JP2023512666A5 - - Google Patents
Info
- Publication number
- JP2023512666A5 JP2023512666A5 JP2022545857A JP2022545857A JP2023512666A5 JP 2023512666 A5 JP2023512666 A5 JP 2023512666A5 JP 2022545857 A JP2022545857 A JP 2022545857A JP 2022545857 A JP2022545857 A JP 2022545857A JP 2023512666 A5 JP2023512666 A5 JP 2023512666A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- ester
- lipid
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025129205A JP2025156488A (ja) | 2020-02-07 | 2025-08-01 | Ｎ４－ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062971559P | 2020-02-07 | 2020-02-07 | |
| US62/971,559 | 2020-02-07 | ||
| US202062988133P | 2020-03-11 | 2020-03-11 | |
| US62/988,133 | 2020-03-11 | ||
| US202062994604P | 2020-03-25 | 2020-03-25 | |
| US62/994,604 | 2020-03-25 | ||
| US202063006625P | 2020-04-07 | 2020-04-07 | |
| US63/006,625 | 2020-04-07 | ||
| PCT/US2021/016984 WO2021159044A1 (en) | 2020-02-07 | 2021-02-07 | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025129205A Division JP2025156488A (ja) | 2020-02-07 | 2025-08-01 | Ｎ４－ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023512666A JP2023512666A (ja) | 2023-03-28 |
| JP2023512666A5 true JP2023512666A5 (https=) | 2023-12-20 |
| JP7745892B2 JP7745892B2 (ja) | 2025-09-30 |
Family
ID=77200593
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022545857A Active JP7745892B2 (ja) | 2020-02-07 | 2021-02-07 | Ｎ４－ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
| JP2025129205A Pending JP2025156488A (ja) | 2020-02-07 | 2025-08-01 | Ｎ４－ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025129205A Pending JP2025156488A (ja) | 2020-02-07 | 2025-08-01 | Ｎ４－ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20210252033A1 (https=) |
| EP (1) | EP4017501A4 (https=) |
| JP (2) | JP7745892B2 (https=) |
| KR (1) | KR20220139914A (https=) |
| CN (2) | CN115666587A (https=) |
| AR (1) | AR127030A2 (https=) |
| AU (1) | AU2021216049A1 (https=) |
| BR (1) | BR112022015479A2 (https=) |
| CA (1) | CA3167054A1 (https=) |
| CL (1) | CL2022000423A1 (https=) |
| CO (1) | CO2022008092A2 (https=) |
| CR (1) | CR20220082A (https=) |
| DO (1) | DOP2022000049A (https=) |
| EC (1) | ECSP22061711A (https=) |
| IL (1) | IL295237B1 (https=) |
| JO (1) | JOP20220179A1 (https=) |
| MX (1) | MX2022009164A (https=) |
| PE (1) | PE20230466A1 (https=) |
| PH (1) | PH12022550438A1 (https=) |
| TW (1) | TW202140040A (https=) |
| UA (1) | UA130623C2 (https=) |
| WO (1) | WO2021159044A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| PT3706762T (pt) | 2017-12-07 | 2024-12-05 | Univ Emory | N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos |
| EP4667008A3 (en) * | 2020-06-02 | 2026-03-18 | Model Medicines, Inc. | Methods and compositions for treating rna viral infections |
| EP4208154A1 (en) * | 2020-09-04 | 2023-07-12 | Mexichem Fluor S.A. de C.V. | Pharmaceutical composition |
| US20220370598A1 (en) * | 2021-05-05 | 2022-11-24 | Inovio Pharmaceuticals, Inc. | Vaccines Against Coronavirus and Methods of Use |
| US12599625B2 (en) | 2021-05-13 | 2026-04-14 | Penland Foundation | Treatment of ARDS and other conditions caused by acutely elevated cytokine levels and post ARDS chronic cytokine production using inhaled anesthetics |
| CN117642410A (zh) * | 2021-06-18 | 2024-03-01 | 苏州春海生物医药有限公司 | N4-羟基胞苷的酯衍生物及其用途 |
| WO2023287726A1 (en) | 2021-07-12 | 2023-01-19 | Penland Foundation | Treatment of cancer using botulinum toxin and nitrous oxide |
| WO2023025319A1 (zh) * | 2021-08-27 | 2023-03-02 | 南京知和医药科技有限公司 | 一种新型的胞苷衍生物及其药物组合物和用途 |
| CN115737665A (zh) * | 2021-09-02 | 2023-03-07 | 广州谷森制药有限公司 | 胞苷衍生物和与其相关的抗病毒用途 |
| WO2023070058A1 (en) * | 2021-10-20 | 2023-04-27 | Merck Sharp & Dohme Llc | Treatment of viruses with antiviral nucleosides |
