JP2023508097A5 - - Google Patents
Info
- Publication number
- JP2023508097A5 JP2023508097A5 JP2022539058A JP2022539058A JP2023508097A5 JP 2023508097 A5 JP2023508097 A5 JP 2023508097A5 JP 2022539058 A JP2022539058 A JP 2022539058A JP 2022539058 A JP2022539058 A JP 2022539058A JP 2023508097 A5 JP2023508097 A5 JP 2023508097A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- acceptable salt
- compound according
- optical isomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911342649 | 2019-12-23 | ||
| CN201911342649.0 | 2019-12-23 | ||
| CN202010200682 | 2020-03-20 | ||
| CN202010200682.6 | 2020-03-20 | ||
| CN202010496353.0 | 2020-06-03 | ||
| CN202010496353 | 2020-06-03 | ||
| CN202011486334 | 2020-12-16 | ||
| CN202011486334.6 | 2020-12-16 | ||
| PCT/CN2020/138572 WO2021129653A1 (zh) | 2019-12-23 | 2020-12-23 | 一种蛋白降解剂化合物的制备方法和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023508097A JP2023508097A (ja) | 2023-02-28 |
| JP2023508097A5 true JP2023508097A5 (enExample) | 2024-01-09 |
| JP7791087B2 JP7791087B2 (ja) | 2025-12-23 |
Family
ID=76573691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022539058A Active JP7791087B2 (ja) | 2019-12-23 | 2020-12-23 | タンパク質分解剤化合物の製造方法及び使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US12441706B2 (enExample) |
| EP (1) | EP4083020A4 (enExample) |
| JP (1) | JP7791087B2 (enExample) |
| KR (1) | KR20220120629A (enExample) |
| CN (2) | CN114829342A (enExample) |
| AU (1) | AU2020414151A1 (enExample) |
| BR (1) | BR112022012385A2 (enExample) |
| CA (1) | CA3162523A1 (enExample) |
| CL (1) | CL2022001724A1 (enExample) |
| CO (1) | CO2022010305A2 (enExample) |
| EC (1) | ECSP22056811A (enExample) |
| IL (1) | IL294225B1 (enExample) |
| JO (1) | JOP20220159A1 (enExample) |
| MX (1) | MX2022007885A (enExample) |
| PE (1) | PE20230114A1 (enExample) |
| PH (1) | PH12022551571A1 (enExample) |
| TW (1) | TWI755992B (enExample) |
| WO (1) | WO2021129653A1 (enExample) |
| ZA (1) | ZA202208051B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL312367A (en) | 2017-01-31 | 2024-06-01 | Arvinas Operations Inc | Cereblon ligands and bifunctional compounds comprising the same |
| AU2020405129A1 (en) | 2019-12-19 | 2022-06-23 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| CR20220630A (es) | 2020-05-09 | 2023-01-23 | Arvinas Operations Inc | Métodos para fabricar un compuesto bifuncional, formas ultrapuras del compuesto bifuncional y formas de dosificación que comprenden el mismo |
| CR20230007A (es) | 2020-06-12 | 2023-06-01 | Shanghai Jemincare Pharmaceuticals Co Ltd | Compuesto de ftalazinona, y método de preparación y uso médico de este. |
| WO2022047145A1 (en) | 2020-08-28 | 2022-03-03 | Arvinas Operations, Inc. | Rapidly accelerating fibrosarcoma protein degrading compounds and associated methods of use |
| IL301690A (en) * | 2020-10-16 | 2023-05-01 | Dana Farber Cancer Inst Inc | Piperidinyl small molecule degraders of helios and methods of use |
| KR20240020735A (ko) | 2021-05-07 | 2024-02-15 | 카이메라 쎄라퓨틱스 인코포레이티드 | Cdk2 분해제 및 그 용도 |
| CA3226162A1 (en) | 2021-07-09 | 2023-01-12 | Plexium, Inc. | Aryl compounds and pharmaceutical compositions that modulate ikzf2 |
| AU2023300784A1 (en) * | 2022-06-30 | 2025-01-02 | Anhorn Medicines Co., Ltd. | Bifunctional compound and pharmaceutical composition comprising the bifunctional compound, and method for treating androgen receptor related diseases by using the same |
| WO2024012570A1 (zh) * | 2022-07-15 | 2024-01-18 | 西藏海思科制药有限公司 | 一种含氮杂环衍生物及其组合物和药学上的应用 |
| WO2024054591A1 (en) | 2022-09-07 | 2024-03-14 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
