JP2010527983A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010527983A5 JP2010527983A5 JP2010508911A JP2010508911A JP2010527983A5 JP 2010527983 A5 JP2010527983 A5 JP 2010527983A5 JP 2010508911 A JP2010508911 A JP 2010508911A JP 2010508911 A JP2010508911 A JP 2010508911A JP 2010527983 A5 JP2010527983 A5 JP 2010527983A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- optionally substituted
- unsubstituted
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *N(*)C(N=CCC1CCCCC1)=* Chemical compound *N(*)C(N=CCC1CCCCC1)=* 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP0700353 | 2007-05-18 | ||
| HU0700353A HUP0700353A2 (en) | 2007-05-18 | 2007-05-18 | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| PCT/HU2008/000046 WO2008142461A1 (en) | 2007-05-18 | 2008-05-15 | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527983A JP2010527983A (ja) | 2010-08-19 |
| JP2010527983A5 true JP2010527983A5 (enExample) | 2011-07-07 |
| JP5406827B2 JP5406827B2 (ja) | 2014-02-05 |
Family
ID=89987527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508911A Active JP5406827B2 (ja) | 2007-05-18 | 2008-05-15 | （チオ）カルバモイル−シクロヘキサン誘導体の代謝物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8765765B2 (enExample) |
| EP (1) | EP2155707B1 (enExample) |
| JP (1) | JP5406827B2 (enExample) |
| CN (1) | CN101679330A (enExample) |
| AP (1) | AP2009005011A0 (enExample) |
| AU (1) | AU2008252619A1 (enExample) |
| BR (1) | BRPI0811744A2 (enExample) |
| CA (1) | CA2684149C (enExample) |
| CO (1) | CO6251252A2 (enExample) |
| CU (1) | CU23852B1 (enExample) |
| EA (1) | EA200971069A1 (enExample) |
| EC (1) | ECSP099819A (enExample) |
| GE (1) | GEP20125523B (enExample) |
| HU (1) | HUP0700353A2 (enExample) |
| IL (1) | IL201534A0 (enExample) |
| MA (1) | MA31432B1 (enExample) |
| MX (1) | MX2009012371A (enExample) |
| MY (1) | MY150784A (enExample) |
| NI (1) | NI200900202A (enExample) |
| NZ (1) | NZ580646A (enExample) |
| TN (1) | TN2009000459A1 (enExample) |
| TW (1) | TW201002324A (enExample) |
| WO (1) | WO2008142461A1 (enExample) |
| ZA (1) | ZA200907425B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0700353A2 (en) | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| US7875610B2 (en) * | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| JP4409630B2 (ja) * | 2008-02-21 | 2010-02-03 | 田辺三菱製薬株式会社 | 経口投与用固形製剤 |
| AP2975A (en) | 2008-07-16 | 2014-09-30 | Richter Gedeon Nyrt | Pharmaceutical formulations containing dopamine receptor ligands |
| HU230067B1 (hu) * | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| HUP0800765A2 (en) * | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
| KR101783632B1 (ko) * | 2009-11-06 | 2017-10-10 | 에스케이바이오팜 주식회사 | 주의력 결핍/과잉행동 장애(ａｄｈｄ)의 치료 방법 |
| US20110117214A1 (en) * | 2009-11-16 | 2011-05-19 | Auspex Pharmaceuticals, Inc. | Cyclohexyl urea modulators of d2 receptors and/or d3 receptors |
| HUP0900790A2 (en) * | 2009-12-17 | 2011-09-28 | Richter Gedeon Nyrt | A new process for the preparation of piperazine and their hydrochloric salts |
| WO2014031162A1 (en) * | 2012-08-20 | 2014-02-27 | Forest Laboratories Holdings Limited | Crystalline form of carbamoyl-cyclohexane derivatives |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| JP7017797B2 (ja) | 2017-02-24 | 2022-02-09 | 深▲チェン▼市霊蘭生物医薬科技有限公司 | 新規なドーパミンｄ３受容体選択的リガンド及びびその調製方法並びに医薬使用 |
| CN108586389B (zh) * | 2018-06-29 | 2020-06-12 | 成都福柯斯医药技术有限公司 | 一种合成卡利拉嗪的方法 |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
| HU231500B1 (hu) | 2019-04-10 | 2024-04-28 | Richter Gedeon Nyrt | Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére |
| CN112239433B (zh) * | 2019-07-17 | 2024-05-14 | 北京盈科瑞创新药物研究有限公司 | 一种环己烷衍生物、制备方法及其应用 |
