JP2023058027A - Cd80バリアント免疫調節タンパク質及びその使用 - Google Patents
Cd80バリアント免疫調節タンパク質及びその使用 Download PDFInfo
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Abstract
Description
本出願は、2017年3月16日に出願された米国仮特許出願第62/472,558号、2017年3月16日に出願された米国仮特許出願第62/472,569号、2017年3月16日に出願された米国仮特許出願第62/472,554号、2017年3月16日に出願された米国仮特許出願第62/472,572号、2017年3月17日に出願された米国仮特許出願第62/472,573号、2017年3月22日に出願された米国仮特許出願第62/475,204号、2017年7月27日に出願された米国仮特許出願第62/537,939号、2017年10月18日に出願された米国仮特許出願第62/574,165号、及び2017年11月6日に出願された米国仮特許出願第62/582,266号からの優先権を主張するものであり、それらの各々の内容は、参照によりその全体が組み込まれる。
本出願は電子フォーマットの配列表と共に出願されている。配列表は、2018年3月12日に作成された761612001640SeqList.TXTという表題の4,888,576バイトサイズのファイルとして提供される。配列表の電子フォーマットの情報は、参照によりその全体が組み込まれる。
本開示は、がん及び免疫疾患の治療における免疫応答を調節するための治療用組成物に関する。いくつかの態様では、本開示は、コグネイト結合パートナーに対する結合親和性または選択性など、例えばCTLA-4及び/またはPD-L1への親和性の増加、及び/またはCD28への親和性の減少などの、変化した結合を示すCD80の特定のバリアントに関する。
抗原提示細胞(APC)または標的細胞とリンパ球との間で形成される免疫学的シナプス(IS)で起こるプロセスに介入することによる免疫応答の調節に関して医学的関心が高まっている。機械論的には、ISの細胞表面タンパク質は、複数のタンパク質標的と、それらが結合する単一タンパク質との、協調的でありかつ同時に起こることが多い相互作用を、伴うことができる。IS相互作用は、2つの細胞の接合部と密接に関連して起こり、この構造体中の単一タンパク質が、同じ細胞上のタンパク質(シス)及び関連細胞上のタンパク質(トランス)の両方と、恐らく同時に相互作用することができる。ISを調節できる治療薬は知られているが、改善された治療薬が必要である。そのようなニーズを満たす、細胞上で発現可能な可溶性タンパク質または膜貫通型免疫調節タンパク質を含む免疫調節タンパク質が提供される。
いくつかの実施形態では、本明細書では、IgVドメインもしくはその特異的結合断片、IgCドメインもしくはその特異的結合断片、またはその両方を含有するバリアントCD80ポリペプチドが提供され、バリアントCD80ポリペプチドは、SEQ ID NO:2の番号付けに基づいた7、23、26、30、34、35、46、51、55、57、58、65、71、73、78、79、82、及び/または84位に対応する、非改変CD80またはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含有する。いくつかの実施形態では、非改変CD80またはその特異的結合断片の1つまたは複数のアミノ酸改変は、SEQ ID NO:2の番号付けに基づいた26、35、46、57、及び/または71位に対応する。任意の実施形態において、アミノ酸改変は、アミノ酸の置換、挿入、または欠失である。
の中から選択される、1つまたは複数のアミノ酸置換を含有し、該アミノ酸置換の位置(複数可)は、SEQ ID NO:2に記載のCD80の位置の番号付けに対応する。
の中から選択される、CD80またはその特異的結合断片における1つまたは複数のアミノ酸置換が含まれ、該アミノ酸置換の位置(複数可)は、SEQ ID NO:2に記載のCD80の位置の番号付けに対応する。
の中から選択される、1つまたは複数のアミノ酸改変を含み、該アミノ酸置換の位置(複数可)は、SEQ ID NO:2に記載のCD80の位置に対応する。
本明細書では、少なくとも1つの標的リガンドコグネイト結合パートナー(カウンター構造体リガンドタンパク質とも呼ばれる)に対する変化した結合活性または親和性を示すCD80及びその特異的結合断片のバリアントまたは変異体であるか、それらを含有する免疫調節タンパク質が提供される。いくつかの実施形態では、バリアントCD80ポリペプチドは、非改変または野生型CD80ポリペプチドと比較して1つまたは複数のアミノ酸改変(例えば、アミノ酸置換、欠失、または付加)を含有する。いくつかの実施形態では、バリアントCD80ポリペプチドは、非改変または野生型CD80ポリペプチドと比較して1つまたは複数のアミノ酸改変(例えば、置換)を含有する。いくつかの実施形態では、1つまたは複数のアミノ酸改変は、非改変または野生型CD80ポリペプチドのIgSFドメイン(例えば、IgV)においてである。
別段の定義のない限り、本明細書において使用される全ての専門用語、表記、ならびに他の技術及び科学用語または術語は、請求される主題が属する技術分野の当業者によって通常理解されているものと同じ意味を有することを意図する。場合によっては、通常理解されている意味を有する用語は、明確化のため及び/またはすぐに参照できるように本明細書において定義され、そして本明細書におけるこのような定義の包含は、必ずしも一般的に当技術分野において理解されているものと大きな差異をなすと解釈されるべきではない。
1つまたは複数のCD80結合パートナーに対して変化した(増加または減少した)結合活性または親和性を示すバリアントCD80ポリペプチドが本明細書において提供される。いくつかの実施形態では、CD80結合パートナーは、CD28、PD-L1、またはCTLA-4である。いくつかの実施形態では、バリアントCD80ポリペプチドは、免疫グロブリンスーパーファミリー(IgSF)ドメイン(IgD)において、野生型もしくは非改変CD80ポリペプチド、またはIgDを含有する野生型もしくは非改変CD80の一部分、またはそれらの特異的結合断片と比べて、1つまたは複数のアミノ酸改変、例えば1つまたは複数の置換(あるいは、「変異」または「交換」)、欠失、または付加を含有する。したがって、提供されるバリアントCD80ポリペプチドは、1つまたは複数のアミノ酸改変(例えば、置換)がIgDにある、バリアントIgD(以下「vIgD」と呼ばれる)であるか、またはそれを含む。
野生型または非改変CD80ポリペプチドに含有されるIgSFドメインと比べて、少なくとも1つの親和性改変IgSFドメイン(例えば、IgVまたはIgC)またはその特異的結合断片を含有し、その結果、該バリアントCD80ポリペプチドが、野生型または非改変CD80ポリペプチドと比較して、1つまたは複数のコグネイト結合パートナーCTLA-4、PD-L1またはCD28に対して変化した(増加または減少した)結合活性または親和性を示すバリアントCD80ポリペプチドが本明細書において提供される。いくつかの実施形態では、バリアントCD80ポリペプチドは、例えば固相ELISAイムノアッセイ、フローサイトメトリーまたは表面プラズモン共鳴(Biacore)アッセイによって測定した場合に、野生型または非改変CD80ポリペプチド対照配列のものとは異なる、CTLA-4、PD-L1またはCD28に対する結合親和性を有する。いくつかの実施形態では、バリアントCD80ポリペプチドは、CTLA-4、PD-L1及び/またはCD28に対して増加した結合親和性を有する。いくつかの実施形態では、バリアントCD80ポリペプチドは、野生型または非改変CD80ポリペプチドと比べて、CD28、PD-L1、及び/またはCTLA-4に対して減少した結合親和性を有する。CD28、PD-L1及び/またはCTLA-4は、哺乳動物タンパク質、例えばヒトタンパク質またはネズミタンパク質であることができる。
の中から選択される1つまたは複数のアミノ酸置換を有する。いくつかの実施形態では、バリアントCD80ポリペプチドは、E7D、E23D、E23G、A26E、A26P、A26S、A26T、I30F、I30T、I30V、K34E、E35D、E35G、D46E、D46V、P51A、N55D、N55I、T57A、T57I、I58V、L65P、A71D、A71G、R73S、G78A、T79A、T79I、T79L、T79P、C82R、V84A、V84I、L85Qから選択される1つまたは複数のアミノ酸置換、またはその保存的アミノ酸置換を有する。いくつかの実施形態では、バリアントCD80ポリペプチドは、任意の2つ以上の前述のアミノ酸置換、例えば2、3、4、5、6、7、8、9、10、11、12、13、14、15、または以上のアミノ酸置換を含む。いくつかの実施形態では、バリアントCD80ポリペプチドは、1つのみの前述のアミノ酸置換を含む非改変または野生型CD80ポリペプチドと比較して、1つのみのアミノ酸差異を含む。
いくつかの実施形態では、バリアントCD80ポリペプチドは、SEQ ID NO:2、76、150、3030、または3031に記載の配列を含む、野生型または非改変CD80ポリペプチドなどの野生型または非改変CD80ポリペプチドと比較してCTLA-4のエクトドメインに対して増加した親和性を示す。いくつかの実施形態では、バリアントCD80ポリペプチドは、例えば、SEQ ID NO:2、76、150、3030、または3031に記載の配列を含む、野生型または非改変CD80ポリペプチドと比較して、CTLA-4のエクトドメインに対して増加した親和性、及びCD28のエクトドメインに対して減少した親和性を示す。いくつかの実施形態では、CTLA-4のエクトドメインに対する増加した親和性は、CTLA-4のエクトドメインへの非改変CD80の結合親和性と比較して1.2倍、1.5倍、2倍、3倍、4倍、5倍、6倍、7倍、8倍、9倍、10倍、20倍、30倍、40倍、50倍、または60倍より大きく増加する。
からなる群から選択される1つまたは複数のアミノ酸置換を有する。いくつかの実施形態では、バリアントCD80ポリペプチドは、
からなる群から選択される1つまたは複数のアミノ酸置換を有する。
である。
いくつかの実施形態では、バリアントCD80ポリペプチドは、野生型または非改変CD80ポリペプチドと比較して、CD28のエクトドメインに対して増加した親和性を示す。いくつかの実施形態では、バリアントCD80ポリペプチドは、例えば、SEQ ID NO:2、76、150、3030、または3031に記載の配列を含む、野生型または非改変CD80ポリペプチドと比較して、CD28のエクトドメインに対して増加した親和性を示す。いくつかの実施形態では、CD28のエクトドメインに対する増加した親和性は、CD28のエクトドメインへの非改変CD80の結合親和性と比較して1.2倍、1.5倍、2倍、3倍、4倍、5倍、6倍、7倍、8倍、9倍、10倍、20倍、30倍、40倍、50倍、60倍、70倍、80倍、90倍、100倍、150倍、または200倍より大きく増加する。
いくつかの実施形態では、バリアントCD80ポリペプチドは、野生型または非改変CD80ポリペプチドと比較して、PD-L1に対して増加した親和性を示す。いくつかの実施形態では、バリアントCD80ポリペプチドは、例えば、SEQ ID NO:2、76、150、3030、または3031に記載の配列を含む、野生型または非改変CD80ポリペプチドと比較して、PD-L1のエクトドメイン及びCTLA-4のエクトドメインに対して増加した親和性を示す。いくつかの実施形態では、PD-L1のエクトドメインに対する増加した親和性は、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、1.2倍、1.5倍、2倍、3倍、4倍、5倍、6倍、7倍、8倍、9倍、10倍、20倍、30倍、40倍、50倍、60倍、70倍、80倍、90倍、100倍、150倍、200倍、250倍、300倍、350倍、400倍、または450倍より大きく増加する。
からなる群から選択される1つまたは複数のアミノ酸置換を有する。いくつかの実施形態では、バリアントCD80ポリペプチドは、
からなる群から選択される1つまたは複数のアミノ酸置換を有する。
vIgDが含まれる本明細書で提供されるバリアントCD80を含む免疫調節ポリペプチドは、可溶性タンパク質、膜結合タンパク質または分泌タンパク質などを含む多種多様な方法でフォーマットをとることができる。いくつかの実施形態では、特定のフォーマットは、所望の治療用途に合わせて選択できる。場合によっては、バリアントCD80ポリペプチドを含む免疫調節ポリペプチドは、その結合パートナー、例えばCTLA-4、CD28、及び/またはPD-L1の活性に拮抗するかまたはそれを遮断するフォーマットで提供される。いくつかの実施形態では、CTLA-4またはPD-L1/PD-1の拮抗作用は、腫瘍学における免疫の促進において有用であり得る。場合によっては、バリアントCD80ポリペプチドを含む免疫調節ポリペプチドは、その結合パートナー、例えばCTLA-4及び/またはCD28の活性を作動させるまたは刺激するフォーマットで提供される。いくつかの実施形態では、CD28の作動作用は、腫瘍学における免疫の促進において有用であり得る。いくつかの実施形態では、CD28の作動作用は、PD-L1のCD80結合に依存し得るか、またはそれにより増強され得る。このようなCD28のPD-L1依存性作動作用は、腫瘍学における免疫の促進において有用であり得る。いくつかの実施形態では、CTLA-4の作動作用は、炎症または自己免疫の治療において有用であり得る。当業者は、例えば1つまたは複数の特異的コグネイト結合パートナーに拮抗するかまたはそれを作動させるための特定のフォーマットの活性を容易に決定することができる。そのような活性を評価するための例示的な方法は、実施例を含む、本明細書において提供される。
いくつかの実施形態では、バリアントCD80ポリペプチドを含有する免疫調節タンパク質は、可溶性タンパク質である。当業者であれば、細胞表面タンパク質が、典型的には、細胞内ドメイン、膜貫通ドメイン、及び細胞外ドメイン(ECD)を有すること、ならびに、細胞外ドメインまたはその免疫学的に活性な配列を使用してそのようなタンパク質の可溶性形態を作製することができることを認識するだろう。したがって、いくつかの実施形態では、バリアントCD80ポリペプチドを含有する免疫調節タンパク質は、膜貫通ドメインまたは膜貫通ドメインの一部分を欠く。いくつかの実施形態では、バリアントCD80を含有する免疫調節タンパク質は、細胞内(細胞質)ドメインを欠いているか、または細胞内ドメインの一部分を欠く。いくつかの実施形態では、バリアントCD80ポリペプチドを含有する免疫調節タンパク質は、アミノ酸改変(複数可)を含有するIgVドメイン及び/またはIgC(例えば、IgC2)ドメイン(複数可)またはその特異的結合断片を含有するECDドメインまたはその一部分を含有するvIgD部分のみを含有する。
いくつかの実施形態では、免疫調節タンパク質は、1つまたは複数の他の免疫グロブリンスーパーファミリー(IgSF)ドメインに直接的または間接的に連結された本明細書において提供されるバリアントCD80ポリペプチドのいずれかを含有することができる(「スタックされた」免疫調節タンパク質構築物、また「II型」免疫調節タンパク質とも呼ばれる)。いくつかの態様では、これは、2つ以上、例えば3つ以上のコグネイト結合パートナーと結合することによって免疫シナプスの多ターゲティング調節を提供する、固有のマルチドメイン免疫調節タンパク質を作製することができる。
であるバリアントCD80ポリペプチドが含まれたものである。いくつかの実施形態では、バリアントCD80ポリペプチドは、SEQ ID NO:3~75、77~149または151~223に記載のポリペプチドではない。
いくつかの実施形態では、IgSFファミリーのIgドメイン(vIgD)のバリアントを含む免疫調節タンパク質である本明細書において提供されるバリアントポリペプチドは、部分、例えばエフェクター部分、例えば別のタンパク質と、直接的または間接的に、コンジュゲートまたは融合して、コンジュゲートを形成することができる(「IgSFコンジュゲート」)。いくつかの実施形態では、結合は、共有結合または非共有結合(例えば、ビオチン-ストレプトアビジン非共有結合性相互作用を介したもの)であることができる。CD80-Fcバリアント融合体のいくつかの実施形態では、任意の2つ以上の前述のコンジュゲートのいずれか1つまたは組み合わせを、FcまたはバリアントCD80ポリペプチドまたは両方に結合させることができる。
免疫調節バリアントCD80ポリペプチドを発現する操作された細胞(あるいは、「操作された細胞」)が本明細書において提供される。いくつかの実施形態では、発現する免疫調節バリアントCD80ポリペプチドは、膜貫通型タンパク質であり、かつ表面に発現する。いくつかの実施形態では、発現する免疫調節バリアントCD80ポリペプチドは発現して、細胞から分泌される。
いくつかの実施形態では、バリアントCD80を含む免疫調節ポリペプチドは、膜結合タンパク質であることができる。以下でより詳細に記載のとおり、免疫調節ポリペプチドは、少なくとも1つの親和性改変IgSFドメイン(IgVまたはIgC)を含有するエクトドメイン、膜貫通ドメイン、及び任意で、細胞質ドメインを含有する、バリアントCD80を含む膜貫通型免疫調節ポリペプチドであることができる。いくつかの実施形態では、膜貫通型免疫調節タンパク質は、リンパ球(例えば、T細胞またはNK細胞)または抗原提示細胞の表面を含む、免疫細胞、例えば哺乳動物細胞の表面上に発現され得る。いくつかの実施形態では、膜貫通型免疫調節タンパク質は、ヘルパーT細胞、細胞傷害性T細胞(あるいは、細胞傷害性Tリンパ球またはCTL)、ナチュラルキラーT細胞、制御性T細胞、メモリーT細胞、またはγδT細胞のようなT細胞を含む、哺乳動物T細胞の表面上に発現する。いくつかの実施形態では、哺乳動物細胞は、抗原提示細胞(APC)である。典型的には、しかし限定するものではないが、エクトドメイン(あるいは、「細胞外ドメイン」)は、本発明のバリアントCD80の1つまたは複数のアミノ酸改変(例えば、アミノ酸置換)を含む。したがって、例えば、いくつかの実施形態では、膜貫通型タンパク質は、本発明のバリアントCD80の1つまたは複数のアミノ酸置換を含むエクトドメインを含む。
いくつかの実施形態では、本明細書に記載されるアミノ酸変異のいずれか1つまたは複数を含有するCD80バリアント免疫調節ポリペプチドは、例えば細胞に発現する際に分泌可能である。そのようなバリアントCD80免疫調節タンパク質は、膜貫通ドメインを含まない。いくつかの実施形態では、バリアントCD80免疫調節タンパク質は、半減期延長部分(例えば、Fcドメインまたは多量体化ドメイン)にコンジュゲートされない。いくつかの実施形態では、バリアントCD80免疫調節タンパク質は、ドメインを細胞外に出すシグナルペプチド、例えば抗体シグナルペプチドまたは他の有効なシグナル配列を含む。免疫調節タンパク質がシグナルペプチドを含み、操作された細胞によって発現される場合、該シグナルペプチドは、免疫調節タンパク質が操作された細胞によって分泌されるようにする。一般的に、シグナルペプチド、または該シグナルペプチドの一部分は、分泌と共に免疫調節タンパク質から切断される。免疫調節タンパク質は、核酸(発現ベクターの一部分であることができる)によってコードされることができる。いくつかの実施形態では、免疫調節タンパク質は、細胞(例えば免疫細胞、例えば初代免疫細胞)によって発現及び分泌される。
提供される免疫調節ポリペプチドのいずれかを発現する操作された細胞が本明細書において提供される。いくつかの実施形態では、操作された細胞は、それらの表面上に、提供される膜貫通型免疫調節ポリペプチドのいずれかを発現する。いくつかの実施形態では、操作された細胞は、免疫調節タンパク質を発現して、タンパク質の分泌に好適な条件下で細胞から分泌可能であるか、または分泌することができる。いくつかの実施形態では、免疫調節タンパク質は、リンパ球、例えば腫瘍浸潤リンパ球(TIL)、T細胞もしくはNK細胞上、または骨髄系細胞上に発現する。いくつかの実施形態では、操作された細胞は、抗原提示細胞(APC)である。いくつかの実施形態では、操作された細胞は、改変された哺乳動物T細胞または改変された哺乳動物抗原提示細胞(APC)である。いくつかの実施形態では、操作されたT細胞またはAPCは、ヒトまたはネズミ細胞である。
また、本明細書に記載の分泌可能な免疫調節タンパク質または膜貫通型免疫調節タンパク質を含むバリアントポリペプチド、例えばCD80 vIgDポリペプチドのいずれかをコードする核酸を含有する感染性物質も提供される。いくつかの実施形態では、そのような感染性物質は、本明細書に記載のバリアント免疫調節ポリペプチド、例えばCD80 vIgDポリペプチドをコードする核酸を、対象の標的細胞、例えば対象の免疫細胞及び/または抗原提示細胞(APC)または腫瘍細胞に送達することができる。また、そのような感染性物質に含有される核酸、及び/または、そのような感染性物質の生成もしくは改変のための核酸、例えばベクター及び/またはプラスミド、ならびにそのような感染性物質を含有する組成物が提供される。
いくつかの実施形態では、感染性物質は、ウイルスである。いくつかの実施形態では、感染性物質は、腫瘍溶解性ウイルス、または、特定の細胞、例えば免疫細胞を標的とするウイルスである。いくつかの実施形態では、感染性物質は、対象の腫瘍細胞及び/またはがん細胞を標的とする。いくつかの実施形態では、感染性物質は、免疫細胞または抗原提示細胞(APC)を標的とする。
いくつかの実施形態では、感染性物質は、細菌である。例えば、いくつかの実施形態では、細菌は、本明細書に記載のバリアント免疫調節ポリペプチドのいずれか、例えば、バリアントCD80ポリペプチドまたは免疫調節タンパク質をコードする核酸を、対象の標的細胞、例えば腫瘍細胞、免疫細胞、抗原提示細胞及び/またはド貪食細胞に送達することができる。いくつかの実施形態では、細菌は、バリアント免疫調節ポリペプチドの発現及び/または分泌のため、及び/または、バリアント免疫調節ポリペプチドの発現のための環境において特定の細胞を標的とするため、対象内の特定の環境、例えば腫瘍微小環境(TME)に優先的に標的とされることができる。
本明細書において提供されるバリアントCD80ポリペプチドまたは免疫調節ポリペプチドの種々の提供される態様のいずれかをコードする、単離された核酸または組換え核酸(まとめて「核酸」と称される)が本明細書において提供される。いくつかの実施形態では、後述の全てを含む本明細書において提供される核酸は、本明細書において提供されるバリアントCD80ポリペプチドまたは免疫調節ポリペプチドの組換え産生(例えば、発現)に有用である。いくつかの実施形態では、後述の全てを含む本明細書において提供される核酸は、細胞、例えば操作された細胞、例えば免疫細胞、または感染性物質細胞における、本明細書において提供されるバリアントCD80ポリペプチドまたは免疫調節ポリペプチドの発現に有用である。本明細書において提供される核酸は、RNAの形態またはDNAの形態であることができ、mRNA、cRNA、組換えまたは合成RNA及びDNA、ならびにcDNAを含むことができる。本明細書において提供される核酸は、典型的には、DNA分子、通常二本鎖のDNA分子である。しかしながら、本発明のヌクレオチド配列のうちのいずれかを含む、一本鎖DNA、一本鎖RNA、二本鎖RNA、及びハイブリッドDNA/RNA核酸またはその組み合わせも提供される。
いくつかの実施形態では、本明細書において提供されるバリアントCD80ポリペプチド(その完全長及び/または特異的結合断片またはコンジュゲート、スタック構築物または誘導体または操作された細胞)は、T細胞活性化を調節する免疫調節活性を示す。いくつかの実施形態では、CD80ポリペプチドは、T細胞アッセイにおいて、野生型または非改変CD80対照と比べてIFN-γ発現を調節する。場合によっては、IFN-γ発現の調節は、対照と比べて、IFN-γ発現を増加または減少させることができる。特異的結合及びIFN-γ発現を決定するアッセイは、当技術分野において周知であり、培養上清中のインターフェロン-γサイトカインレベルを測定するMLR(混合リンパ球反応)アッセイ(Wang et al.,Cancer Immunol Res.2014 Sep:2(9):846-56)、SEB(ブドウ球菌エンテロトキシンB(staphylococcal enterotoxin B))T細胞刺激アッセイ(Wang et al.,Cancer Immunol Res.2014 Sep:2(9):846-56)、及び抗CD3 T細胞刺激アッセイ(Li and Kurlander,J Transl Med.2010:8:104)を含む。
本明細書に記載のバリアントCD80ポリペプチド、免疫調節タンパク質、コンジュゲート、操作された細胞または感染性物質のいずれかを含有する組成物が本明細書において提供される。薬学的組成物は、薬学的に許容し得る賦形剤をさらに含むことができる。例えば、薬学的組成物は、例えば、組成物のpH、モル浸透圧濃度、粘性、透明性、色、等張性、臭気、無菌性、安定性、溶解もしくは放出の速度、吸着または浸透を、修正、維持、または保存するための1つまたは複数の賦形剤を含有することができる。いくつかの態様では、当業者は、細胞を含有する薬学的組成物がタンパク質を含有する薬学的組成物と異なってよいことを理解する。
また、本明細書に記載の薬学的組成物を好適な包装に含む製造物品が本明細書において提供される。本明細書に記載の組成物(例えば、眼科用組成物)用の好適な包装は、当技術分野において公知であり、例えば、バイアル(例えば、密封バイアル)、容器(vessels)、アンプル、ボトル、ジャー、フレキシブル包装(例えば、密封マイラーまたはプラスチック袋)などを含む。これらの製造物品は、さらに滅菌及び/または密封されてよい。
本明細書に記載のバリアントCD80ポリペプチド免疫調節タンパク質、操作された細胞または感染性物質を含有する提供される薬学的組成物を使用して、ヒト患者などの対象の疾患または状態の治療に関連することを含む免疫応答を調節する方法が本明細書において提供される。本明細書に記載の薬学的組成物(本明細書に記載のバリアントCD80ポリペプチド、免疫調節タンパク質、コンジュゲート、及び操作された細胞を含む薬学的組成物を含む)を、多種多様な治療用途、例えば疾患の治療に使用することができる。例えば、いくつかの実施形態では、薬学的組成物を使用して、哺乳動物において炎症性または自己免疫性障害、がん、臓器移植、ウイルス感染、及び/または細菌感染が治療される。薬学的組成物は、免疫応答を調節(例えば増加または減少)して、疾患を治療することができる。いくつかの実施形態では、この方法は、対象の免疫応答を増加させるフォーマットのバリアントCD80ポリペプチドを用いて実施される。いくつかのそのような態様では、免疫応答を増加させることにより、腫瘍またはがんなどの対象の疾患または状態を治療する。いくつかの実施形態では、この方法は、対象の免疫応答を減少させるフォーマットのバリアントCD80ポリペプチドを用いて実施される。いくつかのそのような態様では、免疫応答を低下することにより、炎症性疾患または状態、例えば自己免疫疾患などの対象の疾患または状態を治療する。
いくつかの実施形態では、提供される方法は、治療用途が対象とする疾患または状態を有する、または有すると疑われる対象を治療するためのものである。場合によっては、治療対象は、提供される実施形態のいずれかに従って、提供されるバリアントCD80ポリペプチド、免疫調節タンパク質、コンジュゲート、操作された細胞、または感染性物質のいずれかによる治療を含む治療適合性の判断または治療対象の識別または選択などのため1つまたは複数の特徴またはパラメータに基づいて治療前に選択することができる。
提供される実施形態としては、以下の実施形態が挙げられる。
の中から選択され、該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置に対応する、実施形態1~4のいずれかに記載のバリアントCD80ポリペプチド。
の中から選択される1つまたは複数のアミノ酸改変を含み、該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置の番号付けに対応する、バリアントCD80ポリペプチド。
任意で1つまたは複数のアミノ酸改変が、V20I、V22L、A26E、Q27H、Q33L、Q33R、E35D、E35G、M47I、D46E、D46V、M47L、M47V、T57I、L70M、A71D、A71G、L72V、L85M、L85Q、及びL97Qの中から選択され、
任意で1つまたは複数のアミノ酸改変が、A26E、Q33L、E35D、M47I、M47L、M47V、T57I、L70M、A71D、A71G、及びL85Qの中から選択され、任意で1つまたは複数のアミノ酸改変が、A26E、E35D、D46V、M47L、M47V、L70M、A71G、及びL85Qの中から選択され、
該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置に対応する、
実施形態6または実施形態7に記載のバリアントCD80ポリペプチド。
1つまたは複数のアミノ酸改変が、E35Dを含む、
1つまたは複数のアミノ酸改変が、D46Vを含む、
1つまたは複数のアミノ酸改変が、M47Lを含む、
1つまたは複数のアミノ酸改変が、M47Vを含む、及び/または
1つまたは複数のアミノ酸改変が、A71Gを含み、
該アミノ酸改変の位置(複数可)がSEQ ID NO:2に記載のCD80の位置の番号付けに対応する、
実施形態6~8のいずれかに記載のバリアントCD80ポリペプチド。
該アミノ酸改変の位置(複数可)がSEQ ID NO:2に記載のCD80の位置の番号付けに対応する、実施形態6~9のいずれかに記載のバリアントCD80ポリペプチド。
IgCドメインもしくはその特異的結合断片を含む、
実施形態1~14のいずれかに記載のバリアントCD80ポリペプチド。
IgVドメインの特異的結合断片がSEQ ID NO:1のアミノ酸35~135、35~138、37~138または35~141として記載されるIgVドメインの長さの少なくとも80%である長さを含むか、または、
IgCドメインの特異的結合断片がSEQ ID NO:1のアミノ酸145~230、154~232または142~232として記載されるIgCドメインの長さの少なくとも80%である長さを含む、
実施形態1~15のいずれかに記載のバリアントCD80ポリペプチド。
の中から選択される、1つまたは複数のアミノ酸改変を含み、該アミノ酸改変の位置(複数可)が、SEQ ID NO:2に記載のCD80の位置に対応する、実施形態1~31のいずれかに記載のバリアントCD80ポリペプチド。
の中から選択され、該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置に対応する、実施形態1~33のいずれかに記載のバリアントCD80ポリペプチド。
の中から選択される、1つまたは複数のアミノ酸改変を含み、該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置に対応する、実施形態1~31、39及び40のいずれかに記載のバリアントCD80ポリペプチド。
の中から選択され、該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置に対応する、実施形態1~31及び39~41のいずれかに記載のバリアントCD80ポリペプチド。
の中から選択される、1つまたは複数のアミノ酸改変を含み、該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置に対応する、実施形態1~31、及び44のいずれかに記載のバリアントCD80ポリペプチド。
の中から選択され、該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置に対応する、実施形態1~31及び44~46のいずれかに記載のバリアントCD80ポリペプチド。
細胞表面に発現することができない、
実施形態1~54のいずれかに記載のバリアントCD80ポリペプチド。
またはバリアントFcドメインが、哺乳動物、任意でヒトである非改変Fcドメインと比較して1つまたは複数のアミノ酸改変を含む、
実施形態58に記載のバリアントCD80ポリペプチド。
該Fcドメインが、SEQ ID NO:3039もしくは3040に記載のアミノ酸配列、またはSEQ ID NO:3039もしくは3040に対して少なくとも85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%または99%の配列同一性を示すアミノ酸配列を含む、
実施形態58または実施形態59に記載のバリアントCD80ポリペプチド。
(i)SEQ ID NO:269、734もしくは829のいずれかに記載のIgSFドメインを含む野生型CD112、またはSEQ ID NO:735~828、830~999、1430~1501のいずれかに記載のIgSFドメインを含むバリアントCD112ポリペプチド、
(ii)SEQ ID NO:268、378もしくは421のいずれかに記載のIgSFを含む野生型CD155、またはSEQ ID NO:379~420、422~733、1502~1711のいずれかに記載のIgSFドメインを含むバリアントCD155ポリペプチド、
(iii)SEQ ID NO:251、1000、1721もしくは1196のいずれかに記載のIgSFを含む野生型PD-L1、またはSEQ ID NO:1001~1195、1718~1720、1722~1996のいずれかに記載のIgSFを含むバリアントPD-L1ポリペプチド、
(iv)SEQ ID NO:252、1197もしくは1257のいずれかに記載のIgSFを含む野生型PD-L2、SEQ ID NO:1198~1248、1250~1256、1258~1325、1327~1401、1403~1426のいずれかに記載のIgSFドメインを含むバリアントPD-L2ポリペプチド、
(v)(i)~(iv)のSEQ ID NO:のいずれかに対して少なくとも90%、91%、92%、93%、94%、95%、95%、97%、98%、99%、またはそれ以上の配列同一性を示し、アミノ酸置換を含むアミノ酸配列、または
(vi)(i)~(v)のいずれかの特異的結合断片
から選択される、実施形態102~107及び111~113のいずれかに記載の免疫調節タンパク質。
第1及び/または第2のポリペプチドと同一である;または
第3のポリペプチドが第1及び/または第2のポリペプチドとは異なる、
実施形態115に記載の免疫調節タンパク質。
(i)SEQ ID NO:269、734もしくは829のいずれかに記載のIgSFドメインを含む野生型CD112、またはSEQ ID NO:735~828、830~999、1430~1501のいずれかに記載のIgSFドメインを含むバリアントCD112ポリペプチド、
(ii)SEQ ID NO:268、378もしくは421のいずれかに記載のIgSFを含む野生型CD155、またはSEQ ID NO:379~420、422~733、1502~1711のいずれかに記載のIgSFドメインを含むバリアントCD155ポリペプチド、
(iii)SEQ ID NO:251、1000、1721もしくは1196のいずれかに記載のIgSFを含む野生型PD-L1、またはSEQ ID NO:1001~1195、1718~1720、1722~1996のいずれかに記載のIgSFを含むバリアントPD-L1ポリペプチド、
(iv)SEQ ID NO:252、1197もしくは1257のいずれかに記載のIgSFを含む野生型PD-L2、SEQ ID NO:1198~1248、1250~1256、1258~1325、1327~1401、1403~1426のいずれかに記載のIgSFドメインを含むバリアントPD-L2ポリペプチド、
(v)(i)~(iv)のSEQ ID NO:のいずれかに対して少なくとも90%、91%、92%、93%、94%、95%、95%、97%、98%、99%、またはそれ以上の配列同一性を示し、アミノ酸置換を含むアミノ酸配列、または
(vi)(i)~(v)のいずれかの特異的結合断片
から選択される、実施形態115及び実施形態116に記載の免疫調節タンパク質。
PD-L1に陽性の細胞表面を含む腫瘍を有するものとして対象が選択されており、任意で該細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、
実施形態187~220のいずれかに記載の方法。
(a)対象の腫瘍組織試料をPD-L1のエクトドメインに特異的に結合することができる結合試薬と接触させることと、
(b)該腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で該細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、検出することと、
(c)腫瘍組織試料が検出可能レベルのPD-L1に陽性の細胞表面を含む場合に、治療のために対象を選択することと、
を含む、実施形態221に記載の方法。
CD28に陽性の細胞表面を含む腫瘍を有するものとして対象が選択されており、任意で該細胞が腫瘍浸潤リンパ球であり、任意で該リンパ球がT細胞、任意でCD8+T細胞である、
実施形態187~222のいずれかに記載の方法。
(a)対象の腫瘍組織試料をCD28のエクトドメインに特異的に結合することができる結合試薬と接触させることと、
(b)該腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で該細胞が腫瘍浸潤リンパ球であり、任意で該リンパ球がT細胞、任意でCD8+T細胞である、検出することと、
(c)腫瘍組織試料が検出可能レベルのCD28に陽性の細胞表面を含む場合に、治療のために対象を選択することと、
を含む、実施形態223に記載の方法。
(b)該腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で該細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、検出することと、
(c)腫瘍試料が検出可能レベルのPD-L1に陽性の細胞表面を含む場合に、バリアントCD80ポリペプチドを含む免疫調節タンパク質による治療のために対象を選択することであって、該バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、該バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、PD-L1のエクトドメインに対して増加した結合親和性を示す、選択することと
を含む、治療対象を選択する方法。
の中から選択される、1つまたは複数のアミノ酸改変を含み、該アミノ酸置換の位置(複数可)がSEQ ID NO:2に記載のCD80の位置に対応する、実施形態215~245のいずれかに記載の方法。
(b)生体試料の細胞内または細胞上に結合した結合試薬の存在を検出することと、
を含む、生体試料中のCD80結合パートナーを検出する方法。
以下の実施例は、単に例示を目的に含まれるものであり、本発明の範囲を限定することを意図するものではない。
IgSFドメインの変異体DNA構築物の生成
実施例1は、酵母ディスプレイライブラリーとしての酵母の表面上での翻訳及び発現のための、ヒトCD80 IgSFドメインの変異体DNA構築物の生成について記載する。
ランダムライブラリーもまた構築して、SEQ ID NO:3031(IgVドメインを含有する)に記載のCD80のIgVドメインのバリアントを特定した。野生型CD80 IgVドメインをコードするDNAを、酵母ディスプレイベクターpBYDS03のBamH1とKpn1部位との間にクローニングし、次いで、同じ制限酵素を使用して切り離した。次に、切り離したDNAをGenemorph II Kit(Agilent Genomics、USA)で変異誘発させて、ライブラリーバリアント当たり平均3~5個のアミノ酸変化を生成した。次いで、変異誘発させたDNAを2ステップPCRによって増幅し、ターゲティングライブラリーについて上記のとおりさらに処理した。
酵母へのDNAライブラリーの導入
縮重及びランダムCD80ライブラリーDNAを酵母に導入するために、酵母BJ5464株(ATCC.org;ATCC number 208288)のエレクトロポレーションコンピテント細胞を調製し、基本的に記載されるように上記ステップのエレクトロポレーション可能DNAを用いてGene Pulser II(Biorad,USA)でエレクトロポレーションした(Colby,D.W.et al.2004 Methods Enzymology 388,348-358)。唯一の例外は、改変プラスミドpBYDS03によって担持されるLEU2選択マーカーに対応するために形質転換細胞を非誘導最小選択SCD-Leu培地中で成長させたことであった。1リットルのSCD-Leu培地は、14.7グラムのクエン酸ナトリウム、4.29グラムのクエン酸一水和物、20グラムのデキストロース、6.7グラムの酵母窒素ベース、及び1.6グラムのロイシン不含酵母用合成ドロップアウト培地サプリメントからなる。0.22μMの真空濾過装置を使用して、使用前に培地を滅菌濾過した。
酵母の選択
実施例3は、CD80の親和性改変バリアントを発現する酵母細胞の選択を記載する。CD80へのCTLA4の結合がCD80へのCD28の結合に拮抗することは確立している(Schwartz J.C.et al.Nature 410,604-08,2001)。CD28よりもCTLA4に選択的に結合するCD80変異体を特定するため、CD80変異体ライブラリーの細胞に、反復回の正及び負のFACSソーティングならびに変異誘発を実施した。
Fc融合物として及び様々な免疫調節タンパク質タイプにおける選択アウトプットの再フォーマット化
実施例4は、Fc分子に融合したCD80の親和性改変(バリアント)免疫グロブリン様Vタイプ(IgV)ドメイン(バリアントIgVドメイン-Fc融合分子)を含有する免疫調節タンパク質として実施例3で同定された選択アウトプットの再フォーマット化を記載する。
Fc融合物の発現及び精製
実施例5は、上記実施例に記載されるようなバリアントIgV CD80を含有するFc融合タンパク質のハイスループット発現及び精製を記載する。
親和性成熟IgSFドメイン含有分子の結合の評価
この実施例は、細胞発現CTLA4、PD-L1、及びCD28カウンター構造体への上記の実施例の精製タンパク質のFc融合結合試験を記載し、CD80ドメインバリアント免疫調節タンパク質の特異性及び親和性を評価する。ヒトCTLA4、PD-L1、及びCD28のそれぞれの完全長哺乳動物表面発現構築物は、pcDNA3.1発現ベクター(Life Technologies)で設計され、これはGenscript,USAから供給された。結合試験は、Expi293F一過性トランスフェクションシステム(Life Technologies,USA)を使用して、完全長哺乳動物表面リガンドを発現するために生成されたトランスフェクトHEK293細胞で実施した。対照として、モック(非トランスフェクト)細胞への結合も評価した。実験に必要な細胞数を決定し、そして製造業者の推奨プロトコルを使用して、適切な30mlスケールのトランスフェクションを実施した。CTLA4、PD-L1、CD28またはモックの30mlトランスフェクション毎に、7500万個のExpi293F細胞を発現構築物DNA 30μg及び希釈したExpiFectamine 293試薬1.5mlと48時間インキュベートし、その時点で染色用に細胞を採取した。
追加のバリアントCD80 IgVドメインの選択と結合活性の評価
カウンター構造体CTLA4、CD28、及びPDL1とのCD80 IgVバリアント相互作用の親和性及び機能的効力を改善するため、第2及び第3世代(Gen)のランダム変異誘発及び選択を実施例1~3に実質的に記載された手順を使用して実行した。簡潔に述べると、酵母プラスミドDNAをFACS選択後の成長した酵母から単離し、変異誘発性PCRのテンプレートとして使用した。多様性を最大化するために、特性決定された個々のバリアント及びFACS選択されたバリアントのプールの両方をテンプレートとして使用した。得られたライブラリーは、反復回のFACS選択及び成長に供した。CD28親和性を維持しながらPDL1の親和性を増加させるため、複数のFASCソート進行経路を取った。アウトプットを生成するCD28-及びCTLA4+の選択を交互にする4つのFACS選択を行った第2世代の変異誘発性ライブラリーは、カウンター構造体に対して滴定すると、Fcベクターに再フォーマット化するように選択した。次のFACS選択経路を使用して酵母アウトプットをもたらした第3世代の変異誘発性ライブラリーは、カウンター構造体に対して滴定すると、Fcベクターに再フォーマット化するように選択した:1. 50nM PDL1+、2a. 1nM CTLA4+、2b. 20nM CTLA4-、2a3. 10nM PDL1+、2b3. 10nM PDL1+、2b34. 25nM CD28+。CD80の親和性改変バリアントを発現する酵母の選択後、選択したバリアントをIgV CD80バリアントを含有する追加のFc融合タンパク質を生成するためのFc融合として再フォーマット化した。配列分析後、タンパク質の産生、結合、及び機能的アッセイのために、個々のバリアントを選択した。第1世代の変異誘発のバリアントを表10に示し、第2世代を表11に示し、第3世代を表12及び13に示す。
上記のように、CD28への結合はCD28を発現するJurkat/IL2レポーター細胞を使用して評価し、CTLA-4及びPD-L1への結合はhuCTLA-4またはhuPD-L1を発現するように安定的にトランスフェクトされたCHO細胞を使用して評価した。明記したトランスフェクタントまたは細胞株がプレーティングされ、滴定量のCD80 vIgD-Fcまたは野生型CD80 IgV-Fcで染色した。結合タンパク質は、蛍光色素コンジュゲート抗huFc、及びフローサイトメトリーにより測定された平均蛍光強度(MFI)で検出した。図9Aにて示すように、いくつかの試験したCD80 vIgD-Fcは、野生型CD80よりも高い親和性でヒトPD-L1、ヒトCTLA-4、及びヒトCD28に結合した。
Jurkat/IL2レポーターアッセイを用いた親和性成熟CD80 IgSFドメイン含有分子の生理活性の評価
この実施例は、CD28共刺激の遮断に対するCD80ドメインバリアント免疫調節タンパク質の生理活性を評価するためのJurkat/IL2レポーターアッセイを記載する。
Jurkat/IL2レポーターアッセイを用いた、PD-L1の存在下及び非存在下での親和性成熟CD80 IgSFドメイン含有分子の生理活性の評価
この実施例は、不活性Fc分子(例えば、SEQ ID NO:1714)またはエフェクター活性を媒介することができるFc分子(SEQ ID NO:1429)のいずれかに融合し、PD-L1発現抗原提示細胞の存在下または非存在下でCD28共刺激シグナルを調節するCD80ドメインバリアント免疫調節タンパク質の能力を評価するJurkat/IL2レポーターアッセイを記載する。
IL-2-ルシフェラーゼレポーターを発現するJurkatエフェクター細胞(Promega Corp.,USAから購入)をJurkatアッセイ緩衝液(RPMI1640+5%FBS)に2x106細胞/mLで懸濁した。次にJurkat細胞を50μL/ウェルで、ウェル当たり合計100,000細胞をプレーティングした。
を含有した。図9Bにて示すように、例示的な試験したバリアントCD80 IgVドメイン含有分子は、用量依存的にPD-L1依存性CD28共刺激を誘導した。評価した濃度のいずれかにおいても、野生型CD80 IgV-FcによるPD-L1依存性CD28共刺激は観察されなかった。
上記のK562/OKT3/PDL1 aAPC細胞をマイトマイシンcで処置し、滴定した漸増濃度のCD80 IgV-Fc(不活性)または野生型CD80 IgV-Fc(不活性)の存在下で初代ヒトpan T細胞と共培養した。試験した例示的なバリアントCD80-Fcは、
を含有した。さらなる対照として、初代ヒトpan T細胞もまた、例示的な抗PD-L1デュルバルマブまたはFc(不活性)のみ対照とともに培養した。図9Cに記載の結果は、試験したバリアントCD80-IgV-Fc分子が、培養上清中にIL-2分泌をもたらしたことを示し、これは試験した例示的なバリアントCD80-IgV-Fc分子によってPD-L1依存性共刺激が誘導されたという観察と一致する。野生型CD80-IgV Fcまたは他の試験対照とインキュベートした場合、T細胞培養物ではIL-2産生は観察されなかった。
さらなる実験において、バリアントCD80-IgV-Fc融合タンパク質(そのFcはFc受容体(FcR)への結合を介してエフェクター活性を媒介できるIgG1 Fc(例えばSEQ ID NO:1429)であった)についてCD28共刺激を評価した。実験は上記のパートAで説明したように実施したが、ただしCHO/OKT3及びCHO/OKT3/PD-L1細胞の代わりにOKT3(K562/OKT3)またはOKT3及びPD-L1(K562/OKT3/PD-L1)で安定的に形質導入したCD32発現K562細胞を使用した。その結果を表18に示す。
T細胞刺激アッセイを用いた親和性成熟CD80 IgSFドメイン含有分子の生理活性の評価
不活性FcまたはエフェクターFcのいずれかを含有するCD80-IgV-Fc分子を、サイトカイン放出(IFN-γ及びIL-2)及びT細胞増殖により決定した、人工抗原提示細胞(aAPC)K562/OKT3+/-PD-L1の存在下でのT細胞を刺激するそれらの能力について、1nM、10nM及び100nMの3つの濃度で試験した。
PD-L1/PD-1相互作用またはPD-L1依存性共刺激を遮断するバリアントCD80ポリペプチドの評価
A.PD-L1/PD-1結合及び遮断
PD-L1発現細胞への選択された免疫調節融合タンパク質の結合を評価して、PD-L1/PD-1相互作用の遮断について試験した。CHO/PD-L1細胞をバリアントCD80 IgV-Fcドメイン含有分子の滴定によって染色し、洗浄し、次いで蛍光コンジュゲートPD-1-Fcとインキュベートした。試験した例示的なバリアントCD80 IgVドメイン含有分子は、
を含有した。対照として、抗PD-L1抗体及び野生型CD80 IgV-Fcもまた評価した。試料をフローサイトメーターで取り込み、蛍光標識PD-1のMFIをFlowjoソフトウェア分析によって決定した。図9Dにて示すように、試験した例示的なバリアントCD80 IgV-Fc分子は、PD-1のPD-L1への結合を拮抗またはこれを遮断することが示された。
例示的なバリアントCD80-Fcポリペプチドを、上記のPD-1を発現するJurkat/IL-2レポーター細胞を使用してそれらのPD-L1依存性共刺激を送達する能力について評価した。Jurkat/IL-2レポーター細胞を、上記のK562/OKT3/PD-L1人工抗原提示細胞(aAPC)と、滴定量(40pM~100nMの範囲)の例示的なバリアントCD80 IgV-Fcポリペプチドの存在下でインキュベートした。例示的なバリアントCD80 IgV-Fcポリペプチドには、例示的なFc(EU番号付けによるC220S/L234A/L235E/G237A;SEQ ID NO:1714)に融合した、
のいずれかのバリアントIgVを含有する分子がある。他の試験したバリアントCD80 IgV-Fcポリペプチドは、野生型IgG1(SEQ ID NO:1429)に融合したE35D/M47I/L70M,SEQ ID NO:199;またはE35D/M47L,SEQ ID NO:208)のいずれかのバリアントIgVを含有した。対照として、PD-L1発現細胞はまた、野生型CD80 IgV-Fc(SEQ ID NO:3031)または抗PDL1抗体(BioLegend USA)とインキュベートした。
バリアントCD80ポリペプチドのIn Vivo抗腫瘍活性
A.CD80バリアントの抗腫瘍活性
マウスMC38腫瘍細胞にヒトPD-L1(MC38 hPD-L1)を安定的にトランスフェクトし、C57BL/6マウスに皮下移植した。不活性Fc対照、または不活性Fc分子(例えばSEQ ID NO:1714)もしくはエフェクター活性を媒介できるFc分子(SEQ ID NO:1429)のいずれかを融合したバリアントIgV(E35D/M47I/L70M,SEQ ID NO:199;またはE35D/M47L,SEQ ID NO:208)を含有する例示的なバリアントCD80 IgV-Fc分子を、移植後8、10、13、15、及び17日目に100μg/マウスを腹腔内注射した。腫瘍体積を経時的に追跡した。
1.腫瘍体積(50ug、100ug、及び500ug)
MC38 hPD-L1腫瘍細胞の移植後、約50~51mm3の類似した腫瘍体積を含有する70匹の雌C57CL/6マウスを分類し、それぞれ14匹のマウスを含む5つの処置群に分けた。8、10、及び12日目に、群1(アイソタイプ対照)には、75μgのFc(SEQ ID NO:1714)のみを与え;群2、3、及び4には、GSG4Sリンカー(SEQ ID NO:1716)を介して、不活性なヒトFc(SEQ ID NO:1714)に融合したCD80バリアントE35D/M47L(SEQ ID NO:208)をそれぞれ50、100、及び500μg与え;群5には、100μgのヒト抗PD-L1 mAb(デュルバルマブ)を与えた。腫瘍体積は、7、10、及び12日目に測定した。13日目に、以下のセクションで説明するように、分析のために5匹の動物を屠殺した。17、20、及び27日目に各群の残りの9匹のマウスの腫瘍測定を再開した。26、28、及び31日目に、群1の動物(Fcアイソタイプ対照)に、100μgのE35D/M47L CD80-IgV-Fcの腫瘍内注射を与えた。
MC38腫瘍の酵素消化後、溶解液を遠心分離し、上清を収集し、アッセイの準備ができるまで-80℃で保存した。次に、各試料のマウスIFNγの濃度を、製造元の指示に従って市販のELISAキット(R&D Systems,Inc.)を使用して測定し、腫瘍重量または腫瘍から単離した総細胞数のいずれかに基づいて濃度を正規化した。図12に記載の結果は、最高用量(500μg)のE35D/M47L CD80-IgV-Fcが腫瘍溶解物中の最高濃度のIFNγをもたらしたことを示し、このことは、CD80-IgV-Fcがその処置の結果としてIFNγを産生していることを示唆しており、これは抗腫瘍免疫を促進することが知られている機序である。
95匹の雌C57BL/6マウスにMC38 hPD-L1腫瘍細胞を移植した。腫瘍を7日目に分類し、約60mm3の類似の腫瘍体積を持つ77匹のマウスを、それぞれ11匹のマウスを含む7つの処置群に分けた。7、9、及び11日目に、群1(アイソタイプ対照)には、75μgの不活性Fc(SEQ ID NO:1714)のみを与え;群2には、100μgのCD80バリアントE35D/M47V/N48K/V68M/K89N IgV(SEQ ID NO:2250)-Fc(不活性)を与え;群3には、100μgのCD80バリアントH18Y/A26E/E35D/M47L/V68M/A71G/D90G IgV(SEQ ID NO:2276)-Fc(不活性)を与え;群4には、100μgのCD80バリアントE35D/D46V/M47L/V68M/L85Q/E88D IgV(SEQ ID NO:2280)-Fc(不活性)を与え;群5には、100μgのCD80バリアントE35D/D46E/M47V/V68M/D90G/K93E IgV(SEQ ID NO:2284)-Fc(不活性)を与え;群6には、100μgのCD80バリアントE35D/M47L(SEQ ID NO:208)-Fc(不活性)を与え;群7には、100μgのヒト抗PD-L1 mAb(デュルバルマブ)を与えた。バリアントCD80-IgV-Fc分子の場合、CD80IgVドメインは、GSG4Sリンカー(SEQ ID NO:1716)を介して、SEQ ID NO:1714に記載の不活性なヒトFcに融合した。腫瘍体積を14、17、21、24、28、31、及び37日目に測定した。Fcアイソタイプ対照を投与した動物は、過剰な腫瘍量のために28日目までに死んだ。
hPD-L1 MC38腫瘍細胞を移植してから7日後に、75匹の動物を3つの処置群に分類した。群1には75μgの不活性Fc(SEQ ID NO:1714)を3回注射し、群2には100μgのCD80バリアントH18Y/A26E/E35D/M47L/V68M/A71G/D90G IgV(SEQ ID NO:2276)-Fc(不活性)を3回注射し、群3には100μgのヒト抗PD-L1 mAb(デュルバルマブ)を3回注射した(これらの注射は移植後8、10、及び12日目に行った)。11日目~35日目まで、3~4日毎に腫瘍体積を測定した。1回目、2回目、及び3回目の投与の3日後、各群から4匹のマウスを腫瘍及びLN分析のために屠殺し、13匹のマウスを研究期間を通して腫瘍体積を測定するために残した。
Fc対照、CD80バリアントIgV-Fc、及び抗PD-L1抗体(デュルバルマブ)の2回目の投与の3日後、腫瘍及び流入領域リンパ節(LN)を各処置群の3~4匹のマウスから採取した。組織は単一細胞懸濁液に処理され(腫瘍は処理の一部として酵素的に消化されたが、流入領域LNは酵素的に処理しなかった)、CD45+細胞サブセット(LNまたは腫瘍のいずれかの免疫細胞)でのCD8+T細胞のマルチカラーフローサイトメトリー分析、及び腫瘍細胞に結合した分子(CD80-IgV-Fcまたは抗PD-L1)を検出するためのCD45-細胞サブセット(腫瘍細胞)での%hIgG+染色に供した。結果は図17A~Cに提供する。
追加のバリアントCD80 IgVドメインの生成
A.追加のCD80 IgV結合ドメイン及び結合評価
追加のCD80バリアントを生成し、基本的に実施例2~5に記載されるようにFc融合タンパク質として発現させた。バリアントを、実質的に実施例7に記載されるように結合について試験し、実質的に実施例9に記載される生理活性について試験した。結合及び活性研究の結果を表20~23に提供する。
実施例7に記載した酵母アウトプットから300個のCD80 IgV-Fc構築物を生成した後、追加のCD80 IgVバリアントを選択した。次に、CD80 IgV-Fcタンパク質を含有する上清を、Octet(登録商標)システムを使用して、96ウェルプレートフォーマットでPD-L1結合についてスクリーニングした。上記の実施例7に記載されるように、高いPD-L1結合を示すバリアントを選択し、結合について再スクリーニングし、高いPD-L1結合を示したバリアントを選択した。例示的なバリアント及びFACS結合データを表24に提供する。選択したバリアントはまた、実質的に実施例9に記載される方法を使用して生理活性について評価し、その結果は表25に示されている。
CD80 IgVバリアントのコンセンサスバリアントは、上記の全ての酵母選択からのアウトプットのアラインメントに基づいて設計した。次いで、コンセンサス配列を使用してCD80 IgV-Fcタンパク質を生成し、次いで、上記のように結合及び生理活性について試験した。結合及び生理活性の結果を、それぞれ表26及び27に提供する。
CD80 IgVバリアントのパネルの結合活性の評価
SEQ ID NO:2250、2276、及び2280に記載の選択したバリアントのセットを参照して、結合及び活性に関与する残基を特定するため、復帰(逆)変異のパネルを設計し、実質的に実施例4及び5に記載されるようにFc融合タンパク質として発現させた。生成したバリアントは、表28に記載の様々な組み合わせでSEQ ID NO:2250、2276、及び2280に見いだされた1~6個の変異を含んだ。
NNKライブラリー選択によるバリアント最適化
SEQ ID NO:2250、2276、及び2280に記載の位置に基づいて18、26、35、47、48、68、71、85、88、90、及び93位に変異の組み合わせを有する追加のバリアントCD80 IgVドメイン含有分子を生成した。縮重コドンが全ての潜在的なアミノ酸をコードするが、2つの停止残基TAA及びTGAのコードを防止するように、バリアントを選択した位置でNNKライブラリー(N=A、G、CまたはT、K=TまたはG)から生成した。実質的に実施例2に記載されるようにDNAを含有するNNKを酵母に導入し、酵母ライブラリーを生成した。該ライブラリーを使用して、実質的に実施例3に記載されるようにCD80の親和性改変バリアントを発現する酵母を選択した。
CD80 IgV-Fcリンカーバリアント
CD80 IgV-Fcバリアントを、IgVとFcドメイン間の異なるリンク領域(リンカー)によって構築し、結合及び/または生理活性を評価した。CD80 E35D/M47V/N48K/V68M/K89N IgV-Fc及びE35D/D46V/M47L/V68M/L85Q/E88D IgV-Fcタンパク質を含有する融合タンパク質を、EAAAK(SEQ ID NO:3026)、(EAAAK)3(SEQ ID NO:3027)、GS(G4S)3(SEQ ID NO:3028)、GS(G4S)5(SEQ ID NO:3029)リンカーを含有して生成した。
追加の親和性改変IgSFドメイン
本実施例は、免疫活性化及び阻害の両方で実証された二重の役割を有する免疫シナプス(IS)の他の構成成分である追加の親和性改変CD155、CD112、PD-L1、PD-L2、及びCD86(B7-2)免疫調節タンパク質の設計、作成、及びスクリーニングについて記載する。親和性改変NKp30バリアントもまた生成及びスクリーニングした。これらの実施例は、IgSFドメインの親和性改変により、免疫学的活性の増加及び減少の両方に作用できるタンパク質が生成されることを証明する。これらのドメインの様々な組み合わせは、バリアント親和性改変CD80とペアで融合(すなわち、スタック状)し、II型免疫調節タンパク質を形成し、免疫調節活性を達成する。
抗PD-L1抗体と比較したHuPD-L1形質導入MC38腫瘍細胞に対する細胞傷害性
本実施例は、huPD-L1形質導入MC38腫瘍細胞のin vitro細胞傷害性の評価を記載している。非形質導入またはhuPD-L1によって形質導入したMC38腫瘍細胞をマイトマイシン-Cで処理し、1:5の比率でCFSEで標識したヒトpan T細胞でプレーティングした。WT IgG1 Fcまたは不活性Fcのいずれかとともに、E35D/M47I/L70M(SEQ ID NO:125)を含有するバリアントCD80 IgV-FcをMC38腫瘍細胞に100nMまたは10nMで添加し、細胞とともに72時間培養した。対照として、例示的な抗PD-1抗体ニボルマブまたはFc(不活性)のみの対照もまた評価した。次に、細胞を採取し、7-AAD生存性色素で染色した。フローサイトメーターで試料を取り込んだ後、死細胞の割合を、CFSE-ゲートにおいて7-AAD+細胞をゲーティングすることによってFlowjo分析を使用して計算した。図18にて示すように、huPD-L1形質導入MC38腫瘍細胞(ただし非形質導入MC38親細胞ではない)に対する細胞傷害性の増加を、例示的な評価したバリアントCD80 IgV-Fc分子により観察した。このアッセイでは、細胞傷害活性は、対照抗PD-1抗体の存在下では観察されず、バリアントCD80 IgV Fc分子が抗PD-1抗体対照と比較して改善された活性を示すことを示した。
初代ヒトT細胞及び単球へのCD80バリアント結合
例示的なバリアントCD80-IgV Fc分子の初代CD28+ヒトCD4 T細胞及びヒトPD-L1+単球への結合を評価した。評価した例示的なバリアントCD80 IgV-Fc分子は、
を含有した。
PD-L1媒介性PD-1 SHP2動員のバリアントCD80 IgV-Fc拮抗作用
本実施例では、PD-L1/PD-1相互作用を遮断することによりPD-1への細胞質タンパク質チロシンホスファターゼSHP-2の動員に拮抗するバリアントCD80 IgV-Fc分子の効果を評価するためのJurkat/PD-1/SHP2シグナル伝達アッセイについて説明する。例示的なアッセイでは、組換えβ-ガラクトシダーゼ(β-gal)断片酵素ドナー(ED)タグ付きPD-1受容体及び酵素アクセプター(EA)タグ付きSHP-2ドメインを含有するJurkat細胞株を使用した(例:DiscoverX,USA;cat.93-1106C19)。アッセイでは、PD-1へのSHP-2動員により、EA及びEDが極めて近接し、この2つの酵素断片の相補が基質を加水分解して化学発光シグナルを生成する機能的β-gal酵素の形成を可能にする。
を含有した。対照として、野生型CD80 IgV-Fc(不活性)、抗PD-L1抗体、及びFc(不活性)のみの対照も評価した。Jurkat/PD-1/SHP2細胞(DiscoverX Pathhunter酵素相補断片動員株)を加え、細胞を2時間インキュベートした。β-galの基質(DiscoverXバイオアッセイ検出試薬)をウェルに加え、暗所で室温で1時間インキュベートし、ルシフェラーゼをマイクロプレートリーダー(BioTek Cytation)で測定した。
B7/CTLA-4結合のCD80バリアント拮抗作用
CTLA-4及びB7結合の相互作用に拮抗するCD80 vIgD-Fcの能力を評価するため、表面ヒトCTLA-4を安定して発現するCHO細胞に
または野生型CD80 vIgD-Fc、または陽性対照としての抗CTLA-4抗体(イピリムマブ)を滴定してプレーティングした。洗浄後、細胞を25nMの蛍光色素コンジュゲート野生型CD80-Fcとインキュベートした。結合した蛍光競合タンパク質が検出され、フローサイトメトリーで測定した。図21にて示すように、全てのCD80 vIgD-Fcバリアント(ただし野生型CD80-Fcではない)がCTLA-4へのCD80の結合に拮抗した。
SEQUENCE LISTING
<110> Alpine Immune Sciences, Inc.
<120> CD80 Variant Immunomodulatory Proteins and Uses Thereof
<150> US 62/472,558
<151> 2017-03-16
<150> US 62/472,569
<151> 2017-03-16
<150> US 62/472,554
<151> 2017-03-16
<150> US 62/472,572
<151> 2017-03-16
<150> US 62/472,573
<151> 2017-03-17
<150> US 62/475,204
<151> 2017-03-22
<150> US 62/537,939
<151> 2017-07-27
<150> US 62/574,165
<151> 2017-10-18
<150> US 62/582,266
<151> 2017-11-06
<160> 3040
<170> PatentIn version 3.5
<210> 1
<211> 288
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD80(B7-1)
<400> 1
Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr
1 5 10 15
Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys
20 25 30
Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu
35 40 45
Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile
50 55 60
Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp
65 70 75 80
Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr
85 90 95
Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly
100 105 110
Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg
115 120 125
Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr
130 135 140
Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile
145 150 155 160
Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu
165 170 175
Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp
180 185 190
Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met
195 200 205
Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg
210 215 220
Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro
225 230 235 240
Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly
245 250 255
Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg
260 265 270
Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
275 280 285
<210> 2
<211> 208
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD80(B7-1) ECD
<400> 2
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 3
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v122 ECD
<400> 3
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 4
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v123 ECD
<400> 4
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Phe Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 5
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v124 ECD
<400> 5
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 6
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v125 ECD
<400> 6
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Thr Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 7
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v126 ECD
<400> 7
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Arg
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 8
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v127 ECD
<400> 8
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 9
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v128 ECD
<400> 9
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Arg Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 10
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v130 ECD
<400> 10
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Val Val Leu Thr Met Met Ser Gly Asp Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 11
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v131 ECD
<400> 11
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Thr Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 12
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v132 ECD
<400> 12
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ile Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 13
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v133 ECD
<400> 13
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 14
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v134 ECD
<400> 14
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Thr Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 15
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v135 ECD
<400> 15
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Met Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 16
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v136 ECD
<400> 16
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Ile Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 17
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v137 ECD
<400> 17
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 18
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v138 ECD
<400> 18
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Pro Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 19
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v139 ECD
<400> 19
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Pro Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 20
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v140 ECD
<400> 20
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Ser Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 21
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v141 ECD
<400> 21
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Thr Val Ile Leu Ala Leu Arg Ser Ser Asp Glu Gly Thr Tyr
65 70 75 80
Gly Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Asp His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 22
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v142 ECD
<400> 22
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 23
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v143 ECD
<400> 23
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Ala Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Asn Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 24
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v144 ECD
<400> 24
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 25
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v145 ECD
<400> 25
Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 26
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v146 ECD
<400> 26
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Glu Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 27
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v147 ECD
<400> 27
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Ala Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 28
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v148 ECD
<400> 28
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 29
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v149 ECD
<400> 29
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 30
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v150 ECD
<400> 30
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Arg Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Ala Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 31
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v151 ECD
<400> 31
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Glu Lys Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 32
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v152 ECD
<400> 32
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val His
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 33
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v153 ECD
<400> 33
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 34
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v154 ECD
<400> 34
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 35
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v155 ECD
<400> 35
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Ser Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 36
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v156 ECD
<220>
<221> VARIANT
<222> (24)..(24)
<223> X is a stop codon
<400> 36
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Xaa Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Asn Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Val Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 37
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v157 ECD
<400> 37
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 38
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v158 ECD
<400> 38
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 39
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v159 ECD
<400> 39
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Ile Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 40
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v160 ECD
<400> 40
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Ala Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 41
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v161 ECD
<400> 41
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 42
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v162 ECD
<400> 42
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Ile Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 43
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v163 ECD
<400> 43
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 44
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v164 ECD
<400> 44
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 45
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v165 ECD
<400> 45
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 46
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v166 ECD
<400> 46
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 47
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v167 ECD
<400> 47
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Leu Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 48
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v168 ECD
<400> 48
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Ile Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 49
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v169 ECD
<400> 49
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 50
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v170 ECD
<400> 50
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 51
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v171 ECD
<400> 51
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 52
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v172 ECD
<400> 52
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 53
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v173 ECD
<400> 53
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 54
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v174 ECD
<400> 54
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 55
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v175 ECD
<400> 55
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 56
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v176 ECD
<400> 56
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 57
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v177 ECD
<400> 57
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Phe Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Ile Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 58
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v178 ECD
<400> 58
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 59
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v179 ECD
<400> 59
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Thr Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 60
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v180 ECD
<400> 60
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 61
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v181 ECD
<400> 61
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Val Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Val Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 62
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v182 ECD
<400> 62
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 63
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v183 ECD
<400> 63
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Ile Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Phe Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 64
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v184 ECD
<400> 64
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 65
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v185 ECD
<400> 65
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 66
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v186 ECD
<400> 66
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Val Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 67
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v187 ECD
<400> 67
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 68
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v188 ECD
<400> 68
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Gly Glu Leu Ser Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 69
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v189 ECD
<400> 69
Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 70
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v190 ECD
<400> 70
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser His Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 71
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v191 ECD
<400> 71
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 72
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v192 ECD
<400> 72
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 73
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v193 ECD
<400> 73
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 74
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v194 ECD
<400> 74
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 75
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v195 ECD
<400> 75
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Trp Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 76
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 WT IgV
<400> 76
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 77
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v122 IgV
<400> 77
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 78
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v123 IgV
<400> 78
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Phe Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 79
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v124 IgV
<400> 79
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 80
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v125 IgV
<400> 80
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Thr Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 81
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v126 IgV
<400> 81
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Arg
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 82
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v127 IgV
<400> 82
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 83
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v128 IgV
<400> 83
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Arg Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 84
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v130 IgV
<400> 84
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Val Val Leu Thr Met Met Ser Gly Asp Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 85
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v131 IgV
<400> 85
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Thr Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 86
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v132 IgV
<400> 86
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ile Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 87
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v133 IgV
<400> 87
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 88
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v134 IgV
<400> 88
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Thr Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 89
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v135 IgV
<400> 89
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Met Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 90
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v136 IgV
<400> 90
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Ile Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 91
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v137 IgV
<400> 91
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 92
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v138 IgV
<400> 92
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Pro Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 93
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v139 IgV
<400> 93
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Pro Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 94
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v140 IgV
<400> 94
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Ser Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 95
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v141 IgV
<400> 95
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Thr Val Ile Leu Ala Leu Arg Ser Ser Asp Glu Gly Thr Tyr
65 70 75 80
Gly Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Asp His
85 90 95
Leu Ala Glu Val Thr
100
<210> 96
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v142 IgV
<400> 96
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 97
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v143 IgV
<400> 97
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Ala Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Asn Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 98
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v144 IgV
<400> 98
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 99
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v145 IgV
<400> 99
Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 100
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v146 IgV
<400> 100
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Glu Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 101
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v147 IgV
<400> 101
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Ala Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 102
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v148 IgV
<400> 102
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 103
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v149 IgV
<400> 103
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 104
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v150 IgV
<400> 104
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Arg Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Ala Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 105
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v151 IgV
<400> 105
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Glu Lys Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 106
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v152 IgV
<400> 106
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val His
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 107
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v153 IgV
<400> 107
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 108
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v154 IgV
<400> 108
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 109
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v155 IgV
<400> 109
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Ser Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 110
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v156 IgV
<220>
<221> VARIANT
<222> (24)..(24)
<223> X is a stop codon
<400> 110
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Xaa Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Asn Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Val Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 111
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v157 IgV
<400> 111
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 112
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v158 IgV
<400> 112
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 113
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v159 IgV
<400> 113
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Ile Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 114
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v160 IgV
<400> 114
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Ala Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 115
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v161 IgV
<400> 115
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 116
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v162 IgV
<400> 116
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Ile Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 117
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v163 IgV
<400> 117
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 118
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v164 IgV
<400> 118
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His
85 90 95
Leu Ala Glu Val Thr
100
<210> 119
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v165 IgV
<400> 119
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 120
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v166 IgV
<400> 120
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 121
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v167 IgV
<400> 121
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Leu Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 122
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v168 IgV
<400> 122
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Ile Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 123
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v169 IgV
<400> 123
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 124
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v170 IgV
<400> 124
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 125
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v171 IgV
<400> 125
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 126
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v172 IgV
<400> 126
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 127
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v173 IgV
<400> 127
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 128
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v174 IgV
<400> 128
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 129
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v175 IgV
<400> 129
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 130
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v176 IgV
<400> 130
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 131
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v177 IgV
<400> 131
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Phe Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Ile Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 132
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v178 IgV
<400> 132
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 133
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v179 IgV
<400> 133
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Thr Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 134
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v180 IgV
<400> 134
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 135
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v181 IgV
<400> 135
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Val Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Val Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 136
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v182 IgV
<400> 136
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His
85 90 95
Leu Ala Glu Val Thr
100
<210> 137
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v183 IgV
<400> 137
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Ile Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Phe Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 138
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v184 IgV
<400> 138
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 139
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v185 IgV
<400> 139
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 140
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v186 IgV
<400> 140
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Val Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 141
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v187 IgV
<400> 141
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 142
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v188 IgV
<400> 142
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Gly Glu Leu Ser Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 143
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v189 IgV
<400> 143
Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Leu Ala Glu Val Thr
100
<210> 144
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v190 IgV
<400> 144
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser His Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 145
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v191 IgV
<400> 145
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 146
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v192 IgV
<400> 146
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 147
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v193 IgV
<400> 147
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 148
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v194 IgV
<400> 148
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 149
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v195 IgV
<400> 149
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Trp Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 150
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 WT IgV
<400> 150
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 151
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v122 IgV
<400> 151
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 152
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v123 IgV
<400> 152
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Phe Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 153
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v124 IgV
<400> 153
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 154
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v125 IgV
<400> 154
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Thr Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 155
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v126 IgV
<400> 155
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Arg
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 156
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v127 IgV
<400> 156
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 157
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v128 IgV
<400> 157
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Arg Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 158
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v130 IgV
<400> 158
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Val Val Leu Thr Met Met Ser Gly Asp Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 159
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v131 IgV
<400> 159
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Thr Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 160
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v132 IgV
<400> 160
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ile Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 161
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v133 IgV
<400> 161
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Gly Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 162
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v134 IgV
<400> 162
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Thr Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 163
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v135 IgV
<400> 163
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Met Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 164
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v136 IgV
<400> 164
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Ile Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 165
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v137 IgV
<400> 165
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Pro Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 166
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v138 IgV
<400> 166
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Pro Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 167
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v139 IgV
<400> 167
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Pro Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 168
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v140 IgV
<400> 168
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Ser Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 169
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v141 IgV
<400> 169
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Thr Val Ile Leu Ala Leu Arg Ser Ser Asp Glu Gly Thr Tyr
65 70 75 80
Gly Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Asp His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 170
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v142 IgV
<400> 170
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 171
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v143 IgV
<400> 171
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Ala Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Asn Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 172
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v144 IgV
<400> 172
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 173
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v145 IgV
<400> 173
Val Ile His Val Thr Lys Glu Val Lys Glu Val Val Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 174
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v146 IgV
<400> 174
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Glu Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 175
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v147 IgV
<400> 175
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Ala Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 176
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v148 IgV
<400> 176
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 177
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v149 IgV
<400> 177
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 178
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v150 IgV
<400> 178
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Arg Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Ala Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 179
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v151 IgV
<400> 179
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Glu Lys Glu Lys Lys Met Val Leu Ala Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 180
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v152 IgV
<400> 180
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val His
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 181
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v153 IgV
<400> 181
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Ala Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 182
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v154 IgV
<400> 182
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Pro Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 183
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v155 IgV
<400> 183
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Ser Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 184
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v156 IgV
<220>
<221> VARIANT
<222> (24)..(24)
<223> X is a stop codon
<400> 184
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Xaa Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Asn Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Val Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 185
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v157 IgV
<400> 185
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 186
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v158 IgV
<400> 186
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 187
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v159 IgV
<400> 187
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Ile Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 188
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v160 IgV
<400> 188
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Ala Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 189
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v161 IgV
<400> 189
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 190
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v162 IgV
<400> 190
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Ile Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 191
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v163 IgV
<400> 191
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 192
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v164 IgV
<400> 192
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 193
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v165 IgV
<400> 193
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 194
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v166 IgV
<400> 194
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 195
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v167 IgV
<400> 195
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Leu Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 196
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v168 IgV
<400> 196
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Ile Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 197
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v169 IgV
<400> 197
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 198
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v170 IgV
<400> 198
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 199
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v171 IgV
<400> 199
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 200
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v172 IgV
<400> 200
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 201
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v173 IgV
<400> 201
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 202
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v174 IgV
<400> 202
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 203
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v175 IgV
<400> 203
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 204
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v176 IgV
<400> 204
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 205
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v177 IgV
<400> 205
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Phe Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Ile Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 206
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v178 IgV
<400> 206
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ala Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 207
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v179 IgV
<400> 207
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Thr Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 208
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v180 IgV
<400> 208
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 209
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v181 IgV
<400> 209
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Val Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Val Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 210
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v182 IgV
<400> 210
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Met Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Lys His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 211
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v183 IgV
<400> 211
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Ile Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Phe Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 212
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v184 IgV
<400> 212
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 213
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v185 IgV
<400> 213
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Ile Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Arg Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 214
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v186 IgV
<400> 214
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Val Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 215
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v187 IgV
<400> 215
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Ile Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 216
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v188 IgV
<400> 216
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Gly Glu Leu Ser Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 217
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v189 IgV
<400> 217
Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 218
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v190 IgV
<400> 218
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Leu Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser His Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 219
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v191 IgV
<400> 219
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Gly Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Glu Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Pro Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 220
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v192 IgV
<400> 220
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Gln Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 221
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v193 IgV
<400> 221
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 222
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v194 IgV
<400> 222
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 223
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v195 IgV
<400> 223
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Trp Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 224
<211> 329
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD86(B7-2)
<400> 224
Met Asp Pro Gln Cys Thr Met Gly Leu Ser Asn Ile Leu Phe Val Met
1 5 10 15
Ala Phe Leu Leu Ser Gly Ala Ala Pro Leu Lys Ile Gln Ala Tyr Phe
20 25 30
Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln
35 40 45
Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val
50 55 60
Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser
65 70 75 80
Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg
85 90 95
Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile
100 105 110
His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser
115 120 125
Glu Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Val Pro Ile
130 135 140
Ser Asn Ile Thr Glu Asn Val Tyr Ile Asn Leu Thr Cys Ser Ser Ile
145 150 155 160
His Gly Tyr Pro Glu Pro Lys Lys Met Ser Val Leu Leu Arg Thr Lys
165 170 175
Asn Ser Thr Ile Glu Tyr Asp Gly Val Met Gln Lys Ser Gln Asp Asn
180 185 190
Val Thr Glu Leu Tyr Asp Val Ser Ile Ser Leu Ser Val Ser Phe Pro
195 200 205
Asp Val Thr Ser Asn Met Thr Ile Phe Cys Ile Leu Glu Thr Asp Lys
210 215 220
Thr Arg Leu Leu Ser Ser Pro Phe Ser Ile Glu Leu Glu Asp Pro Gln
225 230 235 240
Pro Pro Pro Asp His Ile Pro Trp Ile Thr Ala Val Leu Pro Thr Val
245 250 255
Ile Ile Cys Val Met Val Phe Cys Leu Ile Leu Trp Lys Trp Lys Lys
260 265 270
Lys Lys Arg Pro Arg Asn Ser Tyr Lys Cys Gly Thr Asn Thr Met Glu
275 280 285
Arg Glu Glu Ser Glu Gln Thr Lys Lys Arg Glu Lys Ile His Ile Pro
290 295 300
Glu Arg Ser Asp Glu Ala Gln Arg Val Phe Lys Ser Ser Lys Thr Ser
305 310 315 320
Ser Cys Asp Lys Ser Asp Thr Cys Phe
325
<210> 225
<211> 290
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD274 (PD-L1, B7-H1)
<400> 225
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu
1 5 10 15
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr
20 25 30
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu
35 40 45
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile
50 55 60
Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser
65 70 75 80
Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn
85 90 95
Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr
100 105 110
Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val
115 120 125
Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val
130 135 140
Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr
145 150 155 160
Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser
165 170 175
Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn
180 185 190
Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr
195 200 205
Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu
210 215 220
Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His
225 230 235 240
Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr
245 250 255
Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys
260 265 270
Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu
275 280 285
Glu Thr
290
<210> 226
<211> 273
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PDCD1LG2(PD-L2, CD273)
<400> 226
Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln
1 5 10 15
Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile
20 25 30
Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser
35 40 45
His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn
50 55 60
Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu
65 70 75 80
Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp
85 90 95
Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr
100 105 110
Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr
115 120 125
His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln
130 135 140
Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val
145 150 155 160
Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val
165 170 175
Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys
180 185 190
Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp
195 200 205
Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His
210 215 220
Ile Phe Ile Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val
225 230 235 240
Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp
245 250 255
Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala
260 265 270
Ile
<210> 227
<211> 302
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> ICOSLG(B7RP1, CD275, ICOSL, B7-H2)
<400> 227
Met Arg Leu Gly Ser Pro Gly Leu Leu Phe Leu Leu Phe Ser Ser Leu
1 5 10 15
Arg Ala Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp
20 25 30
Val Glu Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn
35 40 45
Asp Val Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr
50 55 60
Tyr His Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr
65 70 75 80
Arg Asn Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe
85 90 95
Ser Leu Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His
100 105 110
Cys Leu Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val
115 120 125
Glu Val Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser
130 135 140
Ala Pro His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser
145 150 155 160
Ile Asn Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp
165 170 175
Asn Ser Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn
180 185 190
Met Arg Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr
195 200 205
Pro Ser Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln
210 215 220
Asn Leu Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp
225 230 235 240
Lys Ile Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr
245 250 255
Trp Ser Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala
260 265 270
Ile Gly Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly
275 280 285
Ala Trp Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val
290 295 300
<210> 228
<211> 534
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD276(B7-H3)
<400> 228
Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala
1 5 10 15
Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln
20 25 30
Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu
35 40 45
Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn
50 55 60
Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala
65 70 75 80
Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe
85 90 95
Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val
100 105 110
Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp
115 120 125
Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys
130 135 140
Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr
145 150 155 160
Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val
165 170 175
Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr
180 185 190
Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu
195 200 205
Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn
210 215 220
Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln
225 230 235 240
Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val
245 250 255
Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro
260 265 270
Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr
275 280 285
Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly
290 295 300
Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln
305 310 315 320
Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly
325 330 335
Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val
340 345 350
Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu
355 360 365
Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser
370 375 380
Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln
385 390 395 400
Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu
405 410 415
Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala
420 425 430
Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp
435 440 445
Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro
450 455 460
Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu
465 470 475 480
Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys
485 490 495
Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly
500 505 510
Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp
515 520 525
Asp Gly Gln Glu Ile Ala
530
<210> 229
<211> 282
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> VTCN1(B7-H4)
<400> 229
Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile
1 5 10 15
Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser
20 25 30
Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile
35 40 45
Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu
50 55 60
Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val
65 70 75 80
His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met
85 90 95
Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn
100 105 110
Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr
115 120 125
Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu
130 135 140
Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn
145 150 155 160
Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln
165 170 175
Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser
180 185 190
Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met
195 200 205
Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser
210 215 220
Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val
225 230 235 240
Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser
245 250 255
Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu
260 265 270
Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys
275 280
<210> 230
<211> 220
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD28
<400> 230
Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val
1 5 10 15
Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr
20 25 30
Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser
35 40 45
Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu
50 55 60
Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser
65 70 75 80
Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr
85 90 95
Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys
100 105 110
Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser
115 120 125
Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro
130 135 140
Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly
145 150 155 160
Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile
165 170 175
Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
180 185 190
Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
195 200 205
Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
210 215 220
<210> 231
<211> 223
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CTLA4
<400> 231
Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala
1 5 10 15
Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro
20 25 30
Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala
35 40 45
Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly
50 55 60
Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln
65 70 75 80
Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr
85 90 95
Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val
100 105 110
Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile
115 120 125
Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly
130 135 140
Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser
145 150 155 160
Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe
165 170 175
Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys
180 185 190
Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu
195 200 205
Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn
210 215 220
<210> 232
<211> 288
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PDCD1(PD-1)
<400> 232
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln
1 5 10 15
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp
20 25 30
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp
35 40 45
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val
50 55 60
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
65 70 75 80
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg
85 90 95
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg
100 105 110
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu
115 120 125
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val
130 135 140
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
145 150 155 160
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly
165 170 175
Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys
180 185 190
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro
195 200 205
Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly
210 215 220
Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro
225 230 235 240
Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly
245 250 255
Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg
260 265 270
Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu
275 280 285
<210> 233
<211> 199
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> ICOS
<400> 233
Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys
1 5 10 15
Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile
20 25 30
Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val
35 40 45
Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp
50 55 60
Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu
65 70 75 80
Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu
85 90 95
Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser
100 105 110
Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu
115 120 125
His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro
130 135 140
Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu
145 150 155 160
Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro
165 170 175
Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser
180 185 190
Arg Leu Thr Asp Val Thr Leu
195
<210> 234
<211> 289
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> BTLA(CD272)
<400> 234
Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val
1 5 10 15
Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu
20 25 30
Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile
35 40 45
Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala
50 55 60
Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val
65 70 75 80
Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser
85 90 95
Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser
100 105 110
Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser
115 120 125
Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser
130 135 140
Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro
145 150 155 160
Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys
165 170 175
Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala
180 185 190
Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr
195 200 205
Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly
210 215 220
Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser
225 230 235 240
Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val
245 250 255
Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala
260 265 270
Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg
275 280 285
Ser
<210> 235
<211> 458
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD4
<400> 235
Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu
1 5 10 15
Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys
20 25 30
Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser
35 40 45
Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn
50 55 60
Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala
65 70 75 80
Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile
85 90 95
Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu
100 105 110
Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn
115 120 125
Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu
130 135 140
Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly
145 150 155 160
Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu
165 170 175
Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys
180 185 190
Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser
195 200 205
Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro
210 215 220
Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp
225 230 235 240
Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu
245 250 255
Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu
260 265 270
Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu
275 280 285
Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys
290 295 300
Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr
305 310 315 320
Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro
325 330 335
Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser
340 345 350
Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp
355 360 365
Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile
370 375 380
Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile
385 390 395 400
Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile
405 410 415
Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met
420 425 430
Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro
435 440 445
His Arg Phe Gln Lys Thr Cys Ser Pro Ile
450 455
<210> 236
<211> 235
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD8A(CD8-alpha)
<400> 236
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr
20 25 30
Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser
35 40 45
Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala
50 55 60
Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala
65 70 75 80
Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp
85 90 95
Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr
100 105 110
Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe
115 120 125
Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg
130 135 140
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg
145 150 155 160
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly
165 170 175
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr
180 185 190
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His
195 200 205
Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser
210 215 220
Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val
225 230 235
<210> 237
<211> 210
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD8B(CD8-beta)
<400> 237
Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu
1 5 10 15
His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln
20 25 30
Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser
35 40 45
Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp
50 55 60
Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile
65 70 75 80
His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala
85 90 95
Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly
100 105 110
Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys
115 120 125
Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro
130 135 140
Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro
145 150 155 160
Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu
165 170 175
Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His
180 185 190
Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe
195 200 205
Tyr Lys
210
<210> 238
<211> 525
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> LAG3
<400> 238
Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp
1 5 10 15
Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val
