JP2023510905A5 - - Google Patents
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- Publication number
- JP2023510905A5 JP2023510905A5 JP2022543188A JP2022543188A JP2023510905A5 JP 2023510905 A5 JP2023510905 A5 JP 2023510905A5 JP 2022543188 A JP2022543188 A JP 2022543188A JP 2022543188 A JP2022543188 A JP 2022543188A JP 2023510905 A5 JP2023510905 A5 JP 2023510905A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010073438 | 2020-01-22 | ||
| CN202010073438.8 | 2020-01-22 | ||
| PCT/CN2021/073279 WO2021147993A1 (zh) | 2020-01-22 | 2021-01-22 | 抗trop-2抗体-依喜替康类似物偶联物及其医药用途 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023510905A JP2023510905A (ja) | 2023-03-15 |
| JP2023510905A5 true JP2023510905A5 (https=) | 2024-01-31 |
| JPWO2021147993A5 JPWO2021147993A5 (https=) | 2024-01-31 |
| JP7781064B2 JP7781064B2 (ja) | 2025-12-05 |
Family
ID=76992053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022543188A Active JP7781064B2 (ja) | 2020-01-22 | 2021-01-22 | 抗ｔｒｏｐ－２抗体－エキサテカン類似体複合体及びその医薬用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230101735A1 (https=) |
| EP (1) | EP4095148A4 (https=) |
| JP (1) | JP7781064B2 (https=) |
| KR (1) | KR20220130717A (https=) |
| CN (3) | CN114846021B (https=) |
| AU (1) | AU2021210074A1 (https=) |
| BR (1) | BR112022014189A2 (https=) |
| CA (1) | CA3168260A1 (https=) |
| MX (1) | MX2022008474A (https=) |
| TW (1) | TWI891714B (https=) |
| WO (1) | WO2021147993A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4227309A4 (en) * | 2020-10-12 | 2024-11-27 | Sichuan Baili Pharmaceutical Co. Ltd. | DEUTERATED CAMPTOTHECIN DERIVATIVE AND ANTIBODY-DRUG CONJUGATE THEREOF |
| KR20250120438A (ko) * | 2021-02-05 | 2025-08-08 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 캄프토테신 화합물, 그의 제조방법 및 그의 응용 |
| EP4349371A4 (en) | 2021-06-02 | 2025-06-25 | Bio-Thera Solutions, Ltd. | DRUG CONJUGATE AND USE THEREOF |
| MX2024000895A (es) * | 2021-07-21 | 2024-02-06 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Composicion farmaceutica que contiene el conjugado del farmaco anticuerpo anti-trop2 y su aplicacion. |
| EP4434548A1 (en) | 2021-11-15 | 2024-09-25 | Systimmune, Inc. | Bispecific antibody-camptothecin drug conjugate and pharmaceutical use thereof |
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| AU2022389555A1 (en) * | 2021-11-17 | 2024-07-04 | CSPC Megalith Biopharmaceutical Co., Ltd. | Antibody-drug conjugate and use thereof |
| CN116212044A (zh) * | 2021-12-03 | 2023-06-06 | 成都百利多特生物药业有限责任公司 | 抗人Trop2抗体-喜树碱类药物偶联物及其医药用途 |
| CN119173276A (zh) | 2022-04-13 | 2024-12-20 | 吉利德科学公司 | 用于治疗表达Trop-2的癌症的组合疗法 |
| US20250249115A1 (en) | 2022-04-13 | 2025-08-07 | Gilead Sciences, Inc. | Combination therapy for treating tumor antigen expressing cancers |
| CN119546346A (zh) * | 2022-05-04 | 2025-02-28 | 匹诺生物股份有限公司 | 与ddx5蛋白结合的喜树碱类药物与酸敏感性接头连接的缀合物及使用该缀合物的免疫缀合物 |
| JP2025519421A (ja) * | 2022-06-09 | 2025-06-26 | ベイジーン スイッツァランド ゲーエムベーハー | 抗体薬物複合体 |
| CN119421724A (zh) | 2022-06-27 | 2025-02-11 | 百奥泰生物制药股份有限公司 | 治疗实体瘤的方法 |
| KR20250075560A (ko) | 2022-07-15 | 2025-05-28 | 진콴텀 헬스케어 (쑤저우) 씨오., 엘티디. | 항-trop2 항체 및 이의 접합체 |
| WO2024097812A1 (en) | 2022-11-04 | 2024-05-10 | Gilead Sciences, Inc. | Therapy for treating bladder cancer |
| WO2024114318A1 (zh) * | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
| TW202434309A (zh) | 2023-01-19 | 2024-09-01 | 大陸商上海盛迪醫藥有限公司 | 酪胺酸酶介導的蛋白定點偶聯及其應用 |
| TW202438107A (zh) * | 2023-03-28 | 2024-10-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗trop2抗體聯合靶向trop2的藥物治療癌症的用途 |
| US20250019457A1 (en) * | 2023-06-05 | 2025-01-16 | Ibio, Inc. | Trop2 antibodies |
| IL326764A (en) * | 2023-09-08 | 2026-04-01 | Nextpoint Therapeutics Inc | Antibody-drug conjugates |
