JP2023510905A5 - - Google Patents
Info
- Publication number
- JP2023510905A5 JP2023510905A5 JP2022543188A JP2022543188A JP2023510905A5 JP 2023510905 A5 JP2023510905 A5 JP 2023510905A5 JP 2022543188 A JP2022543188 A JP 2022543188A JP 2022543188 A JP2022543188 A JP 2022543188A JP 2023510905 A5 JP2023510905 A5 JP 2023510905A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- represented
- groups
- trop
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010073438 | 2020-01-22 | ||
| CN202010073438.8 | 2020-01-22 | ||
| PCT/CN2021/073279 WO2021147993A1 (zh) | 2020-01-22 | 2021-01-22 | 抗trop-2抗体-依喜替康类似物偶联物及其医药用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023510905A JP2023510905A (ja) | 2023-03-15 |
| JP2023510905A5 true JP2023510905A5 (https=) | 2024-01-31 |
| JP7781064B2 JP7781064B2 (ja) | 2025-12-05 |
Family
ID=76992053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022543188A Active JP7781064B2 (ja) | 2020-01-22 | 2021-01-22 | 抗ｔｒｏｐ－２抗体－エキサテカン類似体複合体及びその医薬用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230101735A1 (https=) |
| EP (1) | EP4095148A4 (https=) |
| JP (1) | JP7781064B2 (https=) |
| KR (1) | KR20220130717A (https=) |
| CN (3) | CN118787756A (https=) |
| AU (1) | AU2021210074A1 (https=) |
| BR (1) | BR112022014189A2 (https=) |
| CA (1) | CA3168260A1 (https=) |
| MX (1) | MX2022008474A (https=) |
| TW (1) | TWI891714B (https=) |
| WO (1) | WO2021147993A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7753372B2 (ja) * | 2020-10-12 | 2025-10-14 | シーチュアン バイリ ファーム シーオー． エルティーディー | 重水素化カンプトテシン系誘導体及びその抗体薬物複合体 |
| EP4628165A3 (en) * | 2021-02-05 | 2026-03-11 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Camptothecin compound, preparation method therefor, and application thereof |
| CN117295524A (zh) | 2021-06-02 | 2023-12-26 | 百奥泰生物制药股份有限公司 | 药物偶联物及其用途 |
| CA3225598A1 (en) * | 2021-07-21 | 2023-01-26 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition containing anti-trop2 antibody drug conjugate and its application |
| WO2023083381A1 (zh) | 2021-11-15 | 2023-05-19 | 成都百利多特生物药业有限责任公司 | 双特异性抗体-喜树碱类药物偶联物及其医药用途 |
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| AU2022389555A1 (en) * | 2021-11-17 | 2024-07-04 | CSPC Megalith Biopharmaceutical Co., Ltd. | Antibody-drug conjugate and use thereof |
| WO2023098889A1 (zh) * | 2021-12-03 | 2023-06-08 | 成都百利多特生物药业有限责任公司 | 抗人Trop2抗体-喜树碱类药物偶联物及其医药用途 |
| CA3256048A1 (en) | 2022-04-13 | 2023-10-19 | Arcus Biosciences, Inc. | POLYTHERAPY FOR THE TREATMENT OF CANCERS EXPRESSING A TUMOR ANTIGEN |
| JP2025512384A (ja) | 2022-04-13 | 2025-04-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｔｒｏｐ－２発現がんを治療するための併用療法 |
| KR20230155992A (ko) * | 2022-05-04 | 2023-11-13 | 주식회사 피노바이오 | Ddx5 단백질에 결합하는 캄토테신계 약물이 산 민감성 링커에 연결된 접합체 및 이를 이용한 면역접합체 |
| CA3258612A1 (en) * | 2022-06-09 | 2023-12-14 | Beigene, Ltd. | Antibody drug conjugates |
| US20250381283A1 (en) | 2022-06-27 | 2025-12-18 | Bio-Thera Solutions, Ltd. | Method for treating solid tumor |
| IL318296A (en) | 2022-07-15 | 2025-03-01 | Genequantum Healthcare Suzhou Co Ltd | Anti-TROP2 antibody and its conjugate |
| WO2024097812A1 (en) | 2022-11-04 | 2024-05-10 | Gilead Sciences, Inc. | Therapy for treating bladder cancer |
| WO2024114318A1 (zh) * | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
| EP4653020A1 (en) | 2023-01-19 | 2025-11-26 | Shanghai Shengdi Pharmaceutical Co., Ltd | Tyrosinase-mediated protein site-specific conjugation and use thereof |
| WO2024199343A1 (zh) * | 2023-03-28 | 2024-10-03 | 江苏恒瑞医药股份有限公司 | 抗trop2抗体联合靶向trop2的药物治疗癌症的用途 |
| AU2024267522A1 (en) * | 2023-06-05 | 2025-11-20 | Ibio, Inc. | Trop2 antibodies |
| WO2025054560A2 (en) * | 2023-09-08 | 2025-03-13 | Nextpoint Therapeutics, Inc. | Antibody-drug conjugates |
