JP5809985B2 - 4−{(1r)−2−[(6−{2−[(2,6−ジクロロベンジル)オキシ]エトキシ}ヘキシル)アミノ]−1−ヒドロキシエチル}−2−(ヒドロキシメチル)フェノールを含む医薬製剤 - Google Patents
4−{(1r)−2−[(6−{2−[(2,6−ジクロロベンジル)オキシ]エトキシ}ヘキシル)アミノ]−1−ヒドロキシエチル}−2−(ヒドロキシメチル)フェノールを含む医薬製剤 Download PDFInfo
- Publication number
- JP5809985B2 JP5809985B2 JP2011551415A JP2011551415A JP5809985B2 JP 5809985 B2 JP5809985 B2 JP 5809985B2 JP 2011551415 A JP2011551415 A JP 2011551415A JP 2011551415 A JP2011551415 A JP 2011551415A JP 5809985 B2 JP5809985 B2 JP 5809985B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid
- treatment
- pharmaceutical preparation
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C[C@](CC(C(C[C@](C([C@]1(C)C=C2)=CC2=O)F)[C@@]11F)[C@]2(C)C[C@@]1O)[C@@]2(C(S*)=O)OC(c1ccc[o]1)=O Chemical compound C[C@](CC(C(C[C@](C([C@]1(C)C=C2)=CC2=O)F)[C@@]11F)[C@]2(C)C[C@@]1O)[C@@]2(C(S*)=O)OC(c1ccc[o]1)=O 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
ラクトースのような担体およびステアリン酸マグネシウムのような三元剤を含む混合物において提供する。
b)6α,9α−ジフルオロ−17α−[(2−フラニルカルボニル)オキシ]−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスタ−1,4−ジエン−17β−チオカルボン酸 S−フルオロメチルエステル
b)6α,9α−ジフルオロ−17α−[(2−フラニルカルボニル)オキシ]−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスタ−1,4−ジエン−17β−チオカルボン酸 S−フルオロメチルエステル(化合物II)の乾燥粉末製剤。
b)6α,9α−ジフルオロ−17α−[(2−フラニルカルボニル)オキシ]−11β−ヒドロキシ−16α−メチル−3−オキソ−アンドロスタ−1,4−ジエン−17β−チオカルボン酸 S−フルオロメチルエステル(化合物II)を有する乾燥粉末製剤。
α−フェニルケイ皮酸塩およびトリフェニル酢酸塩としての化合物(I)は、単一用量および反復用量研究を含む多くの臨床薬理学研究において、研究された。加えてそれら研究は賦形剤セロビオースオクタアセタートおよびステアリン酸マグネシウムと共にある化合物(I)を評価した。
調合物の調製
Ph.Eur/USNFの要求に応じる医薬等級ラクトース一水和物を使用した。使用前に、物質を非凝集させるためにラクトース一水和物を粗い網(網の大きさが800ミクロン)を通してふるいにかけた。化合物(I)トリフェニル酢酸を使用前に、2〜5ミクロンのMMD(質量中位径)を得るためにAPTMマイクロナイザで微粒子化した。
Claims (20)
- 前記担体がラクトースである請求項1に記載の医薬製剤。
- 化合物(I)が4−{(1R)−2−[(6−{2−[(2,6−ジクロロベンジル)オキシ]エトキシ}ヘキシル)アミノ]−1−ヒドロキシエチル}−2−(ヒドロキシメチル)フェノール トリフェニル酢酸塩である請求項1または2に記載の医薬製剤。
- 口または鼻吸入による投与に適した形状の請求項1から3のいずれか一項に記載の医薬製剤。
- 呼吸器疾患の治療に用いる薬物の製造における請求項1から4のいずれか一項に記載の医薬製剤の使用。
- 喘息の治療のための薬物の製造に用いる請求項5に記載の使用。
- 慢性閉塞肺疾患(COPD)の治療のための薬物の製造に用いる請求項5に記載の使用。
- 前記化合物(I)および化合物(II)が分離投与に適応した形状で存在する請求項8に記載の医薬製剤。
- 前記化合物(I)および前記化合物(II)が反復投与に適した形状で存在する請求項8に記載の医薬製剤。
- 前記化合物(I)および前記化合物(II)が同時投与に適した形状で存在する請求項8記載の医薬製剤。
- 前記化合物(I)および前記化合物(II)が分離した組成物として存在する請求項8から11のいずれか一項に記載の医薬製剤。
- 前記化合物(I)および前記化合物(II)が互いと混合される請求項11に記載の医薬製剤。
- 前記化合物(II)が乾燥粉末組成物の形状で存在する請求項8から13のいずれか一項に記載の医薬製剤。
- 前記化合物(II)を薬学的に許容される担体または賦形剤とともに処方する請求項8から14のいずれか一項に記載の医薬製剤。
- 口または鼻吸入による投与に適した形状である請求項8から15のいずれか一項に記載の医薬製剤。
- 化合物(II)が25mcgから800mcg/用量の量で存在する請求項8から16のいずれか一項に記載の医薬製剤。
- 呼吸器疾患の治療のための薬物の製造における請求項8から17のいずれか一項に記載の医薬製剤の使用。
- 喘息の治療のための薬物の製造に用いる請求項18に記載の使用。
- 慢性閉塞肺疾患(COPD)の治療のための薬物の製造に用いる請求項18に記載の使用。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2009/052306 WO2010097115A1 (en) | 2009-02-26 | 2009-02-26 | Pharmaceutical formulations comprising 4-{(1r)-2- [(6-{2-[(2,6-dichlorobenzyl)oxy] ethoxy}hexyl)amino]-1-hydroxyethyl}-2- (hydroxymethyl)phenol |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012518663A JP2012518663A (ja) | 2012-08-16 |
JP5809985B2 true JP5809985B2 (ja) | 2015-11-11 |
Family
ID=40547825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011551415A Active JP5809985B2 (ja) | 2009-02-26 | 2009-02-26 | 4−{(1r)−2−[(6−{2−[(2,6−ジクロロベンジル)オキシ]エトキシ}ヘキシル)アミノ]−1−ヒドロキシエチル}−2−(ヒドロキシメチル)フェノールを含む医薬製剤 |
Country Status (13)
Country | Link |
---|---|
US (1) | US11116721B2 (ja) |
EP (2) | EP3578169B1 (ja) |
JP (1) | JP5809985B2 (ja) |
CY (1) | CY1121914T1 (ja) |
DK (1) | DK2400950T3 (ja) |
ES (1) | ES2739352T3 (ja) |
HR (1) | HRP20191257T1 (ja) |
HU (1) | HUE045917T2 (ja) |
LT (1) | LT2400950T (ja) |
PL (1) | PL2400950T3 (ja) |
PT (1) | PT2400950T (ja) |
