JP2022023958A5 - - Google Patents
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- Publication number
- JP2022023958A5 JP2022023958A5 JP2021178868A JP2021178868A JP2022023958A5 JP 2022023958 A5 JP2022023958 A5 JP 2022023958A5 JP 2021178868 A JP2021178868 A JP 2021178868A JP 2021178868 A JP2021178868 A JP 2021178868A JP 2022023958 A5 JP2022023958 A5 JP 2022023958A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl group
- halogen atom
- hydrogen atom
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020008757 | 2020-01-22 | ||
| JP2020008757 | 2020-01-22 | ||
| JP2021536299A JP6971432B1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
| PCT/JP2021/002088 WO2021149776A1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536299A Division JP6971432B1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022023958A JP2022023958A (ja) | 2022-02-08 |
| JP2022023958A5 true JP2022023958A5 (enExample) | 2024-01-30 |
| JP7693513B2 JP7693513B2 (ja) | 2025-06-17 |
Family
ID=76992539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536299A Active JP6971432B1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
| JP2021178868A Active JP7693513B2 (ja) | 2020-01-22 | 2021-11-01 | 抗腫瘍活性を有するアリールアミド誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021536299A Active JP6971432B1 (ja) | 2020-01-22 | 2021-01-21 | 抗腫瘍活性を有するアリールアミド誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US11964950B2 (enExample) |
| EP (2) | EP4725941A1 (enExample) |
| JP (2) | JP6971432B1 (enExample) |
| KR (2) | KR102473971B1 (enExample) |
| CN (1) | CN114929669B (enExample) |
| AR (1) | AR121078A1 (enExample) |
| BR (1) | BR112022009518A2 (enExample) |
| CA (1) | CA3168788A1 (enExample) |
| CL (1) | CL2022001938A1 (enExample) |
| CO (1) | CO2022011429A2 (enExample) |
| CR (1) | CR20220390A (enExample) |
| DK (1) | DK4094804T3 (enExample) |
| ES (1) | ES3060503T3 (enExample) |
| FI (1) | FI4094804T3 (enExample) |
| HR (1) | HRP20260094T1 (enExample) |
| IL (1) | IL294916B2 (enExample) |
| LT (1) | LT4094804T (enExample) |
| MA (1) | MA58427B1 (enExample) |
| MX (1) | MX2022008722A (enExample) |
| PE (1) | PE20230239A1 (enExample) |
| PL (1) | PL4094804T3 (enExample) |
| PT (1) | PT4094804T (enExample) |
| RS (1) | RS67669B1 (enExample) |
| SI (1) | SI4094804T1 (enExample) |
| TW (2) | TW202313562A (enExample) |
| WO (1) | WO2021149776A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA53172A (fr) | 2018-07-20 | 2021-05-26 | Hoffmann La Roche | Composés de sulfonimidamide en tant qu'inhibiteurs de l'activité de l'interleukine 1 |
| CN115151533B (zh) | 2020-01-10 | 2025-08-08 | 医疗免疫工程公司 | Mek抑制剂及其治疗用途 |
| AR121078A1 (es) | 2020-01-22 | 2022-04-13 | Chugai Pharmaceutical Co Ltd | Derivados de arilamida con actividad antitumoral |
| BR112022014480A2 (pt) | 2020-01-22 | 2022-09-13 | Hoffmann La Roche | Compostos, composições farmacêutica, método para tratar um distúrbio em um paciente, usos de um composto e de uma composição farmacêutica e kit |
