JP2013518832A5 - - Google Patents
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- Publication number
- JP2013518832A5 JP2013518832A5 JP2012551506A JP2012551506A JP2013518832A5 JP 2013518832 A5 JP2013518832 A5 JP 2013518832A5 JP 2012551506 A JP2012551506 A JP 2012551506A JP 2012551506 A JP2012551506 A JP 2012551506A JP 2013518832 A5 JP2013518832 A5 JP 2013518832A5
- Authority
- JP
- Japan
- Prior art keywords
- cyy
- nyy
- atoms
- het
- hal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 125000004430 oxygen atom Chemical group O* 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000004434 sulfur atom Chemical group 0.000 claims 5
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 239000003607 modifier Substances 0.000 claims 3
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000000169 tricyclic heterocycle group Chemical group 0.000 claims 2
- 102100032187 Androgen receptor Human genes 0.000 claims 1
- 102100038595 Estrogen receptor Human genes 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 108010080146 androgen receptors Proteins 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 108010038795 estrogen receptors Proteins 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 239000004030 hiv protease inhibitor Substances 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 claims 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000027483 retinoid hormone receptors Human genes 0.000 claims 1
- 108091008679 retinoid hormone receptors Proteins 0.000 claims 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
- 239000003558 transferase inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10001251.7 | 2010-02-05 | ||
| EP10001251 | 2010-02-05 | ||
| PCT/EP2010/007743 WO2011095196A1 (en) | 2010-02-05 | 2010-12-17 | Hetaryl-[1,8]naphthyridine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518832A JP2013518832A (ja) | 2013-05-23 |
| JP2013518832A5 true JP2013518832A5 (enExample) | 2014-09-04 |
| JP5675850B2 JP5675850B2 (ja) | 2015-02-25 |
Family
ID=43531801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551506A Expired - Fee Related JP5675850B2 (ja) | 2010-02-05 | 2010-12-17 | ヘタリール−［１，８］ナフチリジン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8614226B2 (enExample) |
| EP (1) | EP2531500B1 (enExample) |
| JP (1) | JP5675850B2 (enExample) |
| KR (1) | KR20120124469A (enExample) |
| CN (1) | CN102741249B (enExample) |
| AU (1) | AU2010344973B2 (enExample) |
| BR (1) | BR112012018954A2 (enExample) |
| CA (1) | CA2789021C (enExample) |
| EA (1) | EA201201081A1 (enExample) |
| ES (1) | ES2667049T3 (enExample) |
| MX (1) | MX2012008550A (enExample) |
| SG (1) | SG182803A1 (enExample) |
| WO (1) | WO2011095196A1 (enExample) |
| ZA (1) | ZA201206630B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012019561A2 (pt) * | 2010-02-22 | 2019-09-24 | Merck Patent Gmbh | hetarilamino naftiridinas |
| JP5826261B2 (ja) * | 2010-06-28 | 2015-12-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 癌に対する使用のためのキナーゼ阻害剤としての２，４−ジアリール置換［１，８］ナフチリジン |
| WO2012006439A2 (en) * | 2010-07-07 | 2012-01-12 | Dow Agrosciences Llc | Production of functionalized linear dna cassette and quantum dot/nanoparticle mediated delivery in plants |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| JP6457942B2 (ja) | 2012-10-05 | 2019-01-23 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｇｄｆ−８阻害剤 |
| US9550750B2 (en) | 2012-10-05 | 2017-01-24 | Merck Sharp & Dohme Corp. | Indoline compounds as aldosterone synthase inhibitors |
| US9156831B2 (en) | 2013-01-23 | 2015-10-13 | Astrazeneca Ab | Chemical compounds |
| CN103113369A (zh) * | 2013-03-21 | 2013-05-22 | 云南大学 | 一种具有抗肿瘤活性的苯并[b][1,8]-萘啶-2-(1H)-亚胺衍生物及合成方法 |
| TWI529171B (zh) * | 2013-07-29 | 2016-04-11 | 赫孚孟拉羅股份公司 | １，７－萘啶衍生物 |
| JP6496731B2 (ja) | 2013-11-27 | 2019-04-03 | シグナルケム・ライフサイエンシーズ・コーポレイションＳｉｇｎａｌｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｔａｍファミリーキナーゼ阻害剤としてのアミノピリジン誘導体 |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| TN2016000270A1 (en) * | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
| JP6767875B2 (ja) * | 2014-04-08 | 2020-10-14 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｔｇｆ−ベータ阻害剤としての２，３−二置換ピリジン化合物および使用方法 |