20 25 30
Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile
35 40 45
Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln
50 55 60
His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu
65 70 75 80
Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro
85 90 95
Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly
100 105 110
Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln
115 120 125
Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala
130 135 140
Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys
145 150 155 160
Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro
165 170 175
Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser
180 185 190
Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln
195 200 205
Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser
210 215 220
Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly
225 230 235 240
Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn
245 250 255
Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala
260 265 270
Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val
275 280 285
Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly
290 295 300
Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu
305 310 315 320
Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His
325 330 335
Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr
340 345 350
Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu
355 360 365
Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser
370 375 380
Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala
385 390 395 400
Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln
405 410 415
Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser
420 425 430
Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly
435 440 445
His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu
450 455 460
Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro
465 470 475 480
Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln
485 490 495
Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro
500 505 510
Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu
515 520 525
<210> 239
<211> 301
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> HAVCR2(TIM-3)
<400> 239
Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu
1 5 10 15
Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln
20 25 30
Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu
35 40 45
Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly
50 55 60
Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser
65 70 75 80
Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr
85 90 95
Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile
100 105 110
Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val
115 120 125
Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe
130 135 140
Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala
145 150 155 160
Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile
165 170 175
Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu
180 185 190
Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly
195 200 205
Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe
210 215 220
Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile
225 230 235 240
Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu
245 250 255
Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr
260 265 270
Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln
275 280 285
Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro
290 295 300
<210> 240
<211> 526
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CEACAM1
<400> 240
Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln
1 5 10 15
Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
20 25 30
Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly
35 40 45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly
50 55 60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val
65 70 75 80
Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser
85 90 95
Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val
100 105 110
Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp
115 120 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu
130 135 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys
145 150 155 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr
165 170 175
Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
180 185 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn
195 200 205
Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn
210 215 220
Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro
225 230 235 240
Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser
245 250 255
Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu
260 265 270
Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
275 280 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser
290 295 300
Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu
305 310 315 320
Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr
325 330 335
Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp
340 345 350
Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser
355 360 365
Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn
370 375 380
Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn
385 390 395 400
Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr
405 410 415
Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly
420 425 430
Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu
435 440 445
Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg
450 455 460
Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His
465 470 475 480
Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu
485 490 495
Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser
500 505 510
Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln
515 520 525
<210> 241
<211> 244
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> TIGIT
<400> 241
Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala
1 5 10 15
Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn
20 25 30
Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser
35 40 45
Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln
50 55 60
Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser
65 70 75 80
Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln
85 90 95
Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr
100 105 110
Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu
115 120 125
Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly
130 135 140
Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val
145 150 155 160
Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu
165 170 175
Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser
180 185 190
Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala
195 200 205
Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp
210 215 220
Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe
225 230 235 240
Thr Glu Thr Gly
<210> 242
<211> 417
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PVR(CD155)
<400> 242
Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu
1 5 10 15
Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln
20 25 30
Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro
35 40 45
Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu
50 55 60
Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln
65 70 75 80
Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala
85 90 95
Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly
100 105 110
Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe
115 120 125
Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys
130 135 140
Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro
145 150 155 160
Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln
165 170 175
Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val
180 185 190
Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu
195 200 205
Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu
210 215 220
His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val
225 230 235 240
Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr
245 250 255
Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro
260 265 270
Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro
275 280 285
Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys
290 295 300
Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala
305 310 315 320
Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu
325 330 335
His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile
340 345 350
Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser
355 360 365
Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser
370 375 380
Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala
385 390 395 400
Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr
405 410 415
Arg
<210> 243
<211> 538
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PVRL2(CD112)
<400> 243
Met Ala Arg Ala Ala Ala Leu Leu Pro Ser Arg Ser Pro Pro Thr Pro
1 5 10 15
Leu Leu Trp Pro Leu Leu Leu Leu Leu Leu Leu Glu Thr Gly Ala Gln
20 25 30
Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly Gly
35 40 45
Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu Tyr
50 55 60
Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His Gln
65 70 75 80
Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser Pro
85 90 95
Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser Thr
100 105 110
Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu His
115 120 125
Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala Thr
130 135 140
Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile Ala
145 150 155 160
Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln Asp
165 170 175
Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro Ala
180 185 190
Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr Gln
195 200 205
Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe Thr
210 215 220
Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys Val
225 230 235 240
Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu Ser
245 250 255
Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn Trp
260 265 270
Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser Asn
275 280 285
Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe Pro
290 295 300
Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val Asp
305 310 315 320
Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val Gly
325 330 335
Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn Thr
340 345 350
Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala Ala
355 360 365
Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg Gln
370 375 380
Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp Leu
385 390 395 400
Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu Glu
405 410 415
Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu His
420 425 430
Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr Glu
435 440 445
Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg Ser
450 455 460
Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro Val
465 470 475 480
Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu Asp
485 490 495
Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro Ile
500 505 510
Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly Lys
515 520 525
Gly Phe Val Met Ser Arg Ala Met Tyr Val
530 535
<210> 244
<211> 336
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD226
<400> 244
Met Asp Tyr Pro Thr Leu Leu Leu Ala Leu Leu His Val Tyr Arg Ala
1 5 10 15
Leu Cys Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn
20 25 30
Met Ser Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val
35 40 45
Glu Trp Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser
50 55 60
Pro Thr His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr
65 70 75 80
Phe Leu Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg
85 90 95
Asn Ala Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr
100 105 110
Tyr Pro Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp
115 120 125
Ser Phe Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro
130 135 140
Gly Lys Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val
145 150 155 160
Gln Ala Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu
165 170 175
Thr Tyr Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro
180 185 190
Arg Gln Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val
195 200 205
Ile Pro Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu
210 215 220
Gln Ala Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val
225 230 235 240
Ala Glu Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly
245 250 255
Thr Val Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val
260 265 270
Ile Phe Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr
275 280 285
Glu Ser Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile
290 295 300
Ser Thr Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp
305 310 315 320
Ile Tyr Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val
325 330 335
<210> 245
<211> 351
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD2
<400> 245
Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn
1 5 10 15
Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu
20 25 30
Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe
35 40 45
Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp
50 55 60
Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu
65 70 75 80
Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His
85 90 95
Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr
100 105 110
Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu
115 120 125
Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu
130 135 140
Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln
145 150 155 160
Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp
165 170 175
Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val
180 185 190
Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu
195 200 205
Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met
210 215 220
Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln
225 230 235 240
Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val
245 250 255
Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr
260 265 270
Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His
275 280 285
Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val
290 295 300
Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val
305 310 315 320
His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys
325 330 335
Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn
340 345 350
<210> 246
<211> 180
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD160
<400> 246
Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu
1 5 10 15
Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser
20 25 30
Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His
35 40 45
Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg
50 55 60
Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys
65 70 75 80
Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met
85 90 95
Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys
100 105 110
Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe
115 120 125
Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys
130 135 140
Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser
145 150 155 160
Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val
165 170 175
Ala Leu Gln Ala
180
<210> 247
<211> 278
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD200
<400> 247
Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr
1 5 10 15
Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val
20 25 30
Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser
35 40 45
Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp
50 55 60
Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu
65 70 75 80
Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile
85 90 95
Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr
100 105 110
Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe
115 120 125
Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile
130 135 140
Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys
145 150 155 160
Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg
165 170 175
Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr
180 185 190
Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val
195 200 205
Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp
210 215 220
Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro Leu Leu
225 230 235 240
Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser Ile Leu
245 250 255
Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu Ser Gln
260 265 270
Gly Val Gln Lys Met Thr
275
<210> 248
<211> 325
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD200R1(CD200R)
<400> 248
Met Leu Cys Pro Trp Arg Thr Ala Asn Leu Gly Leu Leu Leu Ile Leu
1 5 10 15
Thr Ile Phe Leu Val Ala Ala Ser Ser Ser Leu Cys Met Asp Glu Lys
20 25 30
Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser
35 40 45
Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile
50 55 60
Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly
65 70 75 80
Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr Asn Glu Thr Lys
85 90 95
Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp
100 105 110
Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile Thr His Asp Gly
115 120 125
Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly
130 135 140
Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn
145 150 155 160
Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala
165 170 175
Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr
180 185 190
Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val
195 200 205
His Asn Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn
210 215 220
Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser
225 230 235 240
Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile Ile Ile Leu Thr
245 250 255
Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly Cys Arg Lys Tyr
260 265 270
Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu Glu Asp Glu Met
275 280 285
Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro Leu Tyr Asp Thr
290 295 300
Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser Glu Val Asp Thr
305 310 315 320
Asp Leu His Thr Leu
325
<210> 249
<211> 201
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> NC R3 (NKp30)
<400> 249
Met Ala Trp Met Leu Leu Leu Ile Leu Ile Met Val His Pro Gly Ser
1 5 10 15
Cys Ala Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly
20 25 30
Ser Ser Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu
35 40 45
Ala Ile Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys
50 55 60
Glu Val Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu
65 70 75 80
Ala Ser Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg
85 90 95
Asp Val Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val
100 105 110
Leu Gly Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu
115 120 125
Lys Glu His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala
130 135 140
Gly Phe Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val
145 150 155 160
Tyr Tyr Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu
165 170 175
Pro Ala Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala
180 185 190
His Leu Leu Pro Pro Val Pro Gly Gly
195 200
<210> 250
<211> 224
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD86(B7-2) ECD
<400> 250
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro
1 5 10 15
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val
20 25 30
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly
35 40 45
Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser
50 55 60
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys
65 70 75 80
Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly
85 90 95
Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn
100 105 110
Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val
115 120 125
Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys
130 135 140
Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp
145 150 155 160
Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val
165 170 175
Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr
180 185 190
Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro
195 200 205
Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro
210 215 220
<210> 251
<211> 220
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD274 (PD-L1, B7-H1) ECD
<400> 251
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 252
<211> 201
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PDCD1LG2(PD-L2, CD273) ECD
<400> 252
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 253
<211> 238
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> ICOSLG(B7RP1, CD275, ICOSL, B7-H2) ECD
<400> 253
Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu
1 5 10 15
Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val
20 25 30
Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His
35 40 45
Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn
50 55 60
Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu
65 70 75 80
Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu
85 90 95
Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val
100 105 110
Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro
115 120 125
His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn
130 135 140
Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser
145 150 155 160
Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg
165 170 175
Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser
180 185 190
Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu
195 200 205
Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile
210 215 220
Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr
225 230 235
<210> 254
<211> 438
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD276(B7-H3) ECD
<400> 254
Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr
1 5 10 15
Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu
20 25 30
Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val
35 40 45
His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg
50 55 60
Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg
65 70 75 80
Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val
85 90 95
Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala
100 105 110
Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg
115 120 125
Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro
130 135 140
Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly
145 150 155 160
Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val
165 170 175
His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys
180 185 190
Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr
195 200 205
Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro
210 215 220
Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys
225 230 235 240
Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile
245 250 255
Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly
260 265 270
Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp
275 280 285
Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val
290 295 300
Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly
305 310 315 320
Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser
325 330 335
Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr
340 345 350
Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp
355 360 365
Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln
370 375 380
Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val
385 390 395 400
Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val
405 410 415
Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met
420 425 430
Thr Phe Pro Pro Glu Ala
435
<210> 255
<211> 235
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> VTCN1(B7-H4) ECD
<400> 255
Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr
1 5 10 15
Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys
20 25 30
Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu
35 40 45
Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp
50 55 60
Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe
65 70 75 80
Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val
85 90 95
Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys
100 105 110
Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met
115 120 125
Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys
130 135 140
Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln
145 150 155 160
Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu
165 170 175
Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn
180 185 190
Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala
195 200 205
Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg
210 215 220
Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser
225 230 235
<210> 256
<211> 134
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD28 ECD
<400> 256
Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
1 5 10 15
Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
20 25 30
Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
35 40 45
Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
50 55 60
Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
65 70 75 80
Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
85 90 95
Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
100 105 110
Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
115 120 125
Pro Gly Pro Ser Lys Pro
130
<210> 257
<211> 126
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CTLA4 ECD
<400> 257
Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg
1 5 10 15
Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr
20 25 30
Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu
35 40 45
Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp
50 55 60
Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr
65 70 75 80
Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val
85 90 95
Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr
100 105 110
Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp
115 120 125
<210> 258
<211> 150
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PDCD1(PD-1) ECD
<400> 258
Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr
1 5 10 15
Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe
20 25 30
Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr
35 40 45
Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu
50 55 60
Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu
65 70 75 80
Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn
85 90 95
Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala
100 105 110
Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg
115 120 125
Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly
130 135 140
Gln Phe Gln Thr Leu Val
145 150
<210> 259
<211> 120
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> ICOS ECD
<400> 259
Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly
1 5 10 15
Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys
20 25 30
Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr
35 40 45
Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His
50 55 60
Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp
65 70 75 80
His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro
85 90 95
Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu
100 105 110
Ser Gln Leu Cys Cys Gln Leu Lys
115 120
<210> 260
<211> 127
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> BTLA(CD272) ECD
<400> 260
Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His
1 5 10 15
Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr
20 25 30
Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr
35 40 45
Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn
50 55 60
Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn
65 70 75 80
Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser
85 90 95
His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg
100 105 110
Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg
115 120 125
<210> 261
<211> 371
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD4 ECD
<400> 261
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln
50 55 60
Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
65 70 75 80
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
85 90 95
Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln
100 105 110
Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val
115 120 125
Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu
130 135 140
Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr
145 150 155 160
Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val
165 170 175
Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu
180 185 190
Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr
195 200 205
Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys
210 215 220
Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg
225 230 235 240
Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His
245 250 255
Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu
260 265 270
Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn
275 280 285
Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu
290 295 300
Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu
305 310 315 320
Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu
325 330 335
Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln
340 345 350
Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro
355 360 365
Val Gln Pro
370
<210> 262
<211> 161
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD8A(CD8-alpha) ECD
<400> 262
Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu
1 5 10 15
Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly
20 25 30
Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe
35 40 45
Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp
50 55 60
Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr
65 70 75 80
Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala
85 90 95
Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu
100 105 110
Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala
115 120 125
Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg
130 135 140
Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys
145 150 155 160
Asp
<210> 263
<211> 149
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD8B(CD8-beta) ECD
<400> 263
Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val
1 5 10 15
Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr
20 25 30
Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe
35 40 45
Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val
50 55 60
Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu
65 70 75 80
Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met
85 90 95
Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser
100 105 110
Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr
115 120 125
Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly
130 135 140
Pro Leu Cys Ser Pro
145
<210> 264
<211> 422
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> LAG3 ECD
<400> 264
Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys
1 5 10 15
Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly
20 25 30
Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro
35 40 45
Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp
50 55 60
Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly
65 70 75 80
Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu
85 90 95
Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg
100 105 110
Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg
115 120 125
Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr
130 135 140
Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn
145 150 155 160
Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg
165 170 175
Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His
180 185 190
Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser
195 200 205
Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser
210 215 220
Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu
225 230 235 240
Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu
245 250 255
Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro
260 265 270
Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe
275 280 285
Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr
290 295 300
Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu
305 310 315 320
Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu
325 330 335
Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe
340 345 350
Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro
355 360 365
Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys
370 375 380
Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr
385 390 395 400
Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala
405 410 415
Leu Pro Ala Gly His Leu
420
<210> 265
<211> 181
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> HAVCR2(TIM-3) ECD
<400> 265
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
1 5 10 15
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
20 25 30
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
35 40 45
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
50 55 60
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65 70 75 80
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
85 90 95
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
100 105 110
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
115 120 125
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
130 135 140
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145 150 155 160
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
165 170 175
Thr Ile Arg Ile Gly
180
<210> 266
<211> 394
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CEACAM1 ECD
<400> 266
Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu
1 5 10 15
Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser
20 25 30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr
35 40 45
Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg
50 55 60
Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln
65 70 75 80
Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val
85 90 95
Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys
100 105 110
Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala
115 120 125
Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp
130 135 140
Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser
145 150 155 160
Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr
165 170 175
Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser
180 185 190
Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile
195 200 205
Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser
210 215 220
Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn
225 230 235 240
Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr
245 250 255
Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr
260 265 270
Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser
275 280 285
Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr
290 295 300
Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly
305 310 315 320
Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu
325 330 335
Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val
340 345 350
Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile
355 360 365
Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala
370 375 380
Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly
385 390
<210> 267
<211> 120
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> TIGIT ECD
<400> 267
Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys
1 5 10 15
Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln
20 25 30
Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys
35 40 45
Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val
50 55 60
Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn
65 70 75 80
Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr
85 90 95
Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu
100 105 110
His Gly Ala Arg Phe Gln Ile Pro
115 120
<210> 268
<211> 323
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PVR(CD155) ECD
<400> 268
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 269
<211> 329
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PVRL2(CD112) ECD
<400> 269
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 270
<211> 236
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD226 ECD
<400> 270
Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser
1 5 10 15
Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp
20 25 30
Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr
35 40 45
His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu
50 55 60
Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala
65 70 75 80
Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Tyr Pro
85 90 95
Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp Ser Phe
100 105 110
Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro Gly Lys
115 120 125
Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val Gln Ala
130 135 140
Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu Thr Tyr
145 150 155 160
Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro Arg Gln
165 170 175
Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val Ile Pro
180 185 190
Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu Gln Ala
195 200 205
Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val Ala Glu
210 215 220
Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala
225 230 235
<210> 271
<211> 185
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD2 ECD
<400> 271
Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp
1 5 10 15
Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp
20 25 30
Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg
35 40 45
Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys
50 55 60
Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile
65 70 75 80
Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys
85 90 95
Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser
100 105 110
Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr
115 120 125
Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser
130 135 140
Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe
145 150 155 160
Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro
165 170 175
Val Ser Cys Pro Glu Lys Gly Leu Asp
180 185
<210> 272
<211> 133
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD160 ECD
<400> 272
Ile Asn Ile Thr Ser Ser Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu
1 5 10 15
Ile Cys Thr Val Trp His Lys Lys Glu Glu Ala Glu Gly Phe Val Val
20 25 30
Phe Leu Cys Lys Asp Arg Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu
35 40 45
Lys Gln Leu Arg Leu Lys Arg Asp Pro Gly Ile Asp Gly Val Gly Glu
50 55 60
Ile Ser Ser Gln Leu Met Phe Thr Ile Ser Gln Val Thr Pro Leu His
65 70 75 80
Ser Gly Thr Tyr Gln Cys Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg
85 90 95
Leu Gln Gly His Phe Phe Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr
100 105 110
Thr Val Thr Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn
115 120 125
Glu Gly Thr Leu Ser
130
<210> 273
<211> 202
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD200 ECD
<400> 273
Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro
1 5 10 15
Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val
20 25 30
Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe
35 40 45
Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile
50 55 60
Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn
65 70 75 80
Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe
85 90 95
Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln
100 105 110
Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile
115 120 125
Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val
130 135 140
Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn
145 150 155 160
Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn
165 170 175
Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val
180 185 190
Thr Asp Phe Lys Gln Thr Val Asn Lys Gly
195 200
<210> 274
<211> 215
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD200R1(CD200R) ECD
<400> 274
Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu
1 5 10 15
Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys
20 25 30
Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile
35 40 45
Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr
50 55 60
Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val
65 70 75 80
Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile
85 90 95
Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn
100 105 110
Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr
115 120 125
Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly
130 135 140
Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr
145 150 155 160
Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys
165 170 175
His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His
180 185 190
Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly
195 200 205
Ala Lys Lys Ser Ala Lys Leu
210 215
<210> 275
<211> 117
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> NC R3 (NKp30) ECD
<400> 275
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu
100 105 110
His Pro Gln Leu Gly
115
<210> 276
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> VH signal peptide
<400> 276
Met Gly Ser Thr Ala Ile Leu Ala Leu Leu Leu Ala Val Leu Gln Gly
1 5 10 15
Val Ser Ala
<210> 277
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG1 Fc
<400> 277
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 278
<211> 235
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG2 Fc
<400> 278
Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro
1 5 10 15
Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro
20 25 30
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
35 40 45
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn
50 55 60
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
65 70 75 80
Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val
85 90 95
Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
100 105 110
Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys
115 120 125
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu
130 135 140
Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
145 150 155 160
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
165 170 175
Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe
180 185 190
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
195 200 205
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
210 215 220
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
225 230 235
<210> 279
<211> 254
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD80(B7-1)
<400> 279
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly Ile Phe
210 215 220
Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg Glu Arg
225 230 235 240
Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val
245 250
<210> 280
<211> 306
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD86(B7-2)
<400> 280
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro
1 5 10 15
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val
20 25 30
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly
35 40 45
Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser
50 55 60
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys
65 70 75 80
Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly
85 90 95
Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn
100 105 110
Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val
115 120 125
Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys
130 135 140
Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp
145 150 155 160
Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val
165 170 175
Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr
180 185 190
Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro
195 200 205
Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro
210 215 220
Trp Ile Thr Ala Val Leu Pro Thr Val Ile Ile Cys Val Met Val Phe
225 230 235 240
Cys Leu Ile Leu Trp Lys Trp Lys Lys Lys Lys Arg Pro Arg Asn Ser
245 250 255
Tyr Lys Cys Gly Thr Asn Thr Met Glu Arg Glu Glu Ser Glu Gln Thr
260 265 270
Lys Lys Arg Glu Lys Ile His Ile Pro Glu Arg Ser Asp Glu Ala Gln
275 280 285
Arg Val Phe Lys Ser Ser Lys Thr Ser Ser Cys Asp Lys Ser Asp Thr
290 295 300
Cys Phe
305
<210> 281
<211> 272
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD274 (PD-L1, B7-H1)
<400> 281
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu Val
210 215 220
Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe Ile
225 230 235 240
Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile
245 250 255
Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr
260 265 270
<210> 282
<211> 254
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature PDCD1LG2(PD-L2, CD273)
<400> 282
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His Ile Phe Ile
195 200 205
Pro Phe Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val Ile Ala Leu
210 215 220
Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp Thr Thr Lys
225 230 235 240
Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala Ile
245 250
<210> 283
<211> 284
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature ICOSLG(B7RP1, CD275, ICOSL, B7-H2)
<400> 283
Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu
1 5 10 15
Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val
20 25 30
Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His
35 40 45
Ile Pro Gln Asn Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn
50 55 60
Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu
65 70 75 80
Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu
85 90 95
Val Leu Ser Gln Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val
100 105 110
Thr Leu His Val Ala Ala Asn Phe Ser Val Pro Val Val Ser Ala Pro
115 120 125
His Ser Pro Ser Gln Asp Glu Leu Thr Phe Thr Cys Thr Ser Ile Asn
130 135 140
Gly Tyr Pro Arg Pro Asn Val Tyr Trp Ile Asn Lys Thr Asp Asn Ser
145 150 155 160
Leu Leu Asp Gln Ala Leu Gln Asn Asp Thr Val Phe Leu Asn Met Arg
165 170 175
Gly Leu Tyr Asp Val Val Ser Val Leu Arg Ile Ala Arg Thr Pro Ser
180 185 190
Val Asn Ile Gly Cys Cys Ile Glu Asn Val Leu Leu Gln Gln Asn Leu
195 200 205
Thr Val Gly Ser Gln Thr Gly Asn Asp Ile Gly Glu Arg Asp Lys Ile
210 215 220
Thr Glu Asn Pro Val Ser Thr Gly Glu Lys Asn Ala Ala Thr Trp Ser
225 230 235 240
Ile Leu Ala Val Leu Cys Leu Leu Val Val Val Ala Val Ala Ile Gly
245 250 255
Trp Val Cys Arg Asp Arg Cys Leu Gln His Ser Tyr Ala Gly Ala Trp
260 265 270
Ala Val Ser Pro Glu Thr Glu Leu Thr Gly His Val
275 280
<210> 284
<211> 506
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD276(B7-H3)
<400> 284
Leu Glu Val Gln Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr
1 5 10 15
Asp Ala Thr Leu Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu
20 25 30
Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val
35 40 45
His Ser Phe Ala Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg
50 55 60
Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg
65 70 75 80
Leu Gln Arg Val Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val
85 90 95
Ser Ile Arg Asp Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala
100 105 110
Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg
115 120 125
Pro Gly Asp Thr Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro
130 135 140
Glu Ala Glu Val Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly
145 150 155 160
Asn Val Thr Thr Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val
165 170 175
His Ser Ile Leu Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys
180 185 190
Leu Val Arg Asn Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr
195 200 205
Ile Thr Pro Gln Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro
210 215 220
Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys
225 230 235 240
Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile
245 250 255
Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly
260 265 270
Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp
275 280 285
Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val
290 295 300
Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly
305 310 315 320
Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser
325 330 335
Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr
340 345 350
Ile Thr Cys Ser Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp
355 360 365
Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln
370 375 380
Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val
385 390 395 400
Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val
405 410 415
Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met
420 425 430
Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys
435 440 445
Leu Ile Ala Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile
450 455 460
Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly
465 470 475 480
Glu Gly Glu Gly Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp
485 490 495
Ser Lys Glu Asp Asp Gly Gln Glu Ile Ala
500 505
<210> 285
<211> 258
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature VTCN1(B7-H4)
<400> 285
Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr
1 5 10 15
Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys
20 25 30
Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu
35 40 45
Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp
50 55 60
Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe
65 70 75 80
Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val
85 90 95
Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys
100 105 110
Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met
115 120 125
Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys
130 135 140
Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln
145 150 155 160
Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu
165 170 175
Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn
180 185 190
Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala
195 200 205
Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg
210 215 220
Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser
225 230 235 240
Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met
245 250 255
Leu Lys
<210> 286
<211> 202
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD28
<400> 286
Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr Asp Asn
1 5 10 15
Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser Arg Glu
20 25 30
Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu Val Cys
35 40 45
Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser Lys Thr
50 55 60
Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr
65 70 75 80
Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile
85 90 95
Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly
100 105 110
Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe
115 120 125
Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val
130 135 140
Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp
145 150 155 160
Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met
165 170 175
Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala
180 185 190
Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
195 200
<210> 287
<211> 188
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CTLA4
<400> 287
Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg
1 5 10 15
Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr
20 25 30
Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu
35 40 45
Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp
50 55 60
Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr
65 70 75 80
Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val
85 90 95
Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr
100 105 110
Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu
115 120 125
Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe
130 135 140
Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro
145 150 155 160
Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys
165 170 175
Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn
180 185
<210> 288
<211> 268
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature PDCD1(PD-1)
<400> 288
Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr
1 5 10 15
Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe
20 25 30
Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr
35 40 45
Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu
50 55 60
Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu
65 70 75 80
Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn
85 90 95
Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala
100 105 110
Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg
115 120 125
Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly
130 135 140
Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser
145 150 155 160
Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala
165 170 175
Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp
180 185 190
Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe
195 200 205
Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu
210 215 220
Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser
225 230 235 240
Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro
245 250 255
Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu
260 265
<210> 289
<211> 179
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature ICOS
<400> 289
Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile Phe His Asn Gly
1 5 10 15
Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val Gln Gln Phe Lys
20 25 30
Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp Leu Thr Lys Thr
35 40 45
Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu Lys Phe Cys His
50 55 60
Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu Tyr Asn Leu Asp
65 70 75 80
His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser Ile Phe Asp Pro
85 90 95
Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu His Ile Tyr Glu
100 105 110
Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro Ile Gly Cys Ala
115 120 125
Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu
130 135 140
Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr
145 150 155 160
Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp
165 170 175
Val Thr Leu
<210> 290
<211> 259
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature BTLA(CD272)
<400> 290
Lys Glu Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His
1 5 10 15
Ser Ile Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr
20 25 30
Cys Ala Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr
35 40 45
Cys Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn
50 55 60
Ile Ser Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn
65 70 75 80
Gly Ser Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser
85 90 95
His Ser Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg
100 105 110
Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu
115 120 125
Leu Pro Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu
130 135 140
Phe Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp
145 150 155 160
Thr Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu
165 170 175
Gln Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu
180 185 190
Thr Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu
195 200 205
Gly Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly
210 215 220
Ile Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg
225 230 235 240
Leu Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys
245 250 255
Val Arg Ser
<210> 291
<211> 433
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD4
<400> 291
Lys Lys Val Val Leu Gly Lys Lys Gly Asp Thr Val Glu Leu Thr Cys
1 5 10 15
Thr Ala Ser Gln Lys Lys Ser Ile Gln Phe His Trp Lys Asn Ser Asn
20 25 30
Gln Ile Lys Ile Leu Gly Asn Gln Gly Ser Phe Leu Thr Lys Gly Pro
35 40 45
Ser Lys Leu Asn Asp Arg Ala Asp Ser Arg Arg Ser Leu Trp Asp Gln
50 55 60
Gly Asn Phe Pro Leu Ile Ile Lys Asn Leu Lys Ile Glu Asp Ser Asp
65 70 75 80
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu Val Gln Leu Leu
85 90 95
Val Phe Gly Leu Thr Ala Asn Ser Asp Thr His Leu Leu Gln Gly Gln
100 105 110
Ser Leu Thr Leu Thr Leu Glu Ser Pro Pro Gly Ser Ser Pro Ser Val
115 120 125
Gln Cys Arg Ser Pro Arg Gly Lys Asn Ile Gln Gly Gly Lys Thr Leu
130 135 140
Ser Val Ser Gln Leu Glu Leu Gln Asp Ser Gly Thr Trp Thr Cys Thr
145 150 155 160
Val Leu Gln Asn Gln Lys Lys Val Glu Phe Lys Ile Asp Ile Val Val
165 170 175
Leu Ala Phe Gln Lys Ala Ser Ser Ile Val Tyr Lys Lys Glu Gly Glu
180 185 190
Gln Val Glu Phe Ser Phe Pro Leu Ala Phe Thr Val Glu Lys Leu Thr
195 200 205
Gly Ser Gly Glu Leu Trp Trp Gln Ala Glu Arg Ala Ser Ser Ser Lys
210 215 220
Ser Trp Ile Thr Phe Asp Leu Lys Asn Lys Glu Val Ser Val Lys Arg
225 230 235 240
Val Thr Gln Asp Pro Lys Leu Gln Met Gly Lys Lys Leu Pro Leu His
245 250 255
Leu Thr Leu Pro Gln Ala Leu Pro Gln Tyr Ala Gly Ser Gly Asn Leu
260 265 270
Thr Leu Ala Leu Glu Ala Lys Thr Gly Lys Leu His Gln Glu Val Asn
275 280 285
Leu Val Val Met Arg Ala Thr Gln Leu Gln Lys Asn Leu Thr Cys Glu
290 295 300
Val Trp Gly Pro Thr Ser Pro Lys Leu Met Leu Ser Leu Lys Leu Glu
305 310 315 320
Asn Lys Glu Ala Lys Val Ser Lys Arg Glu Lys Ala Val Trp Val Leu
325 330 335
Asn Pro Glu Ala Gly Met Trp Gln Cys Leu Leu Ser Asp Ser Gly Gln
340 345 350
Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro
355 360 365
Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu
370 375 380
Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg
385 390 395 400
Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu
405 410 415
Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro
420 425 430
Ile
<210> 292
<211> 214
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD8A(CD8-alpha)
<400> 292
Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr Trp Asn Leu Gly Glu
1 5 10 15
Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser Asn Pro Thr Ser Gly
20 25 30
Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala Ala Ser Pro Thr Phe
35 40 45
Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala Ala Glu Gly Leu Asp
50 55 60
Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp Thr Phe Val Leu Thr
65 70 75 80
Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr Tyr Phe Cys Ser Ala
85 90 95
Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu
100 105 110
Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala
115 120 125
Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg
130 135 140
Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys
145 150 155 160
Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu
165 170 175
Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Arg Arg Arg
180 185 190
Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser Gly Asp Lys Pro Ser
195 200 205
Leu Ser Ala Arg Tyr Val
210
<210> 293
<211> 189
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD8B(CD8-beta)
<400> 293
Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln Thr Asn Lys Met Val
1 5 10 15
Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser Asn Met Arg Ile Tyr
20 25 30
Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp Ser His His Glu Phe
35 40 45
Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile His Gly Glu Glu Val
50 55 60
Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala Ser Arg Phe Ile Leu
65 70 75 80
Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly Ile Tyr Phe Cys Met
85 90 95
Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys Gly Thr Gln Leu Ser
100 105 110
Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr
115 120 125
Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly
130 135 140
Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu Val Ala Gly Val Leu
145 150 155 160
Val Leu Leu Val Ser Leu Gly Val Ala Ile His Leu Cys Cys Arg Arg
165 170 175
Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe Tyr Lys
180 185
<210> 294
<211> 497
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature LAG3
<400> 294
Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys
1 5 10 15
Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly
20 25 30
Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro
35 40 45
Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp
50 55 60
Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly
65 70 75 80
Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu
85 90 95
Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg
100 105 110
Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg
115 120 125
Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr
130 135 140
Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn
145 150 155 160
Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg
165 170 175
Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His
180 185 190
Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser
195 200 205
Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser
210 215 220
Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu
225 230 235 240
Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu
245 250 255
Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro
260 265 270
Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe
275 280 285
Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr
290 295 300
Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu
305 310 315 320
Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu
325 330 335
Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe
340 345 350
Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro
355 360 365
Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys
370 375 380
Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr
385 390 395 400
Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala
405 410 415
Leu Pro Ala Gly His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser
420 425 430
Leu Leu Leu Leu Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg
435 440 445
Gln Trp Arg Pro Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro
450 455 460
Pro Gln Ala Gln Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro
465 470 475 480
Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln
485 490 495
Leu
<210> 295
<211> 280
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature HAVCR2(TIM-3)
<400> 295
Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro
1 5 10 15
Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp
20 25 30
Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg
35 40 45
Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn
50 55 60
Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr
65 70 75 80
Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile
85 90 95
Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys
100 105 110
Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro
115 120 125
Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu
130 135 140
Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn
145 150 155 160
Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala
165 170 175
Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly Ile Cys Ala Gly Leu
180 185 190
Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe Lys Trp Tyr Ser His
195 200 205
Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile Ser Leu Ala Asn Leu
210 215 220
Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu Gly Ile Arg Ser Glu
225 230 235 240
Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Glu Pro
245 250 255
Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln Gln Pro Ser Gln Pro
260 265 270
Leu Gly Cys Arg Phe Ala Met Pro
275 280
<210> 296
<211> 492
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CEACAM1
<400> 296
Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu
1 5 10 15
Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser
20 25 30
Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr
35 40 45
Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg
50 55 60
Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln
65 70 75 80
Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val
85 90 95
Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys
100 105 110
Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala
115 120 125
Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp
130 135 140
Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser
145 150 155 160
Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr
165 170 175
Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser
180 185 190
Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile
195 200 205
Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser
210 215 220
Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn
225 230 235 240
Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr
245 250 255
Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr
260 265 270
Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser
275 280 285
Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr
290 295 300
Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly
305 310 315 320
Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu
325 330 335
Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val
340 345 350
Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile
355 360 365
Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala
370 375 380
Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly Ile Val
385 390 395 400
Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu Ala Cys
405 410 415
Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg Asp Leu
420 425 430
Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His Ser Asn
435 440 445
Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu Asn Phe
450 455 460
Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser Leu Thr
465 470 475 480
Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln
485 490
<210> 297
<211> 222
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature TIGIT
<400> 297
Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly
1 5 10 15
Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val
20 25 30
Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys Asn
35 40 45
Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala
50 55 60
Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp
65 70 75 80
Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr
85 90 95
Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His
100 105 110
Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly Ala Met Ala Ala Thr Leu
115 120 125
Val Val Ile Cys Thr Ala Val Ile Val Val Val Ala Leu Thr Arg Lys
130 135 140
Lys Lys Ala Leu Arg Ile His Ser Val Glu Gly Asp Leu Arg Arg Lys
145 150 155 160
Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser Ala Pro Ser Pro Pro Gly
165 170 175
Ser Cys Val Gln Ala Glu Ala Ala Pro Ala Gly Leu Cys Gly Glu Gln
180 185 190
Arg Gly Glu Asp Cys Ala Glu Leu His Asp Tyr Phe Asn Val Leu Ser
195 200 205
Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe Thr Glu Thr Gly
210 215 220
<210> 298
<211> 397
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature PVR(CD155)
<400> 298
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile Leu Val Phe Leu
325 330 335
Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser Lys Cys Ser Arg
340 345 350
Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser Thr Glu His Ala
355 360 365
Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala Val Ser Arg Glu
370 375 380
Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr Arg
385 390 395
<210> 299
<211> 507
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature PVRL2(CD112)
<400> 299
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly Ile Ile Gly Gly Ile Ile Ala
325 330 335
Ala Ile Ile Ala Thr Ala Val Ala Ala Thr Gly Ile Leu Ile Cys Arg
340 345 350
Gln Gln Arg Lys Glu Gln Thr Leu Gln Gly Ala Glu Glu Asp Glu Asp
355 360 365
Leu Glu Gly Pro Pro Ser Tyr Lys Pro Pro Thr Pro Lys Ala Lys Leu
370 375 380
Glu Ala Gln Glu Met Pro Ser Gln Leu Phe Thr Leu Gly Ala Ser Glu
385 390 395 400
His Ser Pro Leu Lys Thr Pro Tyr Phe Asp Ala Gly Ala Ser Cys Thr
405 410 415
Glu Gln Glu Met Pro Arg Tyr His Glu Leu Pro Thr Leu Glu Glu Arg
420 425 430
Ser Gly Pro Leu His Pro Gly Ala Thr Ser Leu Gly Ser Pro Ile Pro
435 440 445
Val Pro Pro Gly Pro Pro Ala Val Glu Asp Val Ser Leu Asp Leu Glu
450 455 460
Asp Glu Glu Gly Glu Glu Glu Glu Glu Tyr Leu Asp Lys Ile Asn Pro
465 470 475 480
Ile Tyr Asp Ala Leu Ser Tyr Ser Ser Pro Ser Asp Ser Tyr Gln Gly
485 490 495
Lys Gly Phe Val Met Ser Arg Ala Met Tyr Val
500 505
<210> 300
<211> 318
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD226
<400> 300
Glu Glu Val Leu Trp His Thr Ser Val Pro Phe Ala Glu Asn Met Ser
1 5 10 15
Leu Glu Cys Val Tyr Pro Ser Met Gly Ile Leu Thr Gln Val Glu Trp
20 25 30
Phe Lys Ile Gly Thr Gln Gln Asp Ser Ile Ala Ile Phe Ser Pro Thr
35 40 45
His Gly Met Val Ile Arg Lys Pro Tyr Ala Glu Arg Val Tyr Phe Leu
50 55 60
Asn Ser Thr Met Ala Ser Asn Asn Met Thr Leu Phe Phe Arg Asn Ala
65 70 75 80
Ser Glu Asp Asp Val Gly Tyr Tyr Ser Cys Ser Leu Tyr Thr Tyr Pro
85 90 95
Gln Gly Thr Trp Gln Lys Val Ile Gln Val Val Gln Ser Asp Ser Phe
100 105 110
Glu Ala Ala Val Pro Ser Asn Ser His Ile Val Ser Glu Pro Gly Lys
115 120 125
Asn Val Thr Leu Thr Cys Gln Pro Gln Met Thr Trp Pro Val Gln Ala
130 135 140
Val Arg Trp Glu Lys Ile Gln Pro Arg Gln Ile Asp Leu Leu Thr Tyr
145 150 155 160
Cys Asn Leu Val His Gly Arg Asn Phe Thr Ser Lys Phe Pro Arg Gln
165 170 175
Ile Val Ser Asn Cys Ser His Gly Arg Trp Ser Val Ile Val Ile Pro
180 185 190
Asp Val Thr Val Ser Asp Ser Gly Leu Tyr Arg Cys Tyr Leu Gln Ala
195 200 205
Ser Ala Gly Glu Asn Glu Thr Phe Val Met Arg Leu Thr Val Ala Glu
210 215 220
Gly Lys Thr Asp Asn Gln Tyr Thr Leu Phe Val Ala Gly Gly Thr Val
225 230 235 240
Leu Leu Leu Leu Phe Val Ile Ser Ile Thr Thr Ile Ile Val Ile Phe
245 250 255
Leu Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr Glu Ser
260 265 270
Trp Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile Ser Thr
275 280 285
Ser Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp Ile Tyr
290 295 300
Val Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val
305 310 315
<210> 301
<211> 327
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD2
<400> 301
Lys Glu Ile Thr Asn Ala Leu Glu Thr Trp Gly Ala Leu Gly Gln Asp
1 5 10 15
Ile Asn Leu Asp Ile Pro Ser Phe Gln Met Ser Asp Asp Ile Asp Asp
20 25 30
Ile Lys Trp Glu Lys Thr Ser Asp Lys Lys Lys Ile Ala Gln Phe Arg
35 40 45
Lys Glu Lys Glu Thr Phe Lys Glu Lys Asp Thr Tyr Lys Leu Phe Lys
50 55 60
Asn Gly Thr Leu Lys Ile Lys His Leu Lys Thr Asp Asp Gln Asp Ile
65 70 75 80
Tyr Lys Val Ser Ile Tyr Asp Thr Lys Gly Lys Asn Val Leu Glu Lys
85 90 95
Ile Phe Asp Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser
100 105 110
Trp Thr Cys Ile Asn Thr Thr Leu Thr Cys Glu Val Met Asn Gly Thr
115 120 125
Asp Pro Glu Leu Asn Leu Tyr Gln Asp Gly Lys His Leu Lys Leu Ser
130 135 140
Gln Arg Val Ile Thr His Lys Trp Thr Thr Ser Leu Ser Ala Lys Phe
145 150 155 160
Lys Cys Thr Ala Gly Asn Lys Val Ser Lys Glu Ser Ser Val Glu Pro
165 170 175
Val Ser Cys Pro Glu Lys Gly Leu Asp Ile Tyr Leu Ile Ile Gly Ile
180 185 190
Cys Gly Gly Gly Ser Leu Leu Met Val Phe Val Ala Leu Leu Val Phe
195 200 205
Tyr Ile Thr Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu
210 215 220
Leu Glu Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys
225 230 235 240
Pro His Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln
245 250 255
His Pro Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg
260 265 270
Pro Pro Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro
275 280 285
Pro Ala Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu
290 295 300
Pro Arg Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn
305 310 315 320
Ser Leu Ser Pro Ser Ser Asn
325
<210> 302
<211> 154
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD160
<400> 302
Ile Asn Ile Thr Ser Ser Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu
1 5 10 15
Ile Cys Thr Val Trp His Lys Lys Glu Glu Ala Glu Gly Phe Val Val
20 25 30
Phe Leu Cys Lys Asp Arg Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu
35 40 45
Lys Gln Leu Arg Leu Lys Arg Asp Pro Gly Ile Asp Gly Val Gly Glu
50 55 60
Ile Ser Ser Gln Leu Met Phe Thr Ile Ser Gln Val Thr Pro Leu His
65 70 75 80
Ser Gly Thr Tyr Gln Cys Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg
85 90 95
Leu Gln Gly His Phe Phe Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr
100 105 110
Thr Val Thr Gly Leu Lys Gln Arg Gln His Leu Glu Phe Ser His Asn
115 120 125
Glu Gly Thr Leu Ser Ser Gly Phe Leu Gln Glu Lys Val Trp Val Met
130 135 140
Leu Val Thr Ser Leu Val Ala Leu Gln Ala
145 150
<210> 303
<211> 248
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD200
<400> 303
Gln Val Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro
1 5 10 15
Ala Ser Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val
20 25 30
Thr Trp Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe
35 40 45
Ser Glu Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile
50 55 60
Asn Ile Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn
65 70 75 80
Ile Thr Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe
85 90 95
Gly Phe Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln
100 105 110
Pro Ile Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile
115 120 125
Thr Cys Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val
130 135 140
Pro Arg Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn
145 150 155 160
Gly Thr Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn
165 170 175
Gln Val Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val
180 185 190
Thr Asp Phe Lys Gln Thr Val Asn Lys Gly Tyr Trp Phe Ser Val Pro
195 200 205
Leu Leu Leu Ser Ile Val Ser Leu Val Ile Leu Leu Val Leu Ile Ser
210 215 220
Ile Leu Leu Tyr Trp Lys Arg His Arg Asn Gln Asp Arg Gly Glu Leu
225 230 235 240
Ser Gln Gly Val Gln Lys Met Thr
245
<210> 304
<211> 297
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature CD200R1(CD200R)
<400> 304
Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu
1 5 10 15
Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys
20 25 30
Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile
35 40 45
Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr
50 55 60
Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val
65 70 75 80
Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile
85 90 95
Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn
100 105 110
Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr
115 120 125
Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly
130 135 140
Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr
145 150 155 160
Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys
165 170 175
His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His
180 185 190
Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly
195 200 205
Ala Lys Lys Ser Ala Lys Leu Tyr Ile Pro Tyr Ile Ile Leu Thr Ile
210 215 220
Ile Ile Leu Thr Ile Val Gly Phe Ile Trp Leu Leu Lys Val Asn Gly
225 230 235 240
Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr Pro Val Val Glu
245 250 255
Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu Lys Asn Asn Pro
260 265 270
Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu Ala Leu Gln Ser
275 280 285
Glu Val Asp Thr Asp Leu His Thr Leu
290 295
<210> 305
<211> 183
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature NC R3 (NKp30)
<400> 305
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu
100 105 110
His Pro Gln Leu Gly Ala Gly Thr Val Leu Leu Leu Arg Ala Gly Phe
115 120 125
Tyr Ala Val Ser Phe Leu Ser Val Ala Val Gly Ser Thr Val Tyr Tyr
130 135 140
Gln Gly Lys Cys Leu Thr Trp Lys Gly Pro Arg Arg Gln Leu Pro Ala
145 150 155 160
Val Val Pro Ala Pro Leu Pro Pro Pro Cys Gly Ser Ser Ala His Leu
165 170 175
Leu Pro Pro Val Pro Gly Gly
180
<210> 306
<211> 414
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> VSIG8
<400> 306
Met Arg Val Gly Gly Ala Phe His Leu Leu Leu Val Cys Leu Ser Pro
1 5 10 15
Ala Leu Leu Ser Ala Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu
20 25 30
Tyr Leu Ala Glu Gly Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu
35 40 45
Asp Pro Glu Asp Tyr Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln
50 55 60
Val Asn Ser Asp Pro Ala His His Arg Glu Asn Val Phe Leu Ser Tyr
65 70 75 80
Gln Asp Lys Arg Ile Asn His Gly Ser Leu Pro His Leu Gln Gln Arg
85 90 95
Val Arg Phe Ala Ala Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn
100 105 110
Leu Met Asn Leu Gln Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val
115 120 125
Lys Lys Thr Thr Met Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala
130 135 140
Arg Pro Ala Val Pro Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly
145 150 155 160
Asn Asp Val Val Leu Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu
165 170 175
Ser Tyr Lys Trp Ala Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala
180 185 190
Gly Ser Tyr Thr Ser Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln
195 200 205
Glu Ser Phe His Ser Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu
210 215 220
Val Leu Lys Asp Ile Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr
225 230 235 240
Val Ala Asn Asn Val Gly Tyr Ser Val Cys Val Val Glu Val Lys Val
245 250 255
Ser Asp Ser Arg Arg Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser
260 265 270
Leu Leu Ala Leu Gly Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys
275 280 285
Cys Cys Cys Gly Gly Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly
290 295 300
Tyr Gly Asn Gly Gly Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala
305 310 315 320
Ser Glu Ile Arg Glu Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly
325 330 335
Arg Gly Ser Arg Val Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val
340 345 350
Ser Arg Ser Leu Arg Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro
355 360 365
Glu Asp Val Ala Leu Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala
370 375 380
Gly Pro Ser Pro Val Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp
385 390 395 400
Cys Ala Glu Gly Pro Val Gln Cys Lys Asn Gly Leu Leu Val
405 410
<210> 307
<211> 393
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Mature VSIG8
<400> 307
Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu Tyr Leu Ala Glu Gly
1 5 10 15
Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu Asp Pro Glu Asp Tyr
20 25 30
Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln Val Asn Ser Asp Pro
35 40 45
Ala His His Arg Glu Asn Val Phe Leu Ser Tyr Gln Asp Lys Arg Ile
50 55 60
Asn His Gly Ser Leu Pro His Leu Gln Gln Arg Val Arg Phe Ala Ala
65 70 75 80
Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn Leu Met Asn Leu Gln
85 90 95
Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val Lys Lys Thr Thr Met
100 105 110
Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala Arg Pro Ala Val Pro
115 120 125
Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly Asn Asp Val Val Leu
130 135 140
Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu Ser Tyr Lys Trp Ala
145 150 155 160
Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala Gly Ser Tyr Thr Ser
165 170 175
Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln Glu Ser Phe His Ser
180 185 190
Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu Val Leu Lys Asp Ile
195 200 205
Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr Val Ala Asn Asn Val
210 215 220
Gly Tyr Ser Val Cys Val Val Glu Val Lys Val Ser Asp Ser Arg Arg
225 230 235 240
Ile Gly Val Ile Ile Gly Ile Val Leu Gly Ser Leu Leu Ala Leu Gly
245 250 255
Cys Leu Ala Val Gly Ile Trp Gly Leu Val Cys Cys Cys Cys Gly Gly
260 265 270
Ser Gly Ala Gly Gly Ala Arg Gly Ala Phe Gly Tyr Gly Asn Gly Gly
275 280 285
Gly Val Gly Gly Gly Ala Cys Gly Asp Leu Ala Ser Glu Ile Arg Glu
290 295 300
Asp Ala Val Ala Pro Gly Cys Lys Ala Ser Gly Arg Gly Ser Arg Val
305 310 315 320
Thr His Leu Leu Gly Tyr Pro Thr Gln Asn Val Ser Arg Ser Leu Arg
325 330 335
Arg Lys Tyr Ala Pro Pro Pro Cys Gly Gly Pro Glu Asp Val Ala Leu
340 345 350
Ala Pro Cys Thr Ala Ala Ala Ala Cys Glu Ala Gly Pro Ser Pro Val
355 360 365
Tyr Val Lys Val Lys Ser Ala Glu Pro Ala Asp Cys Ala Glu Gly Pro
370 375 380
Val Gln Cys Lys Asn Gly Leu Leu Val
385 390
<210> 308
<211> 242
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> VSIG8 ECD
<400> 308
Val Arg Ile Asn Gly Asp Gly Gln Glu Val Leu Tyr Leu Ala Glu Gly
1 5 10 15
Asp Asn Val Arg Leu Gly Cys Pro Tyr Val Leu Asp Pro Glu Asp Tyr
20 25 30
Gly Pro Asn Gly Leu Asp Ile Glu Trp Met Gln Val Asn Ser Asp Pro
35 40 45
Ala His His Arg Glu Asn Val Phe Leu Ser Tyr Gln Asp Lys Arg Ile
50 55 60
Asn His Gly Ser Leu Pro His Leu Gln Gln Arg Val Arg Phe Ala Ala
65 70 75 80
Ser Asp Pro Ser Gln Tyr Asp Ala Ser Ile Asn Leu Met Asn Leu Gln
85 90 95
Val Ser Asp Thr Ala Thr Tyr Glu Cys Arg Val Lys Lys Thr Thr Met
100 105 110
Ala Thr Arg Lys Val Ile Val Thr Val Gln Ala Arg Pro Ala Val Pro
115 120 125
Met Cys Trp Thr Glu Gly His Met Thr Tyr Gly Asn Asp Val Val Leu
130 135 140
Lys Cys Tyr Ala Ser Gly Gly Ser Gln Pro Leu Ser Tyr Lys Trp Ala
145 150 155 160
Lys Ile Ser Gly His His Tyr Pro Tyr Arg Ala Gly Ser Tyr Thr Ser
165 170 175
Gln His Ser Tyr His Ser Glu Leu Ser Tyr Gln Glu Ser Phe His Ser
180 185 190
Ser Ile Asn Gln Gly Leu Asn Asn Gly Asp Leu Val Leu Lys Asp Ile
195 200 205
Ser Arg Ala Asp Asp Gly Leu Tyr Gln Cys Thr Val Ala Asn Asn Val
210 215 220
Gly Tyr Ser Val Cys Val Val Glu Val Lys Val Ser Asp Ser Arg Arg
225 230 235 240
Ile Gly
<210> 309
<211> 16
<212> PRT
<213> Artificial Sequence
<220>
<223> CD33 Signal Peptide
<400> 309
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala
1 5 10 15
<210> 310
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> IgGkappa light chain
<400> 310
Met Asp Met Arg Val Leu Ala Gln Leu Leu Gly Leu Leu Leu Leu Cys
1 5 10 15
Phe Pro Gly Ala Arg Cys
20
<210> 311
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> HSA signal peptide
<400> 311
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala
1 5 10 15
Tyr Ser
<210> 312
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> Ig kappa light chain
<400> 312
Met Asp Met Arg Ala Pro Ala Gly Ile Phe Gly Phe Leu Leu Val Leu
1 5 10 15
Phe Pro Gly Tyr Arg Ser
20
<210> 313
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> Human azurocidin preprotein signal sequence
<400> 313
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser
1 5 10 15
Ser Arg Ala
<210> 314
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG heavy chain signal peptide
<400> 314
Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly
1 5 10 15
Val Gln Cys
<210> 315
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG heavy chain signal peptide
<400> 315
Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly
1 5 10 15
Val Gln Cys
<210> 316
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG heavy chain signal peptide
<400> 316
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp
1 5 10 15
Val Leu Ser
<210> 317
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG heavy chain signal peptide
<400> 317
Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly
1 5 10 15
Ala His Ser
<210> 318
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG heavy chain signal peptide
<400> 318
Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly
1 5 10 15
Val Gln Ser
<210> 319
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG heavy chain signal peptide
<400> 319
Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly
1 5 10 15
Val Gln Cys
<210> 320
<211> 19
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG heavy chain signal peptide
<400> 320
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly
1 5 10 15
Val Gln Cys
<210> 321
<211> 26
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG heavy chain signal peptide
<400> 321
Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu
1 5 10 15
Leu Val Ala Ala Pro Arg Trp Val Leu Ser
20 25
<210> 322
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG Kappa light chain signal seqeunce
<400> 322
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
1 5 10 15
Leu Ser Gly Ala Arg Cys
20
<210> 323
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG Kappa light chain signal seqeunce
<400> 323
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala
1 5 10 15
Ala Gln Pro Ala Met Ala
20
<210> 324
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> Gaussia luciferase
<400> 324
Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu
1 5 10 15
Ala
<210> 325
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Human albumin
<400> 325
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala
1 5 10 15
Tyr Ser
<210> 326
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> Human chymotrypsinogen
<400> 326
Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr
1 5 10 15
Phe Gly
<210> 327
<211> 14
<212> PRT
<213> Artificial Sequence
<220>
<223> Human interleukin-2
<400> 327
Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu Val
1 5 10
<210> 328
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> Human trysinogen-2
<400> 328
Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala
1 5 10 15
<210> 329
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> IgV-IgV linker
<400> 329
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1 5 10 15
<210> 330
<211> 10
<212> PRT
<213> Artificial Sequence
<220>
<223> IgV-Fc linker 1
<400> 330
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1 5 10
<210> 331
<211> 13
<212> PRT
<213> Artificial Sequence
<220>
<223> IgV-Fc linker 2
<400> 331
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala
1 5 10
<210> 332
<211> 71
<212> PRT
<213> Artificial Sequence
<220>
<223> CD8-derived hinge and transmembrane domain
<400> 332
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
1 5 10 15
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala
20 25 30
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile
35 40 45
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
50 55 60
Leu Val Ile Thr Leu Tyr Cys
65 70
<210> 333
<211> 112
<212> PRT
<213> Artificial Sequence
<220>
<223> CD3zeta intracellular signaling domain
<400> 333
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
1 5 10 15
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
20 25 30
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
35 40 45
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
50 55 60
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65 70 75 80
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
85 90 95
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
100 105 110
<210> 334
<211> 117
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v1 ECD
<400> 334
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Pro
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu
100 105 110
His Pro Gln Leu Gly
115
<210> 335
<211> 117
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v2 ECD
<400> 335
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu
100 105 110
His Pro Gln Leu Gly
115
<210> 336
<211> 117
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v3 ECD
<400> 336
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu
100 105 110
His Pro Gln Leu Gly
115
<210> 337
<211> 117
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v4 ECD
<400> 337
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Pro
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu
100 105 110
His Pro Gln Leu Gly
115
<210> 338
<211> 117
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v5 ECD
<400> 338
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu
100 105 110
His Pro Gln Leu Gly
115
<210> 339
<211> 224
<212> PRT
