JP2013518832A5 - - Google Patents
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- Publication number
- JP2013518832A5 JP2013518832A5 JP2012551506A JP2012551506A JP2013518832A5 JP 2013518832 A5 JP2013518832 A5 JP 2013518832A5 JP 2012551506 A JP2012551506 A JP 2012551506A JP 2012551506 A JP2012551506 A JP 2012551506A JP 2013518832 A5 JP2013518832 A5 JP 2013518832A5
- Authority
- JP
- Japan
- Prior art keywords
- cyy
- nyy
- atoms
- het
- hal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 125000004430 oxygen atom Chemical group O* 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000004434 sulfur atom Chemical group 0.000 claims 5
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 239000003607 modifier Substances 0.000 claims 3
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000169 tricyclic heterocycle group Chemical group 0.000 claims 2
- 102100032187 Androgen receptor Human genes 0.000 claims 1
- 102100038595 Estrogen receptor Human genes 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 108010080146 androgen receptors Proteins 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 108010038795 estrogen receptors Proteins 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 239000004030 hiv protease inhibitor Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000027483 retinoid hormone receptors Human genes 0.000 claims 1
- 108091008679 retinoid hormone receptors Proteins 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 239000003558 transferase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10001251.7 | 2010-02-05 | ||
| EP10001251 | 2010-02-05 | ||
| PCT/EP2010/007743 WO2011095196A1 (en) | 2010-02-05 | 2010-12-17 | Hetaryl-[1,8]naphthyridine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518832A JP2013518832A (ja) | 2013-05-23 |
| JP2013518832A5 true JP2013518832A5 (enExample) | 2014-09-04 |
| JP5675850B2 JP5675850B2 (ja) | 2015-02-25 |
Family
ID=43531801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551506A Expired - Fee Related JP5675850B2 (ja) | 2010-02-05 | 2010-12-17 | ヘタリール−［１，８］ナフチリジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8614226B2 (enExample) |
| EP (1) | EP2531500B1 (enExample) |
| JP (1) | JP5675850B2 (enExample) |
| KR (1) | KR20120124469A (enExample) |
| CN (1) | CN102741249B (enExample) |
| AU (1) | AU2010344973B2 (enExample) |
| BR (1) | BR112012018954A2 (enExample) |
| CA (1) | CA2789021C (enExample) |
| EA (1) | EA201201081A1 (enExample) |
| ES (1) | ES2667049T3 (enExample) |
| MX (1) | MX2012008550A (enExample) |
| SG (1) | SG182803A1 (enExample) |
| WO (1) | WO2011095196A1 (enExample) |
| ZA (1) | ZA201206630B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130036201A (ko) * | 2010-02-22 | 2013-04-11 | 메르크 파텐트 게엠베하 | 헤타릴아미노나프티리딘 |
| SG186855A1 (en) * | 2010-06-28 | 2013-02-28 | Merck Patent Gmbh | 2,4- diaryl - substituted [1,8] naphthyridines as kinase inhibitors for use against cancer |
| CN103052713A (zh) * | 2010-07-07 | 2013-04-17 | 陶氏益农公司 | 官能化线性dna盒的生成及植物中量子点/纳米颗粒介导的投递 |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| JP6496246B2 (ja) | 2012-10-05 | 2019-04-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | アルドステロンシンターゼインヒビター関連用途としてのインドリン化合物 |
| CN104837832B (zh) | 2012-10-05 | 2019-04-26 | 里格尔药品股份有限公司 | Gdf-8抑制剂 |
| MA38287B1 (fr) | 2013-01-23 | 2018-08-31 | Astrazeneca Ab | Nouveaux dérivés aminopyrazine pour le traitement ou la prévention du cancer |
| CN103113369A (zh) * | 2013-03-21 | 2013-05-22 | 云南大学 | 一种具有抗肿瘤活性的苯并[b][1,8]-萘啶-2-(1H)-亚胺衍生物及合成方法 |
| TWI529171B (zh) * | 2013-07-29 | 2016-04-11 | 赫孚孟拉羅股份公司 | １，７－萘啶衍生物 |
| KR102398473B1 (ko) * | 2013-11-27 | 2022-05-16 | 시그널켐 라이프사이언시즈 코포레이션 | Tam 패밀리 키나제 억제제로서의 아미노피리딘 유도체 |
| TN2016000270A1 (en) | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
| EP3094326A4 (en) | 2014-01-14 | 2017-07-26 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| WO2015157093A1 (en) * | 2014-04-08 | 2015-10-15 | Rigel Pharmaceuticals, Inc. | 2,3-disubstituted pyridine compounds as tgf-beta inhibitors and methods of use |