| CR20200464A (es) | 2018-03-08 | 2021-04-14 | Incyte Corp | Compuestos diólicos de aminopirazina como inhibidores de pi3k-y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| CN115052663B (zh) | 2020-01-08 | 2026-06-09 | 辛瑟斯治疗股份有限公司 | Alk5抑制剂缀合物及其用途 |
| AU2023294765A1 (en) * | 2022-06-17 | 2024-12-12 | Sundance Biosciences, Inc. | Kinase modulators and methods of use thereof |
| WO2024258967A1 (en) | 2023-06-13 | 2024-12-19 | Synthis Therapeutics, Inc. | Anti-cd5 antibodies and their uses |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR207555A1 (es) | 1972-12-04 | 1976-10-15 | Procedimiento para preparar aril-6-piperazinocarboniloxi-5 oxo-7 tetrahidro-2,3,6,7 ditiino(1,4)(2,3-c)pirroles | |
| IT1245712B (it) * | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| US5994367A (en) * | 1997-03-07 | 1999-11-30 | The University Of North Carolina At Chapel Hill | Method for treating tumors using 2-aryl-naphthyridin-4-ones |
| KR100607838B1 (ko) * | 1997-10-27 | 2006-08-04 | 뉴로서치 에이/에스 | 니코틴 작용성 아세틸콜린 수용체상의 콜린 작용성 리간드로서의 호모피페라진 유도체 및 이를 포함하는 약제학적 조성물 |
| EP1187633A4 (en) | 1999-04-08 | 2005-05-11 | Arch Dev Corp | USE OF ANTI-VEGF ANTIBODIES TO ENHANCE RADIATION IN ANTICANCER THERAPY |
| GB0117060D0 (en) * | 2001-07-12 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
| AU2003229305A1 (en) * | 2002-05-17 | 2003-12-02 | Scios, Inc. | TREATMENT OF FIBROPROLIFERATIVE DISORDERS USING TGF-Beta INHIBITORS |
| DE602004014347D1 (de) * | 2003-03-12 | 2008-07-24 | Millennium Pharm Inc | Chinazolin-derivate als tgf-beta-inhibitoren |
| TW200538120A (en) * | 2004-02-20 | 2005-12-01 | Kirin Brewery | Compound having TGF-beta inhibitory activity and pharmaceutical composition containing same |
| MX2007010076A (es) * | 2005-02-17 | 2007-10-16 | Astellas Pharma Inc | Derivado de heterociclico-1-carboxilato que contiene nitrogeno no aromatico de piridilo. |
| DE602006018354D1 (de) | 2005-12-05 | 2010-12-30 | Pfizer Prod Inc | Verfahren zur behandlung von abnormalem zellwachstum |
| JP4751856B2 (ja) | 2007-07-03 | 2011-08-17 | 本田技研工業株式会社 | 車体側部構造 |
| DE102007049451A1 (de) | 2007-10-16 | 2009-04-23 | Merck Patent Gmbh | 5-Cyano-thienopyridine |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| JP2011511005A (ja) | 2008-02-04 | 2011-04-07 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | ２−アミノピリジン系キナーゼ阻害薬 |
| DE102008017853A1 (de) | 2008-04-09 | 2009-10-15 | Merck Patent Gmbh | Thienopyrimidine |
| EP2307402B1 (en) | 2008-04-29 | 2012-11-07 | Novartis AG | Imidazo-pyridine derivatives as activin-like receptor kinase (alk4 or alk5) inhibitors |
| EP2445902A2 (en) * | 2009-06-25 | 2012-05-02 | Amgen, Inc | Heterocyclic compounds and their uses as inhibitors of pi3k activity |
| BR112012019561A2 (pt) * | 2010-02-22 | 2019-09-24 | Merck Patent Gmbh | hetarilamino naftiridinas |
| JP5826261B2 (ja) * | 2010-06-28 | 2015-12-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 癌に対する使用のためのキナーゼ阻害剤としての２，４−ジアリール置換［１，８］ナフチリジン |
-
2010
- 2010-12-17 EP EP10794897.8A patent/EP2531500B1/en not_active Not-in-force
- 2010-12-17 AU AU2010344973A patent/AU2010344973B2/en not_active Ceased
- 2010-12-17 CA CA2789021A patent/CA2789021C/en not_active Expired - Fee Related
- 2010-12-17 BR BR112012018954A patent/BR112012018954A2/pt not_active IP Right Cessation
- 2010-12-17 MX MX2012008550A patent/MX2012008550A/es not_active Application Discontinuation
- 2010-12-17 WO PCT/EP2010/007743 patent/WO2011095196A1/en not_active Ceased
- 2010-12-17 EA EA201201081A patent/EA201201081A1/ru unknown
- 2010-12-17 CN CN201080063064.6A patent/CN102741249B/zh not_active Expired - Fee Related
- 2010-12-17 KR KR1020127022601A patent/KR20120124469A/ko not_active Withdrawn
- 2010-12-17 SG SG2012056495A patent/SG182803A1/en unknown
- 2010-12-17 US US13/574,282 patent/US8614226B2/en not_active Expired - Fee Related
- 2010-12-17 JP JP2012551506A patent/JP5675850B2/ja not_active Expired - Fee Related
- 2010-12-17 ES ES10794897.8T patent/ES2667049T3/es active Active
-
2012
- 2012-09-04 ZA ZA2012/06630A patent/ZA201206630B/en unknown
-
2013
- 2013-10-04 US US14/046,703 patent/US8912216B2/en not_active Expired - Fee Related
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