JP2023520513A5 - - Google Patents

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Publication number
JP2023520513A5
JP2023520513A5 JP2022560199A JP2022560199A JP2023520513A5 JP 2023520513 A5 JP2023520513 A5 JP 2023520513A5 JP 2022560199 A JP2022560199 A JP 2022560199A JP 2022560199 A JP2022560199 A JP 2022560199A JP 2023520513 A5 JP2023520513 A5 JP 2023520513A5
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JP2022560199A
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JPWO2021202984A5 (https=
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Priority claimed from PCT/US2021/025556 external-priority patent/WO2021202984A1/en
Priority to JP2022209755A priority Critical patent/JP7777065B2/ja
Publication of JP2023520513A publication Critical patent/JP2023520513A/ja
Publication of JP2023520513A5 publication Critical patent/JP2023520513A5/ja
Publication of JPWO2021202984A5 publication Critical patent/JPWO2021202984A5/ja
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JP2022560199A 2020-04-02 2021-04-02 Stingアゴニストを含む抗体薬物コンジュゲート Pending JP2023520513A (ja)

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JP2022209755A JP7777065B2 (ja) 2020-04-02 2022-12-27 Stingアゴニストを含む抗体薬物コンジュゲート

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US202063004108P 2020-04-02 2020-04-02
US63/004,108 2020-04-02
US202063040755P 2020-06-18 2020-06-18
US63/040,755 2020-06-18
US202063111820P 2020-11-10 2020-11-10
US63/111,820 2020-11-10
PCT/US2021/025556 WO2021202984A1 (en) 2020-04-02 2021-04-02 Antibody drug conjugates comprising sting agonists

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JP2023520513A JP2023520513A (ja) 2023-05-17
JP2023520513A5 true JP2023520513A5 (https=) 2024-03-22
JPWO2021202984A5 JPWO2021202984A5 (https=) 2024-03-22

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JP2022209755A Active JP7777065B2 (ja) 2020-04-02 2022-12-27 Stingアゴニストを含む抗体薬物コンジュゲート

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US (4) US20220378749A1 (https=)
EP (2) EP4126065A1 (https=)
JP (2) JP2023520513A (https=)
KR (2) KR20230004896A (https=)
CN (2) CN116196435B (https=)
AR (1) AR127344A2 (https=)
AU (2) AU2021248635B2 (https=)
BR (2) BR112022019919A2 (https=)
CA (1) CA3174297A1 (https=)
CL (3) CL2022002711A1 (https=)
CO (1) CO2022015650A2 (https=)
IL (2) IL297859A (https=)
MX (2) MX2022012304A (https=)
MY (1) MY210304A (https=)
PH (1) PH12022552639A1 (https=)
TW (2) TW202203977A (https=)
WO (1) WO2021202984A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220267364A1 (en) * 2019-07-25 2022-08-25 Shanghai Jemincare Pharmaceuticals Co., Ltd. Heterocyclic amide compound, preparation method therefor and use thereof
CA3149482A1 (en) 2019-08-02 2021-02-11 Mersana Therapeutics, Inc. Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer
WO2021202984A1 (en) 2020-04-02 2021-10-07 Mersana Therapeutics, Inc. Antibody drug conjugates comprising sting agonists
JP2024501894A (ja) 2021-01-04 2024-01-16 メルサナ セラピューティクス インコーポレイテッド B7h4ターゲティング抗体-薬物コンジュゲートおよびその使用方法
AU2022300383A1 (en) * 2021-06-25 2024-01-18 Bolt Biotherapeutics, Inc. Bis-benzimidazole sting agonist immunoconjugates, and uses thereof
IL312728A (en) 2021-11-30 2024-07-01 Daiichi Sankyo Co Ltd Protease-cleavable masked antibodies
CN118524854A (zh) * 2021-12-17 2024-08-20 北京加科思新药研发有限公司 包含可用作sting激动剂的新型化合物的化合物-连接基构建体及其用途
JP2025502881A (ja) * 2022-01-11 2025-01-28 ビシケム カンパニー リミテッド Sting作用剤としての縮合ヘテロアリールヒドロキサメート
US20250170255A1 (en) 2022-02-09 2025-05-29 Daiichi Sankyo Company, Limited Environmentally-responsive masked antibody and use thereof
MX2024010916A (es) * 2022-03-07 2024-09-17 Mersana Therapeutics Inc Conjugados anticuerpo-farmaco que comprenden agonistas de sting, combinaciones y metodos de uso.