<213> Artificial Sequence
<220>
<223> CD86 v1 ECD
<400> 339
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro
1 5 10 15
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val
20 25 30
Phe Trp His Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly
35 40 45
Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser
50 55 60
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys
65 70 75 80
Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly
85 90 95
Met Ile Arg Ile His His Met Asn Ser Glu Leu Ser Val Leu Ala Asn
100 105 110
Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val
115 120 125
Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys
130 135 140
Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp
145 150 155 160
Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val
165 170 175
Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr
180 185 190
Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro
195 200 205
Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro
210 215 220
<210> 340
<211> 224
<212> PRT
<213> Artificial Sequence
<220>
<223> CD86 v2 ECD
<400> 340
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro
1 5 10 15
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val
20 25 30
Phe Trp His Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly
35 40 45
Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser
50 55 60
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys
65 70 75 80
Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly
85 90 95
Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn
100 105 110
Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val
115 120 125
Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys
130 135 140
Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp
145 150 155 160
Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val
165 170 175
Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr
180 185 190
Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro
195 200 205
Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro
210 215 220
<210> 341
<211> 224
<212> PRT
<213> Artificial Sequence
<220>
<223> CD86 v3 ECD
<400> 341
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro
1 5 10 15
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val
20 25 30
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly
35 40 45
Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser
50 55 60
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys
65 70 75 80
Asp Lys Gly Leu Tyr Gln Cys Ile Ile Leu His Lys Lys Pro Thr Gly
85 90 95
Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn
100 105 110
Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val
115 120 125
Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys
130 135 140
Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp
145 150 155 160
Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val
165 170 175
Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr
180 185 190
Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro
195 200 205
Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro
210 215 220
<210> 342
<211> 224
<212> PRT
<213> Artificial Sequence
<220>
<223> CD86 v4 ECD
<400> 342
Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro
1 5 10 15
Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val
20 25 30
Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly
35 40 45
Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser
50 55 60
Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys
65 70 75 80
Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly
85 90 95
Met Ile Arg Ile His His Met Asn Ser Glu Leu Ser Val Leu Ala Asn
100 105 110
Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val
115 120 125
Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys
130 135 140
Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp
145 150 155 160
Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val
165 170 175
Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr
180 185 190
Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro
195 200 205
Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro
210 215 220
<210> 343
<211> 108
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> NKp30 WT IgC-like
<400> 343
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val
100 105
<210> 344
<211> 108
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v1 IgC-like
<400> 344
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Pro
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val
100 105
<210> 345
<211> 108
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v2 IgC-like
<400> 345
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val
100 105
<210> 346
<211> 108
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v3 IgC-like
<400> 346
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val
100 105
<210> 347
<211> 108
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v4 IgC-like
<400> 347
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Pro
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Ser Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val
100 105
<210> 348
<211> 108
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v5 IgC-like
<400> 348
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Leu Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Ala Pro Leu Ala Ser
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val
100 105
<210> 349
<211> 99
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD86 WT IgV
<400> 349
Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln
1 5 10 15
Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val
20 25 30
Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser
35 40 45
Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg
50 55 60
Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile
65 70 75 80
His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser
85 90 95
Glu Leu Ser
<210> 350
<211> 99
<212> PRT
<213> Artificial Sequence
<220>
<223> CD86 v1 IgV
<400> 350
Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln
1 5 10 15
Ser Leu Ser Glu Leu Val Val Phe Trp His Asp Gln Glu Asn Leu Val
20 25 30
Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser
35 40 45
Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg
50 55 60
Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile
65 70 75 80
Leu His Lys Lys Pro Thr Gly Met Ile Arg Ile His His Met Asn Ser
85 90 95
Glu Leu Ser
<210> 351
<211> 99
<212> PRT
<213> Artificial Sequence
<220>
<223> CD86 v2 IgV
<400> 351
Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln
1 5 10 15
Ser Leu Ser Glu Leu Val Val Phe Trp His Asp Gln Glu Asn Leu Val
20 25 30
Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser
35 40 45
Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg
50 55 60
Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile
65 70 75 80
His His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser
85 90 95
Glu Leu Ser
<210> 352
<211> 99
<212> PRT
<213> Artificial Sequence
<220>
<223> CD86 v3 IgV
<400> 352
Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln
1 5 10 15
Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val
20 25 30
Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser
35 40 45
Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg
50 55 60
Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile
65 70 75 80
Leu His Lys Lys Pro Thr Gly Met Ile Arg Ile His Gln Met Asn Ser
85 90 95
Glu Leu Ser
<210> 353
<211> 99
<212> PRT
<213> Artificial Sequence
<220>
<223> CD86 v4 IgV
<400> 353
Asn Glu Thr Ala Asp Leu Pro Cys Gln Phe Ala Asn Ser Gln Asn Gln
1 5 10 15
Ser Leu Ser Glu Leu Val Val Phe Trp Gln Asp Gln Glu Asn Leu Val
20 25 30
Leu Asn Glu Val Tyr Leu Gly Lys Glu Lys Phe Asp Ser Val His Ser
35 40 45
Lys Tyr Met Gly Arg Thr Ser Phe Asp Ser Asp Ser Trp Thr Leu Arg
50 55 60
Leu His Asn Leu Gln Ile Lys Asp Lys Gly Leu Tyr Gln Cys Ile Ile
65 70 75 80
His His Lys Lys Pro Thr Gly Met Ile Arg Ile His His Met Asn Ser
85 90 95
Glu Leu Ser
<210> 354
<211> 270
<212> PRT
<213> Artificial Sequence
<220>
<223> Nkp30 stack
<400> 354
Asp Thr Gln Glu Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu
1 5 10 15
Leu Ser Cys Ala Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val
20 25 30
Tyr Val Tyr Trp Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His
35 40 45
Ile Pro Gln His Ser Ser Leu Glu Tyr Val Asp Ser Arg Tyr Arg Asn
50 55 60
Arg Ala Leu Met Ser Pro Ala Gly Met Leu Arg Gly Asp Phe Ser Leu
65 70 75 80
Arg Leu Phe Asn Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu
85 90 95
Val Leu Ser Pro Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val
100 105 110
Thr Leu His Val Ala Ala Asn Phe Ser Val Gly Gly Gly Gly Ser Gly
115 120 125
Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Trp Val Ser Gln Pro Pro
130 135 140
Glu Ile Arg Thr Leu Glu Gly Ser Ser Ala Phe Leu Pro Cys Ser Phe
145 150 155 160
Asn Ala Ser Gln Gly Arg Val Ala Ile Gly Ser Val Thr Trp Phe Arg
165 170 175
Asp Glu Val Val Pro Gly Lys Glu Val Arg Asn Gly Thr Pro Glu Phe
180 185 190
Arg Gly Arg Leu Val Pro Leu Ala Pro Ser Arg Phe Leu His Asp His
195 200 205
Gln Ala Glu Leu His Ile Arg Asp Val Arg Gly His Asp Ala Gly Ile
210 215 220
Tyr Val Cys Arg Val Glu Val Leu Gly Leu Gly Val Gly Thr Gly Asn
225 230 235 240
Gly Thr Arg Leu Val Val Glu Lys Glu His Pro Gln Leu Gly Gly Gly
245 250 255
Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala Glu Pro Lys
260 265 270
<210> 355
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> NKp30 v1 IgC-like (long)
<400> 355
Leu Trp Val Ser Gln Pro Pro Glu Ile Arg Thr Leu Glu Gly Ser Ser
1 5 10 15
Ala Phe Leu Pro Cys Ser Phe Asn Ala Ser Gln Gly Arg Val Ala Ile
20 25 30
Gly Ser Val Thr Trp Phe Arg Asp Glu Val Val Pro Gly Lys Glu Val
35 40 45
Arg Asn Gly Thr Pro Glu Phe Arg Gly Arg Leu Val Pro Leu Ala Pro
50 55 60
Ser Arg Phe Leu His Asp His Gln Ala Glu Leu His Ile Arg Asp Val
65 70 75 80
Arg Gly His Asp Ala Gly Ile Tyr Val Cys Arg Val Glu Val Leu Gly
85 90 95
Leu Gly Val Gly Thr Gly Asn Gly Thr Arg Leu Val Val Glu Lys Glu
100 105 110
His Pro Gln Leu
115
<210> 356
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> Fc (C5S (C220S), R77C, (R292C), N82G (N297G), V87C (V302C))
<400> 356
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln
65 70 75 80
Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 357
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> Fc with C220S/L234A/L235E/G237A
<400> 357
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 358
<211> 231
<212> PRT
<213> Artificial Sequence
<220>
<223> Fc with C220S/E233P/L234V/L235A/G236del/S267K
<400> 358
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
20 25 30
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
35 40 45
Asp Val Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
50 55 60
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
65 70 75 80
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
85 90 95
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
100 105 110
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
115 120 125
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
130 135 140
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
145 150 155 160
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
165 170 175
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
180 185 190
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
195 200 205
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
210 215 220
Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 359
<211> 231
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> wild-type human IgG1-delK
<400> 359
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly
225 230
<210> 360
<211> 431
<212> PRT
<213> Artificial Sequence
<220>
<223> antiCD19z chimeric antigen receptor
<400> 360
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
100 105 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
115 120 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
130 135 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145 150 155 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
165 170 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
180 185 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
195 200 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
210 215 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225 230 235 240
Val Thr Val Ser Ser Ala Ala Ala Lys Pro Thr Thr Thr Pro Ala Pro
245 250 255
Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
260 265 270
Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
275 280 285
Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
290 295 300
Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg
305 310 315 320
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln
325 330 335
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp
340 345 350
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro
355 360 365
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
370 375 380
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg
385 390 395 400
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr
405 410 415
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
420 425 430
<210> 361
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> CD8-derived signal sequence
<400> 361
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro
20
<210> 362
<211> 23
<212> PRT
<213> Artificial Sequence
<220>
<223> CD8-derived signal sequence
<400> 362
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Gly Ser
20
<210> 363
<211> 245
<212> PRT
<213> Artificial Sequence
<220>
<223> anti-CD19 scFv
<400> 363
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
100 105 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
115 120 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
130 135 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145 150 155 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
165 170 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
180 185 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
195 200 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
210 215 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225 230 235 240
Val Thr Val Ser Ser
245
<210> 364
<211> 69
<212> PRT
<213> Artificial Sequence
<220>
<223> CD8-derived hinge and transmembrane domain
<400> 364
Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro
1 5 10 15
Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro
20 25 30
Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
35 40 45
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu
50 55 60
Ser Leu Val Ile Thr
65
<210> 365
<211> 42
<212> PRT
<213> Artificial Sequence
<220>
<223> 4-1BB-derived costimulatory domain
<400> 365
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
1 5 10 15
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
20 25 30
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
35 40
<210> 366
<211> 40
<212> PRT
<213> Artificial Sequence
<220>
<223> CD28-derived costimulatory domain
<400> 366
Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro
1 5 10 15
Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro
20 25 30
Arg Asp Phe Ala Ala Tyr Arg Ser
35 40
<210> 367
<211> 41
<212> PRT
<213> Artificial Sequence
<220>
<223> CD28-derived costimulatory domain
<400> 367
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr
1 5 10 15
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
20 25 30
Pro Arg Asp Phe Ala Ala Tyr Arg Ser
35 40
<210> 368
<211> 44
<212> PRT
<213> Artificial Sequence
<220>
<223> CD28-derived costimulatory domain
<400> 368
Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met
1 5 10 15
Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro
20 25 30
Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
35 40
<210> 369
<211> 20
<212> PRT
<213> Artificial Sequence
<220>
<223> T2A protein
<400> 369
Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu
1 5 10 15
Asn Pro Gly Pro
20
<210> 370
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> Blue fluorescent protein
<400> 370
Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly
1 5 10 15
Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys
20 25 30
Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly
35 40 45
Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly
50 55 60
Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys
65 70 75 80
Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu
85 90 95
Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly
100 105 110
Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn
115 120 125
Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu
130 135 140
Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala
145 150 155 160
Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr
165 170 175
Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr
180 185 190
Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr
195 200 205
Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro
210 215 220
Ser Lys Leu Gly His Lys Leu Asn
225 230
<210> 371
<211> 472
<212> PRT
<213> Artificial Sequence
<220>
<223> 2nd Gen CAR
<400> 371
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
100 105 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
115 120 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
130 135 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145 150 155 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
165 170 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
180 185 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
195 200 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
210 215 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225 230 235 240
Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro
245 250 255
Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
260 265 270
Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
275 280 285
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
290 295 300
Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Lys Arg
305 310 315 320
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
325 330 335
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
340 345 350
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
355 360 365
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
370 375 380
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
385 390 395 400
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
405 410 415
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
420 425 430
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
435 440 445
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
450 455 460
His Met Gln Ala Leu Pro Pro Arg
465 470
<210> 372
<211> 497
<212> PRT
<213> Artificial Sequence
<220>
<223> 2nd Gen CAR
<400> 372
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
100 105 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
115 120 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
130 135 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145 150 155 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
165 170 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
180 185 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
195 200 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
210 215 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225 230 235 240
Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro
245 250 255
Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
260 265 270
Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
275 280 285
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
290 295 300
Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Lys Arg
305 310 315 320
Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro
325 330 335
Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu
340 345 350
Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala
355 360 365
Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu
370 375 380
Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly
385 390 395 400
Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu
405 410 415
Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser
420 425 430
Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly
435 440 445
Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu
450 455 460
His Met Gln Ala Leu Pro Pro Arg Gly Gly Arg Ser Gly Glu Gly Arg
465 470 475 480
Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser
485 490 495
Arg
<210> 373
<211> 471
<212> PRT
<213> Artificial Sequence
<220>
<223> 2nd Gen CAR with CD28-derived costimulatory domain
<400> 373
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
100 105 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
115 120 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
130 135 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145 150 155 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
165 170 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
180 185 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
195 200 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
210 215 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225 230 235 240
Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro
245 250 255
Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
260 265 270
Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
275 280 285
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
290 295 300
Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Arg Ser
305 310 315 320
Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg
325 330 335
Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg
340 345 350
Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp
355 360 365
Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn
370 375 380
Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg
385 390 395 400
Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly
405 410 415
Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu
420 425 430
Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu
435 440 445
Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His
450 455 460
Met Gln Ala Leu Pro Pro Arg
465 470
<210> 374
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> Knob Fc
<400> 374
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 375
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> Hole Fc
<400> 375
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 376
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> Stack Fc (homodimeric)
<400> 376
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 377
<211> 8
<212> PRT
<213> Artificial Sequence
<220>
<223> Stuffer
<400> 377
His Met Ser Ser Val Ser Ala Gln
1 5
<210> 378
<211> 116
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD155 IgV
<400> 378
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 379
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v1 ECD
<400> 379
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Ser
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 380
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v2 ECD
<400> 380
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 381
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v3 ECD
<400> 381
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Pro Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 382
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v4 ECD
<400> 382
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 383
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v5 ECD
<400> 383
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Val Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 384
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v6 ECD
<400> 384
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 385
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v7 ECD
<400> 385
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 386
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v8 ECD
<400> 386
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Pro Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 387
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v9 ECD
<400> 387
Trp Pro Pro Pro Gly Thr Glu Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 388
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v10 ECD
<400> 388
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Asp Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 389
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v11 ECD
<400> 389
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Pro Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 390
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v12 ECD
<400> 390
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Leu Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 391
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v14 ECD
<400> 391
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 392
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v15 ECD
<400> 392
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu His Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 393
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v16 ECD
<400> 393
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 394
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v17 ECD
<400> 394
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Val Glu Pro Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 395
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v18 ECD
<400> 395
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Pro Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 396
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v19 ECD
<400> 396
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu His Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 397
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v20 ECD
<400> 397
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 398
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v21 ECD
<400> 398
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Ala Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 399
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v22 ECD
<400> 399
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Lys Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 400
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v1 IgV
<400> 400
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Ser Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 401
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v2 IgV
<400> 401
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 402
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v3 IgV
<400> 402
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Pro Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 403
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v4 IgV
<400> 403
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 404
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v5 IgV
<400> 404
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Val Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 405
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v6 IgV
<400> 405
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 406
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v7 IgV
<400> 406
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 407
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v8 IgV
<400> 407
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Pro Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 408
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v9 IgV
<400> 408
Pro Gly Thr Glu Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 409
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v10 IgV
<400> 409
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Asp Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 410
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v11 IgV
<400> 410
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Pro Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 411
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v12 IgV
<400> 411
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Leu Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 412
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v14 IgV
<400> 412
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 413
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v15 IgV
<400> 413
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu His Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 414
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v16 IgV
<400> 414
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 415
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v17 IgV
<400> 415
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Val Glu Pro
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 416
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v18 IgV
<400> 416
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Pro Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 417
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v19 IgV
<400> 417
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu His Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 418
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v20 IgV
<400> 418
Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 419
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v21 IgV
<400> 419
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Ala
100 105 110
Asp Ile Trp Leu
115
<210> 420
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v22 IgV
<400> 420
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Lys Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 421
<211> 122
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD155 IgV wildtype
<400> 421
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 422
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v1 IgV
<400> 422
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Ser
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 423
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v2 IgV
<400> 423
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 424
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v3 IgV
<400> 424
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Pro Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 425
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v4 IgV
<400> 425
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 426
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v5 IgV
<400> 426
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Val Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 427
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v6 IgV
<400> 427
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 428
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v7 IgV
<400> 428
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 429
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v8 IgV
<400> 429
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Pro Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 430
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v9 IgV
<400> 430
Trp Pro Pro Pro Gly Thr Glu Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 431
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v10 IgV
<400> 431
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Asp Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 432
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v11 IgV
<400> 432
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Pro Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 433
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v12 IgV
<400> 433
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Leu Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 434
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v14 IgV
<400> 434
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 435
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v15 IgV
<400> 435
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu His Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 436
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v16 IgV
<400> 436
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Cys Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 437
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v17 IgV
<400> 437
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Val Glu Pro Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 438
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v18 IgV
<400> 438
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Pro Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 439
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v19 IgV
<400> 439
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu His Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 440
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v20 IgV
<400> 440
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Val Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 441
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v21 IgV
<400> 441
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Ala Asp Ile Trp Leu Arg Val Leu
115 120
<210> 442
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v22 IgV
<400> 442
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Lys Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 443
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v23 ECD
<400> 443
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 444
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v24 ECD
<400> 444
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 445
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v25 ECD
<400> 445
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 446
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v26 ECD
<400> 446
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 447
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v27 ECD
<400> 447
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 448
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v28 ECD
<400> 448
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 449
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v39 ECD
<400> 449
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 450
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v30 ECD
<400> 450
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 451
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v31 ECD
<400> 451
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 452
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v32 ECD
<400> 452
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 453
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v33 ECD
<400> 453
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 454
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v34 ECD
<400> 454
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 455
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v35 ECD
<400> 455
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 456
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v36 ECD
<400> 456
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gln Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 457
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v37 ECD
<400> 457
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 458
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v38 ECD
<400> 458
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 459
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v39 ECD
<400> 459
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 460
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v40 ECD
<400> 460
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 461
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v41 ECD
<400> 461
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 462
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v42 ECD
<400> 462
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 463
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v43 ECD
<400> 463
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 464
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v44 ECD
<400> 464
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 465
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v45 ECD
<400> 465
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 466
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v46 ECD
<400> 466
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 467
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v47 ECD
<400> 467
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 468
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v48 ECD
<400> 468
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Leu Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 469
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v49 ECD
<400> 469
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 470
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v50 ECD
<400> 470
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 471
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v51 ECD
<400> 471
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 472
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v52 ECD
<400> 472
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 473
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v53 ECD
<400> 473
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 474
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v54 ECD
<400> 474
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 475
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v55 ECD
<400> 475
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 476
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v56 ECD
<400> 476
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 477
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v57 ECD
<400> 477
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 478
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v58 ECD
<400> 478
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 479
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v59 ECD
<400> 479
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 480
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v60 ECD
<400> 480
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Val Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 481
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v61 ECD
<400> 481
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 482
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v62 ECD
<400> 482
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 483
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v63 ECD
<400> 483
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 484
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v64 ECD
<400> 484
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 485
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v65 ECD
<400> 485
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 486
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v66 ECD
<400> 486
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 487
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v67 ECD
<400> 487
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 488
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v68 ECD
<400> 488
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 489
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v69 ECD
<400> 489
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 490
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v70 ECD
<400> 490
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Ala His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
Asn Tyr Leu Glu Ser Lys Arg Leu Gly Phe Val Ala Ala Gly Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 491
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v71 ECD
<400> 491
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
Asn Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 492
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v72 ECD
<400> 492
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 493
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v73 ECD
<400> 493
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
Asn Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 494
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v74 ECD
<400> 494
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 495
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v75 ECD
<400> 495
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 496
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v76 ECD
<400> 496
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 497
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v77 ECD
<400> 497
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 498
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v78 ECD
<400> 498
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
His Tyr His Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 499
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v79 ECD
<400> 499
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 500
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v80 ECD
<400> 500
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gly Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser
65 70 75 80
Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 501
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v81 ECD
<400> 501
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Pro Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 502
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v82 ECD
<400> 502
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 503
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v83 ECD
<400> 503
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Val Arg Leu Ser
65 70 75 80
Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 504
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v84 ECD
<400> 504
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Ser Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser
65 70 75 80
Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 505
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v85 ECD
<400> 505
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 506
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v86 ECD
<400> 506
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr His Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 507
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v87 ECD
<400> 507
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Lys Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 508
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v88 ECD
<400> 508
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 509
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v89 ECD
<400> 509
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 510
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v90 ECD
<400> 510
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Asp
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 511
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v91 ECD
<400> 511
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Thr Phe His Gln Ser Gln Gly Pro
50 55 60
Tyr Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 512
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v92 ECD
<400> 512
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 513
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v94 ECD
<400> 513
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 514
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v94 ECD
<400> 514
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Met Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 515
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v94 ECD
<400> 515
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Ala Gly Gln Leu Gly Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 516
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v96 ECD
<400> 516
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val His Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Ile Trp Ala Arg
35 40 45
His Gly Glu Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro
50 55 60
Asp Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 517
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v97 ECD
<400> 517
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Val Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Leu His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Trp Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 518
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v98 ECD
<400> 518
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ile Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 519
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v99 ECD
<400> 519
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Gly Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Ala Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 520
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v100 ECD
<400> 520
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val His Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Arg Val Gly Gln Leu Ile Trp Ala Arg
35 40 45
His Gly Glu Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro
50 55 60
Asp Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Tyr Phe Leu Thr His Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 521
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v101 ECD
<400> 521
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Val Val Thr His Val Gly Gln Leu Gly Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 522
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v102 ECD
<400> 522
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 523
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v103 ECD
<400> 523
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 524
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v104 ECD
<400> 524
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Leu Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gly Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 525
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v105 ECD
<400> 525
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asn Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 526
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v106 ECD
<400> 526
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser
65 70 75 80
Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 527
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v107 ECD
<400> 527
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Thr Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 528
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v108 ECD
<400> 528
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gly Gly Ser Met Ala Ala Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 529
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v109 ECD
<400> 529
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 530
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v110 ECD
<400> 530
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro
50 55 60
Thr Tyr Ser Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Gly Ser Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asn Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 531
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v111 ECD
<400> 531
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Pro Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Gly Gln Gly Pro
50 55 60
His Tyr Glu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asn Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 532
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v112 ECD
<400> 532
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro
50 55 60
Thr Tyr Ser Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Ala Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 533
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v113 ECD
<400> 533
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro
50 55 60
Thr Tyr Ser Gly Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Gly Ser Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 534
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v114 ECD
<400> 534
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 535
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v115 ECD
<400> 535
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 536
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v116 ECD
<400> 536
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 537
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v117 ECD
<400> 537
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ser Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Lys Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 538
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v118 ECD
<400> 538
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 539
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v119 ECD
<400> 539
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 540
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v23 IgV
<400> 540
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 541
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v24 IgV
<400> 541
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 542
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v25 IgV
<400> 542
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 543
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v26 IgV
<400> 543
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 544
<211> 119
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v27 IgV
<400> 544
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu Arg Val Leu
115
<210> 545
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v28 IgV
<400> 545
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 546
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v29 IgV
<400> 546
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 547
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v30 IgV
<400> 547
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 548
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v31 IgV
<400> 548
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 549
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v32 IgV
<400> 549
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 550
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v33 IgV
<400> 550
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 551
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v34 IgV
<400> 551
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 552
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v35 IgV
<400> 552
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 553
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v36 IgV
<400> 553
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Gln Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 554
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v37 IgV
<400> 554
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 555
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v38 IgV
<400> 555
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 556
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v39 IgV
<400> 556
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 557
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v40 IgV
<400> 557
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 558
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v41 IgV
<400> 558
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 559
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v42 IgV
<400> 559
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 560
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v43 IgV
<400> 560
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 561
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v44 IgV
<400> 561
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 562
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v45 IgV
<400> 562
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Met Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 563
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v46 IgV
<400> 563
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 564
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v47 IgV
<400> 564
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 565
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v48 IgV
<400> 565
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Leu Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 566
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v49 IgV
<400> 566
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 567
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v50 IgV
<400> 567
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 568
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v51 IgV
<400> 568
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 569
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v52 IgV
<400> 569
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Arg Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 570
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v53 IgV
<400> 570
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 571
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v54 IgV
<400> 571
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Arg Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 572
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v55 IgV
<400> 572
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Leu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 573
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v56 IgV
<400> 573
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Met Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 574
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v57 IgV
<400> 574
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 575
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v58 IgV
<400> 575
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 576
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v59 IgV
<400> 576
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 577
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v60 IgV
<400> 577
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Val Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 578
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v61 IgV
<400> 578
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 579
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v62 IgV
<400> 579
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 580
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v63 IgV
<400> 580
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Glu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 581
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v64 IgV
<400> 581
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Met Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 582
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v65 IgV
<400> 582
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 583
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v66 IgV
<400> 583
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 584
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v67 IgV
<400> 584
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 585
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v68 IgV
<400> 585
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 586
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v69 IgV
<400> 586
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 587
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v70 IgV
<400> 587
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Ala His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro Asn Tyr Leu
50 55 60
Glu Ser Lys Arg Leu Gly Phe Val Ala Ala Gly Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 588
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v71 IgV
<400> 588
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro Asn Tyr Leu
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 589
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v72 IgV
<400> 589
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 590
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v73 IgV
<400> 590
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro Asn Tyr Leu
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 591
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v74 IgV
<400> 591
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 592
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v75 IgV
<400> 592
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 593
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v76 IgV
<400> 593
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 594
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v77 IgV
<400> 594
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 595
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v78 IgV
<400> 595
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro His Tyr His
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 596
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v79 IgV
<400> 596
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Glu Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 597
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v80 IgV
<400> 597
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gly Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser Pro Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Tyr
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 598
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v81 IgV
<400> 598
Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Pro Val Thr His Val Pro Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Glu Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 599
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v82 IgV
<400> 599
Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Tyr
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 600
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v83 IgV
<400> 600
Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Val Arg Leu Ser Pro Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Tyr
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 601
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v84 IgV
<400> 601
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Ser Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser Pro Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Tyr
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 602
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v85 IgV
<400> 602
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 603
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v86 IgV
<400> 603
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr His Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 604
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v87 IgV
<400> 604
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Lys Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 605
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v88 IgV
<400> 605
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 606
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v89 IgV
<400> 606
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 607
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v90 IgV
<400> 607
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro Trp Tyr Ala
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Asp Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 608
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v91 IgV
<400> 608
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Thr Phe His Gln Ser Gln Gly Pro Tyr Tyr Ala
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 609
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v92 IgV
<400> 609
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 610
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v93 IgV
<400> 610
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro Trp Tyr Ala
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 611
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v94 IgV
<400> 611
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Met Gln Gly Pro Trp Tyr Ala
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 612
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v95 IgV
<400> 612
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Ala Gly Gln Leu Gly Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 613
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v96 IgV
<400> 613
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val His Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Gly Gln Leu Ile Trp Ala Arg His Gly Glu
35 40 45
Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro Asp Tyr Ser
50 55 60
Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 614
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v97 IgV
<400> 614
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Gly Gln Leu Val Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Leu His Gln Thr Gln Gly Pro Ser Tyr Trp
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 615
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v98 IgV
<400> 615
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Ile Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 616
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v99 IgV
<400> 616
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Gly Gln Leu Gly Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Asn Phe Ala Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 617
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v100 IgV
<400> 617
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val His Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr Arg Val Gly Gln Leu Ile Trp Ala Arg His Gly Glu
35 40 45
Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro Asp Tyr Ser
50 55 60
Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Tyr Phe Leu Thr His Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 618
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v101 IgV
<400> 618
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Val Val Thr His Val Gly Gln Leu Gly Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 619
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v102 IgV
<400> 619
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 620
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v103 IgV
<400> 620
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 621
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v104 IgV
<400> 621
Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Pro Val Thr His Val Leu Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gly Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Glu Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 622
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v105 IgV
<400> 622
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asn Ile Trp Leu
115
<210> 623
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v106 IgV
<400> 623
Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser Pro Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 624
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v107 IgV
<400> 624
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Thr Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 625
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v108 IgV
<400> 625
Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Gly Gly Ser Met Ala Ala Phe His Gln Thr Met Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 626
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v109 IgV
<400> 626
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 627
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v110 IgV
<400> 627
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro Thr Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Gly Ser Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asn Ile Trp Leu
115
<210> 628
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v111 IgV
<400> 628
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Pro Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Gly Gln Gly Pro His Tyr Glu
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asn Ile Trp Leu
115
<210> 629
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v112 IgV
<400> 629
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro Thr Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Ala Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 630
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v113 IgV
<400> 630
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg His Gly Glu
35 40 45
Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro Thr Tyr Ser
50 55 60
Gly Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Gly Ser Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 631
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v114 IgV
<400> 631
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 632
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v115 IgV
<400> 632
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Pro Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg His Gly Glu
35 40 45
Glu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 633
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v116 IgV
<400> 633
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 634
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v117 IgV
<400> 634
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Ser Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Lys Gln Gly Pro Trp Tyr Ala
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 635
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v118 IgV
<400> 635
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 636
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v119 IgV
<400> 636
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Trp Tyr Ala
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 637
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v23 IgV
<400> 637
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 638
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v24 IgV
<400> 638
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 639
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v25 IgV
<400> 639
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 640
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v26 IgV
<400> 640
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 641
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v27 IgV
<400> 641
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 642
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v28 IgV
<400> 642
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 643
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v29 IgV
<400> 643
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 644
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v30 IgV
<400> 644
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 645
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v31 IgV
<400> 645
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 646
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v32 IgV
<400> 646
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Trp Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 647
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v33 IgV
<400> 647
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 648
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v34 IgV
<400> 648
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 649
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v35 IgV
<400> 649
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 650
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v36 IgV
<400> 650
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gln Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 651
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v37 IgV
<400> 651
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 652
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v38 IgV
<400> 652
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 653
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v39 IgV
<400> 653
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 654
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v40 IgV
<400> 654
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 655
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v41 IgV
<400> 655
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 656
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v42 IgV
<400> 656
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 657
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v43 IgV
<400> 657
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 658
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v44 IgV
<400> 658
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 659
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v45 IgV
<400> 659
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 660
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v46 IgV
<400> 660
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 661
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v47 IgV
<400> 661
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 662
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v48 IgV
<400> 662
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Leu Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 663
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v49 IgV
<400> 663
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 664
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v50 IgV
<400> 664
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 665
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v51 IgV
<400> 665
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 666
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v52 IgV
<400> 666
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Trp Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 667
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v53 IgV
<400> 667
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 668
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v54 IgV
<400> 668
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 669
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v55 IgV
<400> 669
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 670
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v56 IgV
<400> 670
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 671
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v57 IgV
<400> 671
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 672
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v58 IgV
<400> 672
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 673
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v59 IgV
<400> 673
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 674
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v60 IgV
<400> 674
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Val Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 675
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v61 IgV
<400> 675
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Arg Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 676
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v62 IgV
<400> 676
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 677
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v63 IgV
<400> 677
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Leu Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 678
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v64 IgV
<400> 678
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Cys Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Met Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 679
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v65 IgV
<400> 679
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Leu Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 680
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v66 IgV
<400> 680
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ala Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 681
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v67 IgV
<400> 681
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Leu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 682
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v68 IgV
<400> 682
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Asn Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 683
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v69 IgV
<400> 683
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 684
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v70 IgV
<400> 684
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Ala His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
Asn Tyr Leu Glu Ser Lys Arg Leu Gly Phe Val Ala Ala Gly Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 685
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v71 IgV
<400> 685
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
Asn Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 686
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v72 IgV
<400> 686
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 687
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v73 IgV
<400> 687
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
Asn Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Pro Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 688
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v74 IgV
<400> 688
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 689
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v75 IgV
<400> 689
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 690
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v76 IgV
<400> 690
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 691
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v77 IgV
<400> 691
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 692
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v78 IgV
<400> 692
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
His Tyr His Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 693
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v79 IgV
<400> 693
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 694
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v80 IgV
<400> 694
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gly Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser
65 70 75 80
Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 695
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v81 IgV
<400> 695
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Pro Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 696
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v82 IgV
<400> 696
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 697
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v83 IgV
<400> 697
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Val Arg Leu Ser
65 70 75 80
Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 698
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v84 IgV
<400> 698
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Ser Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser
65 70 75 80
Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Tyr Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Asn
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 699
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v85 IgV
<400> 699
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 700
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v86 IgV
<400> 700
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr His Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 701
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v87 IgV
<400> 701
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Lys Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 702
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v88 IgV
<400> 702
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 703
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v89 IgV
<400> 703
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 704
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v90 IgV
<400> 704
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Asp
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 705
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v91 IgV
<400> 705
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Thr Phe His Gln Ser Gln Gly Pro
50 55 60
Tyr Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 706
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v92 IgV
<400> 706
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 707
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v93 IgV
<400> 707
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Met Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 708
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v94 IgV
<400> 708
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Met Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 709
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v95 IgV
<400> 709
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Ala Gly Gln Leu Gly Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 710
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v96 IgV
<400> 710
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val His Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Ile Trp Ala Arg
35 40 45
His Gly Glu Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro
50 55 60
Asp Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 711
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v97 IgV
<400> 711
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Val Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Leu His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Trp Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 712
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v98 IgV
<400> 712
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ile Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 713
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v99 IgV
<400> 713
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Gly Gln Leu Gly Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Ala Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 714
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v100 IgV
<400> 714
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val His Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Arg Val Gly Gln Leu Ile Trp Ala Arg
35 40 45
His Gly Glu Thr Arg His Met Ala Leu Phe Glu Gln Ser Gln Gly Pro
50 55 60
Asp Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Tyr Phe Leu Thr His Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 715
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v101 IgV
<400> 715
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Val Val Thr His Val Gly Gln Leu Gly Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Asn Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 716
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v102 IgV
<400> 716
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 717
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v103 IgV
<400> 717
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 718
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v104 IgV
<400> 718
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Leu Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gly Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 719
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v105 IgV
<400> 719
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asn Ile Trp Leu Arg Val Leu
115 120
<210> 720
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v106 IgV
<400> 720
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Ser
65 70 75 80
Pro Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 721
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v107 IgV
<400> 721
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Thr Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 722
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v108 IgV
<400> 722
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Arg Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Tyr Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Pro Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Gly Gly Ser Met Ala Ala Phe His Gln Thr Met Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 723
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v109 IgV
<400> 723
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Tyr Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 724
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v110 IgV
<400> 724
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro
50 55 60
Thr Tyr Ser Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Gly Ser Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asn Ile Trp Leu Arg Val Leu
115 120
<210> 725
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v111 IgV
<400> 725
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Pro Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Gly Gln Gly Pro
50 55 60
His Tyr Glu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asn Ile Trp Leu Arg Val Leu
115 120
<210> 726
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v112 IgV
<400> 726
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro
50 55 60
Thr Tyr Ser Glu Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Ala Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 727
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v113 IgV
<400> 727
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Thr Met Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Glu Gln Gly Ser Met Ala Val Phe His Gln Thr Leu Gly Pro
50 55 60
Thr Tyr Ser Gly Ser Lys Arg Leu Arg Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Gly Ser Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 728
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v114 IgV
<400> 728
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 729
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v115 IgV
<400> 729
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Gln Trp Ala Arg
35 40 45
His Gly Glu Glu Gly Ser Met Ala Val Phe His Gln Thr Phe Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 730
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v116 IgV
<400> 730
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 731
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v117 IgV
<400> 731
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ser Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Lys Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 732
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v118 IgV
<400> 732
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 733
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v119 IgV
<400> 733
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Phe Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 734
<211> 125
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD112 IgV
<400> 734
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 735
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v1 ECD
<400> 735
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Asp Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 736
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v2 ECD
<400> 736
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Gly
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Gly
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Ser Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 737
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v3 ECD
<400> 737
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 738
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v4 ECD
<400> 738
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ile
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 739
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v5 ECD
<400> 739
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 740
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v6 ECD
<400> 740
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 741
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v7 ECD
<400> 741
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 742
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v8 ECD
<400> 742
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn Tyr
35 40 45
Gln Asn Val Ala Ala Ser His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 743
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v9 ECD
<400> 743
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 744
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v10 ECD
<400> 744
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Ser Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 745
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v11 ECD
<400> 745
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 746
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v12 ECD
<400> 746
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 747
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v13 ECD
<400> 747
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 748
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v14 ECD
<400> 748
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Thr Pro
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 749
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v15 ECD
<400> 749
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Ser Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 750
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v16 ECD
<400> 750
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 751
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v17 ECD
<400> 751
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Ser Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 752
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v18 ECD
<400> 752
Gln Asp Val Arg Val Gln Val Leu Ser Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Ser His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 753
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v19 ECD
<400> 753
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys His Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 754
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v20 ECD
<400> 754
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Leu Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 755
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v21 ECD
<400> 755
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Asp Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 756
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v22 ECD
<400> 756
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Pro Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 757
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v23 ECD
<400> 757