| TWI903299B (zh) | 2018-03-08 | 2025-11-01 | 美商英塞特公司 | 作為PI3K-γ抑制劑之胺基吡嗪二醇化合物 |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| US20230090552A1 (en) | 2020-01-08 | 2023-03-23 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| CN121712526A (zh) | 2023-06-13 | 2026-03-20 | 辛瑟斯治疗股份有限公司 | 抗cd5抗体及其用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR207555A1 (es) | 1972-12-04 | 1976-10-15 | Procedimiento para preparar aril-6-piperazinocarboniloxi-5 oxo-7 tetrahidro-2,3,6,7 ditiino(1,4)(2,3-c)pirroles | |
| IT1245712B (it) | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| US5994367A (en) | 1997-03-07 | 1999-11-30 | The University Of North Carolina At Chapel Hill | Method for treating tumors using 2-aryl-naphthyridin-4-ones |
| JP4570773B2 (ja) | 1997-10-27 | 2010-10-27 | ニューロサーチ、アクティーゼルスカブ | ニコチン性アセチルコリンレセプターに於けるコリン作動性リガンドとしてのヘテロアリールジアザシクロアルカン |
| EP1187633A4 (en) | 1999-04-08 | 2005-05-11 | Arch Dev Corp | USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY |
| GB0117060D0 (en) * | 2001-07-12 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
| EP1511738A4 (en) * | 2002-05-17 | 2007-05-09 | Scios Inc | TREATMENT OF FIBROPROLIFERATIVE DISEASES USING TGF BETA INHIBITORS |
| ATE398125T1 (de) | 2003-03-12 | 2008-07-15 | Millennium Pharm Inc | Chinazolin-derivate als tgf-beta-inhibitoren |
| TW200538120A (en) * | 2004-02-20 | 2005-12-01 | Kirin Brewery | Compound having TGF-beta inhibitory activity and pharmaceutical composition containing same |
| EP2607362B1 (en) * | 2005-02-17 | 2014-12-31 | Astellas Pharma Inc. | Piperidine and piperazine carboxylates as FAAH inhibitors |
| DK1959955T3 (da) | 2005-12-05 | 2011-02-07 | Pfizer Prod Inc | Fremgangsmåde til behandling af abnorm cellevækst |
| JP4751856B2 (ja) | 2007-07-03 | 2011-08-17 | 本田技研工業株式会社 | 車体側部構造 |
| DE102007049451A1 (de) | 2007-10-16 | 2009-04-23 | Merck Patent Gmbh | 5-Cyano-thienopyridine |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| EP2265270A1 (en) | 2008-02-04 | 2010-12-29 | OSI Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
| DE102008017853A1 (de) | 2008-04-09 | 2009-10-15 | Merck Patent Gmbh | Thienopyrimidine |
| EA201001687A1 (ru) | 2008-04-29 | 2011-06-30 | Новартис Аг | Производные имидазопиридина в качестве ингибиторов активиноподобной рецепторной киназы ( alk-4 или alk-5 ) |
| JP2012531436A (ja) * | 2009-06-25 | 2012-12-10 | アムジエン・インコーポレーテツド | 複素環式化合物およびそれらのｐｉ３ｋ活性阻害剤としての使用 |
| KR20130036201A (ko) * | 2010-02-22 | 2013-04-11 | 메르크 파텐트 게엠베하 | 헤타릴아미노나프티리딘 |
| SG186855A1 (en) * | 2010-06-28 | 2013-02-28 | Merck Patent Gmbh | 2,4- diaryl - substituted [1,8] naphthyridines as kinase inhibitors for use against cancer |
-
2010
- 2010-12-17 EA EA201201081A patent/EA201201081A1/ru unknown
- 2010-12-17 BR BR112012018954A patent/BR112012018954A2/pt not_active IP Right Cessation
- 2010-12-17 US US13/574,282 patent/US8614226B2/en not_active Expired - Fee Related
- 2010-12-17 EP EP10794897.8A patent/EP2531500B1/en not_active Not-in-force
- 2010-12-17 MX MX2012008550A patent/MX2012008550A/es not_active Application Discontinuation
- 2010-12-17 JP JP2012551506A patent/JP5675850B2/ja not_active Expired - Fee Related
- 2010-12-17 WO PCT/EP2010/007743 patent/WO2011095196A1/en not_active Ceased
- 2010-12-17 CA CA2789021A patent/CA2789021C/en not_active Expired - Fee Related
- 2010-12-17 ES ES10794897.8T patent/ES2667049T3/es active Active
- 2010-12-17 AU AU2010344973A patent/AU2010344973B2/en not_active Ceased
- 2010-12-17 KR KR1020127022601A patent/KR20120124469A/ko not_active Withdrawn
- 2010-12-17 SG SG2012056495A patent/SG182803A1/en unknown
- 2010-12-17 CN CN201080063064.6A patent/CN102741249B/zh not_active Expired - Fee Related
-
2012
- 2012-09-04 ZA ZA2012/06630A patent/ZA201206630B/en unknown
-
2013
- 2013-10-04 US US14/046,703 patent/US8912216B2/en not_active Expired - Fee Related