WO2023215740A1 (en) * 2022-05-06 2023-11-09 Seagen Inc. Immunomodulatory antibody-drug conjugates
AU2023336004A1 (en) 2022-08-29 2025-03-06 Daiichi Sankyo Company, Limited Antibody-drug conjugate including mutant fc region
US20240190958A1 (en) * 2022-10-18 2024-06-13 Tubulis Gmbh Novel antibody drug conjugates with novel napi2b antibodies, therapeutic methods and uses thereof
CN120166939A (zh) * 2022-10-18 2025-06-17 Tubulis 股份有限公司 新型抗napi2b抗体和基于该抗体的抗体-药物-偶联物、治疗方法及其用途
WO2024137619A1 (en) * 2022-12-20 2024-06-27 Bolt Biotherapeutics, Inc. Anti-claudin, bis-benzimid azole sting agonist immunoconjugates, and uses thereof
WO2024186626A1 (en) * 2023-03-03 2024-09-12 Bolt Biotherapeutics, Inc. Aza-bicyclic sting agonist immunoconjugates, and uses thereof
WO2024192017A1 (en) 2023-03-13 2024-09-19 Mersana Therapeutics, Inc. Antibody drug conjugates comprising sting agonists, combinations and methods of use
WO2025233682A1 (en) * 2024-05-08 2025-11-13 Ligachem Biosciences Inc. Antibody drug conjugates comprising sting agonists and uses thereof
WO2026001915A1 (en) * 2024-06-24 2026-01-02 Jacobio Pharmaceuticals Co., Ltd. Drug linker, conjugate thereof, and uses thereof
WO2026078593A1 (en) 2024-10-08 2026-04-16 Sun Pharma Advanced Research Company Limited Sting agonists and antibody drug conjugates thereof

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080070981A1 (en) 2000-02-23 2008-03-20 Henryk Borowy-Borowski Water-soluble compositions of bioactive lipophilic compounds
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
EP1368458A2 (en) 2001-02-26 2003-12-10 Pharma Pacific Pty. Ltd. Interferon-alpha induced gene
ES2350687T3 (es) 2002-07-03 2011-01-26 Ono Pharmaceutical Co., Ltd. Composiciones de inmunopotenciación.
CN1753912B (zh) 2002-12-23 2011-11-02 惠氏公司 抗pd-1抗体及其用途
US7563869B2 (en) 2003-01-23 2009-07-21 Ono Pharmaceutical Co., Ltd. Substance specific to human PD-1
RU2494107C2 (ru) 2005-05-09 2013-09-27 Оно Фармасьютикал Ко., Лтд. Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами
US8367065B2 (en) 2006-09-15 2013-02-05 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
HRP20131167T1 (hr) 2007-06-18 2014-01-03 Merck Sharp & Dohme B.V. Antitijela za humani receptor programirane smrti pd-1
BRPI0812970A2 (pt) 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
WO2009097128A1 (en) 2008-01-29 2009-08-06 Ludwig Institute For Cancer Research Ltd. Membrane transporter napi2b (slc34a2) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy
WO2009114335A2 (en) 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
WO2010098788A2 (en) 2008-08-25 2010-09-02 Amplimmune, Inc. Pd-i antagonists and methods for treating infectious disease
KR101814408B1 (ko) 2008-09-26 2018-01-04 다나-파버 캔서 인스티튜트 인크. 인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도
AU2009333580B2 (en) 2008-12-09 2016-07-07 Genentech, Inc. Anti-PD-L1 antibodies and their use to enhance T-cell function
WO2011066342A2 (en) 2009-11-24 2011-06-03 Amplimmune, Inc. Simultaneous inhibition of pd-l1/pd-l2
JP6238459B2 (ja) 2011-08-01 2017-11-29 ジェネンテック, インコーポレイテッド Pd−1軸結合アンタゴニストとmek阻害剤を使用する癌の治療方法
EP2908818A4 (en) 2012-10-16 2016-07-13 Endocyte Inc CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE
PL2931738T3 (pl) 2012-12-13 2019-07-31 Aduro Biotech, Inc. Kompozycje zawierające cykliczne dinukleotydy purynowe o zdefiniowanej stereochemii i sposoby ich otrzymywania i zastosowania
RS59500B1 (sr) 2013-05-18 2019-12-31 Aduro Biotech Inc Sastavi i metode za aktiviranje signaliziranja koje je zavisno od „stimulatora gena za interferon“
EP2996472B1 (en) 2013-05-18 2019-03-27 Aduro Biotech, Inc. Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling
ES2826398T3 (es) 2013-10-15 2021-05-18 Seagen Inc Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco
RU2692563C2 (ru) * 2014-04-25 2019-06-25 Пьер Фабр Медикамент Конъюгат антитела против igf-1r с лекарственным средством и его применение для лечения рака
PE20170198A1 (es) 2014-06-04 2017-04-08 Glaxosmithkline Ip Dev Ltd Dinucleotidos ciclicos como moduladores de sting
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗her2表位之單株抗體及其使用之方法
EP3546473B1 (en) 2014-12-16 2025-12-10 Kayla Therapeutics Fluorinated cyclic [(2',5')p(3',5')p]-dinucleotides for cytokine induction
WO2016096577A1 (en) 2014-12-16 2016-06-23 Invivogen Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment
GB201501462D0 (en) 2015-01-29 2015-03-18 Glaxosmithkline Ip Dev Ltd Novel compounds
CR20180101A (es) 2015-08-13 2018-04-12 Merck Sharp & Dohme Compuestos di-nucleóticos cíclicos como agonistas de sting
CA3002236A1 (en) 2015-10-28 2017-05-04 Aduro Biotech, Inc. Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
TWI704154B (zh) 2015-12-03 2020-09-11 英商葛蘭素史克智慧財產發展有限公司 新穎化合物
US20170158772A1 (en) * 2015-12-07 2017-06-08 Opi Vi - Ip Holdco Llc Compositions of antibody construct - agonist conjugates and methods of use thereof
EP3386536A4 (en) 2015-12-07 2019-07-31 Opi Vi- IP Holdco LLC COMPOSITION OF ANTIBODY CONSTRUCT AGONIST CONJUGATES AND METHOD FOR USE THEREOF
CN109310885B (zh) 2016-03-15 2022-05-31 梅尔莎纳医疗公司 NaPi2b靶向抗体-药物缀合物及其使用方法
JP2019510802A (ja) 2016-04-07 2019-04-18 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited タンパク質調節物質として有用な複素環アミド
HRP20220936T1 (hr) 2016-04-07 2022-10-28 Glaxosmithkline Intellectual Property Development Limited Heterociklički amidi korisni kao modulatori proteina
US10225009B2 (en) 2016-07-01 2019-03-05 Adtran, Inc. Broadband access devices having a radio link
WO2018009466A1 (en) 2016-07-05 2018-01-11 Aduro Biotech, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
US10414747B2 (en) 2016-10-04 2019-09-17 Merck Sharp & Dohme Corp. Benzo[b]thiophene compounds as sting agonists
US11135307B2 (en) * 2016-11-23 2021-10-05 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
WO2018140831A2 (en) 2017-01-27 2018-08-02 Silverback Therapeutics, Inc. Tumor targeting conjugates and methods of use thereof
TW201834697A (zh) * 2017-02-28 2018-10-01 美商梅爾莎納醫療公司 Her2標靶抗體-藥物結合物之組合療法
AR113224A1 (es) * 2017-04-28 2020-02-19 Novartis Ag Conjugados de anticuerpo que comprenden un agonista de sting
EP3634401A1 (en) 2017-06-07 2020-04-15 Silverback Therapeutics, Inc. Antibody construct conjugates
US11312772B2 (en) 2017-08-04 2022-04-26 Merck Sharp & Dohme Corp. Combinations of PD-1 antagonists and benzo [b] thiophene STING agonists for cancer treatment
US11285131B2 (en) 2017-08-04 2022-03-29 Merck Sharp & Dohme Corp. Benzo[b]thiophene STING agonists for cancer treatment
EP3685166A2 (en) 2017-09-20 2020-07-29 Mersana Therapeutics, Inc. Compositions and methods for predicting response to napi2b-targeted therapy
CA3077337A1 (en) 2017-10-05 2019-04-11 Glaxosmithkline Intellectual Property Development Limited Modulators of stimulator of interferon genes (sting)
US20210238172A1 (en) 2017-10-05 2021-08-05 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators and methods of using the same
CN111194214A (zh) * 2017-10-05 2020-05-22 葛兰素史密斯克莱知识产权发展有限公司 施用sting激动剂的方法
WO2019084060A1 (en) 2017-10-24 2019-05-02 Silverback Therapeutics, Inc. CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
MX2020004691A (es) 2017-11-07 2020-08-20 Regeneron Pharma Enlazadores hidrofilicos para conjugados anticuerpo-farmaco.
CN110016025B (zh) 2018-01-08 2021-08-06 成都先导药物开发股份有限公司 一种免疫调节剂
WO2019134707A1 (zh) 2018-01-08 2019-07-11 成都先导药物开发股份有限公司 一种免疫调节剂
US11702430B2 (en) 2018-04-03 2023-07-18 Merck Sharp & Dohme Llc Aza-benzothiophene compounds as STING agonists
US10793557B2 (en) 2018-04-03 2020-10-06 Merck Sharp & Dohme Corp. Sting agonist compounds
ES2929415T3 (es) 2018-05-25 2022-11-29 Incyte Corp Compuestos heterocíclicos tricíclicos como activadores de STING
CA3101640A1 (en) 2018-06-04 2019-12-12 Trustees Of Tufts College Tumor microenvironment-activated drug-binder conjugates, and uses related thereto
WO2019243825A1 (en) 2018-06-21 2019-12-26 Curadev Pharma Limited Small molecule modulators of human sting, conjugates and therapeutic applications
JP2021530442A (ja) 2018-06-28 2021-11-11 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co., Ltd. 縮合三環系複素環化合物およびその治療上の使用
WO2020010451A1 (en) * 2018-07-10 2020-01-16 Trillium Therapeutics Inc. Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists
US10875872B2 (en) 2018-07-31 2020-12-29 Incyte Corporation Heteroaryl amide compounds as sting activators
JP7584802B2 (ja) 2018-08-24 2024-11-18 アドライ・ノーティ・バイオファーマ・カンパニー・リミテッド 高活性stingタンパク質アゴニスト
CN111655682B (zh) 2018-08-29 2024-05-31 杭州阿诺生物医药科技有限公司 一种高活性sting蛋白激动剂化合物
US20200113912A1 (en) 2018-09-12 2020-04-16 Silverback Therapeutics, Inc. Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates
CN110963997A (zh) 2018-09-28 2020-04-07 四川科伦博泰生物医药股份有限公司 杂环酰胺类化合物、包含其的药物组合物及其制备方法和用途
BR112021009578A2 (pt) 2018-12-06 2021-08-17 Glaxosmithkline Intellectual Property Development Limited formulação farmacêutica
WO2020132549A1 (en) 2018-12-21 2020-06-25 Nimbus Titan, Inc. Sting heterocycle agonists and uses thereof
WO2020132566A1 (en) 2018-12-21 2020-06-25 Nimbus Titan, Inc. Sting pyrazole agonists and uses thereof
WO2020132582A1 (en) * 2018-12-21 2020-06-25 Nimbus Titan, Inc. Sting agonists and uses thereof
CN111393405B (zh) 2019-01-02 2022-11-25 中国科学院上海药物研究所 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用
CN111393404B (zh) 2019-01-02 2023-02-17 中国科学院上海药物研究所 一类苯并噻吩类化合物及其药物组合物及应用
US12129267B2 (en) 2019-01-07 2024-10-29 Incyte Corporation Heteroaryl amide compounds as sting activators
CN111471056B (zh) 2019-01-23 2021-07-02 成都先导药物开发股份有限公司 一种大环类免疫调节剂
EP3919488B1 (en) 2019-01-31 2025-08-27 Hitgen Inc. Immunomodulator
PE20220166A1 (es) 2019-03-05 2022-01-28 F Star Therapeutics Inc Compuestos, composiciones y metodos para el tratamiento de enfermedad
JP7530380B2 (ja) 2019-03-28 2024-08-07 ルピン・リミテッド Stingアゴニストとしての大環状化合物
TW202104214A (zh) 2019-04-05 2021-02-01 英商葛蘭素史密斯克藍智慧財產發展有限公司 化合物
JP2022529183A (ja) 2019-04-17 2022-06-17 アヴィディア テクノロジーズ, インコーポレイテッド リガンド提示および/または薬物送達のためのスターポリマーを製造する組成物および方法
CN111848573B (zh) 2019-04-30 2023-04-07 四川科伦博泰生物医药股份有限公司 苯并噻吩酰胺类化合物及其制备方法和用途
EP3964504A4 (en) 2019-04-30 2022-12-28 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. AMINOPYRIMIDINE COMPOUND, METHOD OF PRODUCTION THEREOF AND USE THEREOF
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity
WO2021000770A1 (zh) 2019-07-02 2021-01-07 凯复制药有限公司 可增强免疫活性的杂环化合物、其制备方法及其在医药上的应用
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
LT4004002T (lt) 2019-07-22 2024-10-25 Lupin Limited Makrocikliniai junginiai kaip sting agonistai ir jų naudojimo būdai bei metodai
US20220267364A1 (en) 2019-07-25 2022-08-25 Shanghai Jemincare Pharmaceuticals Co., Ltd. Heterocyclic amide compound, preparation method therefor and use thereof
CA3149482A1 (en) 2019-08-02 2021-02-11 Mersana Therapeutics, Inc. Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer
WO2021113679A1 (en) 2019-12-06 2021-06-10 Mersana Therapeutics, Inc. Dimeric compounds as sting agonists
CN113248475B (zh) 2020-02-11 2023-03-17 中国科学院上海药物研究所 一类杂环取代的苯并咪唑二聚体或其药学上可接受的盐、组合物及其用途
WO2021202984A1 (en) 2020-04-02 2021-10-07 Mersana Therapeutics, Inc. Antibody drug conjugates comprising sting agonists
JP2024501894A (ja) 2021-01-04 2024-01-16 メルサナ セラピューティクス インコーポレイテッド B7h4ターゲティング抗体-薬物コンジュゲートおよびその使用方法
CN112898286A (zh) 2021-01-28 2021-06-04 中国药科大学 苯并噻吩类化合物或其可药用的盐、异构体及其制备方法、药物组合物和用途
MX2024010916A (es) 2022-03-07 2024-09-17 Mersana Therapeutics Inc Conjugados anticuerpo-farmaco que comprenden agonistas de sting, combinaciones y metodos de uso.

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