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Ala Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 758
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v24 ECD
<400> 758
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Ser Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 759
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v25 ECD
<400> 759
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 760
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v26 ECD
<400> 760
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 761
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v27 ECD
<400> 761
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser
65 70 75 80
Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Ser Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 762
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v28 ECD
<400> 762
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Leu His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 763
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v29 ECD
<400> 763
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 764
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v30 ECD
<400> 764
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 765
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v31 ECD
<400> 765
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 766
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v32 ECD
<400> 766
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 767
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v33 ECD
<400> 767
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Met Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 768
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v34 ECD
<400> 768
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 769
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v35 ECD
<400> 769
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Ser Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 770
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v36 ECD
<400> 770
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys Arg Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Gly Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 771
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v37 ECD
<400> 771
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 772
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v38 ECD
<400> 772
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 773
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v39 ECD
<400> 773
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 774
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v40 ECD
<400> 774
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Ile Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 775
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v41 ECD
<400> 775
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 776
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v42 ECD
<400> 776
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 777
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v43 ECD
<400> 777
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 778
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v44 ECD
<400> 778
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 779
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v45 ECD
<400> 779
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 780
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v46 ECD
<400> 780
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Ile Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 781
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v47 ECD
<400> 781
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Leu Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 782
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v1 IgV
<400> 782
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Asp Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 783
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v2 IgV
<400> 783
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Gly
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Gly
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Ser Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 784
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v3 IgV
<400> 784
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 785
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v4 IgV
<400> 785
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ile
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 786
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v5 IgV
<400> 786
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 787
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v6 IgV
<400> 787
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 788
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v7 IgV
<400> 788
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 789
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v8 IgV
<400> 789
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn Tyr
35 40 45
Gln Asn Val Ala Ala Ser His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 790
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v9 IgV
<400> 790
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 791
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v10 IgV
<400> 791
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Ser Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 792
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v11 IgV
<400> 792
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 793
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v12 IgV
<400> 793
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 794
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v13 IgV
<400> 794
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 795
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v14 IgV
<400> 795
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Thr Pro
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 796
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v15 IgV
<400> 796
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Ser Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 797
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v16 IgV
<400> 797
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 798
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v17 IgV
<400> 798
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Ser Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 799
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v18 IgV
<400> 799
Gln Asp Val Arg Val Gln Val Leu Ser Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Ser His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 800
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v19 IgV
<400> 800
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys His Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 801
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v20 IgV
<400> 801
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Leu Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 802
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v21 IgV
<400> 802
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Asp Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 803
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v22 IgV
<400> 803
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Pro Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 804
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v23 IgV
<400> 804
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Ala Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 805
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v24 IgV
<400> 805
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Ser Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 806
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v25 IgV
<400> 806
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 807
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v26 IgV
<400> 807
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 808
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v27 IgV
<400> 808
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser
65 70 75 80
Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Ser Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 809
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v28 IgV
<400> 809
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Leu His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 810
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v29 IgV
<400> 810
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 811
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v30 IgV
<400> 811
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 812
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v31 IgV
<400> 812
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 813
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v32 IgV
<400> 813
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 814
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v33 IgV
<400> 814
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Met Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 815
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v34 IgV
<400> 815
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 816
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v35 IgV
<400> 816
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Ser Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 817
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v36 IgV
<400> 817
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys Arg Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Gly Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 818
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v37 IgV
<400> 818
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 819
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v38 IgV
<400> 819
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 820
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v39 IgV
<400> 820
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 821
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v40 IgV
<400> 821
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Ile Thr Trp Leu
115 120 125
<210> 822
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v41 IgV
<400> 822
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 823
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v42 IgV
<400> 823
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 824
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v43 IgV
<400> 824
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 825
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v44 IgV
<400> 825
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 826
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v45 IgV
<400> 826
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 827
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v46 IgV
<400> 827
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Ile Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 828
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v47 IgV
<400> 828
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Leu Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 829
<211> 127
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> CD112 IgV Wildtype
<400> 829
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 830
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v1 IgV
<400> 830
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Asp Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 831
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v2 IgV
<400> 831
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Gly
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Gly
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Ser Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 832
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v3 IgV
<400> 832
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 833
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v4 IgV
<400> 833
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ile
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 834
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v5 IgV
<400> 834
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 835
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v6 IgV
<400> 835
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 836
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v7 IgV
<400> 836
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 837
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v8 IgV
<400> 837
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn Tyr
35 40 45
Gln Asn Val Ala Ala Ser His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 838
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v9 IgV
<400> 838
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 839
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v10 IgV
<400> 839
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Ser Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 840
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v11 IgV
<400> 840
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 841
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v12 IgV
<400> 841
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 842
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v13 IgV
<400> 842
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 843
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v14 IgV
<400> 843
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Thr Pro
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 844
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v15 IgV
<400> 844
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Ser Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 845
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v16 IgV
<400> 845
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 846
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v17 IgV
<400> 846
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Ser Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 847
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v18 IgV
<400> 847
Gln Asp Val Arg Val Gln Val Leu Ser Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Ser His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 848
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v19 IgV
<400> 848
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys His Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 849
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v20 IgV
<400> 849
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Leu Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 850
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v21 IgV
<400> 850
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Asp Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 851
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v22 IgV
<400> 851
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Pro Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 852
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v23 IgV
<400> 852
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Ser Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Ala Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 853
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v24 IgV
<400> 853
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Ser Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 854
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v25 IgV
<400> 854
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 855
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v26 IgV
<400> 855
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 856
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v27 IgV
<400> 856
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser
65 70 75 80
Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Ser Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 857
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v28 IgV
<400> 857
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Leu His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 858
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v29 IgV
<400> 858
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 859
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v30 IgV
<400> 859
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Val Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 860
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v31 IgV
<400> 860
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 861
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v32 IgV
<400> 861
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 862
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v33 IgV
<400> 862
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Met Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 863
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v34 IgV
<400> 863
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 864
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v35 IgV
<400> 864
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Ser Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 865
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v36 IgV
<400> 865
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys Arg Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Asn Trp Gln Arg Pro Gly Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 866
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v37 gV
<400> 866
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 867
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v38 gV
<400> 867
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 868
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v39 gV
<400> 868
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 869
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v40 gV
<400> 869
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Ile Thr Trp Leu Arg Val
115 120 125
<210> 870
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v41 gV
<400> 870
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 871
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v42 gV
<400> 871
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 872
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v43 gV
<400> 872
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 873
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v44 gV
<400> 873
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ser Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 874
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v45 IgV
<400> 874
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Ala Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 875
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v46 IgV
<400> 875
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Ile Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 876
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v47 IgV
<400> 876
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Leu Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 877
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v48 ECD
<400> 877
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 878
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v49 ECD
<400> 878
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Arg Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Thr Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 879
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v50 ECD
<400> 879
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Tyr Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 880
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v51 ECD
<400> 880
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 881
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v52 ECD
<400> 881
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Ala Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 882
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v53 ECD
<400> 882
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 883
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v54 ECD
<400> 883
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 884
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v55 ECD
<400> 884
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 885
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v56 ECD
<400> 885
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 886
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v57 ECD
<400> 886
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 887
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v58 ECD
<400> 887
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 888
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v59 ECD
<400> 888
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Ala Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 889
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v60 ECD
<400> 889
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 890
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v61 ECD
<400> 890
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Met Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 891
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v62 ECD
<400> 891
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 892
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v63 ECD
<400> 892
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 893
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v64 ECD
<400> 893
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 894
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v65 ECD
<400> 894
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Ser Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 895
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v66 ECD
<400> 895
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Glu Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 896
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v67 ECD
<400> 896
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Ala Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 897
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v68 ECD
<400> 897
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 898
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v69 ECD
<400> 898
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 899
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v70 ECD
<400> 899
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 900
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v71 ECD
<400> 900
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 901
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v72 ECD
<400> 901
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Ser Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 902
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v73 ECD
<400> 902
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 903
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v74 ECD
<400> 903
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 904
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v75 ECD
<400> 904
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 905
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v76 ECD
<400> 905
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Met Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 906
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v77 ECD
<400> 906
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Ala Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 907
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v78 ECD
<400> 907
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 908
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v79 ECD
<400> 908
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Gly Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 909
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v80 ECD
<400> 909
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 910
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v81 ECD
<400> 910
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 911
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v82 ECD
<400> 911
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Asp Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 912
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v83 ECD
<400> 912
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Ser Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 913
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v84 ECD
<400> 913
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Ser Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 914
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v85 ECD
<400> 914
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 915
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v86 ECD
<400> 915
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 916
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v87 ECD
<400> 916
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 917
<211> 329
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v88 ECD
<400> 917
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 918
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v48 IgV
<400> 918
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 919
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v49 IgV
<400> 919
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Arg Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Thr Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 920
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v50 IgV
<400> 920
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Tyr Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 921
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v51 IgV
<400> 921
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 922
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v52 IgV
<400> 922
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Ala Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 923
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v53 IgV
<400> 923
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 924
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v54 IgV
<400> 924
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 925
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v55 IgV
<400> 925
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 926
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v56 IgV
<400> 926
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 927
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v57 IgV
<400> 927
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 928
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v58 IgV
<400> 928
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 929
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v59 IgV
<400> 929
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Ala Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 930
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v60 IgV
<400> 930
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 931
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v61 IgV
<400> 931
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Met Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 932
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v62 IgV
<400> 932
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 933
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v63 IgV
<400> 933
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 934
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v64 IgV
<400> 934
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 935
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v65 IgV
<400> 935
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Ser Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 936
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v66 IgV
<400> 936
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Glu Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 937
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v67 IgV
<400> 937
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Ala Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 938
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v68 IgV
<400> 938
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 939
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v69 IgV
<400> 939
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 940
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v70 IgV
<400> 940
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 941
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v71 IgV
<400> 941
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 942
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v72 IgV
<400> 942
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Ser Met Thr Trp Leu
115 120 125
<210> 943
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v73 IgV
<400> 943
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 944
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v74 IgV
<400> 944
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 945
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v75 IgV
<400> 945
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 946
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v76 IgV
<400> 946
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Met Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 947
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v77 IgV
<400> 947
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Ala Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 948
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v78 IgV
<400> 948
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 949
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v79 IgV
<400> 949
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Gly Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 950
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v80 IgV
<400> 950
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 951
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v81 IgV
<400> 951
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 952
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v82 IgV
<400> 952
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Asp Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 953
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v83 IgV
<400> 953
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Ser Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 954
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v84 IgV
<400> 954
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Ser Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 955
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v85 IgV
<400> 955
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 956
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v86 IgV
<400> 956
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 957
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v87 IgV
<400> 957
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 958
<211> 125
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v88 IgV
<400> 958
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 959
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v48 IgV
<400> 959
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 960
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v49 IgV
<400> 960
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Arg Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Thr Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 961
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v50 IgV
<400> 961
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Tyr Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 962
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v51 IgV
<400> 962
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Arg Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 963
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v52 IgV
<400> 963
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Ala Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 964
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v53 IgV
<400> 964
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 965
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v54 IgV
<400> 965
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 966
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v55 IgV
<400> 966
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Arg Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 967
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v56 IgV
<400> 967
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Gly Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 968
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v57 IgV
<400> 968
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 969
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v58 IgV
<400> 969
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 970
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v59 IgV
<400> 970
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Ala Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 971
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v60 IgV
<400> 971
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Val Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 972
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v61 IgV
<400> 972
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Met Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 973
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v62 IgV
<400> 973
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 974
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v63 IgV
<400> 974
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 975
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v64 IgV
<400> 975
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 976
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v65 IgV
<400> 976
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Ser Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Met Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 977
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v66 IgV
<400> 977
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Ala Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Glu Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 978
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v67 IgV
<400> 978
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Ala Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 979
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v68 IgV
<400> 979
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 980
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v69 IgV
<400> 980
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 981
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v70 IgV
<400> 981
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 982
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v71 IgV
<400> 982
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 983
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v72 IgV
<400> 983
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Ser Met Thr Trp Leu Arg Val
115 120 125
<210> 984
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v73 IgV
<400> 984
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 985
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v74 IgV
<400> 985
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 986
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v75 IgV
<400> 986
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 987
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v76 IgV
<400> 987
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Met Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 988
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v77 IgV
<400> 988
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Ala Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 989
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v78 IgV
<400> 989
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 990
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v79 IgV
<400> 990
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Gly Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 991
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v80 IgV
<400> 991
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 992
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v81 IgV
<400> 992
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 993
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v82 IgV
<400> 993
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Asp Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 994
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v83 IgV
<400> 994
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Ser Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 995
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v84 IgV
<400> 995
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Ser Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 996
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v85 IgV
<400> 996
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 997
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v86 IgV
<400> 997
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 998
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v87 IgV
<400> 998
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 999
<211> 127
<212> PRT
<213> Artificial Sequence
<220>
<223> CD112 v88 IgV
<400> 999
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1000
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV
<400> 1000
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1001
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v1
<400> 1001
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Asn Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val Asn Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1002
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v2
<400> 1002
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Thr Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1003
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v3
<400> 1003
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Glu Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1004
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v4
<400> 1004
Phe Thr Val Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1005
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v5
<400> 1005
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1006
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v6
<400> 1006
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1007
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v7
<400> 1007
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1008
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v8
<400> 1008
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1009
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v9
<400> 1009
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1010
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v10
<400> 1010
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1011
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v11
<400> 1011
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1012
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v12
<400> 1012
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Gly Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1013
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v13
<400> 1013
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Ser Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1014
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v14
<400> 1014
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1015
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v15
<400> 1015
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1016
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v16
<400> 1016
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1017
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v17
<400> 1017
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1018
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v18
<400> 1018
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1019
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v19
<400> 1019
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Glu Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1020
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v20
<400> 1020
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asn Ile Ile Gln
35 40 45
Phe Val Arg Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1021
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v21
<400> 1021
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln Arg Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1022
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v22
<400> 1022
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1023
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v23
<400> 1023
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Glu Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1024
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v24
<400> 1024
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1025
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v25
<400> 1025
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1026
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v26
<400> 1026
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Val Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1027
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v27
<400> 1027
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1028
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v28
<400> 1028
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Gly Met Glu Val Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1029
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v29
<400> 1029
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Ser Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1030
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v30
<400> 1030
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1031
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v31
<400> 1031
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1032
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v32
<400> 1032
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1033
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v33
<400> 1033
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1034
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v34
<400> 1034
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1035
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v35
<400> 1035
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1036
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v36
<400> 1036
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Met Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1037
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v37
<400> 1037
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1038
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v38
<400> 1038
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Pro Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1039
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v39
<400> 1039
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1040
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v40
<400> 1040
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Arg Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1041
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v41
<400> 1041
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1042
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v42
<400> 1042
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Val Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1043
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v43
<400> 1043
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Gly Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1044
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v44
<400> 1044
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1045
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v45
<400> 1045
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1046
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v46
<400> 1046
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1047
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v47
<400> 1047
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1048
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v48
<400> 1048
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1049
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v49
<400> 1049
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1050
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v50
<400> 1050
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1051
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v51
<400> 1051
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1052
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v52
<400> 1052
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Ala Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val Tyr Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1053
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v53
<400> 1053
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1054
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v54
<400> 1054
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1055
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v55
<400> 1055
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1056
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v56
<400> 1056
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Gly Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1057
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v57
<400> 1057
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1058
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v58
<400> 1058
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1059
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v59
<400> 1059
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Gly Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Asp Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1060
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v60
<400> 1060
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys
100 105 110
Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp
115 120 125
Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro
130 135 140
Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly
145 150 155 160
Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val
165 170 175
Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys
180 185 190
Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val
195 200 205
Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1061
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v61
<400> 1061
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1062
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v62
<400> 1062
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1063
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v63
<400> 1063
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Ile Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Ile Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Lys Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1064
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v64
<400> 1064
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1065
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v65
<400> 1065
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1066
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v1
<400> 1066
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Asn Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln Phe Val Asn Gly Glu
35 40 45
Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1067
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v2
<400> 1067
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asp Ile Thr Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1068
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v3
<400> 1068
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Lys Glu Asp Glu Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1069
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v4
<400> 1069
Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Thr Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1070
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v5
<400> 1070
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1071
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v6
<400> 1071
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1072
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v7
<400> 1072
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1073
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v8
<400> 1073
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1074
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v9
<400> 1074
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1075
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v10
<400> 1075
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1076
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v11
<400> 1076
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1077
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v12
<400> 1077
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asp Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Gly Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1078
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v13
<400> 1078
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Ser Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1079
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v14
<400> 1079
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1080
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v15
<400> 1080
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1081
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v16
<400> 1081
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1082
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v17
<400> 1082
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1083
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v18
<400> 1083
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Lys Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1084
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v19
<400> 1084
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Glu
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1085
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v20
<400> 1085
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Ile Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Lys Glu Gly Lys Asn Ile Ile Gln Phe Val Arg Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1086
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v21
<400> 1086
Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln Arg Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1087
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v22
<400> 1087
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1088
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v23
<400> 1088
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Glu Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1089
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v24
<400> 1089
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Ile Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1090
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v25
<400> 1090
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1091
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v26
<400> 1091
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Val
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1092
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v27
<400> 1092
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1093
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v28
<400> 1093
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Gly Met Glu Val Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1094
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v29
<400> 1094
Pro Lys Asp Leu Tyr Val Val Glu Ser Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1095
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v30
<400> 1095
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1096
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v31
<400> 1096
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1097
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v32
<400> 1097
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1098
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v33
<400> 1098
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1099
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v34
<400> 1099
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1100
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v35
<400> 1100
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1101
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v36
<400> 1101
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Met Lys Val
100 105
<210> 1102
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v37
<400> 1102
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1103
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v38
<400> 1103
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Pro Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1104
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v39
<400> 1104
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1105
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v40
<400> 1105
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Arg Arg Ile Thr Val Lys Val
100 105
<210> 1106
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v41
<400> 1106
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1107
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v42
<400> 1107
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Val Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1108
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v43
<400> 1108
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Gly Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1109
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v44
<400> 1109
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1110
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v45
<400> 1110
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1111
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v46
<400> 1111
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1112
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v47
<400> 1112
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1113
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v48
<400> 1113
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1114
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v49
<400> 1114
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1115
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v50
<400> 1115
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1116
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v51
<400> 1116
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1117
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v52
<400> 1117
Pro Lys Asp Leu Tyr Ala Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val Tyr Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Gly Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1118
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v53
<400> 1118
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Thr Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1119
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v54
<400> 1119
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1120
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v55
<400> 1120
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1121
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v56
<400> 1121
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Gly
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1122
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v57
<400> 1122
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Asp Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1123
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v58
<400> 1123
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1124
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v59
<400> 1124
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Gly Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Asp
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1125
<211> 108
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v60
<400> 1125
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1126
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v61
<400> 1126
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1127
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v62
<400> 1127
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1128
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v63
<400> 1128
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Ile Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Ile Ile Ile Gln Phe Ala His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Lys Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1129
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v64
<400> 1129
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1130
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v65
<400> 1130
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1131
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v1
<400> 1131
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Asn Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val Asn Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1132
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v2
<400> 1132
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Thr Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1133
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v3
<400> 1133
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Glu Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1134
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v4
<400> 1134
Phe Thr Val Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1135
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v5
<400> 1135
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1136
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v6
<400> 1136
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1137
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v7
<400> 1137
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1138
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v8
<400> 1138
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1139
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v9
<400> 1139
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1140
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v10
<400> 1140
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1141
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v11
<400> 1141
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1142
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v12
<400> 1142
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Gly Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1143
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v13
<400> 1143
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Ser Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1144
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v14
<400> 1144
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1145
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v15
<400> 1145
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1146
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v16
<400> 1146
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1147
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v17
<400> 1147
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1148
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v18
<400> 1148
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1149
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v19
<400> 1149
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Glu Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1150
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v20
<400> 1150
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asn Ile Ile Gln
35 40 45
Phe Val Arg Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1151
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v21
<400> 1151
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln Arg Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1152
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v22
<400> 1152
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1153
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v23
<400> 1153
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Glu Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1154
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v24
<400> 1154
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1155
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v25
<400> 1155
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1156
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v26
<400> 1156
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Val Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1157
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v27
<400> 1157
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1158
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v28
<400> 1158
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Gly Met Glu Val Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1159
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v29
<400> 1159
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Ser Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1160
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v30
<400> 1160
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1161
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v31
<400> 1161
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1162
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v32
<400> 1162
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1163
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v33
<400> 1163
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1164
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v34
<400> 1164
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1165
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v35
<400> 1165
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1166
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v36
<400> 1166
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Met Lys Val
100 105 110
Asn Ala
<210> 1167
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v37
<400> 1167
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1168
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v38
<400> 1168
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Pro Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1169
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v39
<400> 1169
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1170
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v40
<400> 1170
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Arg Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1171
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v41
<400> 1171
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1172
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v42
<400> 1172
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Val Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1173
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v43
<400> 1173
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Gly Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1174
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v44
<400> 1174
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1175
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v45
<400> 1175
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1176
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v46
<400> 1176
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1177
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v47
<400> 1177
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1178
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v48
<400> 1178
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1179
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v49
<400> 1179
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1180
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v50
<400> 1180
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1181
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v51
<400> 1181
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1182
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v52
<400> 1182
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Ala Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val Tyr Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1183
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v53
<400> 1183
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1184
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v54
<400> 1184
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1185
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v55
<400> 1185
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1186
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v56
<400> 1186
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Gly Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1187
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v57
<400> 1187
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1188
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v58
<400> 1188
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1189
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v59
<400> 1189
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Gly Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Asp Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1190
<211> 115
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v60
<400> 1190
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys
100 105 110
Val Asn Ala
115
<210> 1191
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v61
<400> 1191
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1192
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v62
<400> 1192
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1193
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v63
<400> 1193
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Ile Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Ile Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Lys Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1194
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v64
<400> 1194
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1195
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v65
<400> 1195
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1196
<211> 114
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PD-L1 IgV wildtype
<400> 1196
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1197
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 IgV
<400> 1197
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1198
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v1
<400> 1198
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1199
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v2
<400> 1199
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1200
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v3
<400> 1200
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1201
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v4
<400> 1201
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1202
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v5
<400> 1202
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1203
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v6
<400> 1203
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Gly Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1204
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v7
<400> 1204
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1205
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v8
<400> 1205
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1206
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v9
<400> 1206
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1207
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v10
<400> 1207
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1208
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v11
<400> 1208
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Arg Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1209
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v12
<400> 1209
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1210
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v13
<400> 1210
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1211
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v14
<400> 1211
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1212
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v15
<400> 1212
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1213
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v16
<400> 1213
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1214
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v17
<400> 1214
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Ser Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1215
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v18
<400> 1215
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1216
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v19
<400> 1216
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1217
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v20
<400> 1217
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Arg Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1218
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v21
<400> 1218
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1219
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v22
<400> 1219
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1220
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v23
<400> 1220
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1221
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v24
<400> 1221
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1222
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v25
<400> 1222
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1223
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v26
<400> 1223
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1224
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v27
<400> 1224
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1225
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v28
<400> 1225
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1226
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v29
<400> 1226
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1227
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v30
<400> 1227
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1228
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v31
<400> 1228
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1229
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v32
<400> 1229
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1230
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v33
<400> 1230
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1231
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v34
<400> 1231
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1232
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v35
<400> 1232
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1233
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v36
<400> 1233
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1234
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v37
<400> 1234
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1235
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v38
<400> 1235
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1236
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v39
<400> 1236
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Arg Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1237
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v40
<400> 1237
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Val Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1238
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v41
<400> 1238
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1239
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v42
<400> 1239
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1240
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v43
<400> 1240
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1241
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v44
<400> 1241
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1242
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v45
<400> 1242
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1243
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v46
<400> 1243
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1244
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v47
<400> 1244
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1245
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v48
<400> 1245
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1246
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v49
<400> 1246
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Met Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1247
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v50
<400> 1247
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1248
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v51
<400> 1248
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Ala Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Ser Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1249
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v52
<220>
<221> VARIANT
<222> (65)..(65)
<223> X is a stop codon
<400> 1249
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Ala Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Xaa Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1250
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v53
<400> 1250
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe Leu Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1251
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v54
<400> 1251
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe Leu Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1252
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v55
<400> 1252
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Val Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1253
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v56
<400> 1253
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asn Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1254
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v57
<400> 1254
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1255
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v58
<400> 1255
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1256
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v59
<400> 1256
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1257
<211> 102
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> PD-L2 IgV wildtype
<400> 1257
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1258
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v61
<400> 1258
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Val Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1259
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v62
<400> 1259
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1260
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v63
<400> 1260
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Pro Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Ser Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1261
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v64
<400> 1261
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1262
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v65
<400> 1262
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1263
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v66
<400> 1263
Leu Leu Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Glu Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1264
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v67
<400> 1264
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Phe Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1265
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v68
<400> 1265
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Gly Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1266
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v69
<400> 1266
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Ser Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1267
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v70
<400> 1267
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Val Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1268
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v71
<400> 1268
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asp Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Ala Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1269
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v72
<400> 1269
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Ala Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Cys
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1270
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v73
<400> 1270
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
His Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1271
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v74
<400> 1271
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1272
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v75
<400> 1272
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Gly Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1273
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v76
<400> 1273
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1274
<211> 201
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L2 ECD v77
<400> 1274
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu
100 105 110
Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly
115 120 125
Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn
130 135 140
Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val
145 150 155 160
Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp
165 170 175
Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser
180 185 190
Gln Met Glu Pro Arg Thr His Pro Thr
195 200
<210> 1275
<211> 98
<212> PRT
<213> Artificial Seqeunce
<220>
<223> PDL-2 IgV v1
<400> 1275
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1276
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v2
<400> 1276
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1277
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v3
<400> 1277
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1278
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v4
<400> 1278
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1279
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v5
<400> 1279
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1280
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v6
<400> 1280
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Gly Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1281
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v7
<400> 1281
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1282
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v8
<400> 1282
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1283
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v9
<400> 1283
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1284
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v10
<400> 1284
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1285
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v11
<400> 1285
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1286
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v12
<400> 1286
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1287
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v13
<400> 1287
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1288
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v14
<400> 1288
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1289
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v15
<400> 1289
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1290
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v16
<400> 1290
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1291
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v17
<400> 1291
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Ser Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1292
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v18
<400> 1292
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1293
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v19
<400> 1293
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1294
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v20
<400> 1294
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Arg Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1295
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v21
<400> 1295
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1296
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v22
<400> 1296
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1297
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v23
<400> 1297
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1298
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v24
<400> 1298
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1299
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v25
<400> 1299
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1300
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v26
<400> 1300
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1301
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v27
<400> 1301
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1302
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v28
<400> 1302
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1303
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v29
<400> 1303
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1304
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v30
<400> 1304
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1305
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v31
<400> 1305
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1306
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v32
<400> 1306
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1307
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v33
<400> 1307
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1308
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v34
<400> 1308
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1309
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v35
<400> 1309
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1310
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v36
<400> 1310
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1311
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v37
<400> 1311
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1312
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v38
<400> 1312
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1313
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v39
<400> 1313
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Arg Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1314
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v40
<400> 1314
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Val Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1315
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v41
<400> 1315
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1316
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v42
<400> 1316
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1317
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v43
<400> 1317
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1318
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v44
<400> 1318
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1319
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v45
<400> 1319
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1320
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v46
<400> 1320
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1321
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v47
<400> 1321
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1322
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v48
<400> 1322
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1323
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v49
<400> 1323
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Met Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1324
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v50
<400> 1324
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1325
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v51
<400> 1325
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Ala Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Ser Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1326
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v52
<220>
<221> VARIANT
<222> (64)..(64)
<223> X is a stop codon
<400> 1326
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly Ser
1 5 10 15