| TW202535392A (zh) | 2023-12-08 | 2025-09-16 | 美商亞文納營運公司 | 使用雄性素受體降解劑治療脊髓延髓性肌肉萎縮 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245804B1 (en) | 1997-05-30 | 2001-06-12 | Schering Aktiengesellschaft | Nonsteroidal gestagens |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US20160058872A1 (en) | 2014-04-14 | 2016-03-03 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| RU2738833C9 (ru) | 2014-04-14 | 2022-02-28 | Арвинас, Оперэйшнз, Инк. | Имидные модуляторы протеолиза и способы их применения |
| JP6817962B2 (ja) * | 2015-01-20 | 2021-01-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | ターゲティングされたアンドロゲン受容体分解のための化合物および方法 |
| CN107709290B (zh) | 2015-04-21 | 2023-02-28 | Gtx公司 | 选择性雄激素受体降解剂(sard)配体和其使用方法 |
| CA2988414C (en) | 2015-06-04 | 2023-09-26 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| CN110506039A (zh) * | 2016-10-11 | 2019-11-26 | 阿尔维纳斯股份有限公司 | 用于雄激素受体靶向降解的化合物和方法 |
| CA3042297A1 (en) * | 2016-11-22 | 2018-05-31 | Dana-Farber Cancer Institute, Inc. | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use |
| WO2018098280A1 (en) * | 2016-11-22 | 2018-05-31 | Dana-Farber Cancer Institute, Inc. | Degradation of protein kinases by conjugation of protein kinase inhibitors with e3 ligase ligand and methods of use |
| IL312367A (en) | 2017-01-31 | 2024-06-01 | Arvinas Operations Inc | Cereblon ligands and bifunctional compounds comprising the same |
| CN110194762B (zh) | 2018-02-27 | 2021-09-10 | 中国科学院上海药物研究所 | 酞嗪酮类衍生物、其制备方法和用途 |
| CN112390852B (zh) | 2019-08-14 | 2022-10-18 | 上海济煜医药科技有限公司 | 作为蛋白降解剂的化合物及其制备方法和应用 |
| CN112457366B (zh) | 2019-09-06 | 2024-03-19 | 江西济民可信集团有限公司 | 作为蛋白降解剂的并环类化合物及其制备方法和应用 |
| CN112457367B (zh) | 2019-09-06 | 2022-08-23 | 上海济煜医药科技有限公司 | 作为蛋白降解剂的连环类化合物及其制备方法和应用 |
| CN118930604A (zh) | 2019-09-29 | 2024-11-12 | 江西济民可信集团有限公司 | 作为蛋白降解剂杂环类化合物及包含其的药物组合物和应用 |
| CN113582974B (zh) | 2020-04-30 | 2022-05-17 | 江西济民可信集团有限公司 | 一类作为蛋白降解剂的化合物及其制备方法和医药用途 |
| CR20230007A (es) | 2020-06-12 | 2023-06-01 | Shanghai Jemincare Pharmaceuticals Co Ltd | Compuesto de ftalazinona, y método de preparación y uso médico de este. |
-
2020
- 2020-12-23 CN CN202080087926.2A patent/CN114829342A/zh active Pending
- 2020-12-23 TW TW109145818A patent/TWI755992B/zh active
- 2020-12-23 KR KR1020227025429A patent/KR20220120629A/ko active Pending
- 2020-12-23 US US17/788,154 patent/US12441706B2/en active Active
- 2020-12-23 IL IL294225A patent/IL294225B1/en unknown
- 2020-12-23 EP EP20908128.0A patent/EP4083020A4/en active Pending
- 2020-12-23 WO PCT/CN2020/138572 patent/WO2021129653A1/zh not_active Ceased
- 2020-12-23 AU AU2020414151A patent/AU2020414151A1/en active Pending
- 2020-12-23 CA CA3162523A patent/CA3162523A1/en active Pending
- 2020-12-23 PH PH1/2022/551571A patent/PH12022551571A1/en unknown
- 2020-12-23 CN CN202011545626.2A patent/CN113087704B/zh active Active
- 2020-12-23 JP JP2022539058A patent/JP7791087B2/ja active Active
- 2020-12-23 MX MX2022007885A patent/MX2022007885A/es unknown
- 2020-12-23 BR BR112022012385A patent/BR112022012385A2/pt unknown
- 2020-12-23 PE PE2022001313A patent/PE20230114A1/es unknown
-
2022
- 2022-06-20 JO JOP/2022/0159A patent/JOP20220159A1/ar unknown
- 2022-06-22 CL CL2022001724A patent/CL2022001724A1/es unknown
- 2022-07-19 ZA ZA2022/08051A patent/ZA202208051B/en unknown
- 2022-07-20 EC ECSENADI202256811A patent/ECSP22056811A/es unknown
- 2022-07-21 CO CONC2022/0010305A patent/CO2022010305A2/es unknown
-
2025
- 2025-08-15 US US19/301,909 patent/US20250376463A1/en active Pending
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