JP2023126265A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2023126265A5 JP2023126265A5 JP2023102781A JP2023102781A JP2023126265A5 JP 2023126265 A5 JP2023126265 A5 JP 2023126265A5 JP 2023102781 A JP2023102781 A JP 2023102781A JP 2023102781 A JP2023102781 A JP 2023102781A JP 2023126265 A5 JP2023126265 A5 JP 2023126265A5
- Authority
- JP
- Japan
- Prior art keywords
- til population
- cells
- population
- til
- tils
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 159
- 238000000034 method Methods 0.000 claims 75
- 210000003162 effector t lymphocyte Anatomy 0.000 claims 23
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 23
- 230000001225 therapeutic effect Effects 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 21
- 239000006143 cell culture medium Substances 0.000 claims 20
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 18
- 108010002350 Interleukin-2 Proteins 0.000 claims 16
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 13
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 13
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 13
- 102100021260 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Human genes 0.000 claims 10
- 101000894906 Homo sapiens Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Proteins 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 238000012258 culturing Methods 0.000 claims 7
- 230000003247 decreasing effect Effects 0.000 claims 7
- 102100027207 CD27 antigen Human genes 0.000 claims 5
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 5
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 5
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 5
- 102000055501 telomere Human genes 0.000 claims 5
- 108091035539 telomere Proteins 0.000 claims 5
- 210000003411 telomere Anatomy 0.000 claims 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- 230000002503 metabolic effect Effects 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 238000003860 storage Methods 0.000 claims 4
- 230000002463 transducing effect Effects 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 230000005754 cellular signaling Effects 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 230000026683 transduction Effects 0.000 claims 2
- 238000010361 transduction Methods 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- -1 OKT-3 Proteins 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 230000034659 glycolysis Effects 0.000 claims 1
- 230000002414 glycolytic effect Effects 0.000 claims 1
- 230000010034 metabolic health Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025167603A JP2026012189A (ja) | 2016-10-26 | 2025-10-03 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413387P | 2016-10-26 | 2016-10-26 | |
| US201662413283P | 2016-10-26 | 2016-10-26 | |
| US62/413,387 | 2016-10-26 | ||
| US62/413,283 | 2016-10-26 | ||
| US201662415452P | 2016-10-31 | 2016-10-31 | |
| US62/415,452 | 2016-10-31 | ||
| JP2019521434A JP2019532652A (ja) | 2016-10-26 | 2017-10-26 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
| PCT/US2017/058610 WO2018081473A1 (en) | 2016-10-26 | 2017-10-26 | Restimulation of cryopreserved tumor infiltrating lymphocytes |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521434A Division JP2019532652A (ja) | 2016-10-26 | 2017-10-26 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025167603A Division JP2026012189A (ja) | 2016-10-26 | 2025-10-03 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023126265A JP2023126265A (ja) | 2023-09-07 |
