IL295237B1 - N4-hydroxycytidine and derivatives and related antiviral uses - Google Patents

N4-hydroxycytidine and derivatives and related antiviral uses

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Publication number
IL295237B1
IL295237B1 IL295237A IL29523722A IL295237B1 IL 295237 B1 IL295237 B1 IL 295237B1 IL 295237 A IL295237 A IL 295237A IL 29523722 A IL29523722 A IL 29523722A IL 295237 B1 IL295237 B1 IL 295237B1
Authority
IL
Israel
Prior art keywords
hydroxycytidine
derivatives
uses related
viral uses
viral
Prior art date
Application number
IL295237A
Other languages
English (en)
Hebrew (he)
Other versions
IL295237A (en
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory filed Critical Univ Emory
Publication of IL295237A publication Critical patent/IL295237A/en
Publication of IL295237B1 publication Critical patent/IL295237B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
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    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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IL295237A 2020-02-07 2022-07-31 N4-hydroxycytidine and derivatives and related antiviral uses IL295237B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062971559P 2020-02-07 2020-02-07
US202062988133P 2020-03-11 2020-03-11
US202062994604P 2020-03-25 2020-03-25
US202063006625P 2020-04-07 2020-04-07
PCT/US2021/016984 WO2021159044A1 (en) 2020-02-07 2021-02-07 N4-hydroxycytidine and derivatives and anti-viral uses related thereto

Publications (2)

Publication Number Publication Date
IL295237A IL295237A (en) 2022-10-01
IL295237B1 true IL295237B1 (en) 2026-03-01

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IL295237A IL295237B1 (en) 2020-02-07 2022-07-31 N4-hydroxycytidine and derivatives and related antiviral uses

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US (2) US20210252033A1 (https=)
EP (1) EP4017501A4 (https=)
JP (2) JP7745892B2 (https=)
KR (1) KR20220139914A (https=)
CN (2) CN115666587A (https=)
AR (1) AR127030A2 (https=)
AU (1) AU2021216049A1 (https=)
BR (1) BR112022015479A2 (https=)
CA (1) CA3167054A1 (https=)
CL (1) CL2022000423A1 (https=)
CO (1) CO2022008092A2 (https=)
CR (1) CR20220082A (https=)
DO (1) DOP2022000049A (https=)
EC (1) ECSP22061711A (https=)
IL (1) IL295237B1 (https=)
JO (1) JOP20220179A1 (https=)
MX (1) MX2022009164A (https=)
PE (1) PE20230466A1 (https=)
PH (1) PH12022550438A1 (https=)
TW (1) TW202140040A (https=)
UA (1) UA130623C2 (https=)
WO (1) WO2021159044A1 (https=)

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