JP2021521178A5 - - Google Patents
Info
- Publication number
- JP2021521178A5 JP2021521178A5 JP2020555501A JP2020555501A JP2021521178A5 JP 2021521178 A5 JP2021521178 A5 JP 2021521178A5 JP 2020555501 A JP2020555501 A JP 2020555501A JP 2020555501 A JP2020555501 A JP 2020555501A JP 2021521178 A5 JP2021521178 A5 JP 2021521178A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- independently
- acceptable salt
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862655741P | 2018-04-10 | 2018-04-10 | |
| US62/655,741 | 2018-04-10 | ||
| PCT/US2019/026634 WO2019199864A1 (en) | 2018-04-10 | 2019-04-09 | Tri-substituted aryl and heteroaryl derivatives as modulators of pi3-kinase and autophagy pathways |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021521178A JP2021521178A (ja) | 2021-08-26 |
| JP2021521178A5 true JP2021521178A5 (enExample) | 2022-04-13 |
| JP7369139B2 JP7369139B2 (ja) | 2023-10-25 |
Family
ID=66248833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020555501A Active JP7369139B2 (ja) | 2018-04-10 | 2019-04-09 | Ｐｉ３キナーゼおよびオートファジー経路の調節因子としての三置換アリールおよびヘテロアリール誘導体 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11492348B2 (enExample) |
| EP (1) | EP3774783B1 (enExample) |
| JP (1) | JP7369139B2 (enExample) |
| KR (1) | KR102803762B1 (enExample) |
| CN (1) | CN112189012B (enExample) |
| AU (1) | AU2019251360B2 (enExample) |
| EA (1) | EA202092444A1 (enExample) |
| ES (1) | ES3032793T3 (enExample) |
| MX (1) | MX2020010576A (enExample) |
| SG (1) | SG11202008832TA (enExample) |
| WO (1) | WO2019199864A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112189012B (zh) * | 2018-04-10 | 2024-02-13 | 神经孔疗法股份有限公司 | 作为pi3激酶和自噬途径的调节剂的三取代芳基和杂芳基衍生物 |
| HUE065486T2 (hu) | 2019-05-10 | 2024-05-28 | Deciphera Pharmaceuticals Llc | Fenilaminopirimidinamid autophágia inhibitorok és azok felhasználási eljárásai |
| HRP20231310T1 (hr) * | 2019-05-10 | 2024-02-02 | Deciphera Pharmaceuticals, Llc | Heteroarilaminopirimidin amidni inhibitori autofagije i postupci njihove primjene |
| ES3072710T3 (en) | 2019-06-17 | 2026-07-03 | Deciphera Pharmaceuticals Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
| CN113121499B (zh) * | 2021-04-13 | 2022-05-31 | 海南锦瑞制药有限公司 | 奥美拉唑的合成方法及应用 |
| US12319655B2 (en) | 2021-12-09 | 2025-06-03 | Deciphera Pharmaceuticals, Llc | RAF kinase inhibitors and methods of use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| PE20081679A1 (es) | 2006-12-07 | 2008-12-18 | Hoffmann La Roche | Compuestos del inhibidor de fosfoinositida 3-cinasa y metodos de uso |
| CA2675558A1 (en) * | 2007-02-06 | 2008-08-14 | Novartis Ag | Pi 3-kinase inhibitors and methods of their use |
| WO2009066084A1 (en) * | 2007-11-21 | 2009-05-28 | F. Hoffmann-La Roche Ag | 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| BRPI0915105A2 (pt) * | 2008-06-13 | 2019-09-24 | Novartis Ag | composto de 2,4'-biripidinila como inibidores da proteína cinase d úteis para o tratamento de ia insuficiência cardíaca e cancer |
| GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| KR20120063515A (ko) | 2009-09-09 | 2012-06-15 | 아빌라 테라퓨틱스, 인크. | Ｐｉ３ 키나제 억제제 및 이들의 용도 |
| CN103501610A (zh) * | 2011-03-09 | 2014-01-08 | 西建阿维拉米斯研究公司 | Pi3激酶抑制剂和其用途 |
| CN107501241B (zh) | 2011-03-28 | 2020-10-13 | 梅制药公司 | 化合物、含有其的药物组合物以及它们在治疗增生性疾病中的用途 |
| BR112016023811B8 (pt) * | 2014-04-22 | 2023-01-10 | Piqur Therapeutics Ag | Método para fabricação para derivados de triazina, pirimidina e piridina, seus intermediários e seus métodos de fabricação |
| JP6397577B2 (ja) * | 2014-12-17 | 2018-09-26 | シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドＳｈａｎｇｈａｉ Ｈａｉｙａｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | ２−モルホリノ−４，６−二置換ピリミジン誘導体、その製法および医薬における使用 |
| PT3416957T (pt) | 2016-02-19 | 2020-09-25 | Sprint Bioscience Ab | Compostos 6-heterociclil-4-morfolin-4-ilpiridin-2-ona úteis para o tratamento do cancro e da diabetes |
| WO2017210545A1 (en) | 2016-06-02 | 2017-12-07 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| CN112189012B (zh) * | 2018-04-10 | 2024-02-13 | 神经孔疗法股份有限公司 | 作为pi3激酶和自噬途径的调节剂的三取代芳基和杂芳基衍生物 |
| US11236079B2 (en) | 2018-04-10 | 2022-02-01 | Neuropore Therapies, Inc. | Morpholine derivates as inhibitors of Vps34 |
-
2019
- 2019-04-09 CN CN201980032054.7A patent/CN112189012B/zh active Active
- 2019-04-09 EP EP19719101.8A patent/EP3774783B1/en active Active
- 2019-04-09 KR KR1020207032213A patent/KR102803762B1/ko active Active
- 2019-04-09 JP JP2020555501A patent/JP7369139B2/ja active Active
- 2019-04-09 US US17/046,746 patent/US11492348B2/en active Active
- 2019-04-09 MX MX2020010576A patent/MX2020010576A/es unknown
- 2019-04-09 ES ES19719101T patent/ES3032793T3/es active Active
- 2019-04-09 SG SG11202008832TA patent/SG11202008832TA/en unknown
- 2019-04-09 EA EA202092444A patent/EA202092444A1/ru unknown
- 2019-04-09 WO PCT/US2019/026634 patent/WO2019199864A1/en not_active Ceased
- 2019-04-09 AU AU2019251360A patent/AU2019251360B2/en active Active
-
2022
- 2022-11-07 US US17/982,425 patent/US12049462B2/en active Active
-
2024
- 2024-06-12 US US18/741,572 patent/US12637450B2/en active Active
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