| JP2023126265A5 true JP2023126265A5 (https=) | 2023-11-01 |
Family
ID=60327390
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521434A Pending JP2019532652A (ja) | 2016-10-26 | 2017-10-26 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
| JP2023102781A Pending JP2023126265A (ja) | 2016-10-26 | 2023-06-22 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
| JP2025167603A Pending JP2026012189A (ja) | 2016-10-26 | 2025-10-03 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521434A Pending JP2019532652A (ja) | 2016-10-26 | 2017-10-26 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025167603A Pending JP2026012189A (ja) | 2016-10-26 | 2025-10-03 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Country Status (24)
| Country | Link |
|---|---|
| US (22) | US11026974B2 (https=) |
| EP (2) | EP4180520A1 (https=) |
| JP (3) | JP2019532652A (https=) |
| KR (2) | KR20190066073A (https=) |
| CN (1) | CN110099998A (https=) |
| AU (1) | AU2017347851B2 (https=) |
| BR (1) | BR112019008305A2 (https=) |
| CA (1) | CA3041678A1 (https=) |
| DK (1) | DK3532607T3 (https=) |
| ES (1) | ES2977118T3 (https=) |
| FI (1) | FI3532607T3 (https=) |
| HR (1) | HRP20240436T1 (https=) |
| HU (1) | HUE066460T2 (https=) |
| IL (1) | IL266209B2 (https=) |
| LT (1) | LT3532607T (https=) |
| MD (1) | MD3532607T2 (https=) |
| MX (2) | MX2019004707A (https=) |
| PL (1) | PL3532607T3 (https=) |
| PT (1) | PT3532607T (https=) |
| RS (1) | RS65448B1 (https=) |
| SG (1) | SG11201903331QA (https=) |
| SI (1) | SI3532607T1 (https=) |
| SM (1) | SMT202400133T1 (https=) |
| WO (1) | WO2018081473A1 (https=) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
| CN109843921B (zh) | 2016-07-07 | 2023-05-26 | 艾欧凡斯生物治疗公司 | 程序性死亡1配体1(pd-l1)结合蛋白及其应用方法 |
| MX2019004707A (es) | 2016-10-26 | 2019-08-12 | Iovance Biotherapeutics Inc | Reestimulacion de linfocitos infiltrantes de tumor crioconservados. |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| US11401507B2 (en) | 2016-11-17 | 2022-08-02 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| BR112019024556A2 (pt) | 2017-05-24 | 2020-06-23 | Novartis Ag | Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer |
| EP3635097A1 (en) | 2017-06-05 | 2020-04-15 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
| EP4501408A3 (en) * | 2017-11-17 | 2025-04-09 | Iovance Biotherapeutics, Inc. | Til expansion from fine needle aspirates and small biopsies |
| SG11202006541UA (en) | 2018-01-08 | 2020-08-28 | Iovance Biotherapeutics Inc | Processes for generating til products enriched for tumor antigen-specific t-cells |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| US20190284553A1 (en) | 2018-03-15 | 2019-09-19 | KSQ Therapeutics, Inc. | Gene-regulating compositions and methods for improved immunotherapy |
| US20210130779A1 (en) | 2018-04-27 | 2021-05-06 | Iovance Biotherapeutics, Inc. | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| WO2019217753A1 (en) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| TW202031273A (zh) * | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | 抗ｐｄ－１抗體難治療性之非小細胞肺癌（ｎｓｃｌｃ）病患的治療 |
| CA3112599A1 (en) * | 2018-09-20 | 2020-03-26 | Iovance Biotherapeutics, Inc. | Expansion of tils from cryopreserved tumor samples |
| JP7600123B2 (ja) | 2018-10-15 | 2024-12-16 | ニューリックス セラピューティクス，インコーポレイテッド | ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物 |
| TW202039830A (zh) | 2018-11-05 | 2020-11-01 | 美商艾歐凡斯生物治療公司 | 用於製造腫瘤浸潤性淋巴細胞之方法及其在免疫療法中之用途 |
