JP2023505708A5 - - Google Patents
Info
- Publication number
- JP2023505708A5 JP2023505708A5 JP2022535591A JP2022535591A JP2023505708A5 JP 2023505708 A5 JP2023505708 A5 JP 2023505708A5 JP 2022535591 A JP2022535591 A JP 2022535591A JP 2022535591 A JP2022535591 A JP 2022535591A JP 2023505708 A5 JP2023505708 A5 JP 2023505708A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- represented
- variable region
- chain variable
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911273041.7 | 2019-12-12 | ||
| CN201911273041 | 2019-12-12 | ||
| CN202011060513.3 | 2020-09-30 | ||
| CN202011060513 | 2020-09-30 | ||
| PCT/CN2020/135680 WO2021115426A1 (zh) | 2019-12-12 | 2020-12-11 | 抗密蛋白抗体药物偶联物及其医药用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023505708A JP2023505708A (ja) | 2023-02-10 |
| JP2023505708A5 true JP2023505708A5 (https=) | 2023-12-18 |
| JP7720305B2 JP7720305B2 (ja) | 2025-08-07 |
Family
ID=76329625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022535591A Active JP7720305B2 (ja) | 2019-12-12 | 2020-12-11 | 抗クローディン抗体薬物複合体及びその医薬用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230054458A1 (https=) |
| EP (1) | EP4074345A4 (https=) |
| JP (1) | JP7720305B2 (https=) |
| KR (1) | KR20220113728A (https=) |
| CN (2) | CN114650845B (https=) |
| AU (1) | AU2020402006A1 (https=) |
| BR (1) | BR112022011032A2 (https=) |
| CA (1) | CA3162754A1 (https=) |
| MX (1) | MX2022006893A (https=) |
| TW (1) | TW202128227A (https=) |
| WO (1) | WO2021115426A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210148216A (ko) * | 2019-04-01 | 2021-12-07 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 항-클라우딘 18.2 항체 및 이의 응용 |
| JP7821733B2 (ja) * | 2020-01-22 | 2026-02-27 | 上海森輝医薬有限公司 | エリブリン誘導体の薬物複合体、その調製方法及びその医薬的応用 |
| JP7781064B2 (ja) * | 2020-01-22 | 2025-12-05 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 抗ｔｒｏｐ－２抗体－エキサテカン類似体複合体及びその医薬用途 |
| CN115103858B (zh) * | 2020-03-25 | 2025-07-15 | 江苏恒瑞医药股份有限公司 | 一种抗体药物偶联物的制备方法 |
| JP7753372B2 (ja) * | 2020-10-12 | 2025-10-14 | シーチュアン バイリ ファーム シーオー． エルティーディー | 重水素化カンプトテシン系誘導体及びその抗体薬物複合体 |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| TW202320858A (zh) | 2021-07-19 | 2023-06-01 | 美商薩諾管理公司 | 免疫接合物及方法 |
| AU2022353890A1 (en) | 2021-09-30 | 2024-04-04 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pyrrolo benzodiazepine derivative, and conjugate, preparation method and use thereof |
| WO2023083381A1 (zh) | 2021-11-15 | 2023-05-19 | 成都百利多特生物药业有限责任公司 | 双特异性抗体-喜树碱类药物偶联物及其医药用途 |
| US11814394B2 (en) | 2021-11-16 | 2023-11-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Exatecan derivatives, linker-payloads, and conjugates and thereof |
| JP7796230B2 (ja) * | 2021-12-17 | 2026-01-08 | フォートビタ バイオロジクス（シンガポール）プライベート リミティド | Ｃｌａｕｄｉｎ１８．２を標的とする抗体―薬物複合体 |
| IL318296A (en) | 2022-07-15 | 2025-03-01 | Genequantum Healthcare Suzhou Co Ltd | Anti-TROP2 antibody and its conjugate |
| US20240116945A1 (en) * | 2022-09-02 | 2024-04-11 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
