HRP20191257T1 - Farmaceutske formulacije koje sadrže 4-{(1r)-2-[(6-{2-[(2,6-diklorbenzil)oksi]etoksi}heksil)amino]-1-hidroksietil}-2-(hidroksimetil)fenol - Google Patents

Farmaceutske formulacije koje sadrže 4-{(1r)-2-[(6-{2-[(2,6-diklorbenzil)oksi]etoksi}heksil)amino]-1-hidroksietil}-2-(hidroksimetil)fenol Download PDF

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Publication number
HRP20191257T1
HRP20191257T1 HRP20191257TT HRP20191257T HRP20191257T1 HR P20191257 T1 HRP20191257 T1 HR P20191257T1 HR P20191257T T HRP20191257T T HR P20191257TT HR P20191257 T HRP20191257 T HR P20191257T HR P20191257 T1 HRP20191257 T1 HR P20191257T1
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HR
Croatia
Prior art keywords
respiratory system
compound
treatment
pharmaceutical formulation
diseases
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HRP20191257TT
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English (en)
Inventor
Darrell Baker
Mark Bruce
Marian Thomas
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Glaxo Group Limited
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40547825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20191257(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HRP20191257T1 publication Critical patent/HRP20191257T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (18)

1. Farmaceutska formulacija, naznačena time što sadrži formulaciju 4-{(1R)-2-[(6-{2-[(2,6-diklorbenzil)oksi]etoksi}heksil)amino]-1-hidroksietil}-2-(hidroksimetil)fenola: ili njegove farmaceutski prihvatljive soli, u obliku suhog praha, nosač i ternarno sredstvo, gdje je ternarno sredstvo magnezijev stearat, te gdje se Spoj (I) primjenjuje inhalacijom u dozi od 12,5, 25 ili 50 µg dnevno, izračunatoj kao slobodna baza namijenjena upotrebi u liječenju bolesti dišnog sustava.
2. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s patentnim zahtjevom 1, naznačena time što se Spoj (I) primjenjuje inhalacijom u dozi od 12,5 µg dnevno, izračunatoj kao slobodna baza.
3. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s patentnim zahtjevom 1, naznačena time što se Spoj (I) primjenjuje inhalacijom u dozi od 25 µg dnevno, izračunatoj kao slobodna baza.
4. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s patentnim zahtjevom 1, naznačena time što se Spoj (I) primjenjuje inhalacijom u dozi od 50 µg dnevno, izračunatoj kao slobodna baza.
5. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačena time što je nosač laktoza.
6. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačena time što je Spoj (I) 4-{(1R)-2-[(6-{2-[(2,6-diklorbenzil)oksi]etoksi}heksil)amino]-1-hidroksietil}-2-(hidroksimetil)fenol-trifenilacetat.
7. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 1 do 6, naznačena time što je u obliku pogodnom za primjenu oralnom ili nazalnom inhalacijom.
8. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačena time što je bolest dišnog sustava astma.
9. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačena time što je bolest dišnog sustava COPD.
10. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 1 do 9, naznačena time što dodatno sadrži S-fluormetilni ester 6α,9α-difluor-17α-[(2-furanilkarbonil)oksi]-11β-hidroksi-16α-metil-3-oksoandrosta-1,4-dien-17β-karbotiojske kiseline: , gdje je Spoj (II) u obliku suhog praha kao pripravka.
11. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s patentnim zahtjevom 10, naznačena time što se Spoj (I) i Spoj (II) daje u obliku prilagođenom za odvojenu primjenu.
12. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s patentnim zahtjevom 10, naznačena time što se Spoj (I) i Spoj (II) daje u obliku prilagođenom za uzastopnu primjenu.
13. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s patentnim zahtjevom 10, naznačena time što se Spoj (I) i Spoj (II) daje u obliku prilagođenom za istodobnu primjenu.
14. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 10 do 13, naznačena time što se Spoj (I) i Spoj (II) daje kao odvojene pripravke.
15. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s patentnim zahtjevom 13, naznačena time što su Spoj (I) i Spoj (II) u smjesi jedan s drugim.
16. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 10 do 15, naznačena time što je Spoj (II) formuliran s farmaceutski prihvatljivim nosačem ili pomoćnom tvari.
17. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 10 do 16, naznačena time što je u obliku pogodnom za primjenu oralnom ili nazalnom inhalacijom.
18. Farmaceutska formulacija namijenjena upotrebi u liječenju bolesti dišnog sustava u skladu s bilo kojim od patentnih zahtjeva 10 do 17, naznačena time što je Spoj (II) prisutan u količini od 25 µg do 800 µg po dozi.
HRP20191257TT 2009-02-26 2019-07-12 Farmaceutske formulacije koje sadrže 4-{(1r)-2-[(6-{2-[(2,6-diklorbenzil)oksi]etoksi}heksil)amino]-1-hidroksietil}-2-(hidroksimetil)fenol HRP20191257T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2009/052306 WO2010097115A1 (en) 2009-02-26 2009-02-26 Pharmaceutical formulations comprising 4-{(1r)-2- [(6-{2-[(2,6-dichlorobenzyl)oxy] ethoxy}hexyl)amino]-1-hydroxyethyl}-2- (hydroxymethyl)phenol
EP09779096.8A EP2400950B1 (en) 2009-02-26 2009-02-26 Pharmaceutical formulations comprising 4-{(1 r)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol

Publications (1)

Publication Number Publication Date
HRP20191257T1 true HRP20191257T1 (hr) 2019-10-18

Family

ID=40547825

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20191257TT HRP20191257T1 (hr) 2009-02-26 2019-07-12 Farmaceutske formulacije koje sadrže 4-{(1r)-2-[(6-{2-[(2,6-diklorbenzil)oksi]etoksi}heksil)amino]-1-hidroksietil}-2-(hidroksimetil)fenol

Country Status (13)

Country Link
US (1) US11116721B2 (hr)
EP (2) EP3578169B1 (hr)
JP (1) JP5809985B2 (hr)
CY (1) CY1121914T1 (hr)
DK (1) DK2400950T3 (hr)
ES (1) ES2739352T3 (hr)
HR (1) HRP20191257T1 (hr)
HU (1) HUE045917T2 (hr)
LT (1) LT2400950T (hr)
PL (1) PL2400950T3 (hr)
PT (1) PT2400950T (hr)
SI (1) SI2400950T1 (hr)
WO (1) WO2010097115A1 (hr)

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EP3578169B1 (en) 2024-06-26
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EP3578169A1 (en) 2019-12-11
JP5809985B2 (ja) 2015-11-11
EP2400950B1 (en) 2019-05-22
LT2400950T (lt) 2019-08-26
DK2400950T3 (da) 2019-07-29
WO2010097115A1 (en) 2010-09-02
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EP2400950A1 (en) 2012-01-04
US11116721B2 (en) 2021-09-14

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