ацильные производные азолонов, способ их получения, фармацевтическая композиция на их основе и способ ее получения |
| RU2241708C2 (ru) * | 1997-02-19 | 2004-12-10 | Берлекс Лабораториз, Инк. | N-гетероциклические производные и их применение в качестве ингибиторов синтазы оксида азота |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
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| Publication number | Publication date |
|---|---|
| AU2005299816B2 (en) | 2011-09-01 |
| NO20072567L (no) | 2007-07-17 |
| IL182664A0 (en) | 2007-09-20 |
| ES2352453T3 (es) | 2011-02-18 |
| AU2005299816A1 (en) | 2006-05-04 |
| HRP20100715T1 (hr) | 2011-02-28 |
| CY1111197T1 (el) | 2015-06-11 |
| SI1811998T1 (sl) | 2011-01-31 |
| ATE485042T1 (de) | 2010-11-15 |
| TW200630090A (en) | 2006-09-01 |
| NZ555088A (en) | 2009-08-28 |
| BRPI0517435A (pt) | 2008-10-07 |
| JP2008517923A (ja) | 2008-05-29 |
| MX2007004841A (es) | 2007-05-21 |
| US7645775B2 (en) | 2010-01-12 |
| KR20070085407A (ko) | 2007-08-27 |
| CN101072556A (zh) | 2007-11-14 |
| PT1811998E (pt) | 2010-12-23 |
| WO2006047256A1 (en) | 2006-05-04 |
| EP1811998A1 (en) | 2007-08-01 |
| DE602005024293D1 (de) | 2010-12-02 |
| US20070270410A1 (en) | 2007-11-22 |
| EP1811998B1 (en) | 2010-10-20 |
| AR054088A1 (es) | 2007-06-06 |
| RU2007118687A (ru) | 2008-11-27 |
| DK1811998T3 (da) | 2011-02-14 |
| CA2584752A1 (en) | 2006-05-04 |
| PL1811998T3 (pl) | 2011-05-31 |
| JP5085330B2 (ja) | 2012-11-28 |
| ZA200703950B (en) | 2008-07-30 |
| AU2005299816A2 (en) | 2006-05-04 |
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