JP2010527983A5 - - Google Patents
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- Publication number
- JP2010527983A5 JP2010527983A5 JP2010508911A JP2010508911A JP2010527983A5 JP 2010527983 A5 JP2010527983 A5 JP 2010527983A5 JP 2010508911 A JP2010508911 A JP 2010508911A JP 2010508911 A JP2010508911 A JP 2010508911A JP 2010527983 A5 JP2010527983 A5 JP 2010527983A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- optionally substituted
- unsubstituted
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *N(*)C(N=CCC1CCCCC1)=* Chemical compound *N(*)C(N=CCC1CCCCC1)=* 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP0700353 | 2007-05-18 | ||
| HU0700353A HUP0700353A2 (en) | 2007-05-18 | 2007-05-18 | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| PCT/HU2008/000046 WO2008142461A1 (en) | 2007-05-18 | 2008-05-15 | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527983A JP2010527983A (ja) | 2010-08-19 |
| JP2010527983A5 true JP2010527983A5 (enExample) | 2011-07-07 |
| JP5406827B2 JP5406827B2 (ja) | 2014-02-05 |
Family
ID=89987527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508911A Active JP5406827B2 (ja) | 2007-05-18 | 2008-05-15 | （チオ）カルバモイル−シクロヘキサン誘導体の代謝物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8765765B2 (enExample) |
| EP (1) | EP2155707B1 (enExample) |
| JP (1) | JP5406827B2 (enExample) |
| CN (1) | CN101679330A (enExample) |
| AP (1) | AP2009005011A0 (enExample) |
| AU (1) | AU2008252619A1 (enExample) |
| BR (1) | BRPI0811744A2 (enExample) |
| CA (1) | CA2684149C (enExample) |
| CO (1) | CO6251252A2 (enExample) |
| CU (1) | CU23852B1 (enExample) |
| EA (1) | EA200971069A1 (enExample) |
| EC (1) | ECSP099819A (enExample) |
| GE (1) | GEP20125523B (enExample) |
| HU (1) | HUP0700353A2 (enExample) |
| IL (1) | IL201534A0 (enExample) |
| MA (1) | MA31432B1 (enExample) |
| MX (1) | MX2009012371A (enExample) |
| MY (1) | MY150784A (enExample) |
| NI (1) | NI200900202A (enExample) |
| NZ (1) | NZ580646A (enExample) |
| TN (1) | TN2009000459A1 (enExample) |
| TW (1) | TW201002324A (enExample) |
| WO (1) | WO2008142461A1 (enExample) |
| ZA (1) | ZA200907425B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0700353A2 (en) | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| US7875610B2 (en) | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| JP4409630B2 (ja) * | 2008-02-21 | 2010-02-03 | 田辺三菱製薬株式会社 | 経口投与用固形製剤 |
| CA2730287C (en) | 2008-07-16 | 2017-02-07 | Forest Laboratories Holdings Limited | Pharmaceutical formulations containing dopamine receptor ligands |
| HU230067B1 (hu) * | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| HUP0800766A2 (en) * | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| CA2779457C (en) * | 2009-11-06 | 2017-10-17 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating attention-deficit/hyperactivity disorder |
| US20110117214A1 (en) * | 2009-11-16 | 2011-05-19 | Auspex Pharmaceuticals, Inc. | Cyclohexyl urea modulators of d2 receptors and/or d3 receptors |
| HUP0900790A2 (en) * | 2009-12-17 | 2011-09-28 | Richter Gedeon Nyrt | A new process for the preparation of piperazine and their hydrochloric salts |
