JP2023126265A5 - - Google Patents
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- JP2023126265A5 JP2023126265A5 JP2023102781A JP2023102781A JP2023126265A5 JP 2023126265 A5 JP2023126265 A5 JP 2023126265A5 JP 2023102781 A JP2023102781 A JP 2023102781A JP 2023102781 A JP2023102781 A JP 2023102781A JP 2023126265 A5 JP2023126265 A5 JP 2023126265A5
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- Prior art keywords
- til population
- cells
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- til
- tils
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 159
- 238000000034 method Methods 0.000 claims 75
- 210000003162 effector t lymphocyte Anatomy 0.000 claims 23
- 210000003071 memory t lymphocyte Anatomy 0.000 claims 23
- 230000001225 therapeutic effect Effects 0.000 claims 23
- 210000004027 cell Anatomy 0.000 claims 21
- 239000006143 cell culture medium Substances 0.000 claims 20
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 18
- 108010002350 Interleukin-2 Proteins 0.000 claims 16
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 13
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 13
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 13
- 102100021260 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Human genes 0.000 claims 10
- 101000894906 Homo sapiens Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Proteins 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 238000012258 culturing Methods 0.000 claims 7
- 230000003247 decreasing effect Effects 0.000 claims 7
- 102100027207 CD27 antigen Human genes 0.000 claims 5
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 5
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 5
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 5
- 102000055501 telomere Human genes 0.000 claims 5
- 108091035539 telomere Proteins 0.000 claims 5
- 210000003411 telomere Anatomy 0.000 claims 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 4
- 239000002609 medium Substances 0.000 claims 4
- 230000002503 metabolic effect Effects 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 238000003860 storage Methods 0.000 claims 4
- 230000002463 transducing effect Effects 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 3
- 230000001747 exhibiting effect Effects 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 230000005754 cellular signaling Effects 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 230000026683 transduction Effects 0.000 claims 2
- 238000010361 transduction Methods 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- -1 OKT-3 Proteins 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 230000034659 glycolysis Effects 0.000 claims 1
- 230000002414 glycolytic effect Effects 0.000 claims 1
- 230000010034 metabolic health Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 238000010257 thawing Methods 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025167603A JP2026012189A (ja) | 2016-10-26 | 2025-10-03 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413387P | 2016-10-26 | 2016-10-26 | |
| US201662413283P | 2016-10-26 | 2016-10-26 | |
| US62/413,387 | 2016-10-26 | ||
| US62/413,283 | 2016-10-26 | ||
| US201662415452P | 2016-10-31 | 2016-10-31 | |
| US62/415,452 | 2016-10-31 | ||
| JP2019521434A JP2019532652A (ja) | 2016-10-26 | 2017-10-26 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
| PCT/US2017/058610 WO2018081473A1 (en) | 2016-10-26 | 2017-10-26 | Restimulation of cryopreserved tumor infiltrating lymphocytes |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521434A Division JP2019532652A (ja) | 2016-10-26 | 2017-10-26 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025167603A Division JP2026012189A (ja) | 2016-10-26 | 2025-10-03 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023126265A JP2023126265A (ja) | 2023-09-07 |
| JP2023126265A5 true JP2023126265A5 (enExample) | 2023-11-01 |
Family
ID=60327390
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521434A Pending JP2019532652A (ja) | 2016-10-26 | 2017-10-26 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
| JP2023102781A Pending JP2023126265A (ja) | 2016-10-26 | 2023-06-22 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
| JP2025167603A Pending JP2026012189A (ja) | 2016-10-26 | 2025-10-03 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521434A Pending JP2019532652A (ja) | 2016-10-26 | 2017-10-26 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025167603A Pending JP2026012189A (ja) | 2016-10-26 | 2025-10-03 | 凍結保存腫瘍浸潤リンパ球の再刺激 |
Country Status (24)
| Country | Link |
|---|---|
| US (22) | US11026974B2 (enExample) |
| EP (2) | EP3532607B1 (enExample) |
| JP (3) | JP2019532652A (enExample) |
| KR (2) | KR20240150531A (enExample) |
| CN (1) | CN110099998A (enExample) |
| AU (1) | AU2017347851B2 (enExample) |
| BR (1) | BR112019008305A2 (enExample) |
| CA (1) | CA3041678A1 (enExample) |
| DK (1) | DK3532607T3 (enExample) |
| ES (1) | ES2977118T3 (enExample) |
| FI (1) | FI3532607T3 (enExample) |
| HR (1) | HRP20240436T1 (enExample) |
| HU (1) | HUE066460T2 (enExample) |
| IL (1) | IL266209B2 (enExample) |
| LT (1) | LT3532607T (enExample) |
| MD (1) | MD3532607T2 (enExample) |
| MX (2) | MX2019004707A (enExample) |
| PL (1) | PL3532607T3 (enExample) |
| PT (1) | PT3532607T (enExample) |
| RS (1) | RS65448B1 (enExample) |
| SG (1) | SG11201903331QA (enExample) |
| SI (1) | SI3532607T1 (enExample) |
| SM (1) | SMT202400133T1 (enExample) |
| WO (1) | WO2018081473A1 (enExample) |
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| KR102618948B1 (ko) | 2016-11-17 | 2023-12-27 | 이오반스 바이오테라퓨틱스, 인크. | 잔유 종양 침윤 림프구 및 그의 제조 및 사용 방법 |
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