| CA3118493A1 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Expansion of tils utilizing akt pathway inhibitors |
| US20230039976A1 (en) * | 2018-11-05 | 2023-02-09 | Iovance Biotherapeutics, Inc. | Selection of improved tumor reactive t-cells |
| TW202039831A (zh) | 2018-11-05 | 2020-11-01 | 美商艾歐凡斯生物治療公司 | 對抗ｐｄ－１抗體呈現難治性之非小細胞肺癌（ｎｓｃｌｃ）病患之治療 |
| JP7710372B2 (ja) | 2018-12-19 | 2025-07-18 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 操作されたサイトカイン受容体対を使用して腫瘍浸潤リンパ球を拡大培養する方法及びその使用 |
| WO2020167518A1 (en) | 2019-02-13 | 2020-08-20 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
| US20220133795A1 (en) * | 2019-03-01 | 2022-05-05 | Iovance Biotherapeutics, Inc. | Expansion of Tumor Infiltrating Lymphocytes From Liquid Tumors and Therapeutic Uses Thereof |
| US20220249559A1 (en) | 2019-05-13 | 2022-08-11 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| GB201911066D0 (en) | 2019-08-02 | 2019-09-18 | Achilles Therapeutics Ltd | T cell therapy |
| US11820781B2 (en) | 2019-12-04 | 2023-11-21 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway |
| US12516291B2 (en) | 2019-12-11 | 2026-01-06 | Iovance Biotherapeutics, Inc. | Processes for the production of tumor infiltrating lymphocytes (TILs) and methods of using the same |
| WO2021123832A1 (en) | 2019-12-20 | 2021-06-24 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
| CA3166420A1 (en) | 2020-01-14 | 2021-07-22 | Synthekine, Inc. | Il2 orthologs and methods of use |
| JP7817937B2 (ja) * | 2020-02-27 | 2026-02-19 | ターンストーン バイオロジクス コーポレイション | 腫瘍反応性ｔ細胞のエクスビボ富化および増大のための方法ならびに関連するその組成物 |
| EP3892720A1 (en) | 2020-04-06 | 2021-10-13 | Innovative Cellular Therapeutics Holdings, Ltd. | Presenting cell and use thereof in cell therapy |
| US12159700B2 (en) | 2020-04-22 | 2024-12-03 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| US12365871B2 (en) | 2020-04-28 | 2025-07-22 | Lyell Immunopharma, Inc. | Methods for culturing cells |
| WO2021219990A1 (en) | 2020-04-28 | 2021-11-04 | Achilles Therapeutics Uk Limited | T cell therapy |
| CN116018158A (zh) * | 2020-04-30 | 2023-04-25 | 转化基因组学研究所 | 新抗原知情的肿瘤浸润性淋巴细胞癌免疫疗法 |
| TW202208616A (zh) | 2020-05-04 | 2022-03-01 | 美商艾歐凡斯生物治療公司 | 改良之腫瘤反應性ｔ細胞的選擇 |
| EP4146794A1 (en) | 2020-05-04 | 2023-03-15 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| JP7785699B2 (ja) | 2020-05-29 | 2025-12-15 | シャンハイ ジュンセル セラピューティクス カンパニー リミテッド | 腫瘍浸潤リンパ球の種細胞培地及びその使用 |
| JP2023542539A (ja) * | 2020-09-24 | 2023-10-10 | ザ ジャクソン ラボラトリー | 免疫細胞療法を評価するためのヒト化マウスモデル |
| US20230372397A1 (en) * | 2020-10-06 | 2023-11-23 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| CN114901805B (zh) * | 2020-11-19 | 2023-07-25 | 苏州沙砾生物科技有限公司 | 肿瘤浸润淋巴细胞的培养方法及其用途 |
| TW202241468A (zh) | 2020-12-11 | 2022-11-01 | 美商艾歐凡斯生物治療公司 | 用腫瘤浸潤性淋巴球療法與ｂｒａｆ抑制劑及／或ｍｅｋ抑制劑組合治療癌症患者 |
| US20240123067A1 (en) * | 2020-12-17 | 2024-04-18 | Iovance Biotherapeutics, Inc. | Treatment of cancers with tumor infiltrating lymphocyte therapies |
| CA3202483A1 (en) | 2020-12-17 | 2022-06-23 | Maria Fardis | Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors |
| CN114686430A (zh) * | 2020-12-31 | 2022-07-01 | 上海赛比曼生物科技有限公司 | 一种制备til的方法 |
| TW202241508A (zh) | 2021-01-29 | 2022-11-01 | 美商艾歐凡斯生物治療公司 | 細胞介素相關之腫瘤浸潤性淋巴球組合物及方法 |
| CA3207359A1 (en) | 2021-02-05 | 2022-08-11 | Cecile Chartier-Courtaud | Adjuvant therapy for cancer |
| WO2022198141A1 (en) | 2021-03-19 | 2022-09-22 | Iovance Biotherapeutics, Inc. | Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils |
| AU2022246174A1 (en) | 2021-03-25 | 2023-09-14 | Iovance Biotherapeutics, Inc. | Methods and compositions for t-cell coculture potency assays and use with cell therapy products |
| EP4320435A1 (en) | 2021-04-09 | 2024-02-14 | Achilles Therapeutics UK Limited | Batch release assay for pharmaceutical products relating to t cell therapies |
| GB202109886D0 (en) | 2021-07-08 | 2021-08-25 | Achilles Therapeutics Uk Ltd | Assay |
| EP4326287A2 (en) | 2021-04-19 | 2024-02-28 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
| WO2022245754A1 (en) | 2021-05-17 | 2022-11-24 | Iovance Biotherapeutics, Inc. | Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy |
| WO2022269250A1 (en) | 2021-06-22 | 2022-12-29 | Achilles Therapeutics Uk Limited | A method for producing antigen-specific t cells |
| TW202310857A (zh) * | 2021-06-24 | 2023-03-16 | 美商英斯特生物科技股份有限公司 | 腫瘤浸潤淋巴球之處理 |
| US20240365776A1 (en) | 2021-07-22 | 2024-11-07 | Iovance Biotherapeutics, Inc | Method for cryopreservation of solid tumor fragments |
| US20240342285A1 (en) | 2021-07-28 | 2024-10-17 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors |
| US20240358835A1 (en) * | 2021-08-17 | 2024-10-31 | Orgenesis Inc. | Tumor infiltrating lymphocytes with increased metabolic activity |
| IL311333A (en) | 2021-09-09 | 2024-05-01 | Iovance Biotherapeutics Inc | Processes for generating til products using pd-1 talen knockdown |
| AU2022379494A1 (en) | 2021-10-26 | 2024-05-30 | Nurix Therapeutics, Inc. | Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk |
| WO2023077015A2 (en) | 2021-10-27 | 2023-05-04 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| EP4430167A1 (en) | 2021-11-10 | 2024-09-18 | Iovance Biotherapeutics, Inc. | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
| WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
| WO2023147488A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
| US20250101380A1 (en) | 2022-01-28 | 2025-03-27 | Iovance Biotherapeutics, Inc. | Tumor infiltrating lymphocytes engineered to express payloads |
| US20250222027A1 (en) | 2022-04-01 | 2025-07-10 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| EP4504220A1 (en) | 2022-04-06 | 2025-02-12 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| CA3248034A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics, Inc. | METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT |
| EP4522202A1 (en) | 2022-05-10 | 2025-03-19 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with an il-15r agonist |
| EP4565683A1 (en) | 2022-08-01 | 2025-06-11 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
| EP4583890A1 (en) | 2022-09-09 | 2025-07-16 | Iovance Biotherapeutics, Inc. | Processes for generating til products using pd-1/tigit talen double knockdown |
| EP4583889A1 (en) | 2022-09-09 | 2025-07-16 | Iovance Biotherapeutics, Inc. | Processes for generating til products using pd-1/tigit talen double knockdown |
| WO2024098027A1 (en) | 2022-11-04 | 2024-05-10 | Iovance Biotherapeutics, Inc. | Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection |
| WO2024112711A2 (en) | 2022-11-21 | 2024-05-30 | Iovance Biotherapeutics, Inc. | Methods for assessing proliferation potency of gene-edited t cells |
| EP4623072A2 (en) | 2022-11-21 | 2025-10-01 | Iovance Biotherapeutics, Inc. | Two-dimensional processes for the expansion of tumor infiltrating lymphocytes and therapies therefrom |
| WO2024118836A1 (en) | 2022-11-30 | 2024-06-06 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes with shortened rep step |