| WO2025106278A1 (en) | 2023-11-17 | 2025-05-22 | Mersana Therapeutics, Inc. | Treatment of cancer using b7-h4-targeted antibody-drug conjugates |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6504029B1 (en) | 1995-04-10 | 2003-01-07 | Daiichi Pharmaceutical Co., Ltd. | Condensed-hexacyclic compounds and a process therefor |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| CA2859965A1 (en) | 2011-12-21 | 2013-06-27 | Ardelyx, Inc. | Non-systemic tgr5 agonists |
| EP2802325B1 (en) | 2012-01-13 | 2016-11-30 | The General Hospital Corporation | Anesthetic compounds and related methods of use |
| ES2773710T3 (es) * | 2012-10-11 | 2020-07-14 | Daiichi Sankyo Co Ltd | Enlazadores para conjugados de anticuerpo - fármaco |
| IL310627B2 (en) | 2014-01-31 | 2026-04-01 | Daiichi Sankyo Co Ltd | Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof |
| WO2016165762A1 (en) | 2015-04-15 | 2016-10-20 | Ganymed Pharmaceuticals Ag | Drug conjugates comprising antibodies against claudin 18.2 |
| CN108101825B (zh) * | 2016-11-25 | 2022-02-22 | 迈威(上海)生物科技股份有限公司 | 用于抗体-药物偶联的双取代马来酰胺类连接子及其制备方法和用途 |
| WO2019034176A1 (zh) * | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | 一种喜树碱-抗体偶联物 |
| SG11202010496WA (en) * | 2018-05-18 | 2020-12-30 | Daiichi Sankyo Co Ltd | Anti-muc1 antibody-drug conjugate |
| WO2019242505A1 (zh) * | 2018-06-17 | 2019-12-26 | 上海健信生物医药科技有限公司 | 靶向cldn18.2的抗体、双特异性抗体、adc和car及其应用 |
| CN111110862A (zh) * | 2018-11-01 | 2020-05-08 | 上海健信生物医药科技有限公司 | 抗cldn18．2抗体的药物偶联体及其制备方法和用途 |
| WO2020063676A1 (zh) * | 2018-09-26 | 2020-04-02 | 江苏恒瑞医药股份有限公司 | 依喜替康类似物的配体-药物偶联物及其制备方法和应用 |
| CA3114474A1 (en) * | 2018-09-30 | 2020-04-02 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-b7h3 antibody-exatecan analog conjugate and medicinal use thereof |
| CN109762067B (zh) * | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | 结合人Claudin 18.2的抗体及其用途 |
| KR20210148216A (ko) | 2019-04-01 | 2021-12-07 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 항-클라우딘 18.2 항체 및 이의 응용 |
| CN111689980A (zh) * | 2019-05-26 | 2020-09-22 | 四川百利药业有限责任公司 | 一种喜树碱药物及其抗体偶联物 |
| US20230072897A1 (en) * | 2019-06-06 | 2023-03-09 | Shanghai Hansoh Biomedical Co., Ltd. | Anti-b7-h4 antibody-drug conjugate and medicinal use thereof |
| CN113766933B (zh) * | 2019-06-28 | 2024-09-06 | 上海复旦张江生物医药股份有限公司 | 一种抗体偶联药物、其中间体、制备方法及应用 |
| AU2021354827A1 (en) * | 2020-09-30 | 2023-06-01 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising antibody-drug conjugate, and use of pharmaceutical composition |
-
2020
- 2020-12-11 US US17/782,980 patent/US20230054458A1/en active Pending
- 2020-12-11 MX MX2022006893A patent/MX2022006893A/es unknown
- 2020-12-11 AU AU2020402006A patent/AU2020402006A1/en active Pending
- 2020-12-11 WO PCT/CN2020/135680 patent/WO2021115426A1/zh not_active Ceased
- 2020-12-11 CA CA3162754A patent/CA3162754A1/en active Pending
- 2020-12-11 KR KR1020227022162A patent/KR20220113728A/ko active Pending
- 2020-12-11 CN CN202080077964.XA patent/CN114650845B/zh active Active
- 2020-12-11 BR BR112022011032A patent/BR112022011032A2/pt unknown
- 2020-12-11 JP JP2022535591A patent/JP7720305B2/ja active Active
- 2020-12-11 TW TW109143889A patent/TW202128227A/zh unknown
- 2020-12-11 CN CN202410509070.3A patent/CN118403182A/zh active Pending
- 2020-12-11 EP EP20898395.7A patent/EP4074345A4/en active Pending
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