| CN113166135B (zh) * | 2019-11-05 | 2024-10-25 | 上海翰森生物医药科技有限公司 | 苯并噻吩类衍生物调节剂、其制备方法和应用 |
| EP4594294A1 (en) * | 2022-09-30 | 2025-08-06 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666911A (en) | 1981-07-14 | 1987-05-19 | Taiho Pharmaceutical Company Limited | Allophanoylpiperazine compound and analgesic composition containing same as active ingredient |
| US4880797A (en) | 1986-03-20 | 1989-11-14 | Banyu Pharmaceutical Co., Ltd. | Cephalosporin derivatives and antibacterial agents |
| JPH01199977A (ja) | 1987-11-16 | 1989-08-11 | Mochida Pharmaceut Co Ltd | セファロスポリン誘導体の結晶、その製造法およびそれらを有効成分とする医薬組成物 |
| GB8802622D0 (en) | 1988-02-05 | 1988-03-02 | Glaxo Group Ltd | Chemical compound |
| US5047406A (en) | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
| US4957921A (en) | 1989-12-06 | 1990-09-18 | Warner-Lambert Company | Substituted cyclohexanols as central nervous system agents |
| JPH04275280A (ja) | 1991-03-04 | 1992-09-30 | Nippon Chem Ind Co Ltd | ４ｈ−２，３−ジヒドロ−２−イミノ−１，３−ベンゾチアジン−４−オン類の製造方法 |
| JPH0532586A (ja) | 1991-07-26 | 1993-02-09 | Mitsubishi Petrochem Co Ltd | ２，６−ナフタレンジカルボン酸の製造方法 |
| JPH05310745A (ja) | 1992-05-13 | 1993-11-22 | Takeda Chem Ind Ltd | ジエラジラクトンおよび抗炎症剤 |
| CA2186371A1 (en) | 1994-03-25 | 1995-10-05 | Robert T. Foster | Enhancement of the efficacy of dihydropyridines by deuteration |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| AU6859096A (en) | 1995-09-22 | 1997-04-09 | Warner-Lambert Company | Substituted cyclohexylamines as central nervous system agents |
| CN1303376A (zh) | 1998-03-31 | 2001-07-11 | 阿卡蒂亚药品公司 | 对毒蕈碱性受体具有活性的化合物 |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| SE9802208D0 (sv) | 1998-06-22 | 1998-06-22 | Astra Pharma Inc | Novel compounds |
| KR20010053010A (ko) | 1998-06-30 | 2001-06-25 | 이베 사치아키 | 엔-페닐-엔'-페닐프로필피페라진 유도체 및 그의제조방법 |
| US6489341B1 (en) | 1999-06-02 | 2002-12-03 | Sepracor Inc. | Methods for the treatment of neuroleptic and related disorders using sertindole derivatives |
| CN1250214C (zh) | 2001-02-27 | 2006-04-12 | 奥索-麦克尼尔药品公司 | 用于预防或治疗双相性精神障碍的氨基甲酸酯化合物 |
| US6566550B2 (en) | 2001-06-21 | 2003-05-20 | Pfizer Inc | Substituted aromatic ethers as inhibitors of glycine transport |
| HU227543B1 (en) | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| SE0200301D0 (sv) * | 2002-02-01 | 2002-02-01 | Axon Biochemicals Bv | Thio-carbostyril derivative |
| US6919342B2 (en) | 2003-06-05 | 2005-07-19 | Abbott Gmbh & Co. Kg | Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
| HU227534B1 (en) | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
| DE102004047517A1 (de) | 2004-09-28 | 2006-03-30 | Merck Patent Gmbh | Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid |
| HUP0500170A3 (en) | 2005-02-03 | 2007-11-28 | Richter Gedeon Nyrt | Piperazine derivatives, process for producing them and pharmaceutical compositions containing them |
| GT200600414A (es) | 2005-09-12 | 2007-09-20 | Sal de glucuranato de compuesto de piperazine | |
| HU230748B1 (hu) | 2007-05-11 | 2018-02-28 | Richter Gedeon Nyrt | Új piperazin só és előállítási eljárása |
| DK2155200T3 (en) * | 2007-05-11 | 2017-03-13 | Richter Gedeon Nyrt | CRYSTALLIC FORM OF A CARBAMOYL-CYCLOHEXAN DERIVATE |
| HUP0700353A2 (en) | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
| HUP0700369A2 (en) | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia |
| HUP0700370A2 (en) | 2007-05-24 | 2009-04-28 | Richter Gedeon Nyrt | Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania |
| JP2011513196A (ja) | 2007-08-01 | 2011-04-28 | ハー・ルンドベック・アクチエゼルスカベット | ドーパミン作動系が破壊された障害もしくは状態の症状を軽減するためまたはその障害もしくは状態を処置するためのｋｃｎｑカリウムチャネル開口薬の使用 |
| US7875610B2 (en) | 2007-12-03 | 2011-01-25 | Richter Gedeon Nyrt. | Pyrimidinyl-piperazines useful as D3/D2 receptor ligands |