| WO2022018875A1 (ja) * | 2020-07-22 | 2022-01-27 | 中外製薬株式会社 | アリールアミド誘導体を含む細胞増殖性疾患の治療又は予防用医薬組成物 |
| KR20230122174A (ko) * | 2020-07-22 | 2023-08-22 | 추가이 세이야쿠 가부시키가이샤 | 아릴 아마이드 유도체를 포함하는 조성물 |
| EP4255895A1 (en) | 2020-12-02 | 2023-10-11 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| WO2022120353A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| BR112023014751A2 (pt) | 2021-01-25 | 2023-10-03 | Ikena Oncology Inc | Combinação de um inibidor de tead de 3-(imidazol-4-il)-4-(amino)-benzenossulfonamida com um inibidor de egfr e/ou inibidor de mek para uso no tratamento de câncer de pulmão |
| CN117642166A (zh) * | 2021-06-09 | 2024-03-01 | 中外制药株式会社 | 用于癌症治疗的组合疗法 |
| AU2022312992A1 (en) * | 2021-07-21 | 2024-02-29 | Chugai Seiyaku Kabushiki Kaisha | Method for producing arylamide derivative |
| WO2023114984A1 (en) | 2021-12-17 | 2023-06-22 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| TW202339786A (zh) | 2022-01-21 | 2023-10-16 | 日商中外製藥股份有限公司 | 癌症之治療或預防用醫藥 |
| WO2023204259A1 (ja) | 2022-04-20 | 2023-10-26 | 中外製薬株式会社 | がんの治療又は予防用医薬 |
| CN119421874A (zh) * | 2022-06-30 | 2025-02-11 | 上海喆邺生物科技有限公司 | 一种芳香酰胺类衍生物及其在抗肿瘤药物中的应用 |
| EP4551558A2 (en) * | 2022-07-08 | 2025-05-14 | Nested Therapeutics, Inc. | Mitogen-activated protein kinase (mek) inhibitors |
| JP2026522033A (ja) | 2023-07-06 | 2026-07-03 | 華健未来（成都）科技股▲フン▼有限公司 | 芳香族アミド誘導体およびその使用 |
| WO2025063275A1 (ja) | 2023-09-21 | 2025-03-27 | 中外製薬株式会社 | アリールアミド誘導体の製造方法 |
| AU2024417154A1 (en) * | 2024-01-01 | 2026-08-13 | Huajian Future (Chengdu) Technology Co., Ltd. | Aromatic hydrazide derivative and medical use thereof |
| WO2026098657A1 (zh) * | 2024-11-08 | 2026-05-15 | 先声再明医药股份有限公司 | 作为mek抑制剂的杂环化合物 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2594720Y2 (ja) | 1993-03-22 | 1999-05-10 | 株式会社アーテックスズキ | 連結式キャビネット |
| JP4931419B2 (ja) | 2003-09-19 | 2012-05-16 | 中外製薬株式会社 | 新規４−フェニルアミノ−ベンズアルドオキシム誘導体並びにそのｍｅｋ阻害剤としての使用 |
| US7732616B2 (en) * | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
| KR101190912B1 (ko) | 2003-11-19 | 2012-10-12 | 어레이 바이오파마 인크. | Ｍｅｋ의 헤테로시클릭 억제제 및 그의 사용 방법 |
| MY144232A (en) * | 2004-07-26 | 2011-08-15 | Chugai Pharmaceutical Co Ltd | 5-substituted-2-phenylamino benzamides as mek inhibitors |
| TWI441637B (zh) | 2005-05-18 | 2014-06-21 | Array Biopharma Inc | Ｍｅｋ雜環抑制劑及其使用方法 |
| AR059339A1 (es) | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
| JP5592253B2 (ja) | 2007-05-11 | 2014-09-17 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 過剰増殖性疾患およびマイトジェン細胞外キナーゼ活性関連性疾患を治療するための置換フェニルアミノ−ベンゼン誘導体 |
| CA2720818A1 (en) * | 2008-04-22 | 2009-10-29 | Marion Hitchcock | Substituted phenoxybenzamides |
| EP2346818B1 (en) * | 2008-11-10 | 2012-12-05 | Bayer Intellectual Property GmbH | Substituted sulphonamido phenoxybenzamides |
| WO2012020742A1 (ja) | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
| US20130123255A1 (en) | 2011-11-10 | 2013-05-16 | Chugai Seiyaku Kabushiki Kaisha | Combination of a pi3k inhibitor and a mek inhibitor |