SI (1) | SI2400950T1 (ja) |
WO (1) | WO2010097115A1 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3578169B1 (en) | 2009-02-26 | 2024-06-26 | Glaxo Group Limited | Pharmaceutical formulations comprising 4-{(1 r)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol |
GB0921075D0 (en) * | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
EP2611423B2 (en) | 2010-08-31 | 2022-09-21 | GlaxoSmithKline Intellectual Property Development Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
SG195262A1 (en) * | 2011-06-08 | 2013-12-30 | Glaxo Group Ltd | Combination comprising umeclidinium and a corticosteroid |
KR20140147891A (ko) | 2012-04-13 | 2014-12-30 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 응집체 입자 |
GB201222679D0 (en) | 2012-12-17 | 2013-01-30 | Glaxo Group Ltd | Pharmaceutical combination products |
GB201305825D0 (en) | 2013-03-28 | 2013-05-15 | Vectura Ltd | New use |
EP2957553A1 (en) * | 2014-06-16 | 2015-12-23 | Arven Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical formulations of vilanterol |
MA39288A (fr) * | 2014-06-16 | 2015-12-23 | Arven Ilac Sanayi Ve Ticaret As | Formulations pharmaceutiques comprenant du vilanterol |
EP2957552B1 (en) * | 2014-06-16 | 2020-01-22 | Arven Ilac Sanayi Ve Ticaret A.S. | Vilanterol formulations |
TR201407010A2 (tr) * | 2014-06-16 | 2015-12-21 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Vilanterol formülasyonları. |
MA40444A (fr) * | 2014-07-09 | 2017-05-17 | Arven Ilac Sanayi Ve Ticaret As | Procédé de préparation de formulations de poudre sèche |
US20170266135A1 (en) * | 2014-07-09 | 2017-09-21 | Arven Ilac Sanayi Ve Ticaret A.S. | Process for preparing the inhalation formulations |
EP3166591A1 (en) * | 2014-07-09 | 2017-05-17 | Arven Ilac Sanayi Ve Ticaret A.S. | Novel process for the preparation of dry powder formulations |
WO2022146257A1 (en) * | 2020-12-31 | 2022-07-07 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | A process for the preparation of dry powder compositions for inhalation |
Family Cites Families (180)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB124009A (en) | 1918-01-12 | 1919-03-12 | Walter Edward Kimber | Improvements in and connected with the Manufacture of Tools for Turning, Planing, Boring and similar purposes. |
GB124010A (en) | 1919-01-10 | 1919-03-20 | Rene Emile Dior | Improved Process for the Manufacture of Synthetic Resins. |
GB1242211A (en) | 1967-08-08 | 1971-08-11 | Fisons Pharmaceuticals Ltd | Pharmaceutical composition |
GB1381872A (en) | 1971-06-22 | 1975-01-29 | Fisons Ltd | Pharmaceutical compositions for inhalation |
FR2182892B1 (ja) | 1972-03-25 | 1976-11-05 | Degussa | |
GB2064336B (en) | 1979-12-06 | 1984-03-14 | Glaxo Group Ltd | Device for dispensing medicaments |
CY1492A (en) | 1981-07-08 | 1990-02-16 | Draco Ab | Powder inhalator |
GB2129691B (en) | 1982-10-08 | 1987-08-05 | Glaxo Group Ltd | Devices for administering medicaments to patients |
GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
NO166268C (no) | 1985-07-30 | 1991-07-03 | Glaxo Group Ltd | Innretning for administrering av medikamenter til pasienter. |
GB8530365D0 (en) | 1985-12-10 | 1986-01-22 | Univ Bath | Manufacture of moulded products |
IT1204826B (it) | 1986-03-04 | 1989-03-10 | Chiesi Farma Spa | Composizioni farmaceutiche per inalazione |
CA1329526C (en) | 1987-08-20 | 1994-05-17 | Hiroshi Ikura | Powdery medicine applicator device |
US4994276A (en) | 1988-09-19 | 1991-02-19 | Edward Mendell Co., Inc. | Directly compressible sustained release excipient |