Asn Val Ala Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Xaa
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1327
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v53
<400> 1327
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe Leu Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1328
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v54
<400> 1328
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe Leu Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1329
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v55
<400> 1329
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Val Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1330
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v56
<400> 1330
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asn Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1331
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v57
<400> 1331
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1332
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v58
<400> 1332
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1333
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v60
<400> 1333
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1334
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v61
<400> 1334
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Val Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1335
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v62
<400> 1335
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Arg
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1336
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v63
<400> 1336
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Pro
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Ser Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1337
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v64
<400> 1337
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1338
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v65
<400> 1338
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1339
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v66
<400> 1339
Leu Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Glu Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1340
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v67
<400> 1340
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Phe
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1341
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v68
<400> 1341
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Gly Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1342
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v69
<400> 1342
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Ser Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1343
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v70
<400> 1343
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Val Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1344
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v71
<400> 1344
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asp Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Ala Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1345
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v72
<400> 1345
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Ala Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Cys Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1346
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v73
<400> 1346
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn His
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1347
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v74
<400> 1347
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1348
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v75
<400> 1348
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Ser Phe His Ile Pro His Val Gln Gly Gly Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1349
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v76
<400> 1349
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1350
<211> 98
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v77
<400> 1350
Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly Ser
1 5 10 15
Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn Leu
20 25 30
Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser Pro
35 40 45
His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly Lys
50 55 60
Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln Tyr
65 70 75 80
Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu Thr
85 90 95
Leu Lys
<210> 1351
<211> 102
<212> PRT
<213> Artificial Seqeunce
<220>
<223> PDL-2 IgV v1
<400> 1351
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1352
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v2
<400> 1352
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1353
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v3
<400> 1353
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1354
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v4
<400> 1354
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1355
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v5
<400> 1355
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1356
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v6
<400> 1356
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Gly Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1357
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v7
<400> 1357
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1358
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v8
<400> 1358
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1359
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v9
<400> 1359
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1360
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v10
<400> 1360
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1361
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v11
<400> 1361
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Arg Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1362
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v12
<400> 1362
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1363
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v13
<400> 1363
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1364
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v14
<400> 1364
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1365
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v15
<400> 1365
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1366
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v16
<400> 1366
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1367
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v17
<400> 1367
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Ser Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1368
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v18
<400> 1368
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1369
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v19
<400> 1369
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1370
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v20
<400> 1370
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Arg Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1371
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v21
<400> 1371
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1372
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v22
<400> 1372
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1373
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v23
<400> 1373
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1374
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v24
<400> 1374
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1375
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v25
<400> 1375
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1376
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v26
<400> 1376
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1377
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v27
<400> 1377
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1378
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v28
<400> 1378
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1379
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v29
<400> 1379
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1380
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v30
<400> 1380
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1381
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v31
<400> 1381
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1382
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v32
<400> 1382
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1383
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v33
<400> 1383
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1384
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v34
<400> 1384
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Phe Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1385
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v35
<400> 1385
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1386
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v36
<400> 1386
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1387
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v37
<400> 1387
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asp
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1388
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v38
<400> 1388
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1389
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v39
<400> 1389
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Arg Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1390
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v40
<400> 1390
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Val Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1391
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v41
<400> 1391
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1392
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v42
<400> 1392
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro His Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1393
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v43
<400> 1393
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1394
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v44
<400> 1394
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1395
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v45
<400> 1395
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1396
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v46
<400> 1396
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1397
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v47
<400> 1397
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1398
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v48
<400> 1398
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1399
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v49
<400> 1399
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Met Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1400
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v50
<400> 1400
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1401
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v51
<400> 1401
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Ala Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Ser Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1402
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v52
<220>
<221> VARIANT
<222> (65)..(65)
<223> X is a stop codon
<400> 1402
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu His Gly
1 5 10 15
Ser Asn Val Ala Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Xaa Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1403
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v53
<400> 1403
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe Leu Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1404
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v54
<400> 1404
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe Leu Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1405
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v55
<400> 1405
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Val Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1406
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v56
<400> 1406
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asn Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1407
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v57
<400> 1407
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1408
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v58
<400> 1408
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1409
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v60
<400> 1409
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asp Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1410
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v61
<400> 1410
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Val Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1411
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v62
<400> 1411
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Arg Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1412
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v63
<400> 1412
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Pro Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Ser Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1413
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v64
<400> 1413
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1414
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v65
<400> 1414
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1415
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v66
<400> 1415
Leu Leu Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Glu Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1416
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v67
<400> 1416
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Phe Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1417
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v68
<400> 1417
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Gly Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1418
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v69
<400> 1418
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Ser Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1419
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v70
<400> 1419
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Val Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1420
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v71
<400> 1420
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asp Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Ala Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1421
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v72
<400> 1421
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Ala Ala Ser Leu Gln Lys Val Asp Asn Asp Thr Cys
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1422
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v73
<400> 1422
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
His Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1423
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v74
<400> 1423
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Gln Cys Ile Ile Thr Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1424
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v75
<400> 1424
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ile Leu Gln Lys Val Asp Asn Asp Thr Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Ser Phe His Ile Pro His Val Gln Gly Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1425
<211> 102
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v76
<400> 1425
Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu Gln Gly
1 5 10 15
Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn
20 25 30
Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Ala Ser
35 40 45
Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly
50 55 60
Lys Ala Leu Phe His Ile Pro Gln Val Gln Val Gly Asp Glu Gly Gln
65 70 75 80
Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr Lys Tyr Leu
85 90 95
Thr Leu Lys Val Lys Ala
100
<210> 1426
<211> 105
<212> PRT
<213> Artificial Sequence
<220>
<223> PDL-2 IgV v77
<400> 1426
Ser Glu Gln Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Val
1 5 10 15
Glu Gln Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser
20 25 30
His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn
35 40 45
Asp Ala Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu
50 55 60
Pro Leu Gly Lys Ala Leu Phe His Ile Pro His Val Gln Val Gly Asp
65 70 75 80
Glu Gly Gln Tyr Arg Cys Ile Ile Ile Tyr Gly Asp Ala Trp Asp Tyr
85 90 95
Lys Tyr Leu Thr Leu Lys Val Lys Ala
100 105
<210> 1427
<211> 229
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG4 Fc
<400> 1427
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe
1 5 10 15
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
20 25 30
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
35 40 45
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
50 55 60
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65 70 75 80
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
85 90 95
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
100 105 110
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
115 120 125
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
130 135 140
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145 150 155 160
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
165 170 175
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
180 185 190
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
195 200 205
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
210 215 220
Leu Ser Leu Gly Lys
225
<210> 1428
<211> 229
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG4 Fc S228P
<400> 1428
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
1 5 10 15
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
20 25 30
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
35 40 45
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
50 55 60
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65 70 75 80
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
85 90 95
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
100 105 110
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
115 120 125
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
130 135 140
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145 150 155 160
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
165 170 175
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
180 185 190
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
195 200 205
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
210 215 220
Leu Ser Leu Gly Lys
225
<210> 1429
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> IgG1 Fc C220S
<400> 1429
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 1430
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v89 ECD
<400> 1430
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1431
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v90 ECD
<400> 1431
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Met Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1432
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v91 ECD
<400> 1432
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1433
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v92 ECD
<400> 1433
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1434
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v93 ECD
<400> 1434
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1435
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v94 ECD
<400> 1435
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1436
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v95 ECD
<400> 1436
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1437
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v96 ECD
<400> 1437
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1438
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v97 ECD
<400> 1438
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Pro Ala Lys Gln Ser
65 70 75 80
Ile Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1439
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v98 ECD
<400> 1439
Gln Asp Val Arg Val Gln Val Leu Arg Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Val Leu Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Met Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Phe Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Val Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Ala Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1440
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v99 ECD
<400> 1440
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1441
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v100 ECD
<400> 1441
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Ala Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1442
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v101 ECD
<400> 1442
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1443
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v102 ECD
<400> 1443
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1444
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v103 ECD
<400> 1444
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1445
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v104 ECD
<400> 1445
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Leu Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1446
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v105 ECD
<400> 1446
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Ala Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1447
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v106 ECD
<400> 1447
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Pro Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1448
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v107 ECD
<400> 1448
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Leu Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1449
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v108 ECD
<400> 1449
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Ser Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Leu Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1450
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v109 ECD
<400> 1450
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Ala Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1451
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v100 ECD
<400> 1451
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1452
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v111 ECD
<400> 1452
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Leu Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1453
<211> 329
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v112 ECD
<400> 1453
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val Ile
115 120 125
Ala Lys Pro Lys Asn Gln Ala Glu Ala Gln Lys Val Thr Phe Ser Gln
130 135 140
Asp Pro Thr Thr Val Ala Leu Cys Ile Ser Lys Glu Gly Arg Pro Pro
145 150 155 160
Ala Arg Ile Ser Trp Leu Ser Ser Leu Asp Trp Glu Ala Lys Glu Thr
165 170 175
Gln Val Ser Gly Thr Leu Ala Gly Thr Val Thr Val Thr Ser Arg Phe
180 185 190
Thr Leu Val Pro Ser Gly Arg Ala Asp Gly Val Thr Val Thr Cys Lys
195 200 205
Val Glu His Glu Ser Phe Glu Glu Pro Ala Leu Ile Pro Val Thr Leu
210 215 220
Ser Val Arg Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asp Asn
225 230 235 240
Trp Tyr Leu Gly Arg Thr Asp Ala Thr Leu Ser Cys Asp Val Arg Ser
245 250 255
Asn Pro Glu Pro Thr Gly Tyr Asp Trp Ser Thr Thr Ser Gly Thr Phe
260 265 270
Pro Thr Ser Ala Val Ala Gln Gly Ser Gln Leu Val Ile His Ala Val
275 280 285
Asp Ser Leu Phe Asn Thr Thr Phe Val Cys Thr Val Thr Asn Ala Val
290 295 300
Gly Met Gly Arg Ala Glu Gln Val Ile Phe Val Arg Glu Thr Pro Asn
305 310 315 320
Thr Ala Gly Ala Gly Ala Thr Gly Gly
325
<210> 1454
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v89 IgV
<400> 1454
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1455
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v90 IgV
<400> 1455
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Met Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1456
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v91 IgV
<400> 1456
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1457
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v92 IgV
<400> 1457
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1458
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v93 IgV
<400> 1458
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1459
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v94 IgV
<400> 1459
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1460
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v95 IgV
<400> 1460
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1461
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v96 IgV
<400> 1461
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1462
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v97 IgV
<400> 1462
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Pro Ala Lys Gln Ser
65 70 75 80
Ile Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1463
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v98 IgV
<400> 1463
Gln Asp Val Arg Val Gln Val Leu Arg Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Val Leu Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Met Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Phe Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Val Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Ala
115 120 125
<210> 1464
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v99 IgV
<400> 1464
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1465
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v100 IgV
<400> 1465
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Ala Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1466
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v101 IgV
<400> 1466
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1467
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v102 IgV
<400> 1467
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1468
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v103 IgV
<400> 1468
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1469
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v104 IgV
<400> 1469
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Leu Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1470
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v105 IgV
<400> 1470
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Ala Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1471
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v106 IgV
<400> 1471
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Pro Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1472
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v107 IgV
<400> 1472
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Leu Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1473
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v108 IgV
<400> 1473
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Ser Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Leu Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1474
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v109 IgV
<400> 1474
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Ala Arg Gly Met Thr Trp Leu
115 120 125
<210> 1475
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v100 IgV
<400> 1475
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1476
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v111 IgV
<400> 1476
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Leu Leu
115 120 125
<210> 1477
<211> 125
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v112 IgV
<400> 1477
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu
115 120 125
<210> 1478
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v89 IgV
<400> 1478
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1479
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v90 IgV
<400> 1479
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Met Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1480
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v91 IgV
<400> 1480
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1481
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v92 IgV
<400> 1481
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1482
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v93 IgV
<400> 1482
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1483
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v94 IgV
<400> 1483
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1484
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v95 IgV
<400> 1484
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Ala Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1485
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v96 IgV
<400> 1485
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1486
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v97 IgV
<400> 1486
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Pro Ala Lys Gln Ser
65 70 75 80
Ile Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Tyr Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1487
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v98 IgV
<400> 1487
Gln Asp Val Arg Val Gln Val Leu Arg Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Val Leu Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Met Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Phe Glu Arg Leu Ser Leu Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Val Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Ala Arg Val
115 120 125
<210> 1488
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v99 IgV
<400> 1488
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1489
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v100 IgV
<400> 1489
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Ala Pro Gly Pro
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1490
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v101 IgV
<400> 1490
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1491
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v102 IgV
<400> 1491
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Trp Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Arg Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1492
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v103 IgV
<400> 1492
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1493
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v104 IgV
<400> 1493
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Leu Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1494
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v105 IgV
<400> 1494
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Ala Trp Gln Arg Pro Asp Ala Pro Thr Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1495
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v106 IgV
<400> 1495
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Ser Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Pro Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Tyr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1496
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v107 IgV
<400> 1496
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Leu Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Met Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1497
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v109 IgV
<400> 1497
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Lys His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Ser Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Lys Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Leu Val
100 105 110
Thr Phe Pro Lys Gly Thr Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1498
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v109 IgV
<400> 1498
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Thr Ala Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1499
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v100 IgV
<400> 1499
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1500
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v111 IgV
<400> 1500
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
His Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Met Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Asn Tyr Thr Cys Glu Phe Ala
100 105 110
Thr Phe Pro Lys Gly Phe Val Arg Gly Met Thr Leu Leu Arg Val
115 120 125
<210> 1501
<211> 127
<212> PRT
<213> Artificial sequence
<220>
<223> CD112 v112 IgV
<400> 1501
Gln Asp Val Arg Val Gln Val Leu Pro Glu Val Arg Gly Gln Leu Gly
1 5 10 15
Gly Thr Val Glu Leu Pro Cys His Leu Leu Pro Pro Val Pro Gly Leu
20 25 30
Tyr Ile Ser Leu Val Thr Trp Gln Arg Pro Asp Ala Pro Ala Asn His
35 40 45
Gln Asn Val Ala Ala Phe His Pro Lys Met Gly Pro Ser Phe Pro Ser
50 55 60
Pro Lys Pro Gly Ser Glu Arg Leu Ser Phe Val Ser Ala Lys Gln Ser
65 70 75 80
Thr Gly Gln Asp Thr Glu Ala Glu Leu Gln Asp Ala Thr Leu Ala Leu
85 90 95
His Gly Leu Thr Val Glu Asp Glu Gly Ile Tyr Thr Cys Glu Phe Val
100 105 110
Thr Phe Pro Lys Gly Ser Val Arg Gly Met Thr Trp Leu Arg Val
115 120 125
<210> 1502
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v120 IgV
<400> 1502
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Gly Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser Trp Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1503
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v121 IgV
<400> 1503
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Gly Ala Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asp
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Leu Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1504
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v122 IgV
<400> 1504
Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Leu Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Lys Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1505
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v123 IgV
<400> 1505
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1506
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v124 IgV
<400> 1506
Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1507
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v125 IgV
<400> 1507
Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Arg Met Ala Val Phe His Pro Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1508
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v126 IgV
<400> 1508
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1509
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v127 IgV
<400> 1509
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1510
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v128 IgV
<400> 1510
Pro Gly Thr Gly Gly Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Ile Glu Ala Thr His Val Ser Gln Leu Thr Trp Ala Arg Gln Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Glu Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser Trp Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1511
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v129 IgV
<400> 1511
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Ser Phe Pro Gln Gly Ser Trp Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1512
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v130 IgV
<400> 1512
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1513
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v131 IgV
<400> 1513
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Asp Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1514
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v132 IgV
<400> 1514
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Arg Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Asp Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1515
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v133 IgV
<400> 1515
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1516
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v134 IgV
<400> 1516
Pro Gly Thr Gly Asp Ile Val Val Lys Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1517
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v135 IgV
<400> 1517
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1518
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v136 IgV
<400> 1518
Pro Gly Thr Gly Asp Ile Ile Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Ser Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Tyr Pro Gln Arg Val Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1519
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v137 IgV
<400> 1519
Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Ser Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1520
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v138 IgV
<400> 1520
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Cys Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1521
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v139 IgV
<400> 1521
Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1522
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v140 IgV
<400> 1522
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Leu Ser Gly Leu Arg Ala Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1523
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v141 IgV
<400> 1523
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Glu
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly Thr Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1524
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v142 IgV
<400> 1524
Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1525
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v120 IgV
<400> 1525
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Gly Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1526
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v121 IgV
<400> 1526
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Gly Ala Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Leu Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1527
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v122 IgV
<400> 1527
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Leu Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Lys Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1528
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v123 IgV
<400> 1528
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1529
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v124 IgV
<400> 1529
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1530
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v125 IgV
<400> 1530
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Arg Met Ala Val Phe His Pro Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1531
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v126 IgV
<400> 1531
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1532
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v127 IgV
<400> 1532
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1533
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v128 IgV
<400> 1533
Trp Pro Pro Pro Gly Thr Gly Gly Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Ile Glu Ala Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Gln Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Glu Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1534
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v129 IgV
<400> 1534
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ser Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1535
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v130 IgV
<400> 1535
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1536
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v131 IgV
<400> 1536
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Asp Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1537
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v132 IgV
<400> 1537
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Arg Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Asp Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1538
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v133 IgV
<400> 1538
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1539
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v134 IgV
<400> 1539
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Lys Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1540
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v135 IgV
<400> 1540
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1541
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v136 IgV
<400> 1541
Trp Pro Pro Pro Gly Thr Gly Asp Ile Ile Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Ser Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Tyr Pro Gln Arg Val
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1542
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v137 IgV
<400> 1542
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Ser Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1543
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v138 IgV
<400> 1543
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Cys Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1544
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v139 IgV
<400> 1544
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1545
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v140 IgV
<400> 1545
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Leu Ser Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1546
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v141 IgV
<400> 1546
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Glu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly
65 70 75 80
Thr Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1547
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v142 IgV
<400> 1547
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1548
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v120 ECD
<400> 1548
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Gly Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1549
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v121 ECD
<400> 1549
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Gly Ala Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Leu Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1550
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v122 ECD
<400> 1550
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Leu Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Lys Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Glu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1551
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v123 ECD
<400> 1551
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Asp Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1552
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v124 ECD
<400> 1552
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1553
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v125 ECD
<400> 1553
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Arg Met Ala Val Phe His Pro Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1554
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v126 ECD
<400> 1554
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1555
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v127 ECD
<400> 1555
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1556
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v128 ECD
<400> 1556
Trp Pro Pro Pro Gly Thr Gly Gly Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Ile Glu Ala Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Gln Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Glu Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ala Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1557
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v129 ECD
<400> 1557
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Ser Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1558
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v130 ECD
<400> 1558
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1559
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v131 ECD
<400> 1559
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Asp Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Asp Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1560
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v132 ECD
<400> 1560
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Arg Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Asp Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1561
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v133 ECD
<400> 1561
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1562
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v134 ECD
<400> 1562
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Lys Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1563
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v135 ECD
<400> 1563
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1564
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v136 ECD
<400> 1564
Trp Pro Pro Pro Gly Thr Gly Asp Ile Ile Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Ser Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Tyr Pro Gln Arg Val
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1565
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v137 ECD
<400> 1565
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Ser Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1566
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v138 ECD
<400> 1566
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Cys Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Val Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1567
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v139 ECD
<400> 1567
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1568
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v140 ECD
<400> 1568
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Leu Ser Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1569
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v141 ECD
<400> 1569
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Glu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly
65 70 75 80
Thr Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1570
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v142 ECD
<400> 1570
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1571
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v143 ECD
<400> 1571
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1572
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v143 IgV
<400> 1572
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Trp Tyr Ala
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1573
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v143 IgV
<400> 1573
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Trp Tyr Ala Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Gln Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1574
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v144 ECD
<400> 1574
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Asp Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Asn Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Gln Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Tyr Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1575
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v145 ECD
<400> 1575
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Leu Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1576
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v146 ECD
<400> 1576
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Gln Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Lys Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Val Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1577
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v147 ECD
<400> 1577
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Arg
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Ala Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1578
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v148 ECD
<400> 1578
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val His Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Ser Ser Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Thr Arg Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1579
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v149 ECD
<400> 1579
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Pro Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Gln Gly Glu Ser Gly Ser Met Ala Val Tyr His Arg Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1580
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v150 ECD
<400> 1580
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Cys Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Thr Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Thr Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1581
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v151 ECD
<400> 1581
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Thr Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Gly Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Trp Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1582
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v152 ECD
<400> 1582
Trp Pro Pro Pro Gly Thr Gly Asp Val Phe Val Gln Ala Pro Ser Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Gln
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Met Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1583
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v153 ECD
<400> 1583
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Met Gly Asp Ser Val Thr Leu Pro Cys Phe Leu Gln
20 25 30
Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Trp Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Gly Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1584
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v154 ECD
<400> 1584
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Val Ser Gly Gly Met Ala Val Phe His Arg Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly
65 70 75 80
Ala Gly Leu Arg Asn Ala Thr Leu Arg Ile Ser Arg Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1585
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v155 ECD
<400> 1585
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr His
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1586
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v156 ECD
<400> 1586
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro
50 55 60
Ser Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Ala Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1587
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v157 ECD
<400> 1587
Trp Pro Pro Pro Gly Thr Gly Gly Ile Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Ala Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Leu Phe Pro Gln Gly Ser
100 105 110
Arg Ser Ala Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1588
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v158 ECD
<400> 1588
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg
35 40 45
His Ser Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1589
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v159 ECD
<400> 1589
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Pro Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1590
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v160 ECD
<400> 1590
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Pro Gly Arg Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1591
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v161 ECD
<400> 1591
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asn Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Asn Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1592
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v162 ECD
<400> 1592
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Ser Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Val Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1593
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v163 ECD
<400> 1593
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe Asn Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Ala Ala Ala Arg Pro Gly
65 70 75 80
Thr Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1594
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v164 ECD
<400> 1594
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Arg Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Asp Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Gly Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1595
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v165 ECD
<400> 1595
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Lys Val Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Thr Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1596
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v166 ECD
<400> 1596
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Leu Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Ile Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1597
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v167 ECD
<400> 1597
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Met Pro Phe Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Leu Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Ser Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1598
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v168 ECD
<400> 1598
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Glu Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1599
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v169 ECD
<400> 1599
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Ile Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Lys Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1600
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v170 ECD
<400> 1600
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His His Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1601
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v171 ECD
<400> 1601
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Arg Tyr Leu Gln
20 25 30
Val Pro Asp Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ala Tyr Gly Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Arg Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1602
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v172 ECD
<400> 1602
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Arg Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Thr Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1603
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v173 ECD
<400> 1603
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1604
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v174 ECD
<400> 1604
Trp Pro Pro Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Ser Leu Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1605
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v175 ECD
<400> 1605
Trp Pro Pro Pro Gly Thr Gly Glu Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Ala Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1606
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v176 ECD
<400> 1606
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Ala Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Cys Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Ser Gly
65 70 75 80
Ala Glu Leu Arg Tyr Ala Ser Pro Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1607
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v177 ECD
<400> 1607
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Glu Gln Ala Pro Thr Gln
1 5 10 15
Val His Gly Tyr Leu Gly Asp Ser Glu Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1608
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v178 ECD
<400> 1608
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Asp
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1609
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v179 ECD
<400> 1609
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Arg Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1610
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v180 ECD
<400> 1610
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Met Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Gly Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Met Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1611
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v181 ECD
<400> 1611
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Tyr Gly Phe Leu Gly Asp Ser Ala Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Gly Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Thr Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1612
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v182 ECD
<400> 1612
Trp Pro Pro Pro Gly Thr Gly Asp Val Gly Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Gln Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1613
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v183 ECD
<400> 1613
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe Arg Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Gly Ala Ser Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1614
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v184 ECD
<400> 1614
Trp Pro Pro Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Gly Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1615
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v185 ECD
<400> 1615
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ala Gly Ser Met Ala Ala Phe His Arg Thr Lys Gly Pro
50 55 60
Cys Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Thr Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Tyr Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1616
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v186 ECD
<400> 1616
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Asp Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Asn Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1617
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v187 ECD
<400> 1617
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Thr Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1618
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v188 ECD
<400> 1618
Trp Pro Pro Pro Gly Thr Gly Asp Asp Val Met Leu Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Val Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Ile Ala Val Phe His Arg Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Gln Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1619
<211> 323
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v189 ECD
<400> 1619
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ser Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys His Leu Leu
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr
115 120 125
Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala
130 135 140
Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His
145 150 155 160
Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu
165 170 175
Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser
180 185 190
Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe
195 200 205
Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro
210 215 220
Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn
225 230 235 240
Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly
245 250 255
Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala
260 265 270
Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr
275 280 285
Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu
290 295 300
Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile
305 310 315 320
Ser Arg Asn
<210> 1620
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v144 IgV
<400> 1620
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Asp
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Asn Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Gln
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Tyr Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1621
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v145 IgV
<400> 1621
Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Leu Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Glu Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1622
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v146 IgV
<400> 1622
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr Gln Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Lys Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Val Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1623
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v147 IgV
<400> 1623
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Arg Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Ala Phe Pro Gln Gly Ser Trp Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1624
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v148 IgV
<400> 1624
Pro Gly Thr Gly Asp Val Val Val His Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Ser Ser Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Ala Phe His Gln Thr Arg Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1625
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v149 IgV
<400> 1625
Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Pro Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Gln Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Tyr His Arg Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1626
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v150 IgV
<400> 1626
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Cys Ala Arg Arg Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Thr Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Thr Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1627
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v151 IgV
<400> 1627
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Thr Gln Leu Thr Trp Ala Arg His Gly Gly
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Trp Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1628
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v152 IgV
<400> 1628
Pro Gly Thr Gly Asp Val Phe Val Gln Ala Pro Ser Gln Val Leu Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Gln His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Met
100 105 110
Asp Ile Trp Leu
115
<210> 1629
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v153 IgV
<400> 1629
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Met Gly Asp Ser Val Thr Leu Pro Cys Phe Leu Gln Val Pro Asp
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Trp Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Gly Ile Trp Leu
115
<210> 1630
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v154 IgV
<400> 1630
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Val
35 40 45
Ser Gly Gly Met Ala Val Phe His Arg Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly Ala Gly Leu
65 70 75 80
Arg Asn Ala Thr Leu Arg Ile Ser Arg Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1631
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v155 IgV
<400> 1631
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr His Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1632
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v156 IgV
<400> 1632
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro Ser Tyr Leu
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Ala
100 105 110
Asp Ile Trp Leu
115
<210> 1633
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v157 IgV
<400> 1633
Pro Gly Thr Gly Gly Ile Val Ala Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Ala Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Leu Phe Pro Gln Gly Ser Arg Ser Ala
100 105 110
Asp Ile Trp Leu
115
<210> 1634
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v158 IgV
<400> 1634
Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg His Ser Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1635
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v159 IgV
<400> 1635
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Pro Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1636
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v160 IgV
<400> 1636
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Pro Gly Arg Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1637
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v161 IgV
<400> 1637
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asn Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Asn Val
100 105 110
Asp Ile Trp Leu
115
<210> 1638
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v162 IgV
<400> 1638
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Ser Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Val
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1639
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v163 IgV
<400> 1639
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe Asn Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Ala Ala Ala Arg Pro Gly Thr Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1640
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v164 IgV
<400> 1640
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Arg Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Asp Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Gly Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1641
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v165 IgV
<400> 1641
Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ala Tyr Val
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Lys Val Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Thr Val
100 105 110
Asp Ile Trp Leu
115
<210> 1642
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v166 IgV
<400> 1642
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Leu Ala Val Phe His Gln Arg Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Ile Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1643
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v167 IgV
<400> 1643
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Met Pro Phe
20 25 30
Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Leu Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Ser Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1644
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v168 IgV
<400> 1644
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Glu Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Trp Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1645
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v169 IgV
<400> 1645
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Ile Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg His Gly Lys
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1646
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v170 IgV
<400> 1646
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His His Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Val Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1647
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v171 IgV
<400> 1647
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Gly Ser Val Thr Leu Pro Arg Tyr Leu Gln Val Pro Asp
20 25 30
Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro Ala Tyr Gly
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Met Phe Pro Arg Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1648
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v172 IgV
<400> 1648
Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Arg Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Thr
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1649
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v173 IgV
<400> 1649
Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1650
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v174 IgV
<400> 1650
Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Ser Leu Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1651
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v175 IgV
<400> 1651
Pro Gly Thr Gly Glu Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Ala Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1652
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v176 IgV
<400> 1652
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Ala Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu
35 40 45
Ser Gly Cys Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Ser Gly Ala Glu Leu
65 70 75 80
Arg Tyr Ala Ser Pro Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1653
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v177 IgV
<400> 1653
Pro Gly Thr Gly Asp Val Val Glu Gln Ala Pro Thr Gln Val His Gly
1 5 10 15
Tyr Leu Gly Asp Ser Glu Thr Leu Pro Cys Tyr Leu Gln Val Pro Ser
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg Arg Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1654
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v178 IgV
<400> 1654
Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Asp Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Ala Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1655
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v179 IgV
<400> 1655
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Arg Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1656
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v180 IgV
<400> 1656
Pro Gly Thr Gly Asp Leu Val Met Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Ser
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Gly Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Met
100 105 110
Asp Ile Trp Leu
115
<210> 1657
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v181 IgV
<400> 1657
Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln Val Tyr Gly
1 5 10 15
Phe Leu Gly Asp Ser Ala Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Gly Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Thr Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1658
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v182 IgV
<400> 1658
Pro Gly Thr Gly Asp Val Gly Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Gln Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1659
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v183 IgV
<400> 1659
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe Arg Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Gly Ala Ser Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1660
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v184 IgV
<400> 1660
Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Gly Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1661
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v185 IgV
<400> 1661
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ala Gly Ser Met Ala Ala Phe His Arg Thr Lys Gly Pro Cys Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Thr Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Tyr Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1662
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v186 IgV
<400> 1662
Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Phe Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asp
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Asp
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Asn Val
100 105 110
Asp Ile Trp Leu
115
<210> 1663
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v187 IgV
<400> 1663
Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln Val Thr Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Ser
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Thr Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1664
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v188 IgV
<400> 1664
Pro Gly Thr Gly Asp Asp Val Met Leu Ala Pro Thr Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln Val Pro Asn
20 25 30
Met Val Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Ile Ala Val Phe His Arg Thr Gln Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Gln Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1665
<211> 116
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v189 IgV
<400> 1665
Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ser Gln Val Ser Gly
1 5 10 15
Phe Leu Gly Asp Ser Val Thr Leu Pro Cys His Leu Leu Val Pro Asn
20 25 30
Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg His Gly Glu
35 40 45
Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro Ser Tyr Ser
50 55 60
Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly Ala Glu Leu
65 70 75 80
Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu Asp Glu Gly
85 90 95
Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser Arg Ser Val
100 105 110
Asp Ile Trp Leu
115
<210> 1666
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v144 IgV
<400> 1666
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Asp Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Asn Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Gln Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Tyr Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1667
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v145 IgV
<400> 1667
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Leu Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Glu Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1668
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v146 IgV
<400> 1668
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr Gln Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Lys Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Val Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1669
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v147 IgV
<400> 1669
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Arg
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Ala Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1670
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v148 IgV
<400> 1670
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val His Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Ser Ser Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Ala Phe His Gln Thr Arg Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1671
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v149 IgV
<400> 1671
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Pro Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Gln Gly Glu Ser Gly Ser Met Ala Val Tyr His Arg Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1672
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v150 IgV
<400> 1672
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Cys Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Thr Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Thr Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1673
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v151 IgV
<400> 1673
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Thr Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Gly Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Trp Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1674
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v152 IgV
<400> 1674
Trp Pro Pro Pro Gly Thr Gly Asp Val Phe Val Gln Ala Pro Ser Gln
1 5 10 15
Val Leu Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Gln
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Met Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1675
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v153 IgV
<400> 1675
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Met Gly Asp Ser Val Thr Leu Pro Cys Phe Leu Gln
20 25 30
Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Trp Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Gly Ile Trp Leu Arg Val Leu
115 120
<210> 1676
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v154 IgV
<400> 1676
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Val Ser Gly Gly Met Ala Val Phe His Arg Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Gln Gly
65 70 75 80
Ala Gly Leu Arg Asn Ala Thr Leu Arg Ile Ser Arg Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1677
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v155 IgV
<400> 1677
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr His
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1678
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v156 IgV
<400> 1678
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Arg Thr Gln Gly Pro
50 55 60
Ser Tyr Leu Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Ala Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1679
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v157 IgV
<400> 1679
Trp Pro Pro Pro Gly Thr Gly Gly Ile Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Pro Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Ala Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Leu Phe Pro Gln Gly Ser
100 105 110
Arg Ser Ala Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1680
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v158 IgV
<400> 1680
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg
35 40 45
His Ser Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Gly Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1681
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v159 IgV
<400> 1681
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Pro Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1682
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v160 IgV
<400> 1682
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Pro Gly Arg Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1683
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v161 IgV
<400> 1683
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asn Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Asn Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1684
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v162 IgV
<400> 1684
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Ser Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Val Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1685
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v163 IgV
<400> 1685
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe Asn Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Ala Ala Ala Arg Pro Gly
65 70 75 80
Thr Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1686
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v164 IgV
<400> 1686
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Arg Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Asp Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Gly Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1687
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v165 IgV
<400> 1687
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Ala Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ala Tyr Val Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Lys Val Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Thr Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1688
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v166 IgV
<400> 1688
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Leu Ala Val Phe His Gln Arg Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Ile Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1689
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v167 IgV
<400> 1689
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ile Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Met Pro Phe Met Glu Val Ser His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Leu Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Ser Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1690
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v168 IgV
<400> 1690
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Glu Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Glu Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Trp Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1691
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v169 IgV
<400> 1691
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Ile Leu Gly Asp Ser Val Met Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Val Arg
35 40 45
His Gly Lys Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1692
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v170 IgV
<400> 1692
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His His Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Val Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1693
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v171 IgV
<400> 1693
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Gly Ser Val Thr Leu Pro Arg Tyr Leu Gln
20 25 30
Val Pro Asp Met Gly Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Ile Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ala Tyr Gly Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Gly Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Arg Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1694
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v172 IgV
<400> 1694
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Glu Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Arg Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Thr Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1695
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v173 IgV
<400> 1695
Trp Pro Pro Pro Gly Thr Gly Asp Ile Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asp Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1696
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v174 IgV
<400> 1696
Trp Pro Pro Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Ser Leu Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1697
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v175 IgV
<400> 1697
Trp Pro Pro Pro Gly Thr Gly Glu Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Ala Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1698
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v176 IgV
<400> 1698
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Ala Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Cys Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Ser Gly
65 70 75 80
Ala Glu Leu Arg Tyr Ala Ser Pro Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1699
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v177 IgV
<400> 1699
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Glu Gln Ala Pro Thr Gln
1 5 10 15
Val His Gly Tyr Leu Gly Asp Ser Glu Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
Arg Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1700
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v178 IgV
<400> 1700
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Ala Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Asp
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Ala Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1701
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v179 IgV
<400> 1701
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Arg Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Arg Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1702
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v180 IgV
<400> 1702
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Met Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Gly Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Met Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1703
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v181 IgV
<400> 1703
Trp Pro Pro Pro Gly Thr Gly Asp Leu Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Tyr Gly Phe Leu Gly Asp Ser Ala Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Gly Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Val Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Thr Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Ile Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1704
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v182 IgV
<400> 1704
Trp Pro Pro Pro Gly Thr Gly Asp Val Gly Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Gln Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1705
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v183 IgV
<400> 1705
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe Arg Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Gly Ala Ser Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1706
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v184 IgV
<400> 1706
Trp Pro Pro Pro Gly Thr Gly Asp Ala Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Thr Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Gly Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Thr Phe Val Thr Phe Pro Gln Arg Ile
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1707
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v185 IgV
<400> 1707
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ala Gly Ser Met Ala Ala Phe His Arg Thr Lys Gly Pro
50 55 60
Cys Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Thr Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Tyr Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1708
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v186 IgV
<400> 1708
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Phe Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asp Met Glu Val Thr His Val Ser Gln Leu Thr Trp Glu Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Lys Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Asp Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Asn Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1709
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v187 IgV
<400> 1709
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Ala Gln Ala Pro Thr Gln
1 5 10 15
Val Thr Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Ser Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Thr Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1710
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v188 IgV
<400> 1710
Trp Pro Pro Pro Gly Thr Gly Asp Asp Val Met Leu Ala Pro Thr Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln
20 25 30
Val Pro Asn Met Val Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Ile Ala Val Phe His Arg Thr Gln Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Gln Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Met Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1711
<211> 122
<212> PRT
<213> Artificial Sequence
<220>
<223> CD155 v189 IgV
<400> 1711
Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Ser Gln
1 5 10 15
Val Ser Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys His Leu Leu
20 25 30
Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg
35 40 45
His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Arg Gly Pro