| WO2025054540A1 (en) | 2023-09-08 | 2025-03-13 | Iovance Biotherapeutics, Inc. | Methods of gene-editing using programmable nucleases |
| WO2025101484A1 (en) | 2023-11-06 | 2025-05-15 | Iovance Biotherapeutics, Inc. | Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| AU7873187A (en) | 1986-08-08 | 1988-02-24 | University Of Minnesota | Method of culturing leukocytes |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US7479269B2 (en) | 1988-11-23 | 2009-01-20 | Genetics Institute, Llc | Methods for selectively enriching TH1 and TH2 cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5126132A (en) | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| ES2382636T3 (es) | 2000-10-31 | 2012-06-12 | Surmodics Pharmaceuticals, Inc. | Método para producir composiciones para la administración mejorada de moléculas bioactivas |
| US20050084967A1 (en) | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| WO2004003142A2 (en) | 2002-06-28 | 2004-01-08 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| AU2003265948B8 (en) | 2002-09-06 | 2009-09-03 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| ITMI20022118A1 (it) | 2002-10-04 | 2004-04-05 | Abiogen Pharma Spa | Procedimento per la coltura su larga scala di t-linfociti in un sistema omogeneo. |
| CN101120083B (zh) | 2003-10-08 | 2013-03-27 | 威尔森沃尔夫制造公司 | 利用透气性材料进行细胞培养的方法及装置 |
| RU2494107C2 (ru) | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
| US8206702B2 (en) | 2005-12-21 | 2012-06-26 | Sentoclone International Ab | Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with cancer |
| EP1966370B1 (en) | 2005-12-21 | 2013-02-20 | SentoClone International AB | Method for obtaining T-lymphocytes |
| US8211424B2 (en) | 2005-12-21 | 2012-07-03 | Sentoclone International Ab | Method for treating malignant melanoma |
| US8007785B2 (en) | 2005-12-21 | 2011-08-30 | Sentoclone International Ab | Method for treating colon cancer with tumour-reactive T-lymphocytes |
| US7951365B2 (en) | 2007-06-27 | 2011-05-31 | Deifiera Falun Ab | Method for expansion of tumour-reactive T-lymphocytes for immunotherapy of patients with specific cancer types |
| EP2203746B1 (en) | 2007-09-24 | 2013-03-06 | Technion Research & Development Foundation Ltd. | T cell subpopulations capable of treating cancer |
| WO2014085437A2 (en) | 2012-11-27 | 2014-06-05 | The Johns Hopkins University | Use of post-transplant cyclophosphamide treated allogeneic marrow infiltrating lymphocytes to augment anti-tumor immunity |
| US20150320798A1 (en) | 2012-11-27 | 2015-11-12 | The Johns Hopkins University | Use of Post-Transplant Cyclophosphamide Treated Allogeneic Marrow Infiltrating Lymphocytes to Augment Anti-Tumor Immunity |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| US8956860B2 (en) | 2009-12-08 | 2015-02-17 | Juan F. Vera | Methods of cell culture for adoptive cell therapy |
| US8809050B2 (en) | 2009-12-08 | 2014-08-19 | Wilson Wolf Manufacturing | Methods of cell culture for adoptive cell therapy |
| US20130115617A1 (en) | 2009-12-08 | 2013-05-09 | John R. Wilson | Methods of cell culture for adoptive cell therapy |
| ES2866674T3 (es) | 2010-11-12 | 2021-10-19 | Nektar Therapeutics | Conjugados de una fracción de IL-2 y un polímero |
| WO2012129201A1 (en) | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| EP2697367B1 (en) | 2011-04-13 | 2018-12-19 | Immunicum AB | Method for proliferation of antigen-specific t cells |
