JP2020500916A5 - - Google Patents
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- JP2020500916A5 JP2020500916A5 JP2019531149A JP2019531149A JP2020500916A5 JP 2020500916 A5 JP2020500916 A5 JP 2020500916A5 JP 2019531149 A JP2019531149 A JP 2019531149A JP 2019531149 A JP2019531149 A JP 2019531149A JP 2020500916 A5 JP2020500916 A5 JP 2020500916A5
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- JP
- Japan
- Prior art keywords
- compound according
- alkoxy
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- bond
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 31
- -1 azetidine-1-yl Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 2
- 239000005977 Ethylene Substances 0.000 claims 2
- 101000577126 Homo sapiens Monocarboxylate transporter 4 Proteins 0.000 claims 2
- 101000577129 Homo sapiens Monocarboxylate transporter 5 Proteins 0.000 claims 2
- 102100025273 Monocarboxylate transporter 5 Human genes 0.000 claims 2
- 102000000562 Monocarboxylic Acid Transporters Human genes 0.000 claims 2
- 101710204259 Monocarboxylic acid transporter Proteins 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 0 CC(CC1)CN1c1c(CCN(C(*)C2)NC2C=C)cccc1 Chemical compound CC(CC1)CN1c1c(CCN(C(*)C2)NC2C=C)cccc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662433113P | 2016-12-12 | 2016-12-12 | |
| US62/433,113 | 2016-12-12 | ||
| PCT/US2017/065864 WO2018111904A1 (en) | 2016-12-12 | 2017-12-12 | Heterocyclic inhibitors of mct4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020500916A JP2020500916A (ja) | 2020-01-16 |
| JP2020500916A5 true JP2020500916A5 (enExample) | 2021-01-28 |
| JP7123929B2 JP7123929B2 (ja) | 2022-08-23 |
Family
ID=62488735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531149A Active JP7123929B2 (ja) | 2016-12-12 | 2017-12-12 | Ｍｃｔ４の複素環阻害剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10214492B2 (enExample) |
| EP (2) | EP4442318A3 (enExample) |
| JP (1) | JP7123929B2 (enExample) |
| KR (1) | KR102615828B1 (enExample) |
| CN (1) | CN110114351B (enExample) |
| AU (1) | AU2017375960B2 (enExample) |
| BR (1) | BR112019011825A2 (enExample) |
| CA (1) | CA3046212A1 (enExample) |
| DK (1) | DK3551625T3 (enExample) |
| ES (1) | ES2986065T3 (enExample) |
| IL (2) | IL279949B2 (enExample) |
| MX (1) | MX391489B (enExample) |
| NZ (1) | NZ754341A (enExample) |
| PH (1) | PH12019501261A1 (enExample) |
| SA (1) | SA519401970B1 (enExample) |
| WO (1) | WO2018111904A1 (enExample) |
| ZA (1) | ZA201904522B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017026535B1 (pt) | 2015-06-12 | 2023-12-19 | Vettore, LLC | Composto e composição farmacêutica |
| CN110114351B (zh) | 2016-12-12 | 2022-09-20 | 维托尔股份有限公司 | Mct4的杂环抑制剂 |
| WO2019188456A1 (ja) * | 2018-03-26 | 2019-10-03 | 学校法人 川崎学園 | 新規抗腫瘍剤 |
| CN111423377B (zh) * | 2020-05-12 | 2021-06-01 | 中国药科大学 | 5-氨基-1h-吡唑衍生物、制备方法及医药用途 |
| WO2021249969A1 (en) * | 2020-06-10 | 2021-12-16 | Merck Patent Gmbh | Combination product for the treatment of cancer diseases |
| EP4340843A1 (en) | 2021-05-21 | 2024-03-27 | CeMM - Forschungszentrum für Molekulare Medizin GmbH | 1,2,4-triazolo[1,5-a]pyrimidine-based slc16a3 inhibitors and their therapeutic use |
| WO2022243574A1 (en) | 2021-05-21 | 2022-11-24 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | 3-(phthalazin-1-yl)benzenesulfonamide-based slc16a3 inhibitors and their therapeutic use |
| WO2023211938A1 (en) * | 2022-04-25 | 2023-11-02 | Cyteir Therapeutics, Inc. | Methods of using a (thiazolyl)benzenesulfonamide derivative |
| EP4568953A1 (en) * | 2022-08-10 | 2025-06-18 | Vettore, LLC | Methods and processes for the preparation of mct4 inhibitors |
| WO2024036243A2 (en) * | 2022-08-10 | 2024-02-15 | Vettore, LLC | Salts of heterocyclic inhibitors of monocarboxylate transporter 4 for the treatment of disease |
| CN118001272A (zh) * | 2022-11-08 | 2024-05-10 | 中山大学 | 吲唑类化合物在治疗炎症小体激活介导的疾病中的应用 |
| WO2025157695A1 (en) * | 2024-01-24 | 2025-07-31 | Syngenta Crop Protection Ag | Herbicidal pyrazole and triazole compounds |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1052111B (it) | 1972-02-29 | 1981-06-20 | Acraf | Acidi i benzil i h indazol 3 carbossilici sostituiti e loro derivati |
| US5078780A (en) * | 1986-10-22 | 1992-01-07 | Ciba-Geigy Corporation | 1,5-diphenylpyrazole-3-carboxylic acid derivatives for the protection of cultivated plants |
| FR2742148B1 (fr) | 1995-12-08 | 1999-10-22 | Sanofi Sa | Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant |
| IT1293795B1 (it) | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| WO2005054852A1 (en) | 2003-11-21 | 2005-06-16 | Astrazeneca Ab | Screening method |
| WO2007100851A1 (en) | 2006-02-28 | 2007-09-07 | Helicon Therapeutics, Inc. | Therapeutic compounds |
| TWI339205B (en) * | 2006-10-02 | 2011-03-21 | Nat Health Research Institutes | Pyrazole compounds and pharmaceutical composition |
| EP2254869B1 (en) * | 2008-03-07 | 2017-05-31 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. | Neue 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of cx3cr1 und p40 |
| CN102093341B (zh) | 2009-12-10 | 2013-07-24 | 天津药物研究院 | 吲哚环取代的吡唑羧酸类内皮素受体拮抗剂及其制备方法和用途 |
| US20130190324A1 (en) | 2011-12-23 | 2013-07-25 | The Regents Of The University Of Colorado, A Body Corporate | Topical ocular drug delivery |
| US9296728B2 (en) | 2012-01-20 | 2016-03-29 | Regents Of The University Of Minnesota | Therapeutic compounds |
| WO2013112881A1 (en) * | 2012-01-27 | 2013-08-01 | Thomas Jefferson University | Mct protein inhibitor-related prognostic and therapeutic methods |
| LT2882715T (lt) | 2012-05-18 | 2017-02-10 | Sanofi | Pirazolo dariniai ir jų panaudojimas kaip lpar5 antagonistų |
| CN107857757A (zh) | 2012-08-16 | 2018-03-30 | 詹森药业有限公司 | 作为n型钙通道阻滞剂的取代的吡唑 |
| WO2014195507A1 (en) | 2013-06-07 | 2014-12-11 | Universite Catholique De Louvain | 3-carboxy substituted coumarin derivatives with a potential utility for the treatment of cancer diseases |
| US10799605B2 (en) * | 2014-06-10 | 2020-10-13 | 3B Pharmaceuticals Gmbh | Conjugate comprising a neurotensin receptor ligand and use thereof |
| DE202015003905U1 (de) | 2015-06-05 | 2016-09-12 | Rudolf King | Methode zur Übermittlung und Differenzierung von Verfassungszuständen während und nach Auslösen eines persönlichen Notfallsystems oder Systems zur Mitteilung an ein soziales Notfallsystem oder Systems zur Mitteilung an ein soziales Notfall-Netzwerk |
| WO2016201416A1 (en) | 2015-06-11 | 2016-12-15 | Cequent Performance Products Inc. | Roof rack crossbar assembly |
| BR112017026535B1 (pt) | 2015-06-12 | 2023-12-19 | Vettore, LLC | Composto e composição farmacêutica |
| CN110114351B (zh) * | 2016-12-12 | 2022-09-20 | 维托尔股份有限公司 | Mct4的杂环抑制剂 |
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2017
- 2017-12-12 CN CN201780081025.0A patent/CN110114351B/zh active Active
- 2017-12-12 JP JP2019531149A patent/JP7123929B2/ja active Active
- 2017-12-12 AU AU2017375960A patent/AU2017375960B2/en active Active
- 2017-12-12 CA CA3046212A patent/CA3046212A1/en active Pending
- 2017-12-12 MX MX2019006893A patent/MX391489B/es unknown
- 2017-12-12 US US15/839,539 patent/US10214492B2/en active Active
- 2017-12-12 ES ES17880801T patent/ES2986065T3/es active Active
- 2017-12-12 BR BR112019011825A patent/BR112019011825A2/pt unknown
- 2017-12-12 EP EP24181492.0A patent/EP4442318A3/en active Pending
- 2017-12-12 NZ NZ754341A patent/NZ754341A/en unknown
- 2017-12-12 EP EP17880801.0A patent/EP3551625B1/en active Active
- 2017-12-12 KR KR1020197019870A patent/KR102615828B1/ko active Active
- 2017-12-12 DK DK17880801.0T patent/DK3551625T3/da active
- 2017-12-12 WO PCT/US2017/065864 patent/WO2018111904A1/en not_active Ceased
- 2017-12-12 IL IL279949A patent/IL279949B2/en unknown
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2018
- 2018-12-17 US US16/222,949 patent/US11292767B2/en active Active
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2019
- 2019-06-06 PH PH12019501261A patent/PH12019501261A1/en unknown
- 2019-06-10 IL IL267183A patent/IL267183A/en unknown
- 2019-06-10 SA SA519401970A patent/SA519401970B1/ar unknown
- 2019-07-10 ZA ZA2019/04522A patent/ZA201904522B/en unknown
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2022
- 2022-02-22 US US17/652,022 patent/US12492171B2/en active Active