50 55 60
Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Pro Gly
65 70 75 80
Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Ser Gly Leu Arg Val Glu
85 90 95
Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Met Phe Pro Gln Gly Ser
100 105 110
Arg Ser Val Asp Ile Trp Leu Arg Val Leu
115 120
<210> 1712
<211> 231
<212> PRT
<213> Artificial Sequence
<220>
<223> Stack Fc Lysine removed (homodimeric)
<400> 1712
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly
225 230
<210> 1713
<211> 231
<212> PRT
<213> artificial Sequence
<220>
<223> Fc (C5S (C220S), R77C, (R292C), N82G (N297G), V87C (V302C),
L232del (K447del))
<400> 1713
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln
65 70 75 80
Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly
225 230
<210> 1714
<211> 231
<212> PRT
<213> Artificial Sequence
<220>
<223> Fc with C220S/L234A/L235E/G237A/K447del
<400> 1714
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly
225 230
<210> 1715
<211> 230
<212> PRT
<213> Artificial Sequence
<220>
<223> Fc with C220S/E233P/L234V/L235A/G236del/S267K/K447del
<400> 1715
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
1 5 10 15
Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
20 25 30
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
35 40 45
Asp Val Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
50 55 60
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
65 70 75 80
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
85 90 95
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
100 105 110
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
115 120 125
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
130 135 140
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
145 150 155 160
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
165 170 175
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
180 185 190
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
195 200 205
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
210 215 220
Leu Ser Leu Ser Pro Gly
225 230
<210> 1716
<211> 7
<212> PRT
<213> Artificial Sequence
<220>
<223> Linker
<400> 1716
Gly Ser Gly Gly Gly Gly Ser
1 5
<210> 1717
<211> 5
<212> PRT
<213> Artificial Sequence
<220>
<223> 4GS Linker
<400> 1717
Gly Gly Gly Gly Ser
1 5
<210> 1718
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v66
<400> 1718
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys
100 105 110
Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp
115 120 125
Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro
130 135 140
Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly
145 150 155 160
Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val
165 170 175
Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys
180 185 190
Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val
195 200 205
Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1719
<211> 108
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV 66
<400> 1719
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Leu Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1720
<211> 115
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v66
<400> 1720
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys
100 105 110
Val Asn Ala
115
<210> 1721
<211> 221
<212> PRT
<213> Homo sapiens
<220>
<221> MISC_FEATURE
<223> Wildtype PD-L1 ECD
<400> 1721
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1722
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v67
<400> 1722
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1723
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v68
<400> 1723
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Leu Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1724
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v69
<400> 1724
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Ser Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1725
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v70
<400> 1725
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ser Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Phe Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1726
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v71
<400> 1726
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Arg Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Leu Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Asn Asn Gln Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Leu
210 215 220
<210> 1727
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v72
<400> 1727
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Leu Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Phe Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1728
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v73
<400> 1728
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Ser Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Arg Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Ser Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1729
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v74
<400> 1729
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Val Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His His Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1730
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v75
<400> 1730
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Ile Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1731
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v76
<400> 1731
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1732
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v77
<400> 1732
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Thr Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Phe Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1733
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v78
<400> 1733
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1734
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v79
<400> 1734
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1735
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v80
<400> 1735
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Val Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1736
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v81
<400> 1736
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1737
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v82
<400> 1737
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Gly Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1738
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v83
<400> 1738
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn Gln Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1739
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v84
<400> 1739
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1740
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v85
<400> 1740
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1741
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v86
<400> 1741
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1742
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v87
<400> 1742
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1743
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v88
<400> 1743
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Thr Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1744
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v89
<400> 1744
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Ala Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1745
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v90
<400> 1745
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Ser Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Ser Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1746
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v91
<400> 1746
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Arg Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Ala
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Ala Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1747
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v92
<400> 1747
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Val Ile Gln
35 40 45
Phe Val His Gly Glu Glu Gly Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Glu Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1748
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v93
<400> 1748
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1749
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v94
<400> 1749
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1750
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v95
<400> 1750
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1751
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v96
<400> 1751
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His His Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Ser Arg Arg Leu Asp Pro Glu Glu Tyr His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1752
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v97
<400> 1752
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1753
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v98
<400> 1753
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Pro Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1754
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v99
<400> 1754
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Gly Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Gly Glu Asn His Thr Ala Glu Leu Ala Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1755
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v100
<400> 1755
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Thr Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1756
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v101
<400> 1756
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Asn
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1757
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v102
<400> 1757
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1758
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v103
<400> 1758
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1759
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v104
<400> 1759
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1760
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v105
<400> 1760
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn Gln Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1761
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v106
<400> 1761
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1762
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v107
<400> 1762
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Ala Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1763
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v108
<400> 1763
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Glu Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1764
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v109
<400> 1764
Phe Thr Val Thr Val Pro Lys Asp Leu Phe Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Arg Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Ala Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1765
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v110
<400> 1765
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1766
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v111
<400> 1766
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Met
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1767
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v112
<400> 1767
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1768
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v113
<400> 1768
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1769
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v114
<400> 1769
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1770
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v115
<400> 1770
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1771
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v116
<400> 1771
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1772
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v117
<400> 1772
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Phe Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1773
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v118
<400> 1773
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Asp Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1774
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v119
<400> 1774
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1775
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v120
<400> 1775
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Thr Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Tyr Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Ser Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1776
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v121
<400> 1776
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Gly Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Pro Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1777
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v122
<400> 1777
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Ile Asn Val Thr
165 170 175
Cys Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1778
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v123
<400> 1778
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1779
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v124
<400> 1779
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Thr Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1780
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v125
<400> 1780
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Tyr Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1781
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v126
<400> 1781
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Tyr Ser Lys Arg Glu Gly Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1782
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v127
<400> 1782
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1783
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v128
<400> 1783
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Phe Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1784
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v129
<400> 1784
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1785
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v131
<400> 1785
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Thr Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1786
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v131
<400> 1786
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Asp Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Val Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1787
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v132
<400> 1787
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Tyr Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Ile Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Ser Asp Pro Glu Glu Asn His Ala Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1788
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v133
<400> 1788
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Ser Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1789
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v134
<400> 1789
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Asp Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Trp Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1790
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v135
<400> 1790
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Val Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Leu Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1791
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v136
<400> 1791
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1792
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v137
<400> 1792
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Thr Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Val Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1793
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v138
<400> 1793
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Ser Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1794
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v139
<400> 1794
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Arg Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Ala Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1795
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v140
<400> 1795
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Ile Thr Asn Ser Arg Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1796
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v141
<400> 1796
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Ile Phe Tyr Cys Ser
180 185 190
Phe Gly Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1797
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v142
<400> 1797
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Thr Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1798
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v143
<400> 1798
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Ala Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1799
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v144
<400> 1799
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Ala Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1800
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v145
<400> 1800
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Ala Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Ile Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1801
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v146
<400> 1801
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Thr Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1802
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v147
<400> 1802
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Arg Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Ile Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1803
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v148
<400> 1803
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Arg Thr Ser Ser Asp His Gln Val Leu Gly Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1804
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v149
<400> 1804
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Arg Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1805
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v150
<400> 1805
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Arg Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Asn Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Thr Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1806
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v151
<400> 1806
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1807
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v152
<400> 1807
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1808
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v153
<400> 1808
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Leu Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Gly Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1809
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v154
<400> 1809
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1810
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v155
<400> 1810
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Glu Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1811
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v156
<400> 1811
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Pro Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1812
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v67
<400> 1812
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1813
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v68
<400> 1813
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Leu Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1814
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v69
<400> 1814
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Ser Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1815
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v70
<400> 1815
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ser Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Phe Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1816
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v72
<400> 1816
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Leu Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Phe Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1817
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v73
<400> 1817
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Ser Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Arg Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Ser Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1818
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v74
<400> 1818
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Val Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His His Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1819
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v75
<400> 1819
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Ile Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1820
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v76
<400> 1820
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1821
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v77
<400> 1821
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Thr Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Lys Asn Gln Thr Ala Glu Phe Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1822
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v78
<400> 1822
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Gln
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1823
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v79
<400> 1823
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1824
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v80
<400> 1824
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Val Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1825
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v81
<400> 1825
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1826
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v82
<400> 1826
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Gly Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1827
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v83
<400> 1827
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn Gln Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1828
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v84
<400> 1828
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1829
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v85
<400> 1829
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1830
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v86
<400> 1830
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Ala Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1831
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v87
<400> 1831
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1832
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v88
<400> 1832
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Thr Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1833
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v89
<400> 1833
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Ala Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1834
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v90
<400> 1834
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Ser Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Ser Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1835
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v91
<400> 1835
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Arg Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Ala
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Ala Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1836
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v92
<400> 1836
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Val Ile Gln
35 40 45
Phe Val His Gly Glu Glu Gly Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Glu Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1837
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v93
<400> 1837
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1838
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v94
<400> 1838
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1839
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v95
<400> 1839
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1840
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v96
<400> 1840
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His His Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Ser Arg Arg Leu Asp Pro Glu Glu Tyr His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1841
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v97
<400> 1841
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1842
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v98
<400> 1842
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Pro Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1843
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v99
<400> 1843
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Gly Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Gly Glu Asn His Thr Ala Glu Leu Ala Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1844
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v100
<400> 1844
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Thr Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1845
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v101
<400> 1845
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Asn
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1846
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v102
<400> 1846
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1847
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v103
<400> 1847
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1848
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v104
<400> 1848
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1849
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v105
<400> 1849
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn Gln Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1850
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v106
<400> 1850
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1851
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v107
<400> 1851
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Ala Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1852
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v108
<400> 1852
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Glu Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1853
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v109
<400> 1853
Phe Thr Val Thr Val Pro Lys Asp Leu Phe Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Arg Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Ala Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1854
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v110
<400> 1854
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1855
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v111
<400> 1855
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Met
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1856
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v112
<400> 1856
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1857
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v113
<400> 1857
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1858
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v114
<400> 1858
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1859
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v115
<400> 1859
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1860
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v116
<400> 1860
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1861
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v117
<400> 1861
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Phe Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1862
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v118
<400> 1862
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Asp Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1863
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v119
<400> 1863
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1864
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v120
<400> 1864
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Thr Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Tyr Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Ser Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1865
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v121
<400> 1865
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Gly Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Pro Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1866
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v122
<400> 1866
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Ile Asn Val Thr
165 170 175
Cys Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1867
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v123
<400> 1867
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1868
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v124
<400> 1868
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Thr Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1869
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v125
<400> 1869
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Tyr Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1870
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v126
<400> 1870
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Tyr Ser Lys Arg Glu Gly Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1871
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v127
<400> 1871
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1872
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v128
<400> 1872
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Phe Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1873
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v129
<400> 1873
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1874
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v131
<400> 1874
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Thr Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1875
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v131
<400> 1875
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Asp Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Val Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1876
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v132
<400> 1876
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Tyr Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Ile Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Ser Asp Pro Glu Glu Asn His Ala Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1877
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v133
<400> 1877
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Ser Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1878
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v134
<400> 1878
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Asp Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Trp Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1879
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v135
<400> 1879
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Val Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Leu Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1880
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v136
<400> 1880
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1881
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v137
<400> 1881
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Thr Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Val Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1882
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v138
<400> 1882
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Ser Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1883
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v139
<400> 1883
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Arg Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Ala Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1884
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v140
<400> 1884
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Ile Thr Asn Ser Arg Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1885
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v141
<400> 1885
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Ala Thr Thr Asn Glu Ile Phe Tyr Cys Ser
180 185 190
Phe Gly Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1886
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v142
<400> 1886
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Thr Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1887
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v143
<400> 1887
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Ala Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1888
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v144
<400> 1888
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Ala Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1889
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v145
<400> 1889
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Ala Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Ile Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Ala Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1890
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v146
<400> 1890
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Thr Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1891
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v147
<400> 1891
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Asn Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Arg Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Ile Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1892
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v148
<400> 1892
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Arg Thr Ser Ser Asp His Gln Val Leu Gly Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Thr Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1893
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v149
<400> 1893
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Arg Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Ser Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1894
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v150
<400> 1894
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Arg Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Asp Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Asn Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Thr Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1895
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v151
<400> 1895
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1896
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v152
<400> 1896
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1897
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v153
<400> 1897
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Leu Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Leu Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Gly Ser Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1898
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v154
<400> 1898
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Val Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1899
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v155
<400> 1899
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Glu Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asp His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1900
<211> 220
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v156
<400> 1900
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Ser Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Glu
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Pro Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Gly Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg
210 215 220
<210> 1901
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v67
<400> 1901
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Gly Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1902
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v75
<400> 1902
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Ile Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Gly Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1903
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v80
<400> 1903
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Val Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Gly Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1904
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v81
<400> 1904
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu Ala Ala Leu Thr Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105
<210> 1905
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v82
<400> 1905
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Gly Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Gly Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1906
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v87
<400> 1906
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ser Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1907
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v94
<400> 1907
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105
<210> 1908
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v98
<400> 1908
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Pro Ser Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105
<210> 1909
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v100
<400> 1909
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Thr Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Thr Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105
<210> 1910
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v102
<400> 1910
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Gly Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1911
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v103
<400> 1911
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asp Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Leu Ile Gly Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1912
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v110
<400> 1912
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1913
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v118
<400> 1913
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Asp Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1914
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v127
<400> 1914
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys Met Val Ser Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1915
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v152
<400> 1915
Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu
1 5 10 15
Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val
20 25 30
Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln Phe Val His Gly Glu
35 40 45
Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser Gln Arg Ala Arg Leu
50 55 60
Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp
65 70 75 80
Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Gly Tyr Gly
85 90 95
Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105
<210> 1916
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v67
<400> 1916
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1917
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v75
<400> 1917
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Ile Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1918
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v80
<400> 1918
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Val Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1919
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v81
<400> 1919
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala
<210> 1920
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v82
<400> 1920
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Gly Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1921
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v87
<400> 1921
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1922
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v94
<400> 1922
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala
<210> 1923
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v98
<400> 1923
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Pro Ser Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala
<210> 1924
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v100
<400> 1924
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Thr Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asn Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Glu Val
100 105 110
Asn Ala
<210> 1925
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v102
<400> 1925
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1926
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v103
<400> 1926
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Leu Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1927
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v110
<400> 1927
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1928
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v118
<400> 1928
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Asp Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1929
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v127
<400> 1929
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Val Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1930
<211> 114
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 IgV v152
<400> 1930
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Ser
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala
<210> 1931
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v1
<400> 1931
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Asn Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val Asn Gly Glu Glu Asp Leu Glu Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1932
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v2
<400> 1932
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Thr Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1933
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v3
<400> 1933
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Glu Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1934
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v4
<400> 1934
Phe Thr Val Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Thr Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1935
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v5
<400> 1935
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1936
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v6
<400> 1936
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1937
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v7
<400> 1937
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1938
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v8
<400> 1938
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1939
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v9
<400> 1939
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1940
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v10
<400> 1940
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1941
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v11
<400> 1941
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1942
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v12
<400> 1942
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asp Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Gly Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1943
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v13
<400> 1943
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Ser Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1944
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v14
<400> 1944
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1945
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v15
<400> 1945
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1946
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v16
<400> 1946
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1947
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v17
<400> 1947
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Val Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1948
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v18
<400> 1948
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1949
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v19
<400> 1949
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Glu Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1950
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v20
<400> 1950
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Ile Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asn Ile Ile Gln
35 40 45
Phe Val Arg Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1951
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v21
<400> 1951
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Glu Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln Arg Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1952
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v22
<400> 1952
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1953
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v23
<400> 1953
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Gly
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Glu Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1954
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v24
<400> 1954
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Ile Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1955
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v25
<400> 1955
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Arg Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1956
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v26
<400> 1956
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Val Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1957
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v27
<400> 1957
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1958
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v28
<400> 1958
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Gly Met Glu Val Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1959
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v29
<400> 1959
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Ser Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1960
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v30
<400> 1960
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1961
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v31
<400> 1961
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1962
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v32
<400> 1962
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1963
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v33
<400> 1963
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1964
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v34
<400> 1964
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1965
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v35
<400> 1965
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ser Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1966
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v36
<400> 1966
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Met Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1967
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v37
<400> 1967
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1968
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v38
<400> 1968
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Pro Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1969
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v39
<400> 1969
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1970
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v40
<400> 1970
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Arg Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1971
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v41
<400> 1971
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1972
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v42
<400> 1972
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Val Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1973
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v43
<400> 1973
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Gly Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1974
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v44
<400> 1974
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1975
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v45
<400> 1975
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1976
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v46
<400> 1976
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1977
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v47
<400> 1977
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1978
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v48
<400> 1978
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1979
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v49
<400> 1979
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1980
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v50
<400> 1980
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1981
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v51
<400> 1981
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1982
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v52
<400> 1982
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Ala Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val Tyr Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Gly Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1983
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v53
<400> 1983
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Thr Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1984
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v54
<400> 1984
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1985
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v55
<400> 1985
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Thr Val Tyr Trp Glu Met Glu Asp Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1986
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v56
<400> 1986
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Glu Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Gly Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1987
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v57
<400> 1987
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Asp Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Pro Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1988
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v58
<400> 1988
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1989
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v59
<400> 1989
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Gly Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Asp Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1990
<211> 222
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v60
<400> 1990
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Gln Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys
100 105 110
Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp
115 120 125
Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro
130 135 140
Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly
145 150 155 160
Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val
165 170 175
Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys
180 185 190
Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val
195 200 205
Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1991
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v61
<400> 1991
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1992
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v62
<400> 1992
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Glu Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1993
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v63
<400> 1993
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Ile Ile Glu Cys Lys Phe Pro Val Gly Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Ile Ile Ile Gln
35 40 45
Phe Ala His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Lys Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1994
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v64
<400> 1994
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Lys Glu Gly Lys Asp Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1995
<211> 221
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v65
<400> 1995
Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser
1 5 10 15
Asn Met Thr Ile Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Asp Leu
20 25 30
Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Thr Ile Ile Gln
35 40 45
Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg
50 55 60
Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Ile Ala Ala
65 70 75 80
Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys
85 90 95
Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val
100 105 110
Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro
115 120 125
Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys
130 135 140
Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys
145 150 155 160
Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr
165 170 175
Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr
180 185 190
Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile
195 200 205
Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr
210 215 220
<210> 1996
<211> 227
<212> PRT
<213> Artificial Sequence
<220>
<223> PD-L1 ECD v66
<400> 1996
Cys His Glu Cys Lys Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val
1 5 10 15
Val Glu Tyr Gly Ser Asn Met Thr Leu Glu Cys Lys Phe Pro Val Glu
20 25 30
Glu Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Gly
35 40 45
Lys Asp Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Ala Gln
50 55 60
His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser
65 70 75 80
Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Arg Asp Ala
85 90 95
Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Gly Ala Asp Tyr Lys
100 105 110
Arg Ile Thr Val Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg
115 120 125
Ile Leu Val Val Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln
130 135 140
Ala Glu Gly Tyr Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His
145 150 155 160
Gln Val Leu Ser Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu
165 170 175
Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn
180 185 190
Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His
195 200 205
Thr Ala Glu Leu Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn
210 215 220
Glu Arg Thr
225
<210> 1997
<211> 68
<212> PRT
<213> Artificial Sequence
<220>
<223> CD8 hinge and transmembrane domain
<400> 1997
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
1 5 10 15
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
20 25 30
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile
35 40 45
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
50 55 60
Leu Val Ile Thr
65
<210> 1998
<211> 431
<212> PRT
<213> Artificial Sequence
<220>
<223> antiCD19 chimeric antigen receptor CAR-2
<400> 1998
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
100 105 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
115 120 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
130 135 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145 150 155 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
165 170 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
180 185 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
195 200 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
210 215 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225 230 235 240
Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro
245 250 255
Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
260 265 270
Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
275 280 285
Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
290 295 300
Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Arg
305 310 315 320
Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln
325 330 335
Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp
340 345 350
Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro
355 360 365
Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp
370 375 380
Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg
385 390 395 400
Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr
405 410 415
Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
420 425 430
<210> 1999
<211> 707
<212> PRT
<213> Artificial Sequence
<220>
<223> antiCD19 chimeric antigen receptor CAR-2
<400> 1999
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu
20 25 30
Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln
35 40 45
Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr
50 55 60
Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro
65 70 75 80
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile
85 90 95
Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly
100 105 110
Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr
115 120 125
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr
130 135 140
Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro
145 150 155 160
Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro
165 170 175
Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu
180 185 190
Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala
195 200 205
Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val
210 215 220
Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr
225 230 235 240
Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp
245 250 255
Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr
260 265 270
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser
275 280 285
Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly
290 295 300
Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Ile Tyr Ile Trp
305 310 315 320
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile
325 330 335
Thr Leu Tyr Cys Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala
340 345 350
Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg
355 360 365
Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu
370 375 380
Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn
385 390 395 400
Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met
405 410 415
Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly
420 425 430
Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala
435 440 445
Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys
450 455 460
Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Ser Glu Leu Ile Lys
465 470 475 480
Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn His
485 490 495
His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr
500 505 510
Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala
515 520 525
Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe Ile
530 535 540
Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro Glu
545 550 555 560
Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val Leu
565 570 575
Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr Asn
580 585 590
Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met Gln
595 600 605
Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala
610 615 620
Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly
625 630 635 640
Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys
645 650 655
Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg
660 665 670
Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His
675 680 685
Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His
690 695 700
Lys Leu Asn
705
<210> 2000
<211> 8708
<212> DNA
<213> Artificial Sequence
<220>
<223> anti-CD19 chimeric antigen receptor CAR-2
<400> 2000
agcttaatgt agtcttatgc aatactcttg tagtcttgca acatggtaac gatgagttag 60
caacatgcct tacaaggaga gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 120
tacgatcgtg ccttattagg aaggcaacag acgggtctga catggattgg acgaaccact 180
gaattgccgc attgcagaga tattgtattt aagtgcctag ctcgatacaa taaacgggtc 240
tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct 300
taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga 360
ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctagcagtgg 420
cgcccgaaca gggacttgaa agcgaaaggg aaaccagagg agctctctcg acgcaggact 480
cggcttgctg aagcgcgcac ggcaagaggc gaggggcggc gactggtgag tacgccaaaa 540
attttgacta gcggaggcta gaaggagaga gatgggtgcg agagcgtcag tattaagcgg 600
gggagaatta gatcgcgatg ggaaaaaatt cggttaaggc cagggggaaa gaaaaaatat 660
aaattaaaac atatagtatg ggcaagcagg gagctagaac gattcgcagt taatcctggc 720
ctgttagaaa catcagaagg ctgtagacaa atactgggac agctacaacc atcccttcag 780
acaggatcag aagaacttag atcattatat aatacagtag caaccctcta ttgtgtgcat 840
caaaggatag agataaaaga caccaaggaa gctttagaca agatagagga agagcaaaac 900
aaaagtaaga ccaccgcaca gcaagcggcc gctgatcttc agacctggag gaggagatat 960
gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg 1020
agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat 1080
aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcctcaat 1140
gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt 1200
gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca 1260
gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat 1320
ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag 1380
taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat 1440
taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa 1500
gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat 1560
aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt 1620
aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt 1680
atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga 1740
agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat ctcgacggta 1800
tcggttaact tttaaaagaa aaggggggat tggggggtac agtgcagggg aaagaatagt 1860
agacataata gcaacagaca tacaaactaa agaattacaa aaacaaatta caaaaattca 1920
aaattttatc gatcacgaga ctagcctcga gaagcttgat atcgaattcc cacggggttg 1980
gacgcgtagg aacagagaaa caggagaata tgggccaaac aggatatctg tggtaagcag 2040
ttcctgcccc ggctcagggc caagaacagt tggaacagca gaatatgggc caaacaggat 2100
atctgtggta agcagttcct gccccggctc agggccaaga acagatggtc cccagatgcg 2160
gtcccgccct cagcagtttc tagagaacca tcagatgttt ccagggtgcc ccaaggacct 2220
gaaatgaccc tgtgccttat ttgaactaac caatcagttc gcttctcgct tctgttcgcg 2280
cgcttctgct ccccgagctc tatataagca gagctcgttt agtgaaccgt cagatcgcct 2340
ggagacgcca tccacgctgt tttgacttcc atagaaggat cccctgcagg taatacgact 2400
cactataggg tccactgccg ccaccatggc tctgcctgtg acagctctgc tgctgcctct 2460
ggccctgctg ctccatgccg ccagacccgg atccgatatc cagatgaccc agaccaccag 2520
cagcctgagc gccagcctgg gcgatagagt gaccatcagc tgcagagcca gccaggacat 2580
cagcaagtac ctgaactggt atcagcagaa acccgacggc accgtgaagc tgctgatcta 2640
ccacaccagc agactgcaca gcggcgtgcc cagcagattt tctggcagcg gctccggcac 2700
cgactacagc ctgaccatct ccaacctgga acaggaagat atcgctacct acttctgtca 2760
gcaaggcaac accctgccct acaccttcgg cggaggcacc aagctggaaa tcaccggcag 2820
cacaagcggc agcggcaagc ctggatctgg cgagggaagc accaagggcg aagtgaaact 2880
gcaggaaagc ggccctggac tggtggcccc aagccagtct ctgagcgtga cctgtaccgt 2940
gtccggcgtg tccctgcctg actatggcgt gtcctggatc agacagccac ccagaaaggg 3000
cctggaatgg ctgggagtga tctggggcag cgagacaacc tactacaaca gcgccctgaa 3060
gtcccggctg accatcatca aggacaactc caagagccag gtgttcctga agatgaacag 3120
cctgcagacc gacgacaccg ccatctacta ctgcgccaag cactactact acggcggcag 3180
ctacgccatg gactactggg gccagggcac aagcgtgacc gtgtccagcg ctagcgccaa 3240
gcccaccacg acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc 3300
cctgtccctg cgcccagagg cgagccggcc agcggcgggg ggcgcagtgc acacgagggg 3360
gctggacttc gccagtgata tctacatctg ggcgcccctg gccgggactt gtggggtcct 3420
tctcctgtca ctggttatca ccctttactg cagagtgaag ttcagcagga gcgcagacgc 3480
ccccgcgtac cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga 3540
ggagtacgat gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag 3600
aaggaagaac cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc 3660
ctacagtgag attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta 3720
ccagggtctc agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc 3780
ccctcgcggc agtggcgagg gcagaggaag tctgctaaca tgcggtgacg tggaggagaa 3840
tccgggcccc tctagaagcg agctgattaa ggagaacatg cacatgaagc tgtacatgga 3900
gggcaccgtg gacaaccatc acttcaagtg cacatccgag ggcgaaggca agccctacga 3960
gggcacccag accatgagaa tcaaggtggt cgagggcggc cctctcccct tcgccttcga 4020
catcctggct actagcttcc tctacggcag caagaccttc atcaaccaca cccagggcat 4080
ccccgacttc ttcaagcagt ccttccctga gggcttcaca tgggagagag tcaccacata 4140
cgaagacggg ggcgtgctga ccgctaccca ggacaccagc ctccaggacg gctgcctcat 4200
ctacaacgtc aagatcagag gggtgaactt cacatccaac ggccctgtga tgcagaagaa 4260
aacactcggc tgggaggcct tcaccgagac gctgtacccc gctgacggcg gcctggaagg 4320
cagaaacgac atggccctga agctcgtggg cgggagccat ctgatcgcaa acatcaagac 4380
cacatataga tccaagaaac ccgctaagaa cctcaagatg cctggcgtct actatgtgga 4440
ctacagactg gaaagaatca aggaggccaa caacgagacc tacgtcgagc agcacgaggt 4500
ggcagtggcc agatactgcg acctccctag caaactgggg cacaagctta attgagtcga 4560
caatcaacct ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc 4620
tccttttacg ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg 4680
tatggctttc attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt 4740
gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac 4800
tggttggggc attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc 4860
tattgccacg gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct 4920
gttgggcact gacaattccg tggtgttgtc ggggaagctg acgtcctttc catggctgct 4980
cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct 5040
caatccagcg gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct 5100
tcgccttcgc cctcagacga gtcggatctc cctttgggcc gcctccccgc ctggaattcg 5160
agctcggtac ctttaagacc aatgacttac aaggcagctg tagatcttag ccacttttta 5220
aaagaaaagg ggggactgga agggctaatt cactcccaac gaagacaaga tctgcttttt 5280
gcttgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta 5340
gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc 5400
cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa 5460
atctctagca gtagtagttc atgtcatctt attattcagt atttataact tgcaaagaaa 5520
tgaatatcag agagtgagag gaacttgttt attgcagctt ataatggtta caaataaagc 5580
aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg 5640
tccaaactca tcaatgtatc ttatcatgtc tggctctagc tatcccgccc ctaactccgc 5700
ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg 5760
aggccgcctc ggcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag 5820
gcttttgcgt cgagacgtac ccaattcgcc ctatagtgag tcgtattacg cgcgctcact 5880
ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc gttacccaac ttaatcgcct 5940
tgcagcacat ccccctttcg ccagctggcg taatagcgaa gaggcccgca ccgatcgccc 6000
ttcccaacag ttgcgcagcc tgaatggcga atggcgcgac gcgccctgta gcggcgcatt 6060
aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc 6120
gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca 6180
agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc 6240
caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt 6300
tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac 6360
aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc 6420
ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaatttta acaaaatatt 6480
aacgtttaca atttcccagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt 6540
ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg 6600
cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt 6660
cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta 6720
aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc 6780
ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa 6840
gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca actcggtcgc 6900
cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga aaagcatctt 6960
acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag tgataacact 7020
gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc ttttttgcac 7080
aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa tgaagccata 7140
ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta 7200
ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg gatggaggcg 7260
gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt tattgctgat 7320
aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg gccagatggt 7380
aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat ggatgaacga 7440
aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact gtcagaccaa 7500
gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa aaggatctag 7560
gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac 7620
tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc 7680
gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat 7740
caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat 7800
actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct 7860
acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt 7920
cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg 7980
gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta 8040
cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg 8100
gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg 8160
tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc 8220
tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg 8280
gccttttgct ggccttttgc tcacatgttc tttcctgcgt tatcccctga ttctgtggat 8340
aaccgtatta ccgcctttga gtgagctgat accgctcgcc gcagccgaac gaccgagcgc 8400
agcgagtcag tgagcgagga agcggaagag cgcccaatac gcaaaccgcc tctccccgcg 8460
cgttggccga ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt 8520
gagcgcaacg caattaatgt gagttagctc actcattagg caccccaggc tttacacttt 8580
atgcttccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac 8640
agctatgacc atgattacgc caagcgcgca attaaccctc actaaaggga acaaaagctg 8700
gagctgca 8708
<210> 2001
<211> 428
<212> PRT
<213> Artificial Sequence
<220>
<223> antiCD19 chimeric antigen receptor CAR-1
<400> 2001
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
100 105 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
115 120 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
130 135 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145 150 155 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
165 170 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
180 185 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
195 200 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
210 215 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225 230 235 240
Val Thr Val Ser Ser Ala Ser Ala Lys Pro Thr Thr Thr Pro Ala Pro
245 250 255
Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu
260 265 270
Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg
275 280 285
Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly
290 295 300
Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Arg Val Lys Phe
305 310 315 320
Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu
325 330 335
Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp
340 345 350
Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys
355 360 365
Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala
370 375 380
Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys
385 390 395 400
Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr
405 410 415
Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
420 425
<210> 2002
<211> 706
<212> PRT
<213> Artificial Sequence
<220>
<223> antiCD19 chimeric antigen receptor CAR-1
<400> 2002
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
1 5 10 15
His Ala Ala Arg Pro Gly Ser Asp Ile Gln Met Thr Gln Thr Thr Ser
20 25 30
Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala
35 40 45
Ser Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp
50 55 60
Gly Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly
65 70 75 80
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu
85 90 95
Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln
100 105 110
Gln Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu
115 120 125
Ile Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly
130 135 140
Ser Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val
145 150 155 160
Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser
165 170 175
Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly
180 185 190
Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn
195 200 205
Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser
210 215 220
Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile
225 230 235 240
Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp
245 250 255
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Ala Lys
260 265 270
Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile
275 280 285
Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala
290 295 300
Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr
305 310 315 320
Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu
325 330 335
Val Ile Thr Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr
340 345 350
Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg
355 360 365
Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met
370 375 380
Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu
385 390 395 400
Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys
405 410 415
Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu
420 425 430
Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu
435 440 445
Pro Pro Arg Gly Gly Arg Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr
450 455 460
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Arg Ser Glu Leu Ile
465 470 475 480
Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly Thr Val Asp Asn
485 490 495
His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly
500 505 510
Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly Pro Leu Pro Phe
515 520 525
Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly Ser Lys Thr Phe
530 535 540
Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys Gln Ser Phe Pro
545 550 555 560
Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu Asp Gly Gly Val
565 570 575
Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Cys Leu Ile Tyr
580 585 590
Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn Gly Pro Val Met
595 600 605
Gln Lys Lys Thr Leu Trp Glu Ala Phe Thr Glu Thr Leu Tyr Pro Ala
610 615 620
Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala Leu Lys Leu Val Gly
625 630 635 640
Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr Tyr Arg Ser Lys Lys
645 650 655
Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr Tyr Val Asp Tyr Arg
660 665 670
Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr Tyr Val Glu Gln His
675 680 685
Glu Val Ala Ala Arg Tyr Cys Asp Leu Pro Ser Lys Leu Gly His Lys
690 695 700
Leu Asn
705
<210> 2003
<211> 232
<212> PRT
<213> Artificial Sequence
<220>
<223> Blue fluorescent protein
<400> 2003
Ser Arg Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met
1 5 10 15
Glu Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu
20 25 30
Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu
35 40 45
Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu
50 55 60
Tyr Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe
65 70 75 80
Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr
85 90 95
Tyr Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln
100 105 110
Asp Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr
115 120 125
Ser Asn Gly Pro Val Met Gln Lys Lys Thr Leu Trp Glu Ala Phe Thr
130 135 140
Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met
145 150 155 160
Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr
165 170 175
Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val
180 185 190
Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu
195 200 205
Thr Tyr Val Glu Gln His Glu Val Ala Ala Arg Tyr Cys Asp Leu Pro
210 215 220
Ser Lys Leu Gly His Lys Leu Asn
225 230
<210> 2004
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> T2A
<400> 2004
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro
1 5 10 15
Gly Pro
<210> 2005
<211> 248
<212> PRT
<213> Artificial Sequence
<220>
<223> Anti-CD19 scFv
<400> 2005
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly
1 5 10 15
Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
35 40 45
Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln
65 70 75 80
Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr
85 90 95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly
100 105 110
Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys
115 120 125
Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser
130 135 140
Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser
145 150 155 160
Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile
165 170 175
Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu
180 185 190
Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn
195 200 205
Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr
210 215 220
Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser
225 230 235 240
Val Thr Val Ser Ser Ala Ala Ala
245
<210> 2006
<211> 1356
<212> DNA
<213> Artificial Sequence
<220>
<223> anti-CD19 chimeric antigen receptor nucleotide
<400> 2006
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg 60
ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc 120
accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa 180
ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca 240
tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag 300
caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga 360
ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc 420
gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc 480
tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta 540
agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt 600
gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc 660
aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac 720
tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc 780
tcagtcaccg tctcctcagc ggccgcaaag cccaccacga cgccagcgcc gcgaccacca 840
acaccggcgc ccaccatcgc gtcgcagccc ctgtccctgc gcccagaggc gagccggcca 900
gcggcggggg gcgcagtgca cacgaggggg ctggacttcg ccagtgatat ctacatctgg 960
gcgcccctgg ccgggacttg tggggtcctt ctcctgtcac tggttatcac cctttactgc 1020
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc 1080
tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc 1140
cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat 1200
gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc 1260
cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc 1320
tacgacgccc ttcacatgca ggccctgccc cctcgc 1356
<210> 2007
<211> 63
<212> DNA
<213> Artificial Sequence
<220>
<223> T2A
Nucleotide
<400> 2007
ggcagtggcg agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctggc 60
cca 63
<210> 2008
<211> 21
<212> PRT
<213> Artificial Sequence
<220>
<223> T2A Protein
<400> 2008
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu
1 5 10 15
Glu Asn Pro Gly Pro
20
<210> 2009
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v196 ECD
<400> 2009
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2010
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v197 ECD
<400> 2010
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2011
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v198 ECD
<400> 2011
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2012
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v199 ECD
<400> 2012
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2013
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v200 ECD
<400> 2013
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2014
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v201 ECD
<400> 2014
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2015
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v202 ECD
<400> 2015
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2016
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v203 ECD
<400> 2016
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2017
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v204 ECD
<400> 2017
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2018
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v205 ECD
<400> 2018
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2019
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v206 ECD
<400> 2019
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2020
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v207 ECD
<400> 2020
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2021
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v208 ECD
<400> 2021
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Ala Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2022
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v209 ECD
<400> 2022
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2023
<211> 208
<212> PRT
<213> Artificial Seuqence
<220>
<223> CD80 v210 ECD
<400> 2023
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2024
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v211 ECD
<400> 2024
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2025
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v212 ECD
<400> 2025
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2026
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v213 ECD
<400> 2026
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Thr Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2027
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v214 ECD
<400> 2027
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2028
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v215 ECD
<400> 2028
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2029
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v216 ECD
<400> 2029
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2030
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v217 ECD
<400> 2030
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Pro Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2031
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v218 ECD
<400> 2031
Val Ile His Val Thr Lys Asp Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2032
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v219 ECD
<400> 2032
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2033
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v220 ECD
<400> 2033
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Glu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2034
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v221 ECD
<400> 2034
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2035
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v222 ECD
<400> 2035
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Ser Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Leu Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2036
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v223 ECD
<400> 2036
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2037
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v224 ECD
<400> 2037
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Lys His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2038
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v225 ECD
<400> 2038
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Arg Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2039
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v226 ECD
<400> 2039
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Ala Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2040
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v227 ECD
<400> 2040
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2041
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v228 ECD
<400> 2041
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2042
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v229 ECD
<400> 2042
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Ala Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2043
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v230 ECD
<400> 2043
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Glu Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2044
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v231 ECD
<400> 2044
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2045
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v232 ECD
<400> 2045
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr His Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2046
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v233 ECD
<400> 2046
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2047
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v234 ECD
<400> 2047
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2048
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v235 ECD
<400> 2048
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2049
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v236 ECD
<400> 2049
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2050
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v237 ECD
<400> 2050
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2051
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v238 ECD
<400> 2051
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2052
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v239 ECD
<400> 2052
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2053
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v240 ECD
<400> 2053
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2054
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v241 ECD
<400> 2054
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Val Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2055