| JP4409630B2 (ja) | 2008-02-21 | 2010-02-03 | 田辺三菱製薬株式会社 | 経口投与用固形製剤 |
| AP2975A (en) | 2008-07-16 | 2014-09-30 | Richter Gedeon Nyrt | Pharmaceutical formulations containing dopamine receptor ligands |
| HU230067B1 (hu) | 2008-12-17 | 2015-06-29 | Richter Gedeon Nyrt | Új piperazin só és eljárás előállítására |
| HUP0800766A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Vegyeszet | Process for the preparation of piperazine derivatives |
| HUP0800765A2 (en) | 2008-12-18 | 2010-11-29 | Richter Gedeon Nyrt | A new process for the preparation of piperazine derivatives and their hydrochloric salts |
-
2007
- 2007-05-18 HU HU0700353A patent/HUP0700353A2/hu unknown
-
2008
- 2008-05-15 JP JP2010508911A patent/JP5406827B2/ja active Active
- 2008-05-15 AU AU2008252619A patent/AU2008252619A1/en not_active Abandoned
- 2008-05-15 US US12/600,826 patent/US8765765B2/en active Active
- 2008-05-15 CN CN200880016466A patent/CN101679330A/zh active Pending
- 2008-05-15 CA CA2684149A patent/CA2684149C/en not_active Expired - Fee Related
- 2008-05-15 GE GEAP200811607A patent/GEP20125523B/en unknown
- 2008-05-15 EP EP08750836A patent/EP2155707B1/en active Active
- 2008-05-15 NZ NZ580646A patent/NZ580646A/en unknown
- 2008-05-15 EA EA200971069A patent/EA200971069A1/ru unknown
- 2008-05-15 WO PCT/HU2008/000046 patent/WO2008142461A1/en not_active Ceased
- 2008-05-15 MX MX2009012371A patent/MX2009012371A/es not_active Application Discontinuation
- 2008-05-15 AP AP2009005011A patent/AP2009005011A0/xx unknown
- 2008-05-15 BR BRPI0811744-6A2A patent/BRPI0811744A2/pt not_active IP Right Cessation
- 2008-05-15 MY MYPI20094707 patent/MY150784A/en unknown
- 2008-07-08 TW TW097125708A patent/TW201002324A/zh unknown
-
2009
- 2009-10-15 IL IL201534A patent/IL201534A0/en unknown
- 2009-10-22 ZA ZA200907425A patent/ZA200907425B/xx unknown
- 2009-10-30 TN TNP2009000459A patent/TN2009000459A1/fr unknown
- 2009-11-09 NI NI200900202A patent/NI200900202A/es unknown
- 2009-11-17 CU CU2009000196A patent/CU23852B1/es not_active IP Right Cessation
- 2009-12-07 MA MA32403A patent/MA31432B1/fr unknown
- 2009-12-16 CO CO09144002A patent/CO6251252A2/es not_active Application Discontinuation
- 2009-12-18 EC EC2009009819A patent/ECSP099819A/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010527983A5 (enExample) | ||
| JP2006524222A5 (enExample) | ||
| TWI537259B (zh) | 吡啶酮衍生物 | |
| JP2006521359A5 (enExample) | ||
| KR20210143803A (ko) | Tead 전사인자의 신규한 소분자 저해제 | |
| RU2004104625A (ru) | Аналоги простагландинов в качестве агонистов рецептора ep4 | |
| FI90980B (fi) | Menetelmä N-heterosyklisten N-(4-piperidyyli)-amidien valmistamiseksi | |
| CA2684149A1 (en) | Metabolites of (thio)carbamoyl-cyclohexane derivatives | |
| JP6427096B2 (ja) | 新規なアルファ２アドレナリン受容体アゴニスト | |
| WO2006040966A1 (ja) | 芳香環縮合ピリミジン誘導体 | |
| JP2006206609A5 (enExample) | ||
| JP2005524660A5 (enExample) | ||
| NZ590355A (en) | Stat3 inhibitor containing quinolinecarboxamide derivative as active ingredient | |
| RU2005133994A (ru) | Оксимные производные и их применение в качестве фармацевтически активных агентов | |
| JP2007517846A5 (enExample) | ||
| RU2011116160A (ru) | Производные пиридина, замещенные гетероциклическим кольцом и y-глутамиламиногруппой и содержащие их противогрибковые средства | |
| RU2007120454A (ru) | Производные хинуклидина и их применение в качестве антагонистов мускариновых рецепторов м3 | |
| JP2010535790A5 (enExample) | ||
| JP2011516511A5 (enExample) | ||
| RU2011133128A (ru) | Противоопухолевые соединения дигидропиран-2-она | |
| JP2014518543A5 (enExample) | ||
| US20130053372A1 (en) | 5-ht receptor modulators | |
| WO2005007651A1 (ja) | ２-アシルアミノチアゾール誘導体又はその塩 | |
| JP2004527567A5 (enExample) | ||
| JP2005527542A5 (enExample) |