MX2012008550A - Derivados de hetaril-[1, 8]naftiridina. - Google Patents
Derivados de hetaril-[1, 8]naftiridina.Info
- Publication number
- MX2012008550A MX2012008550A MX2012008550A MX2012008550A MX2012008550A MX 2012008550 A MX2012008550 A MX 2012008550A MX 2012008550 A MX2012008550 A MX 2012008550A MX 2012008550 A MX2012008550 A MX 2012008550A MX 2012008550 A MX2012008550 A MX 2012008550A
- Authority
- MX
- Mexico
- Prior art keywords
- cyy
- nyy
- phenyl
- hal
- carbon atoms
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| EA022064B1 (ru) * | 2010-02-22 | 2015-10-30 | Мерк Патент Гмбх | Гетариламинонафтиридины в качестве ингибиторов атф-связывающих белков |
| SG186855A1 (en) * | 2010-06-28 | 2013-02-28 | Merck Patent Gmbh | 2,4- diaryl - substituted [1,8] naphthyridines as kinase inhibitors for use against cancer |
| CA2804164C (en) * | 2010-07-07 | 2019-10-22 | Dow Agrosciences Llc | Production of functionalized linear dna cassette and quantum dot/nanoparticle mediated delivery in plants |
| KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
| EP2903978B1 (en) | 2012-10-05 | 2022-12-07 | Rigel Pharmaceuticals, Inc. | Gdf-8 inhibitors |
| EP2903615B1 (en) | 2012-10-05 | 2021-04-07 | Merck Sharp & Dohme Corp. | 5-pyridin-3-yl-2,3-dihydro-1h-indole derivatives as aldosterone synthase (cyp11b2) inhibitors for the treatment of hypertension |
| AU2014208964B2 (en) | 2013-01-23 | 2016-09-01 | Astrazeneca Ab | Chemical compounds |
| CN103113369A (zh) * | 2013-03-21 | 2013-05-22 | 云南大学 | 一种具有抗肿瘤活性的苯并[b][1,8]-萘啶-2-(1H)-亚胺衍生物及合成方法 |
| TWI529171B (zh) * | 2013-07-29 | 2016-04-11 | 赫孚孟拉羅股份公司 | １，７－萘啶衍生物 |
| CN105764514B (zh) * | 2013-11-27 | 2019-07-12 | 圣诺康生命科学公司 | 作为tam族激酶抑制剂的氨基吡啶衍生物 |
| US10202373B2 (en) | 2014-01-14 | 2019-02-12 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US9802960B2 (en) | 2014-01-14 | 2017-10-31 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| CN106536507B (zh) * | 2014-04-08 | 2020-04-07 | 里格尔药品股份有限公司 | 作为TGF-β抑制剂的2,3-二取代的吡啶化合物及其使用方法 |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| CA3164037A1 (en) | 2020-01-08 | 2021-07-15 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| WO2024258967A1 (en) | 2023-06-13 | 2024-12-19 | Synthis Therapeutics, Inc. | Anti-cd5 antibodies and their uses |
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| AR207555A1 (es) * | 1972-12-04 | 1976-10-15 | Procedimiento para preparar aril-6-piperazinocarboniloxi-5 oxo-7 tetrahidro-2,3,6,7 ditiino(1,4)(2,3-c)pirroles | |
| IT1245712B (it) * | 1991-04-09 | 1994-10-14 | Boehringer Mannheim Italia | Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree |
| US5994367A (en) * | 1997-03-07 | 1999-11-30 | The University Of North Carolina At Chapel Hill | Method for treating tumors using 2-aryl-naphthyridin-4-ones |
| NZ503520A (en) | 1997-10-27 | 2002-08-28 | Neurosearch As | Heteroaryl or aryl substituted diazacycloalkanes useful as cholinergic ligands at nicotinic acetylcholine receptors |
| WO2000061186A1 (en) | 1999-04-08 | 2000-10-19 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
| GB0117060D0 (en) * | 2001-07-12 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
| US20040038856A1 (en) * | 2002-05-17 | 2004-02-26 | Sarvajit Chakravarty | Treatment of fibroproliferative disorders using TGF-beta inhibitors |
| DE602004014347D1 (de) * | 2003-03-12 | 2008-07-24 | Millennium Pharm Inc | Chinazolin-derivate als tgf-beta-inhibitoren |
| TW200538120A (en) * | 2004-02-20 | 2005-12-01 | Kirin Brewery | Compound having TGF-beta inhibitory activity and pharmaceutical composition containing same |
| BRPI0608205B8 (pt) | 2005-02-17 | 2021-05-25 | Astellas Pharma Inc | derivado heterocíclico-1-carboxilato de piridila não-aromático nitrogenado, composição farmacêutica e uso do dito composto para o tratamento de frequência urinária, incontinência urinária, bexiga hiperativa e dor |
| EP1959955B1 (en) | 2005-12-05 | 2010-11-17 | Pfizer Products Inc. | Method of treating abnormal cell growth |
| JP4751856B2 (ja) | 2007-07-03 | 2011-08-17 | 本田技研工業株式会社 | 車体側部構造 |
| DE102007049451A1 (de) | 2007-10-16 | 2009-04-23 | Merck Patent Gmbh | 5-Cyano-thienopyridine |
| AR070127A1 (es) | 2008-01-11 | 2010-03-17 | Novartis Ag | Pirrolo - pirimidinas y pirrolo -piridinas |
| WO2009099982A1 (en) | 2008-02-04 | 2009-08-13 | Osi Pharmaceuticals, Inc. | 2-aminopyridine kinase inhibitors |
| DE102008017853A1 (de) | 2008-04-09 | 2009-10-15 | Merck Patent Gmbh | Thienopyrimidine |
| CN102015691B (zh) | 2008-04-29 | 2014-01-08 | 诺华股份有限公司 | 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物 |
| US8765940B2 (en) * | 2009-06-25 | 2014-07-01 | Amgen Inc. | Heterocyclic compounds and their uses |
| EA022064B1 (ru) * | 2010-02-22 | 2015-10-30 | Мерк Патент Гмбх | Гетариламинонафтиридины в качестве ингибиторов атф-связывающих белков |
| SG186855A1 (en) * | 2010-06-28 | 2013-02-28 | Merck Patent Gmbh | 2,4- diaryl - substituted [1,8] naphthyridines as kinase inhibitors for use against cancer |
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| CN102741249B (zh) | 2015-11-25 |
| EP2531500B1 (en) | 2018-01-24 |
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| US20140038960A1 (en) | 2014-02-06 |
| CA2789021C (en) | 2018-02-06 |
| JP2013518832A (ja) | 2013-05-23 |
| KR20120124469A (ko) | 2012-11-13 |
| AU2010344973B2 (en) | 2016-06-16 |
| US8614226B2 (en) | 2013-12-24 |
| CA2789021A1 (en) | 2011-08-11 |
| WO2011095196A1 (en) | 2011-08-11 |
| US8912216B2 (en) | 2014-12-16 |
| ZA201206630B (en) | 2013-05-29 |
| JP5675850B2 (ja) | 2015-02-25 |
| BR112012018954A2 (pt) | 2016-04-12 |
| EA201201081A1 (ru) | 2013-03-29 |
| EP2531500A1 (en) | 2012-12-12 |
| AU2010344973A1 (en) | 2012-09-20 |
| SG182803A1 (en) | 2012-09-27 |
| ES2667049T3 (es) | 2018-05-09 |
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