| AU2012324644B2 (en) | 2011-10-21 | 2014-08-28 | Cell Medica Limited | Device for the aseptic expansion of cells |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| CN102816734A (zh) | 2012-05-09 | 2012-12-12 | 阮润生 | 一种肿瘤抗原特异性t细胞的获取方法 |
| SG11201407226WA (en) | 2012-05-18 | 2014-12-30 | Wolf Wilson Mfg Corp | Improved methods of cell culture for adoptive cell therapy |
| CN104411819B (zh) | 2012-06-11 | 2019-05-10 | 威尔逊沃夫制造公司 | 用于过继细胞疗法的改进的细胞培养方法 |
| RU2671897C2 (ru) | 2013-03-01 | 2018-11-07 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | Способы получения из опухоли обогащенных популяций реактивных в отношении опухоли т-клеток |
| EP3628322A1 (en) | 2013-03-01 | 2020-04-01 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Cd8+ t cells that also express pd-1 and/or tim-3 for the treatment of cancer |
| CN103396991A (zh) * | 2013-05-02 | 2013-11-20 | 陈晚华 | 一种快速高效扩增肿瘤浸润性淋巴细胞的方法 |
| CN118562610A (zh) | 2013-06-24 | 2024-08-30 | 威尔逊沃夫制造公司 | 用于透气性细胞培养过程的封闭系统装置和方法 |
| JP6616295B2 (ja) | 2013-07-15 | 2019-12-04 | アメリカ合衆国 | 抗ヒトパピローマウイルス抗原ｔ細胞の調製方法 |
| WO2015039100A1 (en) | 2013-09-16 | 2015-03-19 | The Trustees Of The University Of Pennsylvania | Cd137 enrichment for efficient tumor infiltrating lymphocyte selection |
| JP2017511375A (ja) | 2014-03-20 | 2017-04-20 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 養子細胞療法のための腫瘍浸潤リンパ球 |
| WO2015157636A1 (en) * | 2014-04-10 | 2015-10-15 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy |
| AU2015273501B2 (en) | 2014-06-11 | 2021-01-21 | Polybiocept Gmbh | Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy |
| EP3155426B1 (en) | 2014-06-13 | 2023-07-19 | Immudex ApS | General detection and isolation of specific cells by binding of labeled molecules |
| US9687510B2 (en) | 2014-09-04 | 2017-06-27 | The Johns Hopkins University | Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions |
| AU2014407539B2 (en) | 2014-10-02 | 2020-10-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation |
| EP3034092A1 (en) * | 2014-12-17 | 2016-06-22 | Université de Lausanne | Adoptive immunotherapy for treating cancer |
| US10544392B2 (en) | 2015-05-01 | 2020-01-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cells and T cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood |
| FR3038324B1 (fr) | 2015-06-30 | 2020-10-30 | Lab Francais Du Fractionnement | Procede de cryoconservation de cellules a visee therapeutique |
| FR3040396A1 (fr) | 2015-06-30 | 2017-03-03 | Chu Nantes | Procede de cryoconservation de lymphocytes infiltrant la tumeur |
| WO2017048614A1 (en) | 2015-09-15 | 2017-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating tumor-reactive t cell receptors from tumor or peripheral blood |
| SG11201803330WA (en) | 2015-10-22 | 2018-05-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| CN108463547A (zh) | 2015-10-28 | 2018-08-28 | 生命技术股份公司 | 通过改变细胞表面信号和信号比选择性扩增不同的t细胞亚群 |
| CN105602901B (zh) * | 2016-03-11 | 2020-01-31 | 广州赛莱拉干细胞科技股份有限公司 | 生物反应器及其搅拌桨和使用其培养til细胞的方法 |
| KR20190037243A (ko) | 2016-06-28 | 2019-04-05 | 지니우스 바이오테크놀로지 인코포레이티드 | 면역치료를 위한 티 세포 조성물 |
| CN106244538A (zh) | 2016-08-04 | 2016-12-21 | 英普乐孚生物技术(上海)有限公司 | 一种恶性腹水来源的til细胞的分离培养方法 |
| KR102561356B1 (ko) | 2016-09-14 | 2023-08-03 | 애브비 바이오테라퓨틱스 인크. | 항-pd-1 항체 및 이의 용도 |
| MX2019004707A (es) | 2016-10-26 | 2019-08-12 | Iovance Biotherapeutics Inc | Reestimulacion de linfocitos infiltrantes de tumor crioconservados. |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| US11401507B2 (en) * | 2016-11-17 | 2022-08-02 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| WO2018102761A1 (en) | 2016-12-02 | 2018-06-07 | City Of Hope | Methods for manufacturing and expanding t cells expressing chimeric antigen receptors and other receptors |