| WO2025179213A1 (en) * | 2024-02-22 | 2025-08-28 | Memorial Sloan-Kettering Cancer Center | Targeting trop-2 in diffuse pleural mesothelioma |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| PT1104760E (pt) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| CA2478047C (en) | 2002-03-01 | 2014-01-21 | Immunomedics, Inc. | Rs7 antibodies |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| EP1934201A1 (en) * | 2005-10-06 | 2008-06-25 | Auspex Pharmaceuticals Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| US20100254979A1 (en) | 2009-03-06 | 2010-10-07 | Cisthera, Incorporated | Humanized PAI-1 Antibodies and Uses Thereof |
| CA2859965A1 (en) | 2011-12-21 | 2013-06-27 | Ardelyx, Inc. | Non-systemic tgr5 agonists |
| EP2802325B1 (en) | 2012-01-13 | 2016-11-30 | The General Hospital Corporation | Anesthetic compounds and related methods of use |
| ES2773710T3 (es) | 2012-10-11 | 2020-07-14 | Daiichi Sankyo Co Ltd | Enlazadores para conjugados de anticuerpo - fármaco |
| AU2014293670B2 (en) | 2013-07-23 | 2019-08-01 | Immunomedics, Inc. | Antibody-SN-38 immunoconjugates with a CL2A linker |
| WO2015047510A1 (en) * | 2013-09-27 | 2015-04-02 | Immunomedics, Inc. | Anti-trop-2 antibody-drug conjugates and uses thereof |
| AU2014371934B2 (en) * | 2013-12-25 | 2020-01-23 | Daiichi Sankyo Company, Limited | Anti-TROP2 antibody-drug conjugate |
| IL310627B2 (en) | 2014-01-31 | 2026-04-01 | Daiichi Sankyo Co Ltd | Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof |
| EP3130608B1 (en) * | 2014-04-10 | 2019-09-04 | Daiichi Sankyo Co., Ltd. | (anti-her2 antibody)-drug conjugate |
| WO2017063509A1 (zh) | 2015-10-15 | 2017-04-20 | 江苏恒瑞医药股份有限公司 | 氧杂螺环类衍生物、其制备方法及其在医药上的应用 |
| CN107446050A (zh) * | 2017-08-11 | 2017-12-08 | 百奥泰生物科技(广州)有限公司 | Trop2阳性疾病治疗的化合物及方法 |
| CN119241554A (zh) * | 2017-12-15 | 2025-01-03 | 四川科伦博泰生物医药股份有限公司 | 生物活性物偶联物及其制备方法和用途 |
| CA3114474A1 (en) * | 2018-09-30 | 2020-04-02 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-b7h3 antibody-exatecan analog conjugate and medicinal use thereof |
| CN111689980A (zh) * | 2019-05-26 | 2020-09-22 | 四川百利药业有限责任公司 | 一种喜树碱药物及其抗体偶联物 |
| US20230072897A1 (en) * | 2019-06-06 | 2023-03-09 | Shanghai Hansoh Biomedical Co., Ltd. | Anti-b7-h4 antibody-drug conjugate and medicinal use thereof |
| US20230054458A1 (en) * | 2019-12-12 | 2023-02-23 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-claudin antibody-drug conjugate and pharmaceutical use thereof |
| KR20220113747A (ko) * | 2019-12-16 | 2022-08-16 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항 cea 항체-엑사테칸 유사체의 접합체 및 이의 약학적 용도 |
| JP7821733B2 (ja) * | 2020-01-22 | 2026-02-27 | 上海森輝医薬有限公司 | エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用 |
| CN115298220B (zh) * | 2020-03-24 | 2024-12-20 | 上海翰森生物医药科技有限公司 | 抗体-药物偶联物及其医药用途 |
-
2021
- 2021-01-22 JP JP2022543188A patent/JP7781064B2/ja active Active
- 2021-01-22 US US17/793,005 patent/US20230101735A1/en active Pending
- 2021-01-22 EP EP21744789.5A patent/EP4095148A4/en active Pending
- 2021-01-22 TW TW110102506A patent/TWI891714B/zh active
- 2021-01-22 AU AU2021210074A patent/AU2021210074A1/en active Pending
- 2021-01-22 BR BR112022014189A patent/BR112022014189A2/pt unknown
- 2021-01-22 WO PCT/CN2021/073279 patent/WO2021147993A1/zh not_active Ceased
- 2021-01-22 CA CA3168260A patent/CA3168260A1/en active Pending
- 2021-01-22 CN CN202410757461.7A patent/CN118787756A/zh active Pending
- 2021-01-22 CN CN202410757639.8A patent/CN118873679A/zh active Pending
- 2021-01-22 CN CN202180007477.0A patent/CN114846021B/zh active Active
- 2021-01-22 MX MX2022008474A patent/MX2022008474A/es unknown
- 2021-01-22 KR KR1020227026893A patent/KR20220130717A/ko active Pending
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