| WO2025179213A1 (en) * | 2024-02-22 | 2025-08-28 | Memorial Sloan-Kettering Cancer Center | Targeting trop-2 in diffuse pleural mesothelioma |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| PT1104760E (pt) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
| WO2003074566A2 (en) | 2002-03-01 | 2003-09-12 | Immunomedics, Inc. | Rs7 antibodies |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| US7498298B2 (en) | 2003-11-06 | 2009-03-03 | Seattle Genetics, Inc. | Monomethylvaline compounds capable of conjugation to ligands |
| CN101309917B (zh) * | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| US20100254979A1 (en) * | 2009-03-06 | 2010-10-07 | Cisthera, Incorporated | Humanized PAI-1 Antibodies and Uses Thereof |
| JP2015506349A (ja) | 2011-12-21 | 2015-03-02 | アルデリックス， インコーポレイテッド | 非全身性ｔｇｒ５アゴニスト |
| DK2802325T3 (en) | 2012-01-13 | 2017-03-13 | Massachusetts Gen Hospital | ANESTHETIC RELATIONS AND RELATED APPLICATIONS THEREOF |
| DK2907824T3 (en) | 2012-10-11 | 2018-07-23 | Daiichi Sankyo Co Ltd | ANTIBODY-drug conjugate |
| AU2014293670B2 (en) | 2013-07-23 | 2019-08-01 | Immunomedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
| CA2920192A1 (en) * | 2013-09-27 | 2015-04-02 | Immunomedics, Inc. | Anti-trop-2 antibody-drug conjugates and uses thereof |
| LT3424955T (lt) * | 2013-12-25 | 2025-06-25 | Daiichi Sankyo Company, Limited | Anti-trop2 antikūno ir vaisto konjugato gamybos būdas |
| SI3466976T1 (sl) | 2014-01-31 | 2021-12-31 | Daiichi Sankyo Company, Limited | Anti-her2 konjugat protitelesa-zdravila |
| JP6612738B2 (ja) * | 2014-04-10 | 2019-11-27 | 第一三共株式会社 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| HUE048032T2 (hu) | 2015-10-15 | 2020-05-28 | Jiangsu Hengrui Medicine Co | Oxaspiro-származék, elõállítási eljárása és alkalmazásai gyógyszerekben |
| CN107446050A (zh) * | 2017-08-11 | 2017-12-08 | 百奥泰生物科技(广州)有限公司 | Trop2阳性疾病治疗的化合物及方法 |
| EP3725798B1 (en) * | 2017-12-15 | 2026-03-04 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Bioactive conjugate, preparation method therefor and use thereof |
| CN112543771B (zh) * | 2018-09-30 | 2023-04-11 | 江苏豪森药业集团有限公司 | 抗b7h3抗体-依喜替康类似物偶联物及其医药用途 |
| CN111689980A (zh) * | 2019-05-26 | 2020-09-22 | 四川百利药业有限责任公司 | 一种喜树碱药物及其抗体偶联物 |
| MX2021014960A (es) * | 2019-06-06 | 2022-03-04 | Shanghai Hansoh Biomedical Co Ltd | Conjugado de farmaco-anticuerpos anti-b7-h4 y uso medicinal del mismo. |
| AU2020402006A1 (en) * | 2019-12-12 | 2022-07-07 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-claudin antibody-drug conjugate and pharmaceutical use thereof |
| AU2020410460A1 (en) * | 2019-12-16 | 2022-06-16 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-CEA antibody-exatecan analog conjugate and pharmaceutical use thereof |
| CN118949063A (zh) * | 2020-01-22 | 2024-11-15 | 上海森辉医药有限公司 | 艾日布林衍生物的药物偶联物、其制备方法及其在医药上的应用 |
| CN115298220B (zh) * | 2020-03-24 | 2024-12-20 | 上海翰森生物医药科技有限公司 | 抗体-药物偶联物及其医药用途 |
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2021
- 2021-01-22 MX MX2022008474A patent/MX2022008474A/es unknown
- 2021-01-22 KR KR1020227026893A patent/KR20220130717A/ko active Pending
- 2021-01-22 US US17/793,005 patent/US20230101735A1/en active Pending
- 2021-01-22 CN CN202180007477.0A patent/CN114846021B/zh active Active
- 2021-01-22 CN CN202410757461.7A patent/CN118787756A/zh active Pending
- 2021-01-22 CA CA3168260A patent/CA3168260A1/en active Pending
- 2021-01-22 WO PCT/CN2021/073279 patent/WO2021147993A1/zh not_active Ceased
- 2021-01-22 EP EP21744789.5A patent/EP4095148A4/en active Pending
- 2021-01-22 BR BR112022014189A patent/BR112022014189A2/pt unknown
- 2021-01-22 JP JP2022543188A patent/JP7781064B2/ja active Active
- 2021-01-22 CN CN202410757639.8A patent/CN118873679A/zh active Pending
- 2021-01-22 AU AU2021210074A patent/AU2021210074A1/en active Pending
- 2021-01-22 TW TW110102506A patent/TWI891714B/zh active