| CN106591232A (zh) | 2017-01-04 | 2017-04-26 | 安徽安龙基因医学检验所有限公司 | 一种高效的pd‑1‑cd8+t细胞的培养方法 |
| BR112019013940A2 (pt) | 2017-01-06 | 2020-02-11 | Iovance Biotherapeutics, Inc. | Método de tratar um câncer com uma população de linfócitos infiltrantes de tumor, processo para preparação de uma população de linfócitos infiltrantes de tumor, população de linfócitos infiltrantes de tumor, e, composição farmacêutica. |
| CA3049165A1 (en) * | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| SG11201908271WA (en) | 2017-03-14 | 2019-10-30 | Juno Therapeutics Inc | Methods for cryogenic storage |
| US11254913B1 (en) * | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| JOP20190224A1 (ar) * | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| US20200224161A1 (en) | 2017-05-10 | 2020-07-16 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| EP3635097A1 (en) | 2017-06-05 | 2020-04-15 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
| CN107384867B (zh) | 2017-08-04 | 2020-09-11 | 北京世纪劲得生物技术有限公司 | 一种肿瘤组织til细胞制备方法及专用培养基 |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| US12159700B2 (en) * | 2020-04-22 | 2024-12-03 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| US11918517B2 (en) * | 2021-10-07 | 2024-03-05 | Stryker Corporation | Cover systems for blocking apertures of patient support apparatuses |
-
2017
- 2017-10-26 MX MX2019004707A patent/MX2019004707A/es unknown
- 2017-10-26 PL PL17798045.5T patent/PL3532607T3/pl unknown
- 2017-10-26 JP JP2019521434A patent/JP2019532652A/ja active Pending
- 2017-10-26 ES ES17798045T patent/ES2977118T3/es active Active
- 2017-10-26 HR HRP20240436TT patent/HRP20240436T1/hr unknown
- 2017-10-26 IL IL266209A patent/IL266209B2/en unknown
- 2017-10-26 US US15/751,440 patent/US11026974B2/en active Active
- 2017-10-26 CN CN201780080304.5A patent/CN110099998A/zh active Pending
- 2017-10-26 BR BR112019008305-7A patent/BR112019008305A2/pt active Search and Examination
- 2017-10-26 RS RS20240474A patent/RS65448B1/sr unknown
- 2017-10-26 SI SI201731498T patent/SI3532607T1/sl unknown
- 2017-10-26 FI FIEP17798045.5T patent/FI3532607T3/fi active
- 2017-10-26 SG SG11201903331QA patent/SG11201903331QA/en unknown
- 2017-10-26 EP EP22203248.4A patent/EP4180520A1/en active Pending
- 2017-10-26 SM SM20240133T patent/SMT202400133T1/it unknown
- 2017-10-26 AU AU2017347851A patent/AU2017347851B2/en active Active
- 2017-10-26 PT PT177980455T patent/PT3532607T/pt unknown
- 2017-10-26 WO PCT/US2017/058610 patent/WO2018081473A1/en not_active Ceased
- 2017-10-26 MD MDE20190983T patent/MD3532607T2/ro unknown
- 2017-10-26 KR KR1020197014832A patent/KR20190066073A/ko not_active Ceased
- 2017-10-26 KR KR1020247032982A patent/KR20240150531A/ko not_active Ceased
- 2017-10-26 CA CA3041678A patent/CA3041678A1/en active Pending
- 2017-10-26 HU HUE17798045A patent/HUE066460T2/hu unknown
- 2017-10-26 DK DK17798045.5T patent/DK3532607T3/da active
- 2017-10-26 EP EP17798045.5A patent/EP3532607B1/en active Active
- 2017-10-26 LT LTEPPCT/US2017/058610T patent/LT3532607T/lt unknown
-
2018
- 2018-02-08 US US15/892,331 patent/US10517894B2/en active Active
-
2019
- 2019-04-23 MX MX2024004500A patent/MX2024004500A/es unknown
-
2021
- 2021-04-08 US US17/225,993 patent/US11058728B1/en active Active
