JP2013501047A5 - - Google Patents
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- Publication number
- JP2013501047A5 JP2013501047A5 JP2012523650A JP2012523650A JP2013501047A5 JP 2013501047 A5 JP2013501047 A5 JP 2013501047A5 JP 2012523650 A JP2012523650 A JP 2012523650A JP 2012523650 A JP2012523650 A JP 2012523650A JP 2013501047 A5 JP2013501047 A5 JP 2013501047A5
- Authority
- JP
- Japan
- Prior art keywords
- atoms
- hal
- nhco
- conh
- nhconh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23187309P | 2009-08-06 | 2009-08-06 | |
| US61/231,873 | 2009-08-06 | ||
| PCT/US2010/043467 WO2011017142A1 (en) | 2009-08-06 | 2010-07-28 | Novel bicyclic urea compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013501047A JP2013501047A (ja) | 2013-01-10 |
| JP2013501047A5 true JP2013501047A5 (enExample) | 2013-09-12 |
| JP5718332B2 JP5718332B2 (ja) | 2015-05-13 |
Family
ID=42985363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012523650A Expired - Fee Related JP5718332B2 (ja) | 2009-08-06 | 2010-07-28 | 新規な二環式尿素化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8569295B2 (enExample) |
| EP (1) | EP2461869B1 (enExample) |
| JP (1) | JP5718332B2 (enExample) |
| KR (1) | KR20120055608A (enExample) |
| CN (1) | CN102573994B (enExample) |
| AU (1) | AU2010281368C1 (enExample) |
| CA (1) | CA2770156C (enExample) |
| EA (1) | EA201200218A1 (enExample) |
| ES (1) | ES2433230T3 (enExample) |
| IL (1) | IL217651A (enExample) |
| MX (1) | MX2012001419A (enExample) |
| SG (1) | SG178271A1 (enExample) |
| WO (1) | WO2011017142A1 (enExample) |
| ZA (1) | ZA201201635B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045095A1 (en) | 2008-10-14 | 2010-04-22 | Ning Xi | Compounds and methods of use |
| AU2010229147B2 (en) | 2009-03-21 | 2012-07-05 | Sunshine Lake Pharma Co., Ltd. | Amino ester derivatives, salts thereof and methods of use |
| US9290485B2 (en) | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| AU2012223639B2 (en) | 2011-02-28 | 2015-03-19 | Sunshine Lake Pharma Co., Ltd. | Substituted quinoline compounds and methods of use |
| JP6001072B2 (ja) * | 2011-08-10 | 2016-10-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ピリド−ピリミジン誘導体 |
| GB201201566D0 (en) | 2012-01-30 | 2012-03-14 | Vernalis R&D Ltd | New chemical compounds |
| US8975282B2 (en) | 2012-07-28 | 2015-03-10 | Sunshine Lake Pharma Co., Ltd. | Substituted pyrazolone compounds and methods of use |
| EP2879676B1 (en) | 2012-07-28 | 2017-06-14 | Calitor Sciences, LLC | Substituted pyrazolone compounds and methods of use |
| CN104602690A (zh) | 2012-08-29 | 2015-05-06 | 默克专利股份有限公司 | 用于治疗骨关节炎的ddr2抑制剂 |
| RU2671496C2 (ru) | 2013-10-14 | 2018-11-01 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные 5-пиперидин-8-цианохинолина |
| PE20160608A1 (es) | 2013-10-14 | 2016-07-08 | Eisai Randd Man Co Ltd | Compuestos de quinolina selectivamente sustituida |
| CN106279147A (zh) * | 2015-05-21 | 2017-01-04 | 中国科学院上海药物研究所 | 一种吡啶并氮杂环化合物及其制备方法和用途 |
| EP3440052B1 (en) | 2016-04-06 | 2023-10-25 | University Of Oulu | Compounds for use in the treatment of cancer |
| EP3630778A1 (en) * | 2017-05-26 | 2020-04-08 | Ichnos Sciences SA | Novel inhibitors of map4k1 |
| GB2575490A (en) * | 2018-07-12 | 2020-01-15 | Recordati Ind Chimica E Farmaceutica Spa | P2X3 receptor antagonists |
| CA3109891A1 (en) * | 2018-08-24 | 2020-02-27 | Nanjing Transthera Biosciences Co., Ltd. | Quinoline derivative inhibitor: tam, ntrk, and csf1r kinases |
| EP3924352A4 (en) * | 2019-02-11 | 2022-11-16 | Phoenix Molecular Designs | CRYSTALLINE FORMS OF AN RSK INHIBITOR |
| CN112625026B (zh) * | 2019-09-24 | 2022-09-09 | 药捷安康(南京)科技股份有限公司 | Tam家族激酶抑制剂的喹啉衍生物 |
| KR20230012473A (ko) | 2020-03-30 | 2023-01-26 | 허치슨 메디파르마 리미티드 | 아미드 화합물 및 그의 용도 |
| CN112225748B (zh) * | 2020-10-20 | 2021-11-30 | 四川大学华西医院 | 一种具有flt3激酶抑制活性的小分子化合物及其应用 |
| WO2022175514A1 (en) | 2021-02-22 | 2022-08-25 | Bayer Aktiengesellschaft | N-(pyridin-2-yl)-acetamides as p2x3 inhibitors |
| KR102726416B1 (ko) * | 2021-12-15 | 2024-11-05 | 한국과학기술연구원 | 엑토뉴클레오티드 피로포스파타아제-포스포디에스터라아제의 저해 활성을 갖는 신규한 피리도피리미딘 유도체 및 이들의 용도 |
| JP2025500917A (ja) | 2021-12-16 | 2025-01-15 | キネート バイオファーマ インク． | Ｍｅｔキナーゼの阻害剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60312154T2 (de) * | 2002-05-29 | 2007-06-21 | Amgen Inc., Thousand Oaks | 2-oxo-1,3,4-trihydrochinazolin derivative zur behandlung von zellproliferationskrankheiten |
| DE102004004731A1 (de) * | 2004-01-30 | 2005-08-18 | Merck Patent Gmbh | Harnstoffderivate |
| EP1858889A1 (en) * | 2005-03-08 | 2007-11-28 | Biota Scientific Management Pty. Ltd. | Bicyclic nucleosides and nucleotides as therapeutic agents |
| JP2008545660A (ja) * | 2005-05-20 | 2008-12-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼ阻害剤として有用なピロロピリジン化合物 |
-
2010
- 2010-07-28 WO PCT/US2010/043467 patent/WO2011017142A1/en not_active Ceased
- 2010-07-28 ES ES10739442T patent/ES2433230T3/es active Active
- 2010-07-28 AU AU2010281368A patent/AU2010281368C1/en not_active Ceased
- 2010-07-28 EP EP10739442.1A patent/EP2461869B1/en not_active Not-in-force
- 2010-07-28 EA EA201200218A patent/EA201200218A1/ru unknown
- 2010-07-28 US US13/388,952 patent/US8569295B2/en not_active Expired - Fee Related
- 2010-07-28 JP JP2012523650A patent/JP5718332B2/ja not_active Expired - Fee Related
- 2010-07-28 SG SG2012008074A patent/SG178271A1/en unknown
- 2010-07-28 CA CA2770156A patent/CA2770156C/en not_active Expired - Fee Related
- 2010-07-28 KR KR1020127005845A patent/KR20120055608A/ko not_active Withdrawn
- 2010-07-28 CN CN201080034738.XA patent/CN102573994B/zh not_active Expired - Fee Related
- 2010-07-28 MX MX2012001419A patent/MX2012001419A/es unknown
-
2012
- 2012-01-19 IL IL217651A patent/IL217651A/en active IP Right Grant
- 2012-03-05 ZA ZA2012/01635A patent/ZA201201635B/en unknown
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