MX2009012371A - Metabolitos de derivados de (tio)-carbamoil-ciclohexano. - Google Patents

Metabolitos de derivados de (tio)-carbamoil-ciclohexano.

Info

Publication number
MX2009012371A
MX2009012371A MX2009012371A MX2009012371A MX2009012371A MX 2009012371 A MX2009012371 A MX 2009012371A MX 2009012371 A MX2009012371 A MX 2009012371A MX 2009012371 A MX2009012371 A MX 2009012371A MX 2009012371 A MX2009012371 A MX 2009012371A
Authority
MX
Mexico
Prior art keywords
metabolites
thio
carbamoyl
cyclohexane derivatives
dimemylcarbamoyl
Prior art date
Application number
MX2009012371A
Other languages
English (en)
Inventor
Istvan Gyertyan
Bela Kiss
Eva Schmidt
Eva Againe Csongor
Norbert Antal Kirschner
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of MX2009012371A publication Critical patent/MX2009012371A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a metabolitos de derivados del (tio)-carbamoil-ciclohexano, particularmente metabolitos de la trans-4-{2-[4-(2,3-diclorofenil)-piperazin-1-i1]-etil)-N,N-dimeti lcarbamoil-ciclohexilamina y sales farmacéuticamente aceptables de la misma, para composiciones farmacéuticas que los contienen y para su uso en el tratamiento y/o prevención de trastornos que requieren la modulación de receptores de dopamina.
MX2009012371A 2007-05-18 2008-05-15 Metabolitos de derivados de (tio)-carbamoil-ciclohexano. MX2009012371A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700353A HUP0700353A2 (en) 2007-05-18 2007-05-18 Metabolites of (thio)carbamoyl-cyclohexane derivatives
PCT/HU2008/000046 WO2008142461A1 (en) 2007-05-18 2008-05-15 Metabolites of (thio)carbamoyl-cyclohexane derivatives

Publications (1)

Publication Number Publication Date
MX2009012371A true MX2009012371A (es) 2009-12-03

Family

ID=89987527

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012371A MX2009012371A (es) 2007-05-18 2008-05-15 Metabolitos de derivados de (tio)-carbamoil-ciclohexano.

Country Status (24)

Country Link
US (1) US8765765B2 (es)
EP (1) EP2155707B1 (es)
JP (1) JP5406827B2 (es)
CN (1) CN101679330A (es)
AP (1) AP2009005011A0 (es)
AU (1) AU2008252619A1 (es)
BR (1) BRPI0811744A2 (es)
CA (1) CA2684149C (es)
CO (1) CO6251252A2 (es)
CU (1) CU23852B1 (es)
EA (1) EA200971069A1 (es)
EC (1) ECSP099819A (es)
GE (1) GEP20125523B (es)
HU (1) HUP0700353A2 (es)
IL (1) IL201534A0 (es)
MA (1) MA31432B1 (es)
MX (1) MX2009012371A (es)
MY (1) MY150784A (es)
NI (1) NI200900202A (es)
NZ (1) NZ580646A (es)
TN (1) TN2009000459A1 (es)
TW (1) TW201002324A (es)
WO (1) WO2008142461A1 (es)
ZA (1) ZA200907425B (es)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
US20110059980A1 (en) * 2008-02-21 2011-03-10 Yasuaki Oobayashi Solid preparation for oral administration
RS53866B1 (en) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. PHARMACEUTICAL FORMULATIONS CONTAINING DOPAMINE RECEPTOR LIGANDS
HU230067B1 (hu) * 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) * 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) * 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
CN102762201B (zh) * 2009-11-06 2013-12-18 爱思开生物制药株式会社 注意力缺陷/多动症的治疗方法
WO2011060363A2 (en) * 2009-11-16 2011-05-19 Auspex Pharmaceuticals, Inc. Cyclohexyl urea modulators of d2 receptors and/or d3 receptors
HUP0900790A2 (en) * 2009-12-17 2011-09-28 Richter Gedeon Nyrt A new process for the preparation of piperazine and their hydrochloric salts
WO2014031162A1 (en) * 2012-08-20 2014-02-27 Forest Laboratories Holdings Limited Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
WO2018153297A1 (zh) * 2017-02-24 2018-08-30 深圳市灵兰生物医药科技有限公司 新型多巴胺d3受体选择性配体及其制备方法和医药应用
CN108586389B (zh) * 2018-06-29 2020-06-12 成都福柯斯医药技术有限公司 一种合成卡利拉嗪的方法
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
HU231500B1 (hu) 2019-04-10 2024-04-28 Richter Gedeon Nyrt Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére
CN112239433B (zh) * 2019-07-17 2024-05-14 北京盈科瑞创新药物研究有限公司 一种环己烷衍生物、制备方法及其应用
WO2021088920A1 (zh) * 2019-11-05 2021-05-14 上海翰森生物医药科技有限公司 苯并噻吩类衍生物调节剂、其制备方法和应用
WO2024072930A1 (en) * 2022-09-30 2024-04-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders

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HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
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US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
US20110059980A1 (en) 2008-02-21 2011-03-10 Yasuaki Oobayashi Solid preparation for oral administration
RS53866B1 (en) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. PHARMACEUTICAL FORMULATIONS CONTAINING DOPAMINE RECEPTOR LIGANDS
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
TW201002324A (en) 2010-01-16
US8765765B2 (en) 2014-07-01
NI200900202A (es) 2010-03-11
IL201534A0 (en) 2010-05-31
JP5406827B2 (ja) 2014-02-05
CU20090196A7 (es) 2011-07-11
JP2010527983A (ja) 2010-08-19
CU23852B1 (es) 2012-10-15
MY150784A (en) 2014-02-28
EA200971069A1 (ru) 2010-04-30
AP2009005011A0 (en) 2009-10-31
BRPI0811744A2 (pt) 2014-11-11
HU0700353D0 (en) 2007-07-30
EP2155707A1 (en) 2010-02-24
MA31432B1 (fr) 2010-06-01
CA2684149C (en) 2012-12-04
GEP20125523B (en) 2012-05-25
CA2684149A1 (en) 2008-11-27
WO2008142461A1 (en) 2008-11-27
NZ580646A (en) 2012-03-30
ZA200907425B (en) 2010-07-28
CO6251252A2 (es) 2011-02-21
HUP0700353A2 (en) 2008-12-29
TN2009000459A1 (en) 2011-03-31
EP2155707B1 (en) 2013-03-13
ECSP099819A (es) 2010-03-31
US20100137335A1 (en) 2010-06-03
AU2008252619A1 (en) 2008-11-27
CN101679330A (zh) 2010-03-24

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