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v242 ECD
<400> 2055
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Ala Val Leu Lys His Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Met Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2056
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v243 ECD
<400> 2056
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2057
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v244 ECD
<400> 2057
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Thr Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2058
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v245 ECD
<400> 2058
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2059
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v246 ECD
<400> 2059
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asp
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2060
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v247 ECD
<400> 2060
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn
35 40 45
Val Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2061
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v248 ECD
<400> 2061
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2062
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v249 ECD
<400> 2062
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2063
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v250 ECD
<400> 2063
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2064
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v251 ECD
<400> 2064
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2065
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v252 ECD
<400> 2065
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Gln Glu Glu Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2066
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v253 ECD
<400> 2066
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2067
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v254 ECD
<400> 2067
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2068
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v255 ECD
<400> 2068
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2069
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v256 ECD
<400> 2069
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2070
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v257 ECD
<400> 2070
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2071
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v258 ECD
<400> 2071
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2072
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v259 ECD
<400> 2072
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Val Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2073
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v260 ECD
<400> 2073
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Cys Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2074
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v261 ECD
<400> 2074
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2075
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v262 ECD
<400> 2075
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2076
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v263 ECD
<400> 2076
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2077
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v264 ECD
<400> 2077
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2078
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v265 ECD
<400> 2078
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2079
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v266 ECD
<400> 2079
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2080
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v267 ECD
<400> 2080
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2081
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v268 ECD
<400> 2081
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2082
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v269 ECD
<400> 2082
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2083
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v270 ECD
<400> 2083
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2084
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v271 ECD
<400> 2084
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2085
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v272 ECD
<400> 2085
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asp
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2086
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v273 ECD
<400> 2086
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2087
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v274 ECD
<400> 2087
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2088
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v275 ECD
<400> 2088
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2089
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v276 ECD
<400> 2089
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Val Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2090
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v277 ECD
<400> 2090
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asp Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2091
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v278 ECD
<400> 2091
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Glu Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2092
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v279 ECD
<400> 2092
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Glu Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2093
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v280 ECD
<400> 2093
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2094
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v281 ECD
<400> 2094
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Tyr Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2095
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v282 ECD
<400> 2095
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Asp Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2096
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v283 ECD
<400> 2096
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2097
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v284 ECD
<400> 2097
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2098
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v285 ECD
<400> 2098
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu His Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2099
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v286 ECD
<400> 2099
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val His Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2100
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v287 ECD
<400> 2100
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2101
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v288 ECD
<400> 2101
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Thr Val Leu Thr Met Met Ser Gly Glu Val Ser
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2102
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v289 ECD
<400> 2102
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2103
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v290 ECD
<400> 2103
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Thr Val Leu Thr Met Val Ser Gly Asp Val Arg
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2104
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v291 ECD
<400> 2104
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Tyr Arg Ile Tyr Trp
20 25 30
His Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2105
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v196 IgV
<400> 2105
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2106
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v197 IgV
<400> 2106
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2107
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v198 IgV
<400> 2107
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2108
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v199 IgV
<400> 2108
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2109
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v200 IgV
<400> 2109
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2110
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v201 IgV
<400> 2110
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2111
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v202 IgV
<400> 2111
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2112
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v203 IgV
<400> 2112
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2113
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v204 IgV
<400> 2113
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2114
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v205 IgV
<400> 2114
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2115
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v206 IgV
<400> 2115
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2116
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v207 IgV
<400> 2116
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2117
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v208 IgV
<400> 2117
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Ala Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2118
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v209 IgV
<400> 2118
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2119
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v210 IgV
<400> 2119
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2120
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v211 IgV
<400> 2120
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2121
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v212 IgV
<400> 2121
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2122
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v213 IgV
<400> 2122
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Thr Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2123
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v214 IgV
<400> 2123
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2124
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v215 IgV
<400> 2124
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2125
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v216 IgV
<400> 2125
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2126
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v217 IgV
<400> 2126
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Pro Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2127
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v218 IgV
<400> 2127
Val Ile His Val Thr Lys Asp Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2128
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v219 IgV
<400> 2128
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2129
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v220 IgV
<400> 2129
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Glu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2130
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v221 IgV
<400> 2130
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2131
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v222 IgV
<400> 2131
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Ser Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Leu Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2132
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v223 IgV
<400> 2132
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2133
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v224 IgV
<400> 2133
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Lys His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2134
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v225 IgV
<400> 2134
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Arg Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2135
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v226 IgV
<400> 2135
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Ala Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2136
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v227 IgV
<400> 2136
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2137
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v228 IgV
<400> 2137
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2138
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v229 IgV
<400> 2138
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Ala Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2139
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v230 IgV
<400> 2139
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Glu Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2140
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v231 IgV
<400> 2140
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2141
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v232 IgV
<400> 2141
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr His Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2142
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v233 IgV
<400> 2142
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2143
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v234 IgV
<400> 2143
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2144
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v235 IgV
<400> 2144
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2145
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v236 IgV
<400> 2145
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2146
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v237 IgV
<400> 2146
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2147
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v238 IgV
<400> 2147
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2148
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v239 IgV
<400> 2148
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2149
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v240 IgV
<400> 2149
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2150
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v241 IgV
<400> 2150
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Val Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2151
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v242 IgV
<400> 2151
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Ala Val Leu Lys His Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Met Ala Glu Val Thr
100
<210> 2152
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v243 IgV
<400> 2152
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2153
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v244 IgV
<400> 2153
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Thr Arg Val His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2154
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v245 IgV
<400> 2154
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2155
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v246 IgV
<400> 2155
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asp
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2156
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v247 IgV
<400> 2156
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn
35 40 45
Val Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2157
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v248 IgV
<400> 2157
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2158
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v249 IgV
<400> 2158
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2159
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v250 IgV
<400> 2159
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2160
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v251 IgV
<400> 2160
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2161
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v252 IgV
<400> 2161
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Gln Glu Glu Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2162
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v253 IgV
<400> 2162
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2163
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v254 IgV
<400> 2163
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2164
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v255 IgV
<400> 2164
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2165
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v256 IgV
<400> 2165
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2166
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v257 IgV
<400> 2166
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2167
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v258 IgV
<400> 2167
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2168
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v259 IgV
<400> 2168
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Val Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2169
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v260 IgV
<400> 2169
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Cys Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2170
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v261 IgV
<400> 2170
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2171
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v262 IgV
<400> 2171
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2172
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v263 IgV
<400> 2172
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2173
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v264 IgV
<400> 2173
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2174
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v265 IgV
<400> 2174
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2175
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v266 IgV
<400> 2175
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2176
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v267 IgV
<400> 2176
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2177
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v268 IgV
<400> 2177
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2178
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v269 IgV
<400> 2178
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2179
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v270 IgV
<400> 2179
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2180
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v271 IgV
<400> 2180
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2181
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v272 IgV
<400> 2181
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asp
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2182
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v273 IgV
<400> 2182
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2183
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v274 IgV
<400> 2183
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2184
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v275 IgV
<400> 2184
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2185
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v276 IgV
<400> 2185
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Val Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2186
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v277 IgV
<400> 2186
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asp Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2187
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v278 IgV
<400> 2187
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Glu Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2188
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v279 IgV
<400> 2188
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Glu Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2189
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v280 IgV
<400> 2189
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2190
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v281 IgV
<400> 2190
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Tyr Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2191
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v282 IgV
<400> 2191
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Asp Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2192
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v283 IgV
<400> 2192
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2193
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v284 IgV
<400> 2193
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2194
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v285 IgV
<400> 2194
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu His Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Arg Ala Glu Val Thr
100
<210> 2195
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v286 IgV
<400> 2195
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val His Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2196
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v287 IgV
<400> 2196
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2197
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v288 IgV
<400> 2197
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Thr Val Leu Thr Met Met Ser Gly Glu Val Ser
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2198
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v289 IgV
<400> 2198
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2199
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v290 IgV
<400> 2199
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Thr Val Leu Thr Met Val Ser Gly Asp Val Arg
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2200
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v291 IgV
<400> 2200
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Tyr Arg Ile Tyr Trp
20 25 30
His Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2201
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v196 IgV
<400> 2201
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2202
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v197 IgV
<400> 2202
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2203
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v198 IgV
<400> 2203
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2204
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v199 IgV
<400> 2204
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2205
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v200 IgV
<400> 2205
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2206
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v201 IgV
<400> 2206
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2207
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v202 IgV
<400> 2207
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2208
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v203 IgV
<400> 2208
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2209
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v204 IgV
<400> 2209
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2210
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v205 IgV
<400> 2210
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2211
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v206 IgV
<400> 2211
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2212
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v207 IgV
<400> 2212
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2213
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v208 IgV
<400> 2213
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Ala Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2214
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v209 IgV
<400> 2214
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2215
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v210 IgV
<400> 2215
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2216
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v211 IgV
<400> 2216
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2217
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v212 IgV
<400> 2217
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2218
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v213 IgV
<400> 2218
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Thr Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2219
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v214 IgV
<400> 2219
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2220
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v215 IgV
<400> 2220
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Asp Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2221
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v216 IgV
<400> 2221
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2222
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v217 IgV
<400> 2222
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Pro Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2223
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v218 IgV
<400> 2223
Val Ile His Val Thr Lys Asp Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2224
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v219 IgV
<400> 2224
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2225
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v220 IgV
<400> 2225
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Arg Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Glu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2226
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v221 IgV
<400> 2226
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2227
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v222 IgV
<400> 2227
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Ser Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Leu Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Gly Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2228
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v223 IgV
<400> 2228
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2229
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v224 IgV
<400> 2229
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Gln Lys His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2230
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v225 IgV
<400> 2230
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Lys Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Glu Asp Ala Phe Arg Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2231
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v226 IgV
<400> 2231
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Ala Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2232
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v227 IgV
<400> 2232
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Glu Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2233
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v228 IgV
<400> 2233
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asp Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2234
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v229 IgV
<400> 2234
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Ala Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2235
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v230 IgV
<400> 2235
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Glu Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2236
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v231 IgV
<400> 2236
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Ser Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2237
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v232 IgV
<400> 2237
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr His Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2238
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v233 IgV
<400> 2238
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Trp Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2239
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v234 IgV
<400> 2239
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2240
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v235 IgV
<400> 2240
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2241
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v236 IgV
<400> 2241
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2242
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v237 IgV
<400> 2242
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2243
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v238 IgV
<400> 2243
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2244
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v239 IgV
<400> 2244
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile His Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2245
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v240 IgV
<400> 2245
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2246
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v241 IgV
<400> 2246
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Val Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2247
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v242 IgV
<400> 2247
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Ala Val Leu Lys His Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Met Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2248
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v243 IgV
<400> 2248
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2249
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v244 IgV
<400> 2249
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Thr Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2250
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v245 IgV
<400> 2250
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2251
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v246 IgV
<400> 2251
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asp
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2252
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v247 IgV
<400> 2252
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr His Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Val Ser Gly Asp Ile Asn
35 40 45
Val Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2253
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v248 IgV
<400> 2253
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2254
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v249 IgV
<400> 2254
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2255
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v250 IgV
<400> 2255
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2256
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v251 IgV
<400> 2256
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2257
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v252 IgV
<400> 2257
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Gln Glu Glu Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2258
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v253 IgV
<400> 2258
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2259
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v254 IgV
<400> 2259
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2260
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v255 IgV
<400> 2260
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2261
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v256 IgV
<400> 2261
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2262
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v257 IgV
<400> 2262
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2263
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v258 IgV
<400> 2263
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2264
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v259 IgV
<400> 2264
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Val Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2265
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v260 IgV
<400> 2265
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Val Cys Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2266
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v261 IgV
<400> 2266
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2267
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v262 IgV
<400> 2267
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2268
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v263 IgV
<400> 2268
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2269
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v264 IgV
<400> 2269
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2270
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v265 IgV
<400> 2270
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2271
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v266 IgV
<400> 2271
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2272
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v267 IgV
<400> 2272
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2273
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v268 IgV
<400> 2273
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2274
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v269 IgV
<400> 2274
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2275
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v270 IgV
<400> 2275
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2276
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v271 IgV
<400> 2276
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2277
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v272 IgV
<400> 2277
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Asp Val Asp
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2278
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v273 IgV
<400> 2278
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2279
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v274 IgV
<400> 2279
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Leu Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2280
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v275 IgV
<400> 2280
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2281
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v276 IgV
<400> 2281
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Val Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2282
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v277 IgV
<400> 2282
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asp Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2283
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v278 IgV
<400> 2283
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Glu Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2284
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v279 IgV
<400> 2284
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Glu Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2285
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v280 IgV
<400> 2285
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2286
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v281 IgV
<400> 2286
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Tyr Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2287
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v282 IgV
<400> 2287
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Val Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Asp Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2288
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v283 IgV
<400> 2288
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2289
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v284 IgV
<400> 2289
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2290
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v285 IgV
<400> 2290
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu His Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2291
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v286 IgV
<400> 2291
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Asp Val His Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Lys Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2292
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v287 IgV
<400> 2292
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2293
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v288 IgV
<400> 2293
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Thr Val Leu Thr Met Met Ser Gly Glu Val Ser
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2294
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v289 IgV
<400> 2294
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2295
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v290 IgV
<400> 2295
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Thr Val Leu Thr Met Val Ser Gly Asp Val Arg
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2296
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v291 IgV
<400> 2296
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Tyr Arg Ile Tyr Trp
20 25 30
His Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2297
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v292 ECD
<400> 2297
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2298
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v293 ECD
<400> 2298
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2299
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v294 ECD
<400> 2299
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2300
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v295 ECD
<400> 2300
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2301
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v296 ECD
<400> 2301
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2302
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v297 ECD
<400> 2302
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2303
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v298 ECD
<400> 2303
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2304
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v299 ECD
<400> 2304
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Phe Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2305
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v300 ECD
<400> 2305
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2306
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v301 ECD
<400> 2306
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2307
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v302 ECD
<400> 2307
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2308
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v303 ECD
<400> 2308
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2309
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v304 ECD
<400> 2309
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2310
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v305 ECD
<400> 2310
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2311
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v306 ECD
<400> 2311
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2312
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v307 ECD
<400> 2312
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2313
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v308 ECD
<400> 2313
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2314
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v309 ECD
<400> 2314
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2315
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v310 ECD
<400> 2315
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2316
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v311 ECD
<400> 2316
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2317
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v312 ECD
<400> 2317
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2318
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v313 ECD
<400> 2318
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2319
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v314 ECD
<400> 2319
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2320
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v315 ECD
<400> 2320
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2321
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v316 ECD
<400> 2321
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2322
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v317 ECD
<400> 2322
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2323
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v318 ECD
<400> 2323
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Arg Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Tyr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2324
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v319 ECD
<400> 2324
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2325
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v320 ECD
<400> 2325
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2326
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v321 ECD
<400> 2326
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Arg Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2327
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v322 ECD
<400> 2327
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Thr Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Ser
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2328
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v323 ECD
<400> 2328
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2329
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v324 ECD
<400> 2329
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2330
<211> 119
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v325 ECD
<400> 2330
Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Leu Ser Val Lys
1 5 10 15
Ala Asp Phe Pro Thr Pro Ser Ile Ser Asp Phe Glu Thr Pro Thr Ser
20 25 30
Asn Ile Arg Arg Ile Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro
35 40 45
His Leu Ser Trp Leu Glu Asn Gly Glu Glu Leu Ser Ala Ile Asn Thr
50 55 60
Thr Val Ser Gln Asp Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys
65 70 75 80
Leu Asp Phe Asn Met Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys
85 90 95
Tyr Gly His Leu Arg Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys
100 105 110
Gln Glu His Phe Pro Asp Asn
115
<210> 2331
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v326 ECD
<400> 2331
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2332
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v327 ECD
<400> 2332
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2333
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v328 ECD
<400> 2333
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2334
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v329 ECD
<400> 2334
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2335
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v330 ECD
<400> 2335
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2336
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v331 ECD
<400> 2336
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2337
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v332 ECD
<400> 2337
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2338
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v333 ECD
<400> 2338
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2339
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v334 ECD
<400> 2339
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2340
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v335 ECD
<400> 2340
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2341
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v336 ECD
<400> 2341
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2342
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v337 ECD
<400> 2342
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2343
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v338 ECD
<400> 2343
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2344
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v339 ECD
<400> 2344
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Cys Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2345
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v340 ECD
<400> 2345
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2346
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v341 ECD
<400> 2346
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Cys Glu Lys Asp Ala Phe Arg Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2347
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v342 ECD
<400> 2347
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2348
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v343 ECD
<400> 2348
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2349
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v344 ECD
<400> 2349
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2350
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v345 ECD
<400> 2350
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2351
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v346 ECD
<400> 2351
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2352
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v347 ECD
<400> 2352
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2353
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v348 ECD
<400> 2353
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2354
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v349 ECD
<400> 2354
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2355
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v350 ECD
<400> 2355
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2356
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v351 ECD
<400> 2356
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2357
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v352 ECD
<400> 2357
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Asp Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2358
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v353 ECD
<400> 2358
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2359
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v354 ECD
<400> 2359
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2360
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v355 ECD
<400> 2360
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2361
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v356 ECD
<400> 2361
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2362
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v357 ECD
<400> 2362
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2363
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v358 ECD
<400> 2363
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2364
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v359 ECD
<400> 2364
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2365
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v360 ECD
<400> 2365
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2366
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v361 ECD
<400> 2366
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2367
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v362 ECD
<400> 2367
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Gln Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2368
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v363 ECD
<400> 2368
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2369
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v364 ECD
<400> 2369
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2370
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v365 ECD
<400> 2370
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2371
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v366 ECD
<400> 2371
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2372
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v367 ECD
<400> 2372
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2373
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v368 ECD
<400> 2373
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2374
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v369 ECD
<400> 2374
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Cys Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2375
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v370 ECD
<400> 2375
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2376
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v371 ECD
<400> 2376
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2377
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v372 ECD
<400> 2377
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2378
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v373 ECD
<400> 2378
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2379
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v374 ECD
<400> 2379
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2380
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v375 ECD
<400> 2380
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2381
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v376 ECD
<400> 2381
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2382
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v377 ECD
<400> 2382
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2383
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v378 ECD
<400> 2383
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2384
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v379 ECD
<400> 2384
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2385
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v380 ECD
<400> 2385
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2386
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v381 ECD
<400> 2386
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2387
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v382 ECD
<400> 2387
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2388
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v383 ECD
<400> 2388
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2389
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v384 ECD
<400> 2389
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2390
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v385 ECD
<400> 2390
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2391
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v386 ECD
<400> 2391
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2392
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v387 ECD
<400> 2392
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2393
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v388 ECD
<400> 2393
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2394
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v389 ECD
<400> 2394
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2395
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v390 ECD
<400> 2395
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2396
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v392 ECD
<400> 2396
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2397
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v393 ECD
<400> 2397
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2398
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v394 ECD
<400> 2398
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2399
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v395 ECD
<400> 2399
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2400
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v396 ECD
<400> 2400
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2401
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v397 ECD
<400> 2401
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2402
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v398 ECD
<400> 2402
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2403
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v399 ECD
<400> 2403
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2404
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v400 ECD
<400> 2404
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2405
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v401 ECD
<400> 2405
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2406
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v402 ECD
<400> 2406
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2407
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v403 ECD
<400> 2407
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2408
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v404 ECD
<400> 2408
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2409
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v405 ECD
<400> 2409
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2410
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v406 ECD
<400> 2410
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2411
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v407 ECD
<400> 2411
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2412
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v408 ECD
<400> 2412
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2413
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v409 ECD
<400> 2413
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2414
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v410 ECD
<400> 2414
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2415
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v411 ECD
<400> 2415
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2416
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v412 ECD
<400> 2416
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2417
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v413 ECD
<400> 2417
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2418
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v414 ECD
<400> 2418
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2419
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v415 ECD
<400> 2419
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2420
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v416 ECD
<400> 2420
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2421
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v417 ECD
<400> 2421
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2422
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v418 ECD
<400> 2422
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2423
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v419 ECD
<400> 2423
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2424
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v420 ECD
<400> 2424
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2425
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v421 ECD
<400> 2425
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2426
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v422 ECD
<400> 2426
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2427
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v423 ECD
<400> 2427
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2428
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v424 ECD
<400> 2428
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2429
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v425 ECD
<400> 2429
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2430
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v426 ECD
<400> 2430
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2431
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v427 ECD
<400> 2431
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2432
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v428 ECD
<400> 2432
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2433
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v429 ECD
<400> 2433
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2434
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v430 ECD
<400> 2434
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2435
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v431 ECD
<400> 2435
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2436
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v432 ECD
<400> 2436
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2437
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v433 ECD
<400> 2437
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2438
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v434 ECD
<400> 2438
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2439
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v435 ECD
<400> 2439
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2440
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v436 ECD
<400> 2440
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2441
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v437 ECD
<400> 2441
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2442
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v438 ECD
<400> 2442
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2443
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v439 ECD
<400> 2443
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2444
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v440 ECD
<400> 2444
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2445
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v441 ECD
<400> 2445
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2446
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v442 ECD
<400> 2446
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2447
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v443 ECD
<400> 2447
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2448
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v444 ECD
<400> 2448
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2449
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v445 ECD
<400> 2449
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2450
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v446 ECD
<400> 2450
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2451
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v447 ECD
<400> 2451
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2452
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v448 ECD
<400> 2452
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2453
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v449 ECD
<400> 2453
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2454
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v450 ECD
<400> 2454
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2455
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v451 ECD
<400> 2455
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2456
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v452 ECD
<400> 2456
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2457
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v453 ECD
<400> 2457
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2458
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v454 ECD
<400> 2458
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2459
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v455 ECD
<400> 2459
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2460
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v456 ECD
<400> 2460
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2461
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v457 ECD
<400> 2461
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2462
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v458 ECD
<400> 2462
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2463
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v459 ECD
<400> 2463
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2464
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v460 ECD
<400> 2464
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2465
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v461 ECD
<400> 2465
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2466
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v462 ECD
<400> 2466
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2467
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v463 ECD
<400> 2467
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2468
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v464 ECD
<400> 2468
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2469
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v465 ECD
<400> 2469
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2470
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v466 ECD
<400> 2470
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2471
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v467 ECD
<400> 2471
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2472
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v468 ECD
<400> 2472
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2473
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v469 ECD
<400> 2473
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2474
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v470 ECD
<400> 2474
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2475
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v471 ECD
<400> 2475
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2476
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v472 ECD
<400> 2476
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2477
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v473 ECD
<400> 2477
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2478
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v474 ECD
<400> 2478
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2479
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v475 ECD
<400> 2479
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2480
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v476 ECD
<400> 2480
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2481
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v477 ECD
<400> 2481
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2482
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v478 ECD
<400> 2482
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2483
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v479 ECD
<400> 2483
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2484
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v480 ECD
<400> 2484
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2485
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v481 ECD
<400> 2485
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2486
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v482 ECD
<400> 2486
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2487
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v483 ECD
<400> 2487
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2488
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v484 ECD
<400> 2488
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2489
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v485 ECD
<400> 2489
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2490
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v486 ECD
<400> 2490
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2491
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v487 ECD
<400> 2491
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2492
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v488 ECD
<400> 2492
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2493
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v489 ECD
<400> 2493
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2494
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v490 ECD
<400> 2494
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2495
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v491 ECD
<400> 2495
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2496
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v492 ECD
<400> 2496
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2497
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v493 ECD
<400> 2497
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2498
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v494 ECD
<400> 2498
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2499
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v495 ECD
<400> 2499
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2500
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v496 ECD
<400> 2500
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2501
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v497 ECD
<400> 2501
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2502
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v498 ECD
<400> 2502
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2503
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v499 ECD
<400> 2503
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2504
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v500 ECD
<400> 2504
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2505
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v501 ECD
<400> 2505
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2506
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v502 ECD
<400> 2506
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2507
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v503 ECD
<400> 2507
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2508
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v292 IgV
<400> 2508
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2509
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v293 IgV
<400> 2509
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2510
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v294 IgV
<400> 2510
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2511
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v295 IgV
<400> 2511
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2512
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v296 IgV
<400> 2512
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2513
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v297 IgV
<400> 2513
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2514
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v298 IgV
<400> 2514
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2515
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v299 IgV
<400> 2515
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Phe Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2516
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v300 IgV
<400> 2516
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2517
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v301 IgV
<400> 2517
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2518
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v302 IgV
<400> 2518
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2519
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v303 IgV
<400> 2519
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2520
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v304 IgV
<400> 2520
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2521
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v305 IgV
<400> 2521
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2522
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v306 IgV
<400> 2522
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2523
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v307 IgV
<400> 2523
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2524
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v308 IgV
<400> 2524
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2525
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v309 IgV
<400> 2525
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2526
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v310 IgV
<400> 2526
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2527
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v311 IgV
<400> 2527
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Arg Ala Glu Val Thr
100
<210> 2528
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v312 IgV
<400> 2528
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2529
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v313 IgV
<400> 2529
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2530
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v314 IgV
<400> 2530
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2531
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v315 IgV
<400> 2531
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2532
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v316 IgV
<400> 2532
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2533
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v317 IgV
<400> 2533
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2534
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v318 IgV
<400> 2534
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Arg Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Tyr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2535
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v319 IgV
<400> 2535
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2536
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v320 IgV
<400> 2536
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2537
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v321 IgV
<400> 2537
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Arg Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2538
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v322 IgV
<400> 2538
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Thr Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Ser
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2539
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v323 IgV
<400> 2539
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2540
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v324 IgV
<400> 2540
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2541
<211> 12
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v325 IgV
<400> 2541
Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr
1 5 10
<210> 2542
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v326 IgV
<400> 2542
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2543
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v327 IgV
<400> 2543
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2544
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v328 IgV
<400> 2544
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2545
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v329 IgV
<400> 2545
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2546
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v330 IgV
<400> 2546
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2547
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v331 IgV
<400> 2547
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2548
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v332 IgV
<400> 2548
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2549
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v333 IgV
<400> 2549
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2550
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v334 IgV
<400> 2550
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2551
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v335 IgV
<400> 2551
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2552
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v336 IgV
<400> 2552
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2553
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v337 IgV
<400> 2553
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2554
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v338 IgV
<400> 2554
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2555
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v339 IgV
<400> 2555
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Cys Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2556
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v340 IgV
<400> 2556
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2557
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v341 IgV
<400> 2557
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Cys Glu Lys Asp Ala Phe Arg Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2558
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v342 IgV
<400> 2558
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2559
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v343 IgV
<400> 2559
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2560
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v344 IgV
<400> 2560
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2561
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v345 IgV
<400> 2561
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2562
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v346 IgV
<400> 2562
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2563
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v347 IgV
<400> 2563
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2564
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v348 IgV
<400> 2564
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2565
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v349 IgV
<400> 2565
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2566
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v350 IgV
<400> 2566
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2567
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v351 IgV
<400> 2567
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2568
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v352 IgV
<400> 2568
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Asp Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2569
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v353 IgV
<400> 2569
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2570
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v354 IgV
<400> 2570
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2571
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v355 IgV
<400> 2571
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2572
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v356 IgV
<400> 2572
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2573
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v357 IgV
<400> 2573
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2574
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v358 IgV
<400> 2574
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2575
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v359 IgV
<400> 2575
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2576
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v360 IgV
<400> 2576
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2577
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v361 IgV
<400> 2577
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2578
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v362 IgV
<400> 2578
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Gln Val His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2579
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v363 IgV
<400> 2579
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2580
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v364 IgV
<400> 2580
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2581
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v365 IgV
<400> 2581
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2582
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v366 IgV
<400> 2582
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2583
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v367 IgV
<400> 2583
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2584
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v368 IgV
<400> 2584
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2585
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v369 IgV
<400> 2585
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Cys Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2586
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v370 IgV
<400> 2586
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2587
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v371 IgV
<400> 2587
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2588
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v372 IgV
<400> 2588
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2589
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v373 IgV
<400> 2589
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2590
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v374 IgV
<400> 2590
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2591
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v375 IgV
<400> 2591
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2592
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v376 IgV
<400> 2592
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2593
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v377 IgV
<400> 2593
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2594
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v378 IgV
<400> 2594
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr
100
<210> 2595
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v379 IgV
<400> 2595
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2596
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v380 IgV
<400> 2596
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2597
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v381 IgV
<400> 2597
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2598
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v382 IgV
<400> 2598
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2599
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v383 IgV
<400> 2599
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2600
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v384 IgV
<400> 2600
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2601
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v385 IgV
<400> 2601
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2602
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v386 IgV
<400> 2602
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2603
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v387 IgV
<400> 2603
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2604
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v388 IgV
<400> 2604
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2605
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v389 IgV
<400> 2605
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2606
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v390 IgV
<400> 2606
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2607
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v392 IgV
<400> 2607
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2608
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v393 IgV
<400> 2608
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2609
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v394 IgV
<400> 2609
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2610
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v395 IgV
<400> 2610
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2611
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v396 IgV
<400> 2611
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2612
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v397 IgV
<400> 2612
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2613
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v398 IgV
<400> 2613
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2614
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v399 IgV
<400> 2614
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2615
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v400 IgV
<400> 2615
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2616
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v401 IgV
<400> 2616
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2617
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v402 IgV
<400> 2617
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2618
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v403 IgV
<400> 2618
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2619
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v404 IgV
<400> 2619
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2620
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v405 IgV
<400> 2620
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2621
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v406 IgV
<400> 2621
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2622
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v407 IgV
<400> 2622
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2623
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v408 IgV
<400> 2623
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2624
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v409 IgV
<400> 2624
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2625
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v410 IgV
<400> 2625
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2626
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v411 IgV
<400> 2626
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2627
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v412 IgV
<400> 2627
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2628
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v413 IgV
<400> 2628
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2629
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v414 IgV
<400> 2629
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2630
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v415 IgV
<400> 2630
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2631
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v416 IgV
<400> 2631
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2632
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v417 IgV
<400> 2632
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2633
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v418 IgV
<400> 2633
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2634
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v419 IgV
<400> 2634
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2635
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v420 IgV
<400> 2635
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2636
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v421 IgV
<400> 2636
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2637
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v422 IgV
<400> 2637
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2638
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v423 IgV
<400> 2638
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2639
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v424 IgV
<400> 2639
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2640
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v425 IgV
<400> 2640
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2641
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v426 IgV
<400> 2641
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2642
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v427 IgV
<400> 2642
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2643
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v428 IgV
<400> 2643
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2644
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v429 IgV
<400> 2644
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2645
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v430 IgV
<400> 2645
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2646
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v431 IgV
<400> 2646
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2647
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v432 IgV
<400> 2647
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2648
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v433 IgV
<400> 2648
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2649
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v434 IgV
<400> 2649
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2650
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v435 IgV
<400> 2650
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2651
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v436 IgV
<400> 2651
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2652
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v437 IgV
<400> 2652
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2653
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v438 IgV
<400> 2653
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2654
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v439 IgV
<400> 2654
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2655
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v440 IgV
<400> 2655
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2656
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v441 IgV
<400> 2656
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2657
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v442 IgV
<400> 2657
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2658
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v443 IgV
<400> 2658
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2659
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v444 IgV
<400> 2659
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2660
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v445 IgV
<400> 2660
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2661
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v446 IgV
<400> 2661
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2662
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v447 IgV
<400> 2662
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2663
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v448 IgV
<400> 2663