| JP2016034900A (ja) | 2012-11-26 | 2016-03-17 | 中外製薬株式会社 | ５−置換−２−フェニルアミノ−ベンズアミド類の製造方法 |
| WO2014164942A1 (en) | 2013-03-13 | 2014-10-09 | The Regents Of The University Of Michigan | Dual mek/pi3k inhibitors and therapeutic methods using the same |
| US20160222014A1 (en) | 2013-09-10 | 2016-08-04 | Asana Biosciences, Llc | Compounds for regulating fak and/or src pathways |
| EP3061747B1 (en) * | 2013-10-25 | 2021-04-07 | Shanghai Hengrui Pharmaceutical Co. Ltd. | Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof |
| CN109988105A (zh) | 2014-01-27 | 2019-07-09 | 天津滨江药物研发有限公司 | 作为蛋白激酶抑制剂的氮杂环类化合物及其制备方法 |
| CN105384738B (zh) | 2014-08-21 | 2017-08-29 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途 |
| AR121078A1 (es) | 2020-01-22 | 2022-04-13 | Chugai Pharmaceutical Co Ltd | Derivados de arilamida con actividad antitumoral |
| KR20230122174A (ko) | 2020-07-22 | 2023-08-22 | 추가이 세이야쿠 가부시키가이샤 | 아릴 아마이드 유도체를 포함하는 조성물 |
-
2021
- 2021-01-20 AR ARP210100120A patent/AR121078A1/es unknown
- 2021-01-21 EP EP25226973.3A patent/EP4725941A1/en active Pending
- 2021-01-21 KR KR1020227002880A patent/KR102473971B1/ko active Active
- 2021-01-21 PT PT217440619T patent/PT4094804T/pt unknown
- 2021-01-21 MA MA58427A patent/MA58427B1/fr unknown
- 2021-01-21 DK DK21744061.9T patent/DK4094804T3/da active
- 2021-01-21 MX MX2022008722A patent/MX2022008722A/es unknown
- 2021-01-21 ES ES21744061T patent/ES3060503T3/es active Active
- 2021-01-21 CN CN202180008024.XA patent/CN114929669B/zh active Active
- 2021-01-21 EP EP21744061.9A patent/EP4094804B1/en active Active
- 2021-01-21 BR BR112022009518A patent/BR112022009518A2/pt unknown
- 2021-01-21 PL PL21744061.9T patent/PL4094804T3/pl unknown
- 2021-01-21 KR KR1020227041183A patent/KR102904379B1/ko active Active
- 2021-01-21 LT LTEPPCT/JP2021/002088T patent/LT4094804T/lt unknown
- 2021-01-21 JP JP2021536299A patent/JP6971432B1/ja active Active
- 2021-01-21 CR CR20220390A patent/CR20220390A/es unknown
- 2021-01-21 TW TW111146325A patent/TW202313562A/zh unknown
- 2021-01-21 RS RS20260093A patent/RS67669B1/sr unknown
- 2021-01-21 CA CA3168788A patent/CA3168788A1/en active Pending
- 2021-01-21 SI SI202130384T patent/SI4094804T1/sl unknown
- 2021-01-21 WO PCT/JP2021/002088 patent/WO2021149776A1/ja not_active Ceased
- 2021-01-21 HR HRP20260094TT patent/HRP20260094T1/hr unknown
- 2021-01-21 TW TW110102277A patent/TWI788763B/zh active
- 2021-01-21 FI FIEP21744061.9T patent/FI4094804T3/fi active
- 2021-01-21 PE PE2022001439A patent/PE20230239A1/es unknown
- 2021-11-01 JP JP2021178868A patent/JP7693513B2/ja active Active
-
2022
- 2022-07-19 CL CL2022001938A patent/CL2022001938A1/es unknown
- 2022-07-20 IL IL294916A patent/IL294916B2/en unknown
- 2022-07-20 US US17/869,226 patent/US11964950B2/en active Active
- 2022-08-12 CO CONC2022/0011429A patent/CO2022011429A2/es unknown
-
2024
- 2024-03-18 US US18/608,369 patent/US20240246922A1/en not_active Abandoned
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