GB8820353D0 (en) | 1988-08-26 | 1988-09-28 | Staniforth J N | Controlled release tablet |
US5135757A (en) | 1988-09-19 | 1992-08-04 | Edward Mendell Co., Inc. | Compressible sustained release solid dosage forms |
US5376386A (en) | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
SK280968B6 (sk) | 1990-03-02 | 2000-10-09 | Glaxo Group Limited | Balenie medikamentu na použite v inhalačnom prístroji |
GB9004781D0 (en) | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
MY105368A (en) | 1990-03-02 | 1994-09-30 | Glaxo Group Ltd | Inhalation device. |
FR2660634B1 (fr) | 1990-04-06 | 1992-10-16 | Airsec Ind Sa | Conditionnement pour produits necessitant l'usage d'un agent deshydratant. |
JPH0471560A (ja) | 1990-07-10 | 1992-03-06 | Mect Corp | 包装体 |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
DE4140689B4 (de) | 1991-12-10 | 2007-11-22 | Boehringer Ingelheim Kg | Inhalationspulver und Verfahren zu ihrer Herstellung |
ES2177544T3 (es) | 1992-06-12 | 2002-12-16 | Teijin Ltd | Polvo ultrafinno para inhalar y metodo para su preparacion. |
DE69330672T2 (de) | 1992-06-12 | 2002-06-27 | Teijin Ltd | Pharmazeutische zubereitung zur anwendung in den atemwegen |
GB2269992A (en) | 1992-08-14 | 1994-03-02 | Rh Ne Poulenc Rorer Limited | Powder inhalation formulations |
ES2102210T3 (es) | 1992-09-09 | 1997-07-16 | Fisons Plc | Envase para medicamentos. |
SE9203743D0 (sv) | 1992-12-11 | 1992-12-11 | Astra Ab | Efficient use |
JP2924924B2 (ja) | 1992-12-18 | 1999-07-26 | シェリング・コーポレーション | 粉末薬物のための吸入器 |
US5441060A (en) | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
US5730785A (en) | 1993-04-01 | 1998-03-24 | Multisorb Technologies, Inc. | Desiccant canister for desiccants and other particulate material |
US5506203C1 (en) | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
IS1796B (is) | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
DE4323636A1 (de) | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
GB9322014D0 (en) | 1993-10-26 | 1993-12-15 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
US5503662A (en) | 1994-03-29 | 1996-04-02 | Multiform Desiccants, Inc. | Canister with porous plastic ends |
FI95441C (fi) | 1994-05-31 | 1996-02-12 | Leiras Oy | Inhalointilaitteen lääkeainekammio |
US5641425A (en) | 1994-09-08 | 1997-06-24 | Multiform Desiccants, Inc. | Oxygen absorbing composition |
US6156231A (en) | 1994-09-08 | 2000-12-05 | Multisorb Technologies, Inc. | Oxygen absorbing composition with cover layer |
AR002009A1 (es) | 1994-12-22 | 1998-01-07 | Astra Ab | Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco. |
GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
US6279736B1 (en) | 1995-04-19 | 2001-08-28 | Capitol Specialty Plastics, Inc. | Barrier pack having an absorbing agent applied to the interior of the pack |
PL322946A1 (en) | 1995-04-19 | 1998-03-02 | Capitol Vial Inc | Dessicating material enclosed in a closed container |
GB9515182D0 (en) | 1995-07-24 | 1995-09-20 | Co Ordinated Drug Dev | Improvements in and relating to powders for use in dry powder inhalers |
GB9700226D0 (en) | 1997-01-08 | 1997-02-26 | Glaxo Group Ltd | Inhalation device |
US6103141A (en) | 1997-01-23 | 2000-08-15 | Multisorb Technologies, Inc. | Desiccant deposit |
AU6700998A (en) | 1997-03-14 | 1998-09-29 | University Of Houston, The | Methods for making fluorinated surface modifying agents, methods of using same and products made using same |
US5985415A (en) | 1997-11-17 | 1999-11-16 | Reconnx, Inc. | Finger joint architecture for wood products, and method and apparatus for formation thereof |
US6086376A (en) | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
ES2254603T5 (es) | 1998-02-05 | 2013-07-31 | Design Technology And Innovation Limited | Uso de un aparato para aumentar la humedad |
CA2328882A1 (en) | 1998-04-18 | 1999-10-28 | Glaxo Group Limited | Pharmaceutical aerosol formulation |
US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
CA2347856C (en) | 1998-11-13 | 2009-02-17 | Jago Research Ag | Dry powder for inhalation |
US20070212422A1 (en) * | 1999-11-10 | 2007-09-13 | Manfred Keller | Dry powder for inhalation |
GB9827145D0 (en) | 1998-12-09 | 1999-02-03 | Co Ordinated Drug Dev | Improvements in or relating to powders |
US6390291B1 (en) | 1998-12-18 | 2002-05-21 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
US6119853A (en) | 1998-12-18 | 2000-09-19 | Glaxo Wellcome Inc. | Method and package for storing a pressurized container containing a drug |
US6352152B1 (en) | 1998-12-18 | 2002-03-05 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
US6315112B1 (en) | 1998-12-18 | 2001-11-13 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
IT1309592B1 (it) | 1999-03-05 | 2002-01-24 | Chiesi Farma Spa | Particelle veicolo modificate da utilizzarsi nella preparazione diformulazioni farmaceutiche sotto forma di polimeri per inalazione e |
SI1158958T1 (sl) | 1999-03-05 | 2007-10-31 | Chiesi Farma Spa | Izboljĺ ani praĺ kasti farmacevtski sestavki za inhalacijo |
US6303991B1 (en) | 1999-05-27 | 2001-10-16 | Fci Americas Technology, Inc. | Electronic package and contact therefor |
USD440874S1 (en) | 1999-07-29 | 2001-04-24 | The Gillette Company | Container |
ATE259868T1 (de) | 1999-10-11 | 2004-03-15 | Innovata Biomed Ltd | Medikamentenabgabevorrichtung mit einer feuchtigkeitsbeständigen beschichtung |
DE19957802A1 (de) | 1999-12-01 | 2001-06-07 | Trw Repa Gmbh | Gurtaufrollersystem |
GB0008660D0 (en) | 2000-04-07 | 2000-05-31 | Arakis Ltd | The treatment of respiratory diseases |
WO2001078735A1 (en) | 2000-04-13 | 2001-10-25 | Innovata Biomed Limited | Medicaments for treating respiratory disorders comprising formoterol and fluticasone |
PE20011227A1 (es) | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
JP2004501032A (ja) | 2000-05-15 | 2004-01-15 | グラクソ グループ リミテッド | 乾燥剤を含むエアロゾルmdi上蓋 |
GB0015043D0 (en) | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
AU2001270074A1 (en) | 2000-06-22 | 2002-01-02 | Glaxo Group Limited | Method and package for storing a pressurized container containing a drug |
US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
WO2002012265A1 (en) | 2000-08-05 | 2002-02-14 | Glaxo Group Limited | 6.ALPHA., 9.ALPHA.-DIFLUORO-17.ALPHA.-`(2-FURANYLCARBOXYL) OXY!-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4,-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT |
GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
DE10056855A1 (de) | 2000-11-16 | 2002-05-29 | Lohmann Therapie Syst Lts | Verbundlaminat mit Sauerstoff und Feuchtigkeit absorbierender Schicht und Verfahren zu seiner Herstellung |
DK1337240T4 (en) | 2000-11-30 | 2015-01-05 | Vectura Ltd | A process for the preparation of particles for use in a pharmaceutical composition |
ATE446085T1 (de) | 2000-11-30 | 2009-11-15 | Vectura Ltd | Partikel zur verwendung in einer pharmazeutischen zusammensetzung |
EP1241110A1 (en) | 2001-03-16 | 2002-09-18 | Pfizer Products Inc. | Dispensing unit for oxygen-sensitive drugs |
EP1243524A3 (en) | 2001-03-16 | 2004-04-07 | Pfizer Products Inc. | Pharmaceutical kit for oxygen-sensitive drugs |
UA77656C2 (en) | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
DE10126924A1 (de) | 2001-06-01 | 2002-12-05 | Boehringer Ingelheim Pharma | Inhalationskapseln |
PL393155A1 (pl) * | 2001-09-14 | 2011-03-28 | Glaxo Group Limited | Pochodne fenetanoloaminy do leczenia chorób układu oddechowego |
AU2002351271A1 (en) | 2001-12-21 | 2003-07-24 | Nektar Therapeutics | Capsule package with moisture barrier |
GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
US20030203141A1 (en) | 2002-04-25 | 2003-10-30 | Blum John B. | Blister package |
US20040131805A1 (en) | 2002-06-20 | 2004-07-08 | Merical Rick L. | Films having a desiccant material incorporated therein and methods of use and manufacture |
US8003179B2 (en) | 2002-06-20 | 2011-08-23 | Alcan Packaging Flexible France | Films having a desiccant material incorporated therein and methods of use and manufacture |
US20060269708A1 (en) | 2002-06-20 | 2006-11-30 | Rick Merical | Films having a desiccant material incorporated therein and methods of use and manufacture |
US20030235664A1 (en) | 2002-06-20 | 2003-12-25 | Rick Merical | Films having a desiccant material incorporated therein and methods of use and manufacture |
WO2004101390A1 (en) | 2003-05-19 | 2004-11-25 | Stopak (Pty) Ltd | Dessicant container |
GB0312148D0 (en) | 2003-05-28 | 2003-07-02 | Aventis Pharma Ltd | Stabilized pharmaceutical products |
SE527191C2 (sv) | 2003-06-19 | 2006-01-17 | Microdrug Ag | Inhalatoranordning samt kombinerade doser av tiotropium och fluticason |
GB0315889D0 (en) | 2003-07-08 | 2003-08-13 | Aventis Pharma Ltd | Stable pharmaceutical products |
MXPA06000370A (es) | 2003-07-09 | 2006-03-28 | Chong Kun Dang Pharm Corp | Dispersion solida de tacrolimus. |
GB0316341D0 (en) | 2003-07-11 | 2003-08-13 | Glaxo Group Ltd | Pharmaceutical formulations |
EP1643973A1 (en) * | 2003-07-11 | 2006-04-12 | Glaxo Group Limited | Pharmaceutical formulations comprising magnesium stearate |
JP2009514779A (ja) * | 2003-07-11 | 2009-04-09 | グラクソ グループ リミテッド | 医薬製剤 |
EP1643974A1 (en) * | 2003-07-11 | 2006-04-12 | Glaxo Group Limited | Inhalable pharmaceutical formulations comprising a sugar ester |
US20050072958A1 (en) | 2003-10-02 | 2005-04-07 | Thomas Powers | Oxygen scavenger for low moisture environment and methods of using the same |
TW200811171A (en) | 2003-10-14 | 2008-03-01 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
WO2005044186A2 (en) | 2003-10-28 | 2005-05-19 | Glaxo Group Limited | Inhalable pharmaceutical formulations employing desiccating agents and methods of administering the same |
GB0326632D0 (en) | 2003-11-14 | 2003-12-17 | Jagotec Ag | Dry powder formulations |
BRPI0417097A (pt) | 2003-12-03 | 2007-03-13 | Microdrug Ag | inalador de pó seco de dose previamente medida para medicamentos sensìveis à umidade |
AU2004294889B2 (en) | 2003-12-03 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Medical product containing tiotropium |
SE0303269L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | Medicinsk produkt |
SE0303569L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | DPI för avlämning av fuktkänsliga medikament |
SE0303570L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
SE0303270L (sv) | 2003-12-03 | 2005-06-04 | Microdrug Ag | Metod för administration av tiotropium |
GB2410192B (en) | 2004-01-23 | 2005-12-07 | Eg Technology Ltd | An inhaler |
TWI363759B (en) | 2004-04-27 | 2012-05-11 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
GB0409703D0 (en) | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
ES2257152B1 (es) | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
PL1891974T3 (pl) | 2004-05-31 | 2010-12-31 | Almirall Sa | Kombinacje zawierające środki przeciwmuskarynowe i inhibitory PDE4 |
SE530006C2 (sv) | 2004-06-18 | 2008-02-05 | Mederio Ag | Inhalator som använder balja |
SE0401654D0 (sv) | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | A support structure for a medicament |
GB0416397D0 (en) | 2004-07-22 | 2004-08-25 | Glaxo Group Ltd | Pharmaceutical formulations |
US7528253B2 (en) | 2004-08-16 | 2009-05-05 | Theravance, Inc. | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
CA2583995A1 (en) | 2004-10-21 | 2006-05-04 | Boehringer Ingelheim International Gmbh | Blister for inhalers |
US7501011B2 (en) | 2004-11-09 | 2009-03-10 | Multisorb Technologies, Inc. | Humidity control device |
SE0402976L (sv) | 2004-12-03 | 2006-06-04 | Mederio Ag | Medicinsk produkt |
PE20060826A1 (es) | 2004-12-06 | 2006-10-08 | Smithkline Beecham Corp | Derivado oleofinico de 8-azoniabiciclo[3.2.1]octano y combinacion farmaceutica que lo comprende |
PE20061162A1 (es) | 2004-12-06 | 2006-10-14 | Smithkline Beecham Corp | Compuestos derivados olefinicos de 8-azoniabiciclo[3.2.1]octanos |
US7938580B2 (en) | 2004-12-08 | 2011-05-10 | Perfecseal, Inc. | Sterilizable package with a high barrier to oxygen |
KR20070100720A (ko) | 2004-12-27 | 2007-10-11 | 킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨 | 임의로 산소 스캐빈저를 포함하는 산소-불투과성 포장,안정화된 갑상선 호르몬 조성물 및 갑상선 호르몬 약제학적조성물의 보관 방법 |
US20060144733A1 (en) | 2004-12-30 | 2006-07-06 | 3M Innovative Properties Company | Container assembly and method for humidity control |
US20090029901A1 (en) | 2005-02-10 | 2009-01-29 | Marian Wood-Kaczmar | Process for Crystallizing Lactose Particles for Use in Pharmaceutical Formulations |
JP5156397B2 (ja) | 2005-02-10 | 2013-03-06 | グラクソ グループ リミテッド | 予備分級技術を用いて乳糖を製造する方法及びその乳糖から形成させた医薬製剤 |
DE202005002409U1 (de) | 2005-02-15 | 2005-07-07 | Microdrug Ag | Inhalierbares Tiotropium und Behälter dafür |
DE202005004659U1 (de) | 2005-03-22 | 2005-07-07 | Microdrug Ag | Vordosierter Trockenpulverinhalator für feuchtigkeitsempfindliche Medikamente |
GB0507165D0 (en) | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
JP4659523B2 (ja) | 2005-04-26 | 2011-03-30 | 共同印刷株式会社 | ブリスター用フィルム及びブリスター用包装容器 |
WO2006124556A2 (en) | 2005-05-13 | 2006-11-23 | Glaxo Group Limited | Inhalable pharmaceutical formulations employing lactose anhydrate and methods of administering the same |
DE102005022862A1 (de) | 2005-05-18 | 2006-12-14 | Airsec S.A.S | Kapseln für Inhalatoren |
US20060278965A1 (en) | 2005-06-10 | 2006-12-14 | Foust Donald F | Hermetically sealed package and methods of making the same |
GB0515584D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
AU2006295478A1 (en) | 2005-09-28 | 2007-04-05 | Mederio Ag | Inhaler device for moisture sensitive drugs and method of operating an inhaler device. |
GB0520794D0 (en) | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
PL1780005T3 (pl) | 2005-10-18 | 2009-07-31 | Alcan Tech & Management Ltd | Laminat formowalny na zimno dla korpusu blistra |
EP1787800A1 (de) | 2005-11-17 | 2007-05-23 | Alcan Technology & Management Ltd. | Kaltverformbares Laminat für Blisterbodenteile |
AR058289A1 (es) | 2005-12-12 | 2008-01-30 | Glaxo Group Ltd | Colector para ser usado en dispensador de medicamento |
JP5047156B2 (ja) | 2006-02-27 | 2012-10-10 | 武田薬品工業株式会社 | 医薬パッケージ |
KR100764640B1 (ko) | 2006-03-08 | 2007-10-10 | 세원셀론텍(주) | 지방조직 수복용 키트 |
US20090308772A1 (en) | 2006-03-17 | 2009-12-17 | Abrams William S | Moisture-tight primary packaging for a dry powder inhaler |
AU2007234990A1 (en) * | 2006-03-22 | 2007-10-18 | 3M Innovative Properties Company | Novel formulations |
CN101415428A (zh) * | 2006-03-22 | 2009-04-22 | 葛兰素集团有限公司 | 新型制剂 |
US20090169586A1 (en) | 2006-03-24 | 2009-07-02 | Ian Simon Tracton | Stable packaged dosage form and process therefor |
CA2650813A1 (en) * | 2006-05-24 | 2007-11-29 | Boehringer Ingelheim International Gmbh | New long-acting drug combinations for the treatment of respiratory diseases |
GB0615108D0 (en) | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel formulations |
CA2659558A1 (en) | 2006-08-03 | 2008-02-07 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Pack containing pharmaceutical administration forms |
WO2008021142A2 (en) * | 2006-08-09 | 2008-02-21 | Glaxo Group Limited | Process for manufacturing lactose |
WO2008021858A2 (en) | 2006-08-09 | 2008-02-21 | Glaxo Group Limited | Process for manufacturing lactose |
FI20065636A0 (fi) | 2006-10-04 | 2006-10-04 | Lab Pharma Ltd | Dessikanttijärjestelmä irtohaloitavien jauheiden kosteuden säätämiseksi |
JP2010507617A (ja) | 2006-10-26 | 2010-03-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 呼吸器系及び消化器系障害の治療用の新規な医薬組成物 |
US20080178559A1 (en) | 2007-01-26 | 2008-07-31 | Multisorb Technologies, Inc. | Sorbent Packaging |
KR101358054B1 (ko) | 2007-03-29 | 2014-02-13 | 멀티서브 테크놀로지스 인코포레이티드 | 패키징 용도를 위한 흡착성 복합물 장벽을 선택하는 방법 |
US7549272B2 (en) | 2007-04-16 | 2009-06-23 | Multisorb Technologies, Inc. | Sorbent canister with beveled edges |
EP2155582B2 (en) | 2007-05-07 | 2018-10-03 | Clariant Production (France) S.A.S. | Container with moisture control capacity |
UY31235A1 (es) | 2007-07-21 | 2009-03-02 | Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente | |
UY31233A1 (es) | 2007-07-21 | 2009-03-02 | Unidades de envasado con un agente desecante | |
WO2009029029A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | Inhaler for powdered substances with desiccant compartment |
JP2010539182A (ja) | 2007-09-12 | 2010-12-16 | グラクソ グループ リミテッド | 治療剤の新規組み合わせ |
EP2080523A1 (en) | 2008-01-15 | 2009-07-22 | CHIESI FARMACEUTICI S.p.A. | Compositions comprising an antimuscarinic and a long-acting beta-agonist |
CA2716124A1 (en) | 2008-02-20 | 2009-08-27 | Boehringer Ingelheim International Gmbh | Powder inhalers |
JP4983657B2 (ja) | 2008-03-11 | 2012-07-25 | 富士通株式会社 | 電子メール管理プログラム、該プログラムを記録した記録媒体、通信端末、および電子メール管理方法 |
EP2127628A1 (en) | 2008-05-27 | 2009-12-02 | Ranbaxy Laboratories Limited | Unit dose pack |
US9095324B2 (en) | 2008-06-20 | 2015-08-04 | Boston Scientific Scimed, Inc. | Package assembly |
WO2010038086A2 (en) | 2008-10-02 | 2010-04-08 | Respivert Limited | Novel compounds |
UY32297A (es) | 2008-12-22 | 2010-05-31 | Almirall Sa | Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico |
EP3578169B1 (en) | 2009-02-26 | 2024-06-26 | Glaxo Group Limited | Pharmaceutical formulations comprising 4-{(1 r)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol |
WO2010097114A1 (en) | 2009-02-26 | 2010-09-02 | Glaxo Group Limited | Novel combination of therapeutic agents |
US8985102B2 (en) | 2009-05-18 | 2015-03-24 | Adamis Pharmaceuticals Corporation | Dry powder inhalers |
EP2277799B8 (en) | 2009-07-23 | 2012-04-11 | Airsec S.A.S. | Hydrated humidity control substance and process for its preparation |
GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
EP2611423B2 (en) | 2010-08-31 | 2022-09-21 | GlaxoSmithKline Intellectual Property Development Limited | Dry powder inhalation drug products exhibiting moisture control properties and methods of administering the same |
RU2013153202A (ru) | 2011-06-08 | 2015-07-20 | Глаксо Груп Лимитед | Композиции для ингалятора сухого порошка, содержащие умеклидиний |
SG195262A1 (en) | 2011-06-08 | 2013-12-30 | Glaxo Group Ltd | Combination comprising umeclidinium and a corticosteroid |
GB201222679D0 (en) | 2012-12-17 | 2013-01-30 | Glaxo Group Ltd | Pharmaceutical combination products |
-
2009
- 2009-02-26 EP EP19175120.5A patent/EP3578169B1/en active Active
- 2009-02-26 SI SI200931991T patent/SI2400950T1/sl unknown
- 2009-02-26 LT LTEP09779096.8T patent/LT2400950T/lt unknown
- 2009-02-26 JP JP2011551415A patent/JP5809985B2/ja active Active
- 2009-02-26 PL PL09779096T patent/PL2400950T3/pl unknown
- 2009-02-26 DK DK09779096.8T patent/DK2400950T3/da active
- 2009-02-26 HU HUE09779096A patent/HUE045917T2/hu unknown
- 2009-02-26 US US13/148,982 patent/US11116721B2/en active Active
- 2009-02-26 ES ES09779096T patent/ES2739352T3/es active Active
- 2009-02-26 WO PCT/EP2009/052306 patent/WO2010097115A1/en active Application Filing
- 2009-02-26 EP EP09779096.8A patent/EP2400950B1/en active Active
- 2009-02-26 PT PT09779096T patent/PT2400950T/pt unknown
-
2019
- 2019-07-12 HR HRP20191257TT patent/HRP20191257T1/hr unknown
- 2019-08-13 CY CY20191100870T patent/CY1121914T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HUE045917T2 (hu) | 2020-01-28 |
SI2400950T1 (sl) | 2019-09-30 |
EP3578169B1 (en) | 2024-06-26 |
PL2400950T3 (pl) | 2019-12-31 |
CY1121914T1 (el) | 2020-10-14 |
PT2400950T (pt) | 2019-08-29 |
WO2010097115A1 (en) | 2010-09-02 |
JP2012518663A (ja) | 2012-08-16 |
EP3578169A1 (en) | 2019-12-11 |
US20110319371A1 (en) | 2011-12-29 |
HRP20191257T1 (hr) | 2019-10-18 |
DK2400950T3 (da) | 2019-07-29 |
EP2400950B1 (en) | 2019-05-22 |
US11116721B2 (en) | 2021-09-14 |
EP2400950A1 (en) | 2012-01-04 |
ES2739352T3 (es) | 2020-01-30 |
LT2400950T (lt) | 2019-08-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5809985B2 (ja) | 4−{(1r)−2−[(6−{2−[(2,6−ジクロロベンジル)オキシ]エトキシ}ヘキシル)アミノ]−1−ヒドロキシエチル}−2−(ヒドロキシメチル)フェノールを含む医薬製剤 | |
US11090294B2 (en) | Combinations of a muscarinic receptor antagonist and a beta-2 adrenoreceptor agonist | |
JP2014518894A (ja) | ウメクリジニウムを含む乾燥粉末インヘラー組成物 | |
WO2010097114A1 (en) | Novel combination of therapeutic agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111108 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20111206 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130618 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130917 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20140114 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140513 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20140513 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20140520 |
|
C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20140527 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20140620 |
|
C211 | Notice of termination of reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C211 Effective date: 20140624 |
|
C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20150630 |
|
C03 | Trial/appeal decision taken |
Free format text: JAPANESE INTERMEDIATE CODE: C03 Effective date: 20150818 |
|
C30A | Notification sent |
Free format text: JAPANESE INTERMEDIATE CODE: C3012 Effective date: 20150818 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150914 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5809985 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R153 | Grant of patent term extension |
Free format text: JAPANESE INTERMEDIATE CODE: R153 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |