MX2022012304A - Conjugados de anticuerpo-farmaco que comprenden agonistas de sting. - Google Patents

Conjugados de anticuerpo-farmaco que comprenden agonistas de sting.

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Publication number
MX2022012304A
MX2022012304A MX2022012304A MX2022012304A MX2022012304A MX 2022012304 A MX2022012304 A MX 2022012304A MX 2022012304 A MX2022012304 A MX 2022012304A MX 2022012304 A MX2022012304 A MX 2022012304A MX 2022012304 A MX2022012304 A MX 2022012304A
Authority
MX
Mexico
Prior art keywords
drug conjugates
antibody drug
sting agonists
sting
adcs
Prior art date
Application number
MX2022012304A
Other languages
English (en)
Spanish (es)
Inventor
Timothy B Lowinger
Joshua D Thomas
Dorin Toader
Jeremy R Duvall
Keith W Bentley
Eugene W Kelleher
Marc I Damelin
Raghida A Bukhalid
Naniye Cetinbas
Ling Xu
Liping Yang
Original Assignee
Mersana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mersana Therapeutics Inc filed Critical Mersana Therapeutics Inc
Publication of MX2022012304A publication Critical patent/MX2022012304A/es

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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification

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