- 2021-04-16 US US17/233,290 patent/US11179419B2/en active Active
- 2021-04-16 US US17/233,299 patent/US11141438B2/en active Active
- 2021-04-16 US US17/233,295 patent/US11123371B2/en active Active
- 2021-08-27 US US17/459,988 patent/US11304980B2/en active Active
- 2021-09-21 US US17/480,916 patent/US11351197B2/en active Active
- 2021-09-21 US US17/480,900 patent/US11311578B2/en active Active
- 2021-09-21 US US17/480,919 patent/US11351198B2/en active Active
- 2021-09-21 US US17/480,941 patent/US11266694B2/en active Active
- 2021-09-21 US US17/480,935 patent/US11344580B2/en active Active
- 2021-12-09 US US17/547,192 patent/US11351199B2/en active Active
- 2021-12-09 US US17/547,190 patent/US11344581B2/en active Active
- 2021-12-11 US US17/548,504 patent/US11369637B2/en active Active
- 2021-12-11 US US17/548,502 patent/US11364266B2/en active Active
-
2022
- 2022-05-31 US US17/829,087 patent/US20220378837A1/en active Pending
- 2022-08-11 US US17/819,209 patent/US11857573B2/en active Active
- 2022-08-11 US US17/819,214 patent/US11969444B2/en active Active
- 2022-08-11 US US17/819,219 patent/US11975028B2/en active Active
- 2022-08-15 US US17/819,909 patent/US12188048B2/en active Active
- 2022-08-15 US US17/819,910 patent/US11865140B2/en active Active
-
2023
- 2023-06-22 JP JP2023102781A patent/JP2023126265A/ja active Pending
-
2025
- 2025-10-03 JP JP2025167603A patent/JP2026012189A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023126265A5 (https=) | ||
| FI3532607T3 (fi) | Kryosäilytettyjen kasvaimiin infiltroituvien lymfosyyttien uudelleen stimulointi | |
| JP2020515257A5 (https=) | ||
| Farber et al. | Human memory T cells: generation, compartmentalization and homeostasis | |
| Klapper et al. | Single-pass, closed-system rapid expansion of lymphocyte cultures for adoptive cell therapy | |
| IL274584B1 (en) | Til expansion from fine needle aspirates and small biopsies | |
| JP2024041873A5 (https=) | ||
| JP2021511790A5 (https=) | ||
| JP2021104048A5 (https=) | ||
| CN104938477B (zh) | 一种cik细胞冻存液及冻存方法 | |
| FI3722415T3 (fi) | Prosesseja kasvaimeen tunkeutuvien lymfosyyttien tuottamiseksi ja niiden käyttöjä immunoterapiassa | |
| JPWO2019210131A5 (https=) | ||
| Arsuaga et al. | The Gravettian occipital bone from the site of Malladetes (Barx, Valencia, Spain) | |
| Luo et al. | The state of T cells before cryopreservation: Effects on post-thaw proliferation and function | |
| CN108977494B (zh) | 一种预测药物疗效的方法 | |
| JPWO2020112493A5 (https=) | ||
| CN112813029B (zh) | 一种髓母细胞瘤细胞的3d培养方法及其在药物筛选中的应用 | |
| CN110628699B (zh) | 一种肺硬度基底体外细胞培养平台的制备方法 | |
| CN108486055B (zh) | 培养基及其在中央记忆型t淋巴细胞培养中的应用 | |
| Erlichman et al. | Growth and characterization of multicellular tumor spheroids of human bladder carcinoma origin | |
| JPWO2021092097A5 (https=) | ||
| Wardell et al. | A cryopreserved tumor infiltrating lymphocyte (TIL) product for LN-144, generated with an abbreviated method suitable for high throughput commercial manufacturing exhibits favorable quality attributes for adoptive cell transfer [poster] | |
| Qin et al. | Study on the relationship between immune cell infiltration pattern and clinical characteristics and prognosis of cervical cancer based on TCGA database. | |
| Mbuguiro et al. | Computational modeling of hormone-and cytokine-dependent proliferation of endometrial cells in 3D co-culture | |
| Felgueres et al. | Selective expansion of anti-tumor innate lymphocytes in long-term cultures after a single BCG pulse |