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2664
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v449 IgV
<400> 2664
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2665
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v450 IgV
<400> 2665
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2666
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v451 IgV
<400> 2666
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2667
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v452 IgV
<400> 2667
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2668
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v453 IgV
<400> 2668
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2669
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v454 IgV
<400> 2669
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2670
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v455 IgV
<400> 2670
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2671
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v456 IgV
<400> 2671
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2672
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v457 IgV
<400> 2672
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2673
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v458 IgV
<400> 2673
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2674
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v459 IgV
<400> 2674
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2675
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v460 IgV
<400> 2675
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2676
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v461 IgV
<400> 2676
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2677
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v462 IgV
<400> 2677
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2678
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v463 IgV
<400> 2678
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2679
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v464 IgV
<400> 2679
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2680
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v465 IgV
<400> 2680
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2681
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v466 IgV
<400> 2681
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2682
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v467 IgV
<400> 2682
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2683
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v468 IgV
<400> 2683
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2684
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v469 IgV
<400> 2684
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2685
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v470 IgV
<400> 2685
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2686
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v471 IgV
<400> 2686
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2687
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v472 IgV
<400> 2687
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2688
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v473 IgV
<400> 2688
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2689
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v474 IgV
<400> 2689
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2690
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v475 IgV
<400> 2690
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2691
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v476 IgV
<400> 2691
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2692
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v477 IgV
<400> 2692
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2693
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v478 IgV
<400> 2693
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2694
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v479 IgV
<400> 2694
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2695
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v480 IgV
<400> 2695
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2696
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v481 IgV
<400> 2696
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2697
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v482 IgV
<400> 2697
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2698
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v483 IgV
<400> 2698
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2699
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v484 IgV
<400> 2699
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2700
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v485 IgV
<400> 2700
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2701
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v486 IgV
<400> 2701
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2702
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v487 IgV
<400> 2702
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2703
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v488 IgV
<400> 2703
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2704
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v489 IgV
<400> 2704
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2705
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v490 IgV
<400> 2705
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2706
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v491 IgV
<400> 2706
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2707
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v492 IgV
<400> 2707
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2708
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v493 IgV
<400> 2708
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2709
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v494 IgV
<400> 2709
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2710
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v495 IgV
<400> 2710
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2711
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v496 IgV
<400> 2711
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2712
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v497 IgV
<400> 2712
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2713
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v498 IgV
<400> 2713
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2714
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v499 IgV
<400> 2714
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2715
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v500 IgV
<400> 2715
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2716
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v501 IgV
<400> 2716
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2717
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v502 IgV
<400> 2717
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2718
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v503 IgV
<400> 2718
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2719
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v292 IgV
<400> 2719
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Val Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2720
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v293 IgV
<400> 2720
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Met Thr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2721
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v294 IgV
<400> 2721
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2722
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v295 IgV
<400> 2722
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2723
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v296 IgV
<400> 2723
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2724
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v297 IgV
<400> 2724
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2725
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v298 IgV
<400> 2725
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ser Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2726
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v299 IgV
<400> 2726
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Phe Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2727
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v300 IgV
<400> 2727
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2728
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v301 IgV
<400> 2728
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2729
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v302 IgV
<400> 2729
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2730
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v303 IgV
<400> 2730
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2731
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v304 IgV
<400> 2731
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2732
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v305 IgV
<400> 2732
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2733
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v306 IgV
<400> 2733
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2734
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v307 IgV
<400> 2734
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala His Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2735
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v308 IgV
<400> 2735
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2736
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v309 IgV
<400> 2736
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2737
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v310 IgV
<400> 2737
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2738
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v311 IgV
<400> 2738
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Arg Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2739
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v312 IgV
<400> 2739
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2740
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v313 IgV
<400> 2740
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2741
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v314 IgV
<400> 2741
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Val Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2742
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v315 IgV
<400> 2742
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2743
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v316 IgV
<400> 2743
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2744
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v317 IgV
<400> 2744
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2745
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v318 IgV
<400> 2745
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Arg Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Tyr
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2746
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v319 IgV
<400> 2746
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Leu Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2747
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v320 IgV
<400> 2747
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2748
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v321 IgV
<400> 2748
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Arg Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2749
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v322 IgV
<400> 2749
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Thr Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Ser
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asn Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2750
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v323 IgV
<400> 2750
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2751
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v324 IgV
<400> 2751
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2752
<211> 18
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v325 IgV
<400> 2752
Val Ile His Val Thr Lys Glu Val Lys Glu Val Thr Leu Ser Val Lys
1 5 10 15
Ala Asp
<210> 2753
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v326 IgV
<400> 2753
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2754
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v327 IgV
<400> 2754
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Ala Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Asn Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Gly Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2755
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v328 IgV
<400> 2755
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2756
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v329 IgV
<400> 2756
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2757
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v330 IgV
<400> 2757
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Asp Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2758
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v331 IgV
<400> 2758
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2759
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v332 IgV
<400> 2759
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2760
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v333 IgV
<400> 2760
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2761
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v334 IgV
<400> 2761
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2762
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v335 IgV
<400> 2762
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2763
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v336 IgV
<400> 2763
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Met Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2764
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v337 IgV
<400> 2764
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2765
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v338 IgV
<400> 2765
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2766
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v339 IgV
<400> 2766
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ala Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Cys Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2767
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v340 IgV
<400> 2767
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2768
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v341 IgV
<400> 2768
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Cys Glu Lys Asp Ala Phe Arg Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2769
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v342 IgV
<400> 2769
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2770
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v343 IgV
<400> 2770
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2771
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v344 IgV
<400> 2771
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2772
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v345 IgV
<400> 2772
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Ile Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2773
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v346 IgV
<400> 2773
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2774
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v347 IgV
<400> 2774
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2775
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v348 IgV
<400> 2775
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2776
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v349 IgV
<400> 2776
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2777
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v350 IgV
<400> 2777
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2778
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v351 IgV
<400> 2778
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2779
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v352 IgV
<400> 2779
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Asp Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2780
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v353 IgV
<400> 2780
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2781
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v354 IgV
<400> 2781
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2782
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v355 IgV
<400> 2782
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2783
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v356 IgV
<400> 2783
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Asn Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2784
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v357 IgV
<400> 2784
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2785
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v358 IgV
<400> 2785
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2786
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v359 IgV
<400> 2786
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2787
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v360 IgV
<400> 2787
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Phe Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Arg Arg Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2788
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v361 IgV
<400> 2788
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2789
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v362 IgV
<400> 2789
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Gln Val His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2790
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v363 IgV
<400> 2790
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2791
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v364 IgV
<400> 2791
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Met Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2792
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v365 IgV
<400> 2792
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Asp Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2793
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v366 IgV
<400> 2793
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2794
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v367 IgV
<400> 2794
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2795
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v368 IgV
<400> 2795
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2796
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v369 IgV
<400> 2796
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Cys Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2797
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v370 IgV
<400> 2797
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2798
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v371 IgV
<400> 2798
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Pro Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Glu Met Val Leu Thr Met Met Ser Gly Glu Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Leu Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2799
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v372 IgV
<400> 2799
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2800
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v373 IgV
<400> 2800
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2801
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v374 IgV
<400> 2801
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Leu Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Ser Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2802
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v375 IgV
<400> 2802
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2803
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v376 IgV
<400> 2803
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Leu Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Ser Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2804
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v377 IgV
<400> 2804
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2805
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v378 IgV
<400> 2805
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Val His
85 90 95
Gln Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2806
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v379 IgV
<400> 2806
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2807
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v380 IgV
<400> 2807
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Ile Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Gln Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2808
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v381 IgV
<400> 2808
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2809
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v382 IgV
<400> 2809
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Arg Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Arg Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2810
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v383 IgV
<400> 2810
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2811
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v384 IgV
<400> 2811
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Met Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2812
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v385 IgV
<400> 2812
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Asp Glu Asp Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2813
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v386 IgV
<400> 2813
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2814
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v387 IgV
<400> 2814
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2815
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v388 IgV
<400> 2815
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2816
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v389 IgV
<400> 2816
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2817
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v390 IgV
<400> 2817
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2818
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v392 IgV
<400> 2818
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2819
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v393 IgV
<400> 2819
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2820
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v394 IgV
<400> 2820
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2821
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v395 IgV
<400> 2821
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2822
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v396 IgV
<400> 2822
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2823
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v397 IgV
<400> 2823
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2824
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v398 IgV
<400> 2824
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2825
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v399 IgV
<400> 2825
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2826
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v400 IgV
<400> 2826
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2827
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v401 IgV
<400> 2827
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2828
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v402 IgV
<400> 2828
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2829
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v403 IgV
<400> 2829
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2830
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v404 IgV
<400> 2830
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2831
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v405 IgV
<400> 2831
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2832
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v406 IgV
<400> 2832
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2833
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v407 IgV
<400> 2833
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2834
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v408 IgV
<400> 2834
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2835
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v409 IgV
<400> 2835
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2836
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v410 IgV
<400> 2836
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2837
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v411 IgV
<400> 2837
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Val Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2838
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v412 IgV
<400> 2838
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2839
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v413 IgV
<400> 2839
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2840
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v414 IgV
<400> 2840
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2841
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v415 IgV
<400> 2841
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2842
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v416 IgV
<400> 2842
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2843
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v417 IgV
<400> 2843
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2844
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v418 IgV
<400> 2844
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2845
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v419 IgV
<400> 2845
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2846
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v420 IgV
<400> 2846
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2847
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v421 IgV
<400> 2847
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2848
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v422 IgV
<400> 2848
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2849
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v423 IgV
<400> 2849
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2850
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v424 IgV
<400> 2850
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2851
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v425 IgV
<400> 2851
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2852
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v426 IgV
<400> 2852
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2853
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v427 IgV
<400> 2853
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2854
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v428 IgV
<400> 2854
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2855
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v429 IgV
<400> 2855
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2856
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v430 IgV
<400> 2856
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2857
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v431 IgV
<400> 2857
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2858
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v432 IgV
<400> 2858
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2859
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v433 IgV
<400> 2859
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2860
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v434 IgV
<400> 2860
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2861
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v435 IgV
<400> 2861
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2862
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v436 IgV
<400> 2862
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2863
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v437 IgV
<400> 2863
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2864
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v438 IgV
<400> 2864
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2865
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v439 IgV
<400> 2865
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Val Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2866
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v440 IgV
<400> 2866
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Lys
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2867
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v441 IgV
<400> 2867
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Gln Lys Tyr Glu Asn Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2868
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v442 IgV
<400> 2868
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2869
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v443 IgV
<400> 2869
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2870
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v444 IgV
<400> 2870
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2871
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v445 IgV
<400> 2871
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2872
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v446 IgV
<400> 2872
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2873
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v447 IgV
<400> 2873
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2874
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v448 IgV
<400> 2874
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2875
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v449 IgV
<400> 2875
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2876
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v450 IgV
<400> 2876
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2877
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v451 IgV
<400> 2877
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2878
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v452 IgV
<400> 2878
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2879
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v453 IgV
<400> 2879
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2880
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v454 IgV
<400> 2880
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2881
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v455 IgV
<400> 2881
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2882
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v456 IgV
<400> 2882
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2883
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v457 IgV
<400> 2883
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2884
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v458 IgV
<400> 2884
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2885
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v459 IgV
<400> 2885
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2886
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v460 IgV
<400> 2886
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2887
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v461 IgV
<400> 2887
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2888
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v462 IgV
<400> 2888
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2889
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v463 IgV
<400> 2889
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2890
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v464 IgV
<400> 2890
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2891
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v465 IgV
<400> 2891
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2892
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v466 IgV
<400> 2892
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2893
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v467 IgV
<400> 2893
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2894
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v468 IgV
<400> 2894
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2895
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v469 IgV
<400> 2895
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2896
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v470 IgV
<400> 2896
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2897
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v471 IgV
<400> 2897
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2898
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v472 IgV
<400> 2898
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2899
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v473 IgV
<400> 2899
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2900
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v474 IgV
<400> 2900
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2901
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v475 IgV
<400> 2901
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2902
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v476 IgV
<400> 2902
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2903
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v477 IgV
<400> 2903
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2904
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v478 IgV
<400> 2904
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2905
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v479 IgV
<400> 2905
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2906
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v480 IgV
<400> 2906
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2907
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v481 IgV
<400> 2907
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2908
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v482 IgV
<400> 2908
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2909
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v483 IgV
<400> 2909
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2910
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v484 IgV
<400> 2910
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2911
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v485 IgV
<400> 2911
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2912
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v486 IgV
<400> 2912
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2913
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v487 IgV
<400> 2913
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2914
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v488 IgV
<400> 2914
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2915
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v489 IgV
<400> 2915
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2916
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v490 IgV
<400> 2916
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2917
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v491 IgV
<400> 2917
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2918
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v492 IgV
<400> 2918
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2919
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v493 IgV
<400> 2919
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2920
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v494 IgV
<400> 2920
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2921
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v495 IgV
<400> 2921
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2922
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v496 IgV
<400> 2922
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2923
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v497 IgV
<400> 2923
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2924
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v498 IgV
<400> 2924
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2925
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v499 IgV
<400> 2925
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2926
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v500 IgV
<400> 2926
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2927
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v501 IgV
<400> 2927
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2928
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v502 IgV
<400> 2928
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2929
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v503 IgV
<400> 2929
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Glu Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2930
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v504 ECD
<400> 2930
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2931
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v505 ECD
<400> 2931
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Cys Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2932
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v506 ECD
<400> 2932
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ile Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2933
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v507 ECD
<400> 2933
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2934
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v508 ECD
<400> 2934
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2935
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v509 ECD
<400> 2935
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Thr Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2936
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v510 ECD
<400> 2936
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Lys Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2937
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v511 ECD
<400> 2937
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2938
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v512 ECD
<400> 2938
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2939
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v513 ECD
<400> 2939
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2940
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v514 ECD
<400> 2940
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2941
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v515 ECD
<400> 2941
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2942
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v516 ECD
<400> 2942
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2943
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v517 ECD
<400> 2943
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2944
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v518 ECD
<400> 2944
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2945
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v519 ECD
<400> 2945
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2946
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v520 ECD
<400> 2946
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Gly Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2947
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v521 ECD
<400> 2947
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Ser Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2948
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v522 ECD
<400> 2948
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Arg Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2949
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v523 ECD
<400> 2949
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Asp Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2950
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v524 ECD
<400> 2950
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Gln Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2951
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v525 ECD
<400> 2951
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ala Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2952
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v526 ECD
<400> 2952
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ala Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2953
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v527 ECD
<400> 2953
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2954
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v528 ECD
<400> 2954
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu His Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2955
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v529 ECD
<400> 2955
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Lys Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2956
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v530 ECD
<400> 2956
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Phe Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2957
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v531 ECD
<400> 2957
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Tyr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Ile Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2958
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v532 ECD
<400> 2958
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Gln Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2959
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v533 ECD
<400> 2959
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Arg Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asn Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Pro Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2960
<211> 208
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v534 ECD
<400> 2960
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Asp Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Thr Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Ser Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
<210> 2961
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v504 IgV
<400> 2961
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2962
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v505 IgV
<400> 2962
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Cys Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2963
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v506 IgV
<400> 2963
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ile Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2964
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v507 IgV
<400> 2964
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2965
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v508 IgV
<400> 2965
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2966
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v509 IgV
<400> 2966
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Thr Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2967
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v510 IgV
<400> 2967
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Lys Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2968
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v511 IgV
<400> 2968
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2969
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v512 IgV
<400> 2969
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2970
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v513 IgV
<400> 2970
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2971
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v514 IgV
<400> 2971
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2972
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v515 IgV
<400> 2972
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2973
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v516 IgV
<400> 2973
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2974
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v517 IgV
<400> 2974
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2975
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v518 IgV
<400> 2975
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2976
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v519 IgV
<400> 2976
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2977
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v520 IgV
<400> 2977
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Gly Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2978
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v521 IgV
<400> 2978
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Ser Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2979
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v522 IgV
<400> 2979
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Arg Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2980
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v523 IgV
<400> 2980
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Asp Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2981
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v524 IgV
<400> 2981
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Gln Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2982
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v525 IgV
<400> 2982
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ala Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2983
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v526 IgV
<400> 2983
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ala Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2984
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v527 IgV
<400> 2984
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2985
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v528 IgV
<400> 2985
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu His Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2986
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v529 IgV
<400> 2986
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Lys Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2987
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v530 IgV
<400> 2987
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Phe Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2988
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v531 IgV
<400> 2988
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Tyr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Ile Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2989
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v532 IgV
<400> 2989
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Gln Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2990
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v533 IgV
<400> 2990
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Arg Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asn Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Pro Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2991
<211> 101
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v534 IgV
<400> 2991
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Asp Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr
100
<210> 2992
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v504 IgV
<400> 2992
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2993
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v505 IgV
<400> 2993
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Cys Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2994
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v506 IgV
<400> 2994
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ile Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2995
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v507 IgV
<400> 2995
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2996
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v508 IgV
<400> 2996
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Leu Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2997
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v509 IgV
<400> 2997
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Thr Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2998
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v510 IgV
<400> 2998
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Lys Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 2999
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v511 IgV
<400> 2999
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3000
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v512 IgV
<400> 3000
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3001
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v513 IgV
<400> 3001
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3002
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v514 IgV
<400> 3002
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3003
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v515 IgV
<400> 3003
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3004
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v516 IgV
<400> 3004
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3005
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v517 IgV
<400> 3005
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3006
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v518 IgV
<400> 3006
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3007
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v519 IgV
<400> 3007
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3008
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v520 IgV
<400> 3008
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Gly Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3009
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v521 IgV
<400> 3009
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Ser Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3010
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v522 IgV
<400> 3010
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Arg Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3011
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v523 IgV
<400> 3011
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Asp Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3012
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v524 IgV
<400> 3012
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Val Asn Val Ser Val Glu Glu Leu Gln Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Leu Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3013
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v525 IgV
<400> 3013
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ala Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3014
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v526 IgV
<400> 3014
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Ala Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3015
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v527 IgV
<400> 3015
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Ile Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3016
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v528 IgV
<400> 3016
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu His Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Leu Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3017
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v529 IgV
<400> 3017
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Lys Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3018
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v530 IgV
<400> 3018
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Asn Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Phe Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3019
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v531 IgV
<400> 3019
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Tyr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Ile Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3020
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v532 IgV
<400> 3020
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Tyr Asn Val Ser Val Glu Glu Leu Gln Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3021
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v533 IgV
<400> 3021
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Arg Asn Val Ser Val Glu Glu Leu Pro Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Asn Val Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Pro Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3022
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 v534 IgV
<400> 3022
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly Phe Asn Val Ser Val Glu Glu Leu Asp Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Asp Lys Lys Met Val Leu Thr Met Met Ser Gly Glu Thr Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Met Ile Leu Gly Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Gly Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3023
<211> 440
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 ECD-Fc
<400> 3023
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
210 215 220
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225 230 235 240
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
245 250 255
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
260 265 270
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
275 280 285
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
290 295 300
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
305 310 315 320
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
325 330 335
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
340 345 350
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
355 360 365
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
370 375 380
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385 390 395 400
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
405 410 415
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
420 425 430
Ser Leu Ser Leu Ser Pro Gly Lys
435 440
<210> 3024
<211> 440
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 ECD-Fc
<400> 3024
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser
100 105 110
Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys
115 120 125
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn
130 135 140
Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu
145 150 155 160
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr
165 170 175
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn
180 185 190
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn
195 200 205
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
210 215 220
Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
225 230 235 240
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
245 250 255
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
260 265 270
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
275 280 285
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
290 295 300
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
305 310 315 320
Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
325 330 335
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
340 345 350
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
355 360 365
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
370 375 380
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
385 390 395 400
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
405 410 415
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
420 425 430
Ser Leu Ser Leu Ser Pro Gly Lys
435 440
<210> 3025
<211> 225
<212> PRT
<213> Artificial Sequence
<220>
<223> Fc1.1 delta EPKSSD
<400> 3025
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala
1 5 10 15
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
20 25 30
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
35 40 45
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
50 55 60
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
65 70 75 80
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
85 90 95
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
100 105 110
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
115 120 125
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
130 135 140
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
145 150 155 160
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
165 170 175
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
180 185 190
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
195 200 205
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
210 215 220
Gly
225
<210> 3026
<211> 5
<212> PRT
<213> Artificial Sequence
<220>
<223> EAAAK linker
<400> 3026
Glu Ala Ala Ala Lys
1 5
<210> 3027
<211> 15
<212> PRT
<213> Artificial Sequence
<220>
<223> (EAAAK)3 linker
<400> 3027
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys
1 5 10 15
<210> 3028
<211> 17
<212> PRT
<213> Artificial Sequence
<220>
<223> GS(G4S)3 linker
<400> 3028
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
1 5 10 15
Ser
<210> 3029
<211> 27
<212> PRT
<213> Artificial Sequence
<220>
<223> GS(G4S)5 linker
<400> 3029
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
1 5 10 15
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
20 25
<210> 3030
<211> 104
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 WT IgV
<400> 3030
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val
100
<210> 3031
<211> 107
<212> PRT
<213> Artificial Sequence
<220>
<223> CD80 WT IgV
<400> 3031
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys
1 5 10 15
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp
20 25 30
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn
35 40 45
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn
50 55 60
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr
65 70 75 80
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His
85 90 95
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp
100 105
<210> 3032
<211> 22
<212> PRT
<213> Artificial Sequence
<220>
<223> P2A protein
<400> 3032
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val
1 5 10 15
Glu Glu Asn Pro Gly Pro
20
<210> 3033
<211> 237
<212> PRT
<213> Artificial Sequence
<220>
<223> eGFP
<400> 3033
Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu
1 5 10 15
Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly
20 25 30
Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr
35 40 45
Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr
50 55 60
Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His
65 70 75 80
Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr
85 90 95
Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys
100 105 110
Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp
115 120 125
Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr
130 135 140
Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile
145 150 155 160
Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln
165 170 175
Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val
180 185 190
Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys
195 200 205
Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr
210 215 220
Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys
225 230 235
<210> 3034
<211> 237
<212> PRT
<213> Artificial Sequence
<220>
<223> Green fluorescent protein
<400> 3034
Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu
1 5 10 15
Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly
20 25 30
Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr
35 40 45
Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Ser
50 55 60
Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His
65 70 75 80
Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr
85 90 95
Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys
100 105 110
Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp
115 120 125
Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr
130 135 140
Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile
145 150 155 160
Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln
165 170 175
Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val
180 185 190
Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys
195 200 205
Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr
210 215 220
Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys
225 230 235
<210> 3035
<211> 239
<212> PRT
<213> Artificial Sequence
<220>
<223> eGFP
<400> 3035
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu
1 5 10 15
Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly
20 25 30
Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile
35 40 45
Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr
50 55 60
Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys
65 70 75 80
Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu
85 90 95
Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu
100 105 110
Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly
115 120 125
Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr
130 135 140
Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn
145 150 155 160
Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser
165 170 175
Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly
180 185 190
Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu
195 200 205
Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe
210 215 220
Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys
225 230 235
<210> 3036
<211> 25
<212> PRT
<213> Artificial Sequence
<220>
<223> (EAAAK)5 linker
<400> 3036
Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu
1 5 10 15
Ala Ala Ala Lys Glu Ala Ala Ala Lys
20 25
<210> 3037
<211> 8
<212> PRT
<213> Artificial Sequence
<220>
<223> FLAG-tag
<400> 3037
Asp Tyr Lys Asp Asp Asp Asp Lys
1 5
<210> 3038
<211> 6
<212> PRT
<213> Artificial Sequence
<220>
<223> 6xHis tag
<400> 3038
His His His His His His
1 5
<210> 3039
<211> 228
<212> PRT
<213> Artificial Sequence
<220>
<223> rabbit Fc
<400> 3039
Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu
1 5 10 15
Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu
20 25 30
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
35 40 45
Glu Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln
50 55 60
Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr
65 70 75 80
Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Glu Asp Trp Leu Arg
85 90 95
Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro
100 105 110
Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys
115 120 125
Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val
130 135 140
Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val
145 150 155 160
Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro
165 170 175
Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser
180 185 190
Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val
195 200 205
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg
210 215 220
Ser Pro Gly Lys
225
<210> 3040
<211> 238
<212> PRT
<213> Artificial Sequence
<220>
<223> mouse Fc2b
<400> 3040
Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys
1 5 10 15
Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val
20 25 30
Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr
35 40 45
Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp
50 55 60
Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln
65 70 75 80
Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser
85 90 95
Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys
100 105 110
Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile
115 120 125
Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro
130 135 140
Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu
145 150 155 160
Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn
165 170 175
Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser
180 185 190
Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys
195 200 205
Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu
210 215 220
Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly
225 230 235
[本発明1001]
IgVドメインもしくはその特異的結合断片、IgCドメインもしくはその特異的結合断片、またはその両方を含むバリアントCD80ポリペプチドであって、
SEQ ID NO:2に記載の位置の番号付けに基づいた35、46、71、7、23、26、30、34、51、55、57、58、65、73、78、79、82、または84に対応する、非改変CD80またはその特異的結合断片の1つまたは複数の位置に、1つまたは複数のアミノ酸改変を含み、
最大14個のアミノ酸改変を含む、
前記バリアントCD80ポリペプチド。
[本発明1002]
IgVドメインもしくはその特異的結合断片、IgCドメインもしくはその特異的結合断片、またはその両方を含むバリアントCD80ポリペプチドであって、
前記バリアントCD80ポリペプチドが、SEQ ID NO:2に記載の位置の番号付けに基づいた35、46、71、7、23、26、30、34、51、55、57、58、65、73、78、79、82、または84に対応する、非改変CD80またはその特異的結合断片の1つまたは複数の位置に、1つまたは複数のアミノ酸改変を含み、
前記IgVドメインまたはその特異的結合断片が、バリアントCD80ポリペプチドの唯一のCD80部分である、
前記バリアントCD80ポリペプチド。
[本発明1003]
SEQ ID NO:2の番号付けに基づいた1つまたは複数の位置26、35、46、57、または71位に対応する1つまたは複数のアミノ酸改変を含む、本発明1001または本発明1002のバリアントCD80ポリペプチド。
[本発明1004]
IgVドメインもしくはその特異的結合断片、IgCドメインもしくはその特異的結合断片、またはその両方を含むバリアントCD80ポリペプチドであって、
非改変CD80またはその特異的結合断片に、SEQ ID NO:2に記載の位置の番号付けに基づいた
に対応する1つまたは複数のアミノ酸改変を含み、
最大14個のアミノ酸改変を含む、
前記バリアントCD80ポリペプチド。
[本発明1005]
IgVドメインもしくはその特異的結合断片、IgCドメインもしくはその特異的結合断片、またはその両方を含むバリアントCD80ポリペプチドであって、
前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片に、SEQ ID NO:2に記載の位置の番号付けに基づいた
に対応するアミノ酸改変を含み、
前記IgVドメインまたはその特異的結合断片が、バリアントCD80ポリペプチドの唯一のCD80部分である、
前記バリアントCD80ポリペプチド。
[本発明1006]
アミノ酸改変A26E、
アミノ酸改変E35D、
アミノ酸改変D46E、
アミノ酸改変D46V、または
アミノ酸改変A71G
を含む、本発明1001~1005のいずれかのバリアントCD80ポリペプチド、
[本発明1007]
アミノ酸改変M47Lを含む、本発明1004または本発明1005のバリアントCD80ポリペプチド。
[本発明1008]
IgVドメインもしくはその特異的結合断片、IgCドメインもしくはその特異的結合断片、またはその両方を含むバリアントCD80ポリペプチドであって、
SEQ ID NO:2に記載の位置の番号付けに基づいた
から選択されるアミノ酸改変を含む、
前記バリアントCD80ポリペプチド。
[本発明1009]
アミノ酸改変
を含む、本発明1001~1008のいずれかのバリアントCD80ポリペプチド。
[本発明1010]
アミノ酸改変E35D/M47I、E35D/M47L、E35D/M47V、またはE35D/V68Mを含む、本発明1004~1009のいずれかのバリアントCD80ポリペプチド。
[本発明1011]
アミノ酸改変E35D/M47L/V68MまたはE35D/M47V/V68Mを含む、本発明1004~1010のいずれかのバリアントCD80ポリペプチド。
[本発明1012]
ヒトPD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、ヒトPD-L1のエクトドメインに対して増加した結合親和性を示す、本発明1001~1011のいずれかのバリアントCD80ポリペプチド。
[本発明1013]
前記親和性が、前記PD-L1のエクトドメインへの前記非改変CD80の結合親和性と比較して1.2倍、1.5倍、2倍、3倍、4倍、5倍、6倍、7倍、8倍、9倍、10倍、20倍、30倍、40倍、50倍、60倍、80倍、100倍、150倍、200倍、250倍、300倍、400倍、または450倍より多く増加する、本発明1012のバリアントCD80ポリペプチド。
[本発明1014]
SEQ ID NO:2に記載の位置の番号付けに基づいたアミノ酸改変
を含む、本発明1004~1013のいずれかのバリアントCD80ポリペプチド。
[本発明1015]
前記アミノ酸改変が、E35D/M47I/L70Mを含む、本発明1004~1009及び1011~1013のいずれかのバリアントCD80ポリペプチド。
[本発明1016]
前記アミノ酸改変が、E35D/M47V/N48K/V68M/K89Nを含む、本発明1004~1013のいずれかのバリアントCD80ポリペプチド。
[本発明1017]
前記アミノ酸改変が、H18Y/A26E/E35D/M47L/V68M/A71G/D90Gを含む、本発明1004~1013のいずれかのバリアントCD80ポリペプチド。
[本発明1018]
前記アミノ酸改変が、E35D/D46E/M47V/V68M/D90G/K93Eを含む、本発明1004~1013のいずれかのバリアントCD80ポリペプチド。
[本発明1019]
前記アミノ酸改変が、E35D/D46V/M47L/V68M/L85Q/E88Dを含む、本発明1004~1013のいずれかのバリアントCD80ポリペプチド。
[本発明1020]
前記非改変CD80が、(i)SEQ ID NO:2に記載のアミノ酸の配列を含むか、(ii)SEQ ID NO:2に対して少なくとも95%の配列同一性を有するアミノ酸の配列を含むか、または(iii)IgVドメインもしくはその特異的結合断片を含む(i)もしくは(ii)の一部分である、本発明1001~1019のいずれかのバリアントCD80ポリペプチド。
[本発明1021]
前記IgVドメインもしくはその特異的結合断片であるか、またはそれを含む、本発明1001~1019のいずれかのバリアントCD80ポリペプチド。
[本発明1022]
前記IgVドメインまたはその特異的結合断片が、前記バリアントCD80ポリペプチドの唯一のCD80部分である、本発明1001~1021のいずれかのバリアントCD80ポリペプチド。
[本発明1023]
最大1、2、3、4、5、6、7、8、9、10、11、12、または13個のアミノ酸改変を含む、本発明1001~1022のいずれかのバリアントCD80ポリペプチド。
[本発明1024]
SEQ ID NO:3~75、2009~2104、2297~2507、または2930~2960のいずれかに記載のアミノ酸の配列もしくはその特異的結合断片、またはSEQ ID NO:3~75、2009~2104、2297~2507、または2930~2960のいずれかに対して少なくとも95%の配列同一性を示し、かつ1つまたは複数のそれらのアミノ酸改変を含有する、アミノ酸の配列もしくはその特異的結合断片、または
SEQ ID NO:77~149、151~223、2105~2296、2508~2929、もしくは2961~3022のいずれかに記載のアミノ酸の配列もしくはその特異的結合断片、SEQ ID NO:77~149、151~223、2105~2296、2508~2929、もしくは2961~3022のいずれかに対して少なくとも95%の配列同一性を示し、かつ1つまたは複数のそれらのアミノ酸改変を含有する、アミノ酸の配列もしくはその特異的結合断片
を含む、本発明1001~1023のいずれかのバリアントCD80ポリペプチド。
[本発明1025]
SEQ ID NO:199、208、2250、2276、2280、または2284のいずれかに記載のアミノ酸の配列を含む、本発明1001~1024のいずれかのバリアントCD80ポリペプチド。
[本発明1026]
CD80膜貫通ドメイン及び細胞内シグナル伝達ドメインを欠き、かつ/または
細胞表面に発現することができない、
実施形態1001~1025のいずれかのバリアントCD80ポリペプチド。
[本発明1027]
前記ポリペプチドの生物学的半減期を延長する部分に連結された、本発明1001~1026のいずれかのバリアントCD80ポリペプチド。
[本発明1028]
多量体化ドメインに連結された、本発明1001~1027のいずれかのバリアントCD80ポリペプチド。
[本発明1029]
前記多量体化ドメインが、Fcドメインであるか、または低下したエフェクター機能を有するバリアントFcドメインである、本発明1028のバリアントCD80ポリペプチド。
[本発明1030]
膜貫通ドメイン及び/または細胞質シグナル伝達ドメインをさらに含む、膜貫通型免疫調節タンパク質である本発明1001~1029のいずれかのバリアントCD80ポリペプチド。
[本発明1031]
第1の多量体化ドメインに連結された本発明1001~1029のいずれかの第1のバリアントCD80ポリペプチド及び第2の多量体化ドメインに連結された本発明1001~1029のいずれかの第2のバリアントCD80ポリペプチドを含む多量体であり、前記第1及び第2の多量体化ドメインが、相互作用して第1及び第2のバリアントCD80ポリペプチドを含む多量体を形成する、免疫調節タンパク質。
[本発明1032]
前記多量体が、二量体、任意でホモ二量体である、本発明1031の免疫調節タンパク質。
[本発明1033]
前記第1のバリアントCD80ポリペプチド及び第2のバリアントCD80ポリペプチドが同一である、本発明1031または本発明1032の免疫調節タンパク質。
[本発明1034]
前記多量体化ドメインが、免疫グロブリンのFc領域であるかまたはそれを含み、任意で、前記免疫グロブリンタンパク質がヒトである、及び/または前記Fc領域がヒトである、本発明1031~1033のいずれかの免疫調節タンパク質。
[本発明1035]
前記Fc領域が、免疫グロブリンG1(IgG1)または免疫グロブリンG2(IgG2)タンパク質のものである、本発明1034の免疫調節タンパク質。
[本発明1036]
前記Fc領域が、1つまたは複数のエフェクター機能を示す、本発明1034または本発明1035の免疫調節タンパク質。
[本発明1037]
Fc依存性CD28共刺激を示す、本発明1031~1036のいずれかの免疫調節タンパク質。
[本発明1038]
前記Fc領域が、野生型Fc領域に1つまたは複数のアミノ酸置換を含むバリアントFc領域であり、前記バリアントFc領域が、前記野生型Fc領域と比較して低下した1つまたは複数のエフェクター機能を示し、任意で、野生型ヒトFcがヒトIgG1のものである、本発明1031~1034のいずれかの免疫調節タンパク質。
[本発明1039]
前記Fc領域が、アミノ酸置換N297Gを含み、前記残基が、KabatのEUインデックスに従って番号付けされる、本発明1038の免疫調節タンパク質。
[本発明1040]
前記Fc領域が、アミノ酸置換R292C/N297G/V302Cを含み、前記残基が、KabatのEUインデックスに従って番号付けされる、本発明1038の免疫調節タンパク質。
[本発明1041]
前記Fc領域が、アミノ酸置換L234A/L235E/G237Aを含み、前記残基が、KabatのEUインデックスに従って番号付けされる、本発明1038の免疫調節タンパク質。
[本発明1042]
前記バリアントFc領域が、アミノ酸置換C220Sをさらに含み、前記残基が、KabatのEUインデックスに従って番号付けされる、本発明1039~1041のいずれかの免疫調節タンパク質。
[本発明1043]
前記Fc領域が、K447delを含み、前記残基が、KabatのEUインデックスに従って番号付けされる、本発明1038~1042のいずれかの免疫調節タンパク質。
[本発明1044]
本発明1012~1029のいずれかのバリアントCD80ポリペプチドを含む、本発明1038~1043のいずれかの免疫調節タンパク質。
[本発明1045]
PD-L1依存性CD28共刺激を示す、本発明1038~1044のいずれかの免疫調節タンパク質。
[本発明1046]
免疫グロブリンスーパーファミリー(IgSF)メンバーのIgSFドメインを含む第2のポリペプチドに直接的またはリンカーを介して間接的に連結された本発明1001~1029のいずれかのバリアントCD80ポリペプチドを含む、免疫調節タンパク質。
[本発明1047]
前記IgSFドメインが、親和性改変IgSFドメインであり、前記親和性改変IgSFドメインが、前記IgSFファミリーメンバーの非改変または野生型IgSFドメインと比較して1つまたは複数のアミノ酸改変を含む、本発明1046の免疫調節タンパク質。
[本発明1048]
前記IgSFドメインが、前記IgSFファミリーメンバーの非改変または野生型IgSFドメインの同一の1つまたは複数のコグネイト結合パートナー(複数可)への結合と比較して、1つまたは複数のそのコグネイト結合パートナー(複数可)への増加した結合を示す親和性改変IgSFドメインである、本発明1047の免疫調節タンパク質。
[本発明1049]
細胞表面の分子に特異的に結合するターゲティング部分に連結された本発明1001~1029のいずれかのバリアントCD80ポリペプチドを含む、コンジュゲート。
[本発明1050]
前記細胞が、免疫細胞または腫瘍細胞である、本発明1049のコンジュゲート。
[本発明1051]
前記部分が、タンパク質、ペプチド、核酸、小分子またはナノ粒子である、本発明1049または本発明1050のコンジュゲート。
[本発明1052]
前記部分が、抗体または抗原結合断片である、本発明1049~1051のいずれかのコンジュゲート。
[本発明1053]
融合タンパク質である、本発明1050~1052のいずれかのコンジュゲート。
[本発明1054]
本発明1001~1030のいずれかのバリアントCD80ポリペプチド、本発明1031~1048のいずれかの免疫調節タンパク質、または本発明1049~1053のいずれかの融合タンパク質であるコンジュゲート、をコードする核酸分子。
[本発明1055]
本発明1054の核酸分子を含む、ベクター。
[本発明1056]
発現ベクターである、本発明1055のベクター。
[本発明1057]
本発明1055または本発明1056のベクターを含む、細胞。
[本発明1058]
バリアントCD80ポリペプチドまたは免疫調節タンパク質の産生方法であって、本発明1054の核酸分子または本発明1055もしくは本発明1056のベクターを宿主細胞に、前記細胞内で前記タンパク質を発現する条件下で導入することを含む、前記産生方法。
[本発明1059]
前記細胞からバリアントCD80ポリペプチドまたは免疫調節タンパク質を単離または精製することをさらに含む、本発明1058の方法。
[本発明1060]
バリアントCD80バリアントポリペプチドを発現する細胞を操作する方法であって、実施形態1001~1030のいずれかのバリアントCD80ポリペプチドをコードする核酸分子を宿主細胞に、前記ポリペプチドが前記細胞内で発現される条件下で導入することを含む、前記方法。
[本発明1061]
本発明1001~1030のいずれかのバリアントCD80ポリペプチド、本発明1031~1048のいずれかの免疫調節タンパク質、本発明1049~1053のいずれかの融合タンパク質であるコンジュゲート、本発明1054の核酸分子、または本発明1055もしくは1056のベクターを含む、操作された細胞。
[本発明1062]
前記バリアントCD80ポリペプチドが、膜貫通ドメインを含まない、及び/または前記細胞の表面に発現しない;及び/または
前記バリアントCD80ポリペプチドが、発現した際に前記操作された細胞から分泌されることができる、
本発明1061の操作された細胞。
[本発明1063]
前記バリアントCD80ポリペプチドが、膜貫通ドメインを含むか、本発明1029の膜貫通型免疫調節タンパク質であり;及び/または
前記バリアントCD80ポリペプチドが、前記細胞の表面に発現する、
本発明1061の操作された細胞。
[本発明1064]
前記細胞が免疫細胞であり、任意で抗原提示細胞(APC)またはリンパ球、任意でT細胞である、本発明1061~1063のいずれかの操作された細胞。
[本発明1065]
キメラ抗原受容体(CAR)または操作されたT細胞受容体(TCR)をさらに含む、本発明1061~1064のいずれかの操作された細胞。
[本発明1066]
実施形態1001~1030のいずれかのバリアントCD80ポリペプチド、実施形態1031~1047のいずれかの免疫調節タンパク質、または実施形態1048~1052のいずれかの融合タンパク質であるコンジュゲート、をコードする核酸分子を含む、感染性物質。
[本発明1067]
細菌またはウイルスである、本発明1066の感染性物質。
[本発明1068]
前記感染性物質がウイルスであり、前記ウイルスが腫瘍溶解性ウイルスである、本発明1067の感染性物質。
[本発明1069]
本発明1001~1030のいずれかのバリアントCD80ポリペプチド、本発明1031~1048のいずれかの免疫調節タンパク質、本発明1049~1053のいずれかのコンジュゲート、本発明1061~1065のいずれかの操作された細胞、または本発明1066~1068のいずれかの感染性物質を含む、薬学的組成物。
[本発明1070]
薬学的に許容し得る賦形剤を含む、本発明1069の薬学的組成物。
[本発明1071]
前記薬学的組成物が無菌である、本発明1069または本発明1070の薬学的組成物。
[本発明1072]
バイアル内に本発明1069~1071のいずれかの薬学的組成物を含む製造物品。
[本発明1073]
前記バイアルが密封された、本発明1072の製造物品。
[本発明1074]
本発明1069~1071のいずれかの薬学的組成物、または本発明1072もしくは本発明1073の製造物品、及び使用説明書を含む、キット。
[本発明1075]
本発明1069~1071のいずれかの薬学的組成物を投与することを含む、対象において免疫応答を調節する方法。
[本発明1076]
本発明1031~1048のいずれかの免疫調節タンパク質を投与することを含む、対象において免疫応答を調節する方法。
[本発明1077]
前記免疫調節タンパク質が、Fc依存性CD28共刺激を示す本発明1037の免疫調節タンパク質である、本発明1076の方法。
[本発明1078]
前記免疫調節タンパク質が、PD-L1依存性CD28共刺激を示す本発明1044の免疫調節タンパク質であり、任意で前記免疫調節タンパク質が、本発明1012~1029のいずれかのバリアントCD80ポリペプチドを含む、本発明1074の方法。
[本発明1079]
本発明1061~1065のいずれかの操作された細胞を投与することを含む、対象において免疫応答を調節する方法。
[本発明1080]
前記操作された細胞が、前記対象に対して自家である、本発明1079の方法。
[本発明1081]
前記免疫応答を調節することにより、前記対象の疾患または状態を治療する、本発明1075~1080のいずれかの方法。
[本発明1082]
前記免疫応答が増加される、本発明1075~1081のいずれかの方法。
[本発明1083]
バリアントCD80ポリペプチドを含む免疫調節タンパク質を投与することを含む、対象において免疫応答を増加させる方法であって、前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、前記免疫調節タンパク質が、PD-L1依存性CD28共刺激を示す、前記方法。
[本発明1084]
前記バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、PD-L1のエクトドメインに対して増加した結合親和性を示す、本発明1083の方法。
[本発明1085]
バリアントCD80ポリペプチドを含む免疫調節タンパク質を投与することを含む、対象においてPD-L1依存性CD28共刺激によりCD28作動作用を媒介する方法であって、前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、前記バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、
PD-L1のエクトドメインに対して増加した結合親和性を示す、前記方法。
[本発明1086]
疾患または状態の治療に使用するためのものである、本発明1083~1085のいずれかの方法。
[本発明1087]
前記投与の前に、表面PD-L1に陽性の細胞を含む腫瘍を有する治療対象を選択し、任意で、前記細胞が腫瘍細胞もしくは腫瘍浸潤免疫細胞である;または
前記対象がPD-L1に陽性の細胞表面を含む腫瘍を有するものとして選択され、任意で、前記細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、
本発明1075~1086のいずれかの方法。
[本発明1088]
対象の選択が、
(a)対象由来の腫瘍組織試料を、PD-L1のエクトドメインに特異的に結合することができる結合試薬と接触させることと、
(b)前記腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で前記細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、前記検出することと、
(c)前記腫瘍組織試料が検出可能レベルのPD-L1に陽性の細胞表面を含む場合に、治療のために前記対象を選択することと
を含む、本発明1087の方法。
[本発明1089]
前記投与の前に、CD28に陽性の細胞表面を含む腫瘍を有する治療対象を選択し、任意で前記細胞が腫瘍浸潤リンパ球であり、任意で前記リンパ球がT細胞、任意でCD8+T細胞である;または
前記対象が、CD28に陽性の細胞表面を含む腫瘍を有するものとして選択され、任意で前記細胞が腫瘍浸潤リンパ球であり、任意で前記リンパ球がT細胞、任意でCD8+T細胞である、
本発明1075~1088のいずれかの方法。
[本発明1090]
前記対象の選択が、
(a)対象由来の腫瘍組織試料を、CD28のエクトドメインに特異的に結合することができる結合試薬と接触させることと、
(b)前記腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で前記細胞が腫瘍浸潤リンパ球であり、任意で前記リンパ球がT細胞、任意でCD8+T細胞である、前記検出することと、
(c)前記腫瘍組織試料が検出可能レベルのCD28に陽性の細胞表面を含む場合に、治療のために前記対象を選択することと
を含む、本発明1089の方法。
[本発明1091]
(a)対象由来の腫瘍組織試料を、PD-L1に特異的に結合することができる結合試薬と接触させることと、
(b)前記腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で前記細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、前記検出することと、
(c)前記腫瘍試料が検出可能レベルのPD-L1に陽性の細胞表面を含む場合、バリアントCD80ポリペプチドを含む免疫調節タンパク質による治療のための対象を選択することであって、前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、前記バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、PD-L1のエクトドメインに対して増加した結合親和性を示す、前記選択することと
を含む、治療対象を選択する方法。
[本発明1092]
前記腫瘍組織試料を、CD28に特異的に結合することができる結合試薬と接触させることを含み、前記腫瘍組織試料が、検出可能レベルのCD28に陽性の腫瘍浸潤リンパ球をさらに含む場合に、前記対象が選択され、任意で前記リンパ球がT細胞、任意でCD8+T細胞である、本発明1091の方法。
[本発明1093]
前記腫瘍組織試料が、腫瘍浸潤免疫細胞、腫瘍細胞、間質細胞、またはそれらの任意の組み合わせを含む、本発明1088及び1090~1092のいずれかの方法。
[本発明1094]
前記結合試薬が、抗体もしくは抗原結合断片、タンパク質リガンドもしくは結合パートナー、アプタマー、アフィマー、ペプチド、またはハプテンである、本発明1088及び1090~1093の方法。
[本発明1095]
前記結合試薬が、抗PD-L1抗体または抗原結合断片である、本発明1088、1091、1093または1094の方法。
[本発明1096]
前記結合試薬が、本発明1001~1030のいずれかのバリアントCD80ポリペプチドを含む、本発明1088~1094のいずれかの方法。
[本発明1097]
前記バリアントCD80ポリペプチドが、前記IgVドメインまたはその特異的結合断片を含む、本発明1096の方法。
[本発明1098]
前記IgVドメインまたはその特異的結合断片が、前記結合試薬の唯一のCD80部分である本発明1096または1097の方法。
[本発明1099]
前記バリアントCD80ポリペプチドが、前記野生型または非改変CD80ポリペプチドと比較してPD-L1への結合に対する増加した親和性を示す、本発明1096~1098のいずれかの方法。
[本発明1100]
前記結合試薬が、検出可能部分または検出することのできる部分である部分に直接または間接的に連結される、本発明1088及び1090~1099のいずれかの方法。
[本発明1101]
前記部分がFc領域である、本発明1100の方法。
[本発明1102]
前記Fc領域が非ヒト、任意でマウスまたはウサギである、本発明1101の方法。
[本発明1103]
結合した結合試薬の存在の検出が、免疫組織化学、偽免疫組織化学、免疫蛍光、フローサイトメトリー、ELISA、または免疫ブロッティングによる、本発明1088及び1090~1102のいずれかの方法。
[本発明1104]
前記免疫調節タンパク質を前記対象に投与することをさらに含む、本発明1091~1103のいずれかの方法。
[本発明1105]
前記免疫調節タンパク質が、第1の多量体化ドメインに連結された第1のバリアントCD80ポリペプチド及び第2の多量体化ドメインに連結された第2のバリアントCD80ポリペプチドを含む多量体であり、前記第1及び第2の多量体化ドメインが、相互作用して前記第1及び第2のバリアントCD80ポリペプチドを含む多量体を形成する、本発明1083~1104のいずれかの方法。
[本発明1106]
前記多量体が二量体である、本発明1105の方法。
[本発明1107]
前記第1のバリアントCD80ポリペプチド及び前記第2のバリアントCD80ポリペプチドが同一である、本発明1105または本発明1106の方法。
[本発明1108]
前記多量体化ドメインが、Fc領域であるか、またはそれを含む、本発明1105~1107のいずれかの方法。
[本発明1109]
前記Fc領域が、野生型Fc領域と比較して1つまたは複数のアミノ酸置換を含むバリアントFc領域であり、前記Fc領域が、前記野生型Fc領域と比較して低下した1つまたは複数のエフェクター機能を示し、任意で前記野生型Fcが、ヒトIgG1である、本発明1108の方法。
[本発明1110]
前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片に、SEQ ID NO:2に記載の位置の番号付けに基づいた7、12、13、15、16、18、21、20、22、23、24、25、26、27、28、29、30、31、33、34、35、36、37、38、41、42、43、44、46、47、48、51、53、54、55、57、58、61、62、63、64、65、67、68、69、70、71、72、73、74、76、77、78、79、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、及び/または97に対応する1つまたは複数のアミノ酸改変を含む、本発明1083~1109のいずれかの方法。
[本発明1111]
前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片に、SEQ ID NO:2に記載の位置の番号付けに基づいた
に対応する1つまたは複数のアミノ酸改変を含む、本発明1083~1110のいずれかの方法。
[本発明1112]
前記バリアントCD80ポリペプチドが、1つまたは複数の位置13、18、21、22、24、26、27、33、35、37、38、41、43、46、47、48、53、61、62、68、70、71、79、85、87、88、90、91、93、94、95または97位に対応する1つまたは複数のアミノ酸改変を含み、任意で前記1つまたは複数のアミノ酸改変が、SEQ ID NO:2の番号付けに基づいた
から選択される、本発明1083~1110のいずれかの方法。
[本発明1113]
前記1つまたは複数のアミノ酸改変が、SEQ ID NO:2に記載の位置の番号付けに基づいた
から選択される、本発明1083~1112のいずれかの方法。
[本発明1114]
前記バリアントCD80ポリペプチドが、
アミノ酸改変H18Y、
アミノ酸改変A26E、
アミノ酸改変E35D、
アミノ酸改変D46E、
アミノ酸改変D46V、
アミノ酸改変M47I、
アミノ酸改変M47L、
アミノ酸改変V68M、
アミノ酸改変A71G、
アミノ酸改変L85Q、または
アミノ酸改変D90G
を含む、本発明1083~1113のいずれかの方法。
[本発明1115]
前記バリアントCD80ポリペプチドが、アミノ酸改変
を含む、本発明1083~1114のいずれかの方法。
[本発明1116]
前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/M47I、E35D/M47L、E35D/M47V、またはE35D/V68Mを含む、本発明1083~1115のいずれかの方法。
[本発明1117]
前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/M47L/V68MまたはE35D/M47V/V68Mを含む、本発明1083~1116のいずれかの方法。
[本発明1118]
前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/M47I/L70Mを含む、本発明1083~1116のいずれかの方法。
[本発明1119]
前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/M47V/N48K/V68M/K89Nを含む、本発明1083~1117のいずれかの方法。
[本発明1120]
前記バリアントCD80ポリペプチドが、アミノ酸改変H18Y/A26E/E35D/M47L/V68M/A71G/D90Gを含む、本発明1083~1117のいずれかの方法。
[本発明1121]
前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/D46E/M47V/V68M/D90G/K93Eを含む、本発明1083~1117のいずれかの方法。
[本発明1122]
前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/D46V/M47L/V68M/L85Q/E88Dを含む、本発明1083~1117のいずれかの方法。
[本発明1123]
前記免疫調節タンパク質が可溶性であり、任意で、前記バリアントCD80ポリペプチドが、CD80膜貫通ドメイン及び細胞内シグナル伝達ドメインを欠く、本発明1083~1122のいずれかの方法。
[本発明1124]
前記非改変CD80が、(i)SEQ ID NO:2に記載のアミノ酸の配列を含むか、(ii)SEQ ID NO:2に対して少なくとも95%の配列同一性を有するアミノ酸の配列を含むか、または(iii)IgVドメインもしくはその特異的結合断片を含む(i)もしくは(ii)の一部分である、本発明1083~1123のいずれかの方法。
[本発明1125]
前記バリアントCD80ポリペプチドが、IgVドメインもしくはその特異的結合断片であるか、またはそれを含む、本発明1083~1124のいずれかの方法。
[本発明1126]
前記IgVドメインまたはその特異的結合断片が、前記免疫調節タンパク質の唯一のCD80部分である、本発明1083~1125のいずれかの方法。
[本発明1127]
前記バリアントCD80ポリペプチドが、最大1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19または20個のアミノ酸改変を含む、本発明1083~1126のいずれかの方法。
[本発明1128]
前記免疫調節タンパク質がFc融合タンパク質である、本発明1083~1127のいずれかの方法。
[本発明1129]
前記疾患または状態が、腫瘍またはがんである、本発明1081、1082、及び1086~1128のいずれかの方法。
[本発明1130]
前記対象が、PD-1/PD-L1またはPD-1/PD-L2の拮抗物質による治療後、寛解後に再発したか、不応性になったか、またはノンレスポンダーである、本発明1075~1129のいずれかの方法。
[本発明1131]
前記拮抗物質が抗PD-1抗体、任意でニボルマブまたはペンブロリズマブである、本発明1130の方法。
[本発明1132]
前記免疫応答が減少される、本発明1075~1081のいずれかの方法。
[本発明1133]
前記疾患または状態が、炎症性または自己免疫性疾患または状態である、本発明1075~1081及び1132のいずれかの方法。
[本発明1134]
生体試料中のCD80結合パートナーを検出する方法であって、
(a)生体試料を、本発明1001~1030のいずれかのバリアントCD80ポリペプチドを含む結合試薬と接触させることと、
(b)前記生体試料の細胞内または細胞上に結合した前記結合試薬の存在を検出することと
を含む、前記方法。
[本発明1135]
前記結合パートナーが、PD-L1、CD28、CTLA-4またはこれらの組み合わせである、本発明1134の方法。
[本発明1136]
前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、前記バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較してPD-L1のエクトドメインに対して増加した結合親和性を示す、本発明1134または本発明1135の方法。
[本発明1137]
前記生体試料が、体液、細胞、もしくは組織試料であるか、またはそれを含む、本発明1134~1136のいずれかの方法。
[本発明1138]
前記体液が、血清、血漿、または尿である、本発明1137の方法。
[本発明1139]
前記組織試料が、腫瘍組織試料である、本発明1137の方法。
[本発明1140]
前記腫瘍組織試料が、腫瘍浸潤免疫細胞、腫瘍細胞、間質細胞、またはそれらの任意の組み合わせを含む、本発明1139の方法。
[本発明1141]
前記IgVドメインまたはその特異的結合断片を含む、本発明1134~1140のいずれかのバリアントCD80ポリペプチド。
[本発明1142]
前記IgVドメインまたはその特異的結合断片が、前記結合試薬の唯一のCD80部分である、本発明1141の方法。
[本発明1143]
前記結合試薬が、検出可能部分である標識にまたは検出することのできる部分に直接または間接的に連結される、本発明1134~1142のいずれかの方法。
[本発明1144]
前記部分がFc領域である、本発明1143の方法。
[本発明1145]
前記Fc領域が非ヒト、任意でマウスまたはウサギである、本発明1144の方法。
[本発明1146]
結合した結合試薬の存在の検出が、免疫組織化学、偽免疫組織化学、免疫蛍光、フローサイトメトリー、ELISA、または免疫ブロッティングによる、本発明1134~1145のいずれかの方法。
Claims (146)
- IgVドメインもしくはその特異的結合断片、IgCドメインもしくはその特異的結合断片、またはその両方を含むバリアントCD80ポリペプチドであって、
SEQ ID NO:2に記載の位置の番号付けに基づいた35、46、71、7、23、26、30、34、51、55、57、58、65、73、78、79、82、または84に対応する、非改変CD80またはその特異的結合断片の1つまたは複数の位置に、1つまたは複数のアミノ酸改変を含み、
最大14個のアミノ酸改変を含む、
前記バリアントCD80ポリペプチド。 - IgVドメインもしくはその特異的結合断片、IgCドメインもしくはその特異的結合断片、またはその両方を含むバリアントCD80ポリペプチドであって、
前記バリアントCD80ポリペプチドが、SEQ ID NO:2に記載の位置の番号付けに基づいた35、46、71、7、23、26、30、34、51、55、57、58、65、73、78、79、82、または84に対応する、非改変CD80またはその特異的結合断片の1つまたは複数の位置に、1つまたは複数のアミノ酸改変を含み、
前記IgVドメインまたはその特異的結合断片が、バリアントCD80ポリペプチドの唯一のCD80部分である、
前記バリアントCD80ポリペプチド。 - SEQ ID NO:2の番号付けに基づいた1つまたは複数の位置26、35、46、57、または71位に対応する1つまたは複数のアミノ酸改変を含む、請求項1または請求項2に記載のバリアントCD80ポリペプチド。
- アミノ酸改変A26E、
アミノ酸改変E35D、
アミノ酸改変D46E、
アミノ酸改変D46V、または
アミノ酸改変A71G
を含む、請求項1~5のいずれか1項に記載のバリアントCD80ポリペプチド、 - アミノ酸改変M47Lを含む、請求項4または請求項5に記載のバリアントCD80ポリペプチド。
- アミノ酸改変E35D/M47I、E35D/M47L、E35D/M47V、またはE35D/V68Mを含む、請求項4~9のいずれか1項に記載のバリアントCD80ポリペプチド。
- アミノ酸改変E35D/M47L/V68MまたはE35D/M47V/V68Mを含む、請求項4~10のいずれか1項に記載のバリアントCD80ポリペプチド。
- ヒトPD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、ヒトPD-L1のエクトドメインに対して増加した結合親和性を示す、請求項1~11のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記親和性が、前記PD-L1のエクトドメインへの前記非改変CD80の結合親和性と比較して1.2倍、1.5倍、2倍、3倍、4倍、5倍、6倍、7倍、8倍、9倍、10倍、20倍、30倍、40倍、50倍、60倍、80倍、100倍、150倍、200倍、250倍、300倍、400倍、または450倍より多く増加する、請求項12に記載のバリアントCD80ポリペプチド。
- 前記アミノ酸改変が、E35D/M47I/L70Mを含む、請求項4~9及び11~13のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記アミノ酸改変が、E35D/M47V/N48K/V68M/K89Nを含む、請求項4~13のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記アミノ酸改変が、H18Y/A26E/E35D/M47L/V68M/A71G/D90Gを含む、請求項4~13のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記アミノ酸改変が、E35D/D46E/M47V/V68M/D90G/K93Eを含む、請求項4~13のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記アミノ酸改変が、E35D/D46V/M47L/V68M/L85Q/E88Dを含む、請求項4~13のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記非改変CD80が、(i)SEQ ID NO:2に記載のアミノ酸の配列を含むか、(ii)SEQ ID NO:2に対して少なくとも95%の配列同一性を有するアミノ酸の配列を含むか、または(iii)IgVドメインもしくはその特異的結合断片を含む(i)もしくは(ii)の一部分である、請求項1~19のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記IgVドメインもしくはその特異的結合断片であるか、またはそれを含む、請求項1~19のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記IgVドメインまたはその特異的結合断片が、前記バリアントCD80ポリペプチドの唯一のCD80部分である、請求項1~21のいずれか1項に記載のバリアントCD80ポリペプチド。
- 最大1、2、3、4、5、6、7、8、9、10、11、12、または13個のアミノ酸改変を含む、請求項1~22のいずれか1項に記載のバリアントCD80ポリペプチド。
- SEQ ID NO:3~75、2009~2104、2297~2507、または2930~2960のいずれかに記載のアミノ酸の配列もしくはその特異的結合断片、またはSEQ ID NO:3~75、2009~2104、2297~2507、または2930~2960のいずれかに対して少なくとも95%の配列同一性を示し、かつ1つまたは複数のそれらのアミノ酸改変を含有する、アミノ酸の配列もしくはその特異的結合断片、または
SEQ ID NO:77~149、151~223、2105~2296、2508~2929、もしくは2961~3022のいずれかに記載のアミノ酸の配列もしくはその特異的結合断片、SEQ ID NO:77~149、151~223、2105~2296、2508~2929、もしくは2961~3022のいずれかに対して少なくとも95%の配列同一性を示し、かつ1つまたは複数のそれらのアミノ酸改変を含有する、アミノ酸の配列もしくはその特異的結合断片
を含む、請求項1~23のいずれか1項に記載のバリアントCD80ポリペプチド。 - SEQ ID NO:199、208、2250、2276、2280、または2284のいずれかに記載のアミノ酸の配列を含む、請求項1~24のいずれか1項に記載のバリアントCD80ポリペプチド。
- CD80膜貫通ドメイン及び細胞内シグナル伝達ドメインを欠き、かつ/または
細胞表面に発現することができない、
実施形態1~25のいずれかに記載のバリアントCD80ポリペプチド。 - 前記ポリペプチドの生物学的半減期を延長する部分に連結された、請求項1~26のいずれか1項に記載のバリアントCD80ポリペプチド。
- 多量体化ドメインに連結された、請求項1~27のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記多量体化ドメインが、Fcドメインであるか、または低下したエフェクター機能を有するバリアントFcドメインである、請求項28に記載のバリアントCD80ポリペプチド。
- 膜貫通ドメイン及び/または細胞質シグナル伝達ドメインをさらに含む、膜貫通型免疫調節タンパク質である請求項1~29のいずれか1項に記載のバリアントCD80ポリペプチド。
- 第1の多量体化ドメインに連結された請求項1~29のいずれか1項に記載の第1のバリアントCD80ポリペプチド及び第2の多量体化ドメインに連結された請求項1~29のいずれか1項に記載の第2のバリアントCD80ポリペプチドを含む多量体であり、前記第1及び第2の多量体化ドメインが、相互作用して第1及び第2のバリアントCD80ポリペプチドを含む多量体を形成する、免疫調節タンパク質。
- 前記多量体が、二量体、任意でホモ二量体である、請求項31に記載の免疫調節タンパク質。
- 前記第1のバリアントCD80ポリペプチド及び第2のバリアントCD80ポリペプチドが同一である、請求項31または請求項32に記載の免疫調節タンパク質。
- 前記多量体化ドメインが、免疫グロブリンのFc領域であるかまたはそれを含み、任意で、前記免疫グロブリンタンパク質がヒトである、及び/または前記Fc領域がヒトである、請求項31~33のいずれか1項に記載の免疫調節タンパク質。
- 前記Fc領域が、免疫グロブリンG1(IgG1)または免疫グロブリンG2(IgG2)タンパク質のものである、請求項34に記載の免疫調節タンパク質。
- 前記Fc領域が、1つまたは複数のエフェクター機能を示す、請求項34または請求項35に記載の免疫調節タンパク質。
- Fc依存性CD28共刺激を示す、請求項31~36のいずれか1項に記載の免疫調節タンパク質。
- 前記Fc領域が、野生型Fc領域に1つまたは複数のアミノ酸置換を含むバリアントFc領域であり、前記バリアントFc領域が、前記野生型Fc領域と比較して低下した1つまたは複数のエフェクター機能を示し、任意で、野生型ヒトFcがヒトIgG1のものである、請求項31~34のいずれか1項に記載の免疫調節タンパク質。
- 前記Fc領域が、アミノ酸置換N297Gを含み、前記残基が、KabatのEUインデックスに従って番号付けされる、請求項38に記載の免疫調節タンパク質。
- 前記Fc領域が、アミノ酸置換R292C/N297G/V302Cを含み、前記残基が、KabatのEUインデックスに従って番号付けされる、請求項38に記載の免疫調節タンパク質。
- 前記Fc領域が、アミノ酸置換L234A/L235E/G237Aを含み、前記残基が、KabatのEUインデックスに従って番号付けされる、請求項38に記載の免疫調節タンパク質。
- 前記バリアントFc領域が、アミノ酸置換C220Sをさらに含み、前記残基が、KabatのEUインデックスに従って番号付けされる、請求項39~41のいずれか1項に記載の免疫調節タンパク質。
- 前記Fc領域が、K447delを含み、前記残基が、KabatのEUインデックスに従って番号付けされる、請求項38~42のいずれか1項に記載の免疫調節タンパク質。
- 請求項12~29のいずれか1項に記載のバリアントCD80ポリペプチドを含む、請求項38~43のいずれか1項に記載の免疫調節タンパク質。
- PD-L1依存性CD28共刺激を示す、請求項38~44のいずれか1項に記載の免疫調節タンパク質。
- 免疫グロブリンスーパーファミリー(IgSF)メンバーのIgSFドメインを含む第2のポリペプチドに直接的またはリンカーを介して間接的に連結された請求項1~29のいずれか1項に記載のバリアントCD80ポリペプチドを含む、免疫調節タンパク質。
- 前記IgSFドメインが、親和性改変IgSFドメインであり、前記親和性改変IgSFドメインが、前記IgSFファミリーメンバーの非改変または野生型IgSFドメインと比較して1つまたは複数のアミノ酸改変を含む、請求項46に記載の免疫調節タンパク質。
- 前記IgSFドメインが、前記IgSFファミリーメンバーの非改変または野生型IgSFドメインの同一の1つまたは複数のコグネイト結合パートナー(複数可)への結合と比較して、1つまたは複数のそのコグネイト結合パートナー(複数可)への増加した結合を示す親和性改変IgSFドメインである、請求項47に記載の免疫調節タンパク質。
- 細胞表面の分子に特異的に結合するターゲティング部分に連結された請求項1~29のいずれか1項に記載のバリアントCD80ポリペプチドを含む、コンジュゲート。
- 前記細胞が、免疫細胞または腫瘍細胞である、請求項49に記載のコンジュゲート。
- 前記部分が、タンパク質、ペプチド、核酸、小分子またはナノ粒子である、請求項49または請求項50に記載のコンジュゲート。
- 前記部分が、抗体または抗原結合断片である、請求項49~51のいずれか1項に記載のコンジュゲート。
- 融合タンパク質である、請求項50~52のいずれか1項に記載のコンジュゲート。
- 請求項1~30のいずれか1項に記載のバリアントCD80ポリペプチド、請求項31~48のいずれか1項に記載の免疫調節タンパク質、または請求項49~53のいずれか1項に記載の融合タンパク質であるコンジュゲート、をコードする核酸分子。
- 請求項54に記載の核酸分子を含む、ベクター。
- 発現ベクターである、請求項55に記載のベクター。
- 請求項55または請求項56に記載のベクターを含む、細胞。
- バリアントCD80ポリペプチドまたは免疫調節タンパク質の産生方法であって、請求項54に記載の核酸分子または請求項55もしくは請求項56に記載のベクターを宿主細胞に、前記細胞内で前記タンパク質を発現する条件下で導入することを含む、前記産生方法。
- 前記細胞からバリアントCD80ポリペプチドまたは免疫調節タンパク質を単離または精製することをさらに含む、請求項58に記載の方法。
- バリアントCD80バリアントポリペプチドを発現する細胞を操作する方法であって、実施形態1~30のいずれかに記載のバリアントCD80ポリペプチドをコードする核酸分子を宿主細胞に、前記ポリペプチドが前記細胞内で発現される条件下で導入することを含む、前記方法。
- 請求項1~30のいずれか1項に記載のバリアントCD80ポリペプチド、請求項31~48のいずれか1項に記載の免疫調節タンパク質、請求項49~53のいずれか1項に記載の融合タンパク質であるコンジュゲート、請求項54に記載の核酸分子、または請求項55もしくは56に記載のベクターを含む、操作された細胞。
- 前記バリアントCD80ポリペプチドが、膜貫通ドメインを含まない、及び/または前記細胞の表面に発現しない;及び/または
前記バリアントCD80ポリペプチドが、発現した際に前記操作された細胞から分泌されることができる、
請求項61に記載の操作された細胞。 - 前記バリアントCD80ポリペプチドが、膜貫通ドメインを含むか、請求項29に記載の膜貫通型免疫調節タンパク質であり;及び/または
前記バリアントCD80ポリペプチドが、前記細胞の表面に発現する、
請求項61に記載の操作された細胞。 - 前記細胞が免疫細胞であり、任意で抗原提示細胞(APC)またはリンパ球、任意でT細胞である、請求項61~63のいずれか1項に記載の操作された細胞。
- キメラ抗原受容体(CAR)または操作されたT細胞受容体(TCR)をさらに含む、請求項61~64のいずれか1項に記載の操作された細胞。
- 実施形態1~30のいずれかに記載のバリアントCD80ポリペプチド、実施形態31~47のいずれかに記載の免疫調節タンパク質、または実施形態48~52のいずれかに記載の融合タンパク質であるコンジュゲート、をコードする核酸分子を含む、感染性物質。
- 細菌またはウイルスである、請求項66に記載の感染性物