| WO2023067623A1 (en) * | 2021-10-20 | 2023-04-27 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) | A short and cost effective synthetic route towards anti viral eidd-1931 and its hydrate polymorphs |
| CN114306254B (zh) * | 2021-11-30 | 2023-11-03 | 南京正济医药研究有限公司 | 一种Molnupiravir口服固体制剂及其制备方法 |
| US11541071B1 (en) | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
| CN116496334A (zh) * | 2022-01-25 | 2023-07-28 | 上海和誉生物医药科技有限公司 | 一种抗病毒抑制剂及其在药学上的应用 |
| CN114948982A (zh) * | 2022-02-14 | 2022-08-30 | 广州谷森制药有限公司 | 一种具有协同增效效应的药物组合物及其其抗病毒用途 |
| CN116589518B (zh) * | 2022-06-10 | 2026-04-28 | 南京知和医药科技有限公司 | 一种新型的胞苷衍生物及其药物组合物和用途 |
| CN117756870A (zh) * | 2022-09-23 | 2024-03-26 | 上海和誉生物医药科技有限公司 | 一种核苷抗病毒抑制剂及其应用 |
| WO2024123207A1 (ru) * | 2022-12-08 | 2024-06-13 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | 5'-о-(3-фенилпропионил)-n4-гидроксицитидин и его применение |
| WO2024123206A1 (ru) * | 2022-12-08 | 2024-06-13 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Способ получения 5',-о-(3-фенилпропионил)-n4-гидроксицитидина |
| WO2024125604A1 (en) * | 2022-12-16 | 2024-06-20 | Suzhou Spring-Sea Bio-Pharmaceuticals Co. Ltd. | Diester derivatives of n4-hydroxycytidine and use thereof |
| CN116217644B (zh) * | 2023-04-24 | 2023-08-08 | 南京颐媛生物医学研究院有限公司 | 抗冠状病毒核糖核苷类化合物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7381190B2 (ja) * | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | Ｎ４－ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| WO2017106710A1 (en) * | 2015-12-17 | 2017-06-22 | Emory University | Nucleotide and nucleoside therapeutic compositions and uses related thereto |
| US10874683B2 (en) * | 2016-03-10 | 2020-12-29 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| CN109470677B (zh) * | 2017-09-08 | 2021-11-05 | 清华大学 | 分子检测装置 |
| PT3706762T (pt) * | 2017-12-07 | 2024-12-05 | Univ Emory | N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos |
-
2021
- 2021-02-07 WO PCT/US2021/016984 patent/WO2021159044A1/en not_active Ceased
- 2021-02-07 CA CA3167054A patent/CA3167054A1/en active Pending
- 2021-02-07 BR BR112022015479A patent/BR112022015479A2/pt unknown
- 2021-02-07 MX MX2022009164A patent/MX2022009164A/es unknown
- 2021-02-07 JP JP2022545857A patent/JP7745892B2/ja active Active
- 2021-02-07 PE PE2022001688A patent/PE20230466A1/es unknown
- 2021-02-07 PH PH1/2022/550438A patent/PH12022550438A1/en unknown
- 2021-02-07 JO JOP/2022/0179A patent/JOP20220179A1/ar unknown
- 2021-02-07 UA UAA202203239A patent/UA130623C2/uk unknown
- 2021-02-07 CN CN202180013336.XA patent/CN115666587A/zh active Pending
- 2021-02-07 CR CR20220082A patent/CR20220082A/es unknown
- 2021-02-07 AU AU2021216049A patent/AU2021216049A1/en active Pending
- 2021-02-07 CN CN202510130407.4A patent/CN120284995A/zh active Pending
- 2021-02-07 EP EP21750787.0A patent/EP4017501A4/en active Pending
- 2021-02-07 KR KR1020227030290A patent/KR20220139914A/ko active Pending
- 2021-02-08 TW TW110104831A patent/TW202140040A/zh unknown
- 2021-02-08 US US17/170,172 patent/US20210252033A1/en not_active Abandoned
-
2022
- 2022-02-22 CL CL2022000423A patent/CL2022000423A1/es unknown
- 2022-02-28 DO DO2022000049A patent/DOP2022000049A/es unknown
- 2022-06-07 CO CONC2022/0008092A patent/CO2022008092A2/es unknown
- 2022-07-31 IL IL295237A patent/IL295237B1/en unknown
- 2022-08-05 EC ECSENADI202261711A patent/ECSP22061711A/es unknown
- 2022-09-09 AR ARP220102457A patent/AR127030A2/es unknown
-
2024
- 2024-11-07 US US18/940,253 patent/US20250064844A1/en active Pending
-
2025
- 2025-08-01 JP JP2025129205A patent/JP2025156488A/ja active Pending
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