| US8912197B2 (en) | 2012-08-20 | 2014-12-16 | Forest Laboratories Holdings Ltd. | Crystalline form of carbamoyl-cyclohexane derivatives |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| US12319659B2 (en) | 2017-02-24 | 2025-06-03 | Shenzhen Linglan Bio-Pharmaceutical Technology Co., Ltd | Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof |
| CN108586389B (zh) * | 2018-06-29 | 2020-06-12 | 成都福柯斯医药技术有限公司 | 一种合成卡利拉嗪的方法 |
| HU231500B1 (hu) | 2019-04-10 | 2024-04-28 | Richter Gedeon Nyrt | Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| CN112239433B (zh) * | 2019-07-17 | 2024-05-14 | 北京盈科瑞创新药物研究有限公司 | 一种环己烷衍生物、制备方法及其应用 |
| CN113166135B (zh) * | 2019-11-05 | 2024-10-25 | 上海翰森生物医药科技有限公司 | 苯并噻吩类衍生物调节剂、其制备方法和应用 |
| WO2024072930A1 (en) * | 2022-09-30 | 2024-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666911A (en) * | 1981-07-14 | 1987-05-19 | Taiho Pharmaceutical Company Limited | Allophanoylpiperazine compound and analgesic composition containing same as active ingredient |
| US4880797A (en) | 1986-03-20 | 1989-11-14 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives and antibacterial agents |
| JPH01199977A (ja) | 1987-11-16 | 1989-08-11 | Mochida Pharmaceut Co Ltd | セファロスポリン誘導体の結晶、その製造法およびそれらを有効成分とする医薬組成物 |
| GB8802622D0 (en) * | 1988-02-05 | 1988-03-02 | Glaxo Group Ltd | Chemical compound |
| US5047406A (en) | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
| US4957921A (en) * | 1989-12-06 | 1990-09-18 | Warner-Lambert Company | Substituted cyclohexanols as central nervous system agents |
| JPH04275280A (ja) | 1991-03-04 | 1992-09-30 | Nippon Chem Ind Co Ltd | ４ｈ−２，３−ジヒドロ−２−イミノ−１，３−ベンゾチアジン−４−オン類の製造方法 |
| JPH0532586A (ja) | 1991-07-26 | 1993-02-09 | Mitsubishi Petrochem Co Ltd | ２，６−ナフタレンジカルボン酸の製造方法 |
| JPH05310745A (ja) | 1992-05-13 | 1993-11-22 | Takeda Chem Ind Ltd | ジエラジラクトンおよび抗炎症剤 |
| US6334997B1 (en) * | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| KR100477070B1 (ko) * | 1994-03-25 | 2006-04-21 | 이소테크니카 인코포레이티드 | 중수소화작용에의한의약품의효능강화법 |
| WO1997011070A1 (en) | 1995-09-22 | 1997-03-27 | Warner-Lambert Company | Substituted cyclohexylamines as central nervous system agents |
| MXPA00009569A (es) | 1998-03-31 | 2002-08-06 | Acadia Pharm Inc | Compuestos con actividad en receptores muscarinicos. |
| US6528529B1 (en) * | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| SE9802208D0 (sv) | 1998-06-22 | 1998-06-22 | Astra Pharma Inc | Novel compounds |
| TR200003884T2 (tr) * | 1998-06-30 | 2001-05-21 | Zeria Pharmaceutical Co., Ltd. | N-Fenil-N'-Fenilpropilpiperazin türevleri ve bunların hazırlanma prosesi |
| US6489341B1 (en) * | 1999-06-02 | 2002-12-03 | Sepracor Inc. | Methods for the treatment of neuroleptic and related disorders using sertindole derivatives |
| ATE378046T1 (de) * | 2001-02-27 | 2007-11-15 | Ortho Mcneil Pharm Inc | Carbamatverbindungen zur vorbeugung oder behandlung bipolarer erkrankungen |
| US6566550B2 (en) * | 2001-06-21 | 2003-05-20 | Pfizer Inc | Substituted aromatic ethers as inhibitors of glycine transport |
| HU227543B1 (en) | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| SE0200301D0 (sv) * | 2002-02-01 | 2002-02-01 | Axon Biochemicals Bv | Thio-carbostyril derivative |
| US6919342B2 (en) * | 2003-06-05 | 2005-07-19 | Abbott Gmbh & Co. Kg | Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
| HU227534B1 (en) | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| DE102004047517A1 (de) * | 2004-09-28 | 2006-03-30 | Merck Patent Gmbh | Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid |
| HUP0500170A3 (en) | 2005-02-03 | 2007-11-28 | Richter Gedeon Nyrt | Piperazine derivatives, process for producing them and pharmaceutical compositions containing them |
| GT200600414A (es) | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| WO2008141135A1 (en) * | 2007-05-11 | 2008-11-20 | Forest Laboratories Holdings Limited | Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives |
| HU230748B1 (hu) * | 2007-05-11 | 2018-02-28 | Richter Gedeon Nyrt | Új piperazin só és előállítási eljárása |
| HUP0700353A2 (en) | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| HUP0700369A2 (en) * | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia |
| HUP0700370A2 (en) * | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania |
| KR20100050502A (ko) * | 2007-08-01 | 2010-05-13 | 하. 룬드벡 아크티에셀스카브 | 도파민계가 붕괴되어 있는 장애 또는 병태의 증상을 감소 또는 치료하기 위한 ｋｃｎｑ 포타슘 채널 개방제의 용도 |
| US7875610B2 (en) * | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| JP4409630B2 (ja) * | 2008-02-21 | 2010-02-03 | 田辺三菱製薬株式会社 | 経口投与用固形製剤 |
| CA2730287C (en) | 2008-07-16 | 2017-02-07 | Forest Laboratories Holdings Limited | Pharmaceutical formulations containing dopamine receptor ligands |
| HU230067B1 (hu) * | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800765A2 (en) * | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| HUP0800766A2 (en) * | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
-
2007
- 2007-05-18 HU HU0700353A patent/HUP0700353A2/hu unknown
-
2008
- 2008-05-15 BR BRPI0811744-6A2A patent/BRPI0811744A2/pt not_active IP Right Cessation
- 2008-05-15 EA EA200971069A patent/EA200971069A1/ru unknown
- 2008-05-15 JP JP2010508911A patent/JP5406827B2/ja active Active
- 2008-05-15 EP EP08750836A patent/EP2155707B1/en active Active
- 2008-05-15 AU AU2008252619A patent/AU2008252619A1/en not_active Abandoned
- 2008-05-15 CN CN200880016466A patent/CN101679330A/zh active Pending
- 2008-05-15 WO PCT/HU2008/000046 patent/WO2008142461A1/en not_active Ceased
- 2008-05-15 MY MYPI20094707 patent/MY150784A/en unknown
- 2008-05-15 MX MX2009012371A patent/MX2009012371A/es not_active Application Discontinuation
- 2008-05-15 US US12/600,826 patent/US8765765B2/en active Active
- 2008-05-15 NZ NZ580646A patent/NZ580646A/en unknown
- 2008-05-15 GE GEAP200811607A patent/GEP20125523B/en unknown
- 2008-05-15 CA CA2684149A patent/CA2684149C/en not_active Expired - Fee Related
- 2008-05-15 AP AP2009005011A patent/AP2009005011A0/xx unknown
- 2008-07-08 TW TW097125708A patent/TW201002324A/zh unknown
-
2009
- 2009-10-15 IL IL201534A patent/IL201534A0/en unknown
- 2009-10-22 ZA ZA200907425A patent/ZA200907425B/xx unknown
- 2009-10-30 TN TNP2009000459A patent/TN2009000459A1/fr unknown
- 2009-11-09 NI NI200900202A patent/NI200900202A/es unknown
- 2009-11-17 CU CU2009000196A patent/CU23852B1/es not_active IP Right Cessation
- 2009-12-07 MA MA32403A patent/MA31432B1/fr unknown
- 2009-12-16 CO CO09144002A patent/CO6251252A2/es not_active Application Discontinuation
- 2009-12-18 EC EC2009009819A patent/ECSP099819A/es unknown
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