JP2023508097A5 - - Google Patents
Info
- Publication number
- JP2023508097A5 JP2023508097A5 JP2022539058A JP2022539058A JP2023508097A5 JP 2023508097 A5 JP2023508097 A5 JP 2023508097A5 JP 2022539058 A JP2022539058 A JP 2022539058A JP 2022539058 A JP2022539058 A JP 2022539058A JP 2023508097 A5 JP2023508097 A5 JP 2023508097A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- acceptable salt
- compound according
- optical isomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911342649 | 2019-12-23 | ||
| CN201911342649.0 | 2019-12-23 | ||
| CN202010200682 | 2020-03-20 | ||
| CN202010200682.6 | 2020-03-20 | ||
| CN202010496353.0 | 2020-06-03 | ||
| CN202010496353 | 2020-06-03 | ||
| CN202011486334.6 | 2020-12-16 | ||
| CN202011486334 | 2020-12-16 | ||
| PCT/CN2020/138572 WO2021129653A1 (zh) | 2019-12-23 | 2020-12-23 | 一种蛋白降解剂化合物的制备方法和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023508097A JP2023508097A (ja) | 2023-02-28 |
| JP2023508097A5 true JP2023508097A5 (enExample) | 2024-01-09 |
| JP7791087B2 JP7791087B2 (ja) | 2025-12-23 |
Family
ID=76573691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022539058A Active JP7791087B2 (ja) | 2019-12-23 | 2020-12-23 | タンパク質分解剤化合物の製造方法及び使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US12441706B2 (enExample) |
| EP (1) | EP4083020A4 (enExample) |
| JP (1) | JP7791087B2 (enExample) |
| KR (1) | KR20220120629A (enExample) |
| CN (2) | CN113087704B (enExample) |
| AU (1) | AU2020414151A1 (enExample) |
| BR (1) | BR112022012385A2 (enExample) |
| CA (1) | CA3162523A1 (enExample) |
| CL (1) | CL2022001724A1 (enExample) |
| CO (1) | CO2022010305A2 (enExample) |
| EC (1) | ECSP22056811A (enExample) |
| IL (1) | IL294225B2 (enExample) |
| JO (1) | JOP20220159A1 (enExample) |
| MX (1) | MX2022007885A (enExample) |
| PE (1) | PE20230114A1 (enExample) |
| PH (1) | PH12022551571A1 (enExample) |
| TW (1) | TWI755992B (enExample) |
| WO (1) | WO2021129653A1 (enExample) |
| ZA (1) | ZA202208051B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL319363A (en) | 2017-01-31 | 2025-05-01 | Arvinas Operations Inc | Cervalon ligands and bifunctional compounds containing them |
| WO2021127443A1 (en) | 2019-12-19 | 2021-06-24 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| CN115996918A (zh) | 2020-05-09 | 2023-04-21 | 阿尔维纳斯运营股份有限公司 | 制造双官能团化合物的方法、双官能团化合物的超纯形式以及包括所述双官能团化合物的剂型 |
| KR20230024328A (ko) | 2020-06-12 | 2023-02-20 | 상하이 제민케어 파마슈티칼스 컴퍼니 리미티드 | 프탈라지논 화합물, 이의 제조 방법 및 이의 의학적 용도 |
| WO2022047145A1 (en) | 2020-08-28 | 2022-03-03 | Arvinas Operations, Inc. | Rapidly accelerating fibrosarcoma protein degrading compounds and associated methods of use |
| IL301690A (en) * | 2020-10-16 | 2023-05-01 | Dana Farber Cancer Inst Inc | Piperidinyl small molecule degraders of helios and methods of use |
| CA3217792A1 (en) | 2021-05-07 | 2022-11-10 | Kymera Therapeutics, Inc | Cdk2 degraders and uses thereof |
| TW202317546A (zh) | 2021-07-09 | 2023-05-01 | 美商普萊克斯姆公司 | 調節ikzf2之芳基化合物及醫藥組合物 |
| WO2024002205A1 (en) * | 2022-06-30 | 2024-01-04 | Anhorn Medicines Co., Ltd. | Bifunctional compound and pharmaceutical composition comprising the bifunctional compound, and method for treating androgen receptor related disease by using the same |
| CN119948021A (zh) * | 2022-07-15 | 2025-05-06 | 西藏海思科制药有限公司 | 一种含氮杂环衍生物及其组合物和药学上的应用 |
| EP4584258A1 (en) | 2022-09-07 | 2025-07-16 | Arvinas Operations, Inc. | Rapidly accelerated fibrosarcoma (raf) degrading compounds and associated methods of use |
| AU2024392985A1 (en) | 2023-12-08 | 2026-06-04 | Arvinas Operations, Inc. | Use of androgen receptor degrader for the treatment of spinal and bulbar muscular atrophy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245804B1 (en) | 1997-05-30 | 2001-06-12 | Schering Aktiengesellschaft | Nonsteroidal gestagens |
| US20180228907A1 (en) * | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US20160058872A1 (en) | 2014-04-14 | 2016-03-03 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| EP4649963A3 (en) | 2014-04-14 | 2026-05-13 | Arvinas Operations, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| JP6817962B2 (ja) | 2015-01-20 | 2021-01-20 | アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． | ターゲティングされたアンドロゲン受容体分解のための化合物および方法 |
| RU2689988C2 (ru) | 2015-04-21 | 2019-05-30 | Джи Ти Икс, ИНК. | Селективные лиганды-разрушители андрогенных рецепторов (sard) и способы их применения |
| CA2988414C (en) | 2015-06-04 | 2023-09-26 | Arvinas, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| WO2017007612A1 (en) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
| SI3526202T1 (sl) * | 2016-10-11 | 2025-04-30 | Arvinas Operations, Inc. | Spojine in postopki za ciljno razgradnjo androgenskih receptorjev |
| AU2017363257B2 (en) * | 2016-11-22 | 2021-08-19 | Dana-Farber Cancer Institute, Inc. | Degradation of protein kinases by conjugation of protein kinase inhibitors with E3 ligase ligand and methods of use |
| US10842878B2 (en) | 2016-11-22 | 2020-11-24 | Dana-Farber Cancer Institute, Inc. | Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use |
| IL319363A (en) | 2017-01-31 | 2025-05-01 | Arvinas Operations Inc | Cervalon ligands and bifunctional compounds containing them |
| CN110194762B (zh) | 2018-02-27 | 2021-09-10 | 中国科学院上海药物研究所 | 酞嗪酮类衍生物、其制备方法和用途 |
| CN112390852B (zh) | 2019-08-14 | 2022-10-18 | 上海济煜医药科技有限公司 | 作为蛋白降解剂的化合物及其制备方法和应用 |
| CN112457367B (zh) | 2019-09-06 | 2022-08-23 | 上海济煜医药科技有限公司 | 作为蛋白降解剂的连环类化合物及其制备方法和应用 |
| CN118085015A (zh) | 2019-09-06 | 2024-05-28 | 江西济民可信集团有限公司 | 作为蛋白降解剂的并环类化合物及其制备方法和用途 |
| CN112574278B (zh) | 2019-09-29 | 2024-08-23 | 江西济民可信集团有限公司 | 作为蛋白降解剂杂环类化合物及其制备方法和医药应用 |
| CN113582974B (zh) | 2020-04-30 | 2022-05-17 | 江西济民可信集团有限公司 | 一类作为蛋白降解剂的化合物及其制备方法和医药用途 |
| KR20230024328A (ko) | 2020-06-12 | 2023-02-20 | 상하이 제민케어 파마슈티칼스 컴퍼니 리미티드 | 프탈라지논 화합물, 이의 제조 방법 및 이의 의학적 용도 |
-
2020
- 2020-12-23 AU AU2020414151A patent/AU2020414151A1/en active Pending
- 2020-12-23 MX MX2022007885A patent/MX2022007885A/es unknown
- 2020-12-23 US US17/788,154 patent/US12441706B2/en active Active
- 2020-12-23 CN CN202011545626.2A patent/CN113087704B/zh active Active
- 2020-12-23 KR KR1020227025429A patent/KR20220120629A/ko active Pending
- 2020-12-23 WO PCT/CN2020/138572 patent/WO2021129653A1/zh not_active Ceased
- 2020-12-23 PH PH1/2022/551571A patent/PH12022551571A1/en unknown
- 2020-12-23 TW TW109145818A patent/TWI755992B/zh active
- 2020-12-23 PE PE2022001313A patent/PE20230114A1/es unknown
- 2020-12-23 EP EP20908128.0A patent/EP4083020A4/en active Pending
- 2020-12-23 BR BR112022012385A patent/BR112022012385A2/pt unknown
- 2020-12-23 CA CA3162523A patent/CA3162523A1/en active Pending
- 2020-12-23 CN CN202080087926.2A patent/CN114829342A/zh active Pending
- 2020-12-23 IL IL294225A patent/IL294225B2/en unknown
- 2020-12-23 JP JP2022539058A patent/JP7791087B2/ja active Active
-
2022
- 2022-06-20 JO JOP/2022/0159A patent/JOP20220159A1/ar unknown
- 2022-06-22 CL CL2022001724A patent/CL2022001724A1/es unknown
- 2022-07-19 ZA ZA2022/08051A patent/ZA202208051B/en unknown
- 2022-07-20 EC ECSENADI202256811A patent/ECSP22056811A/es unknown
- 2022-07-21 CO CONC2022/0010305A patent/CO2022010305A2/es unknown
-
2025
- 2025-08-15 US US19/301,909 patent/US20250376463A1/en not_active Abandoned
-
2026
- 2026-03-02 US US19/553,703 patent/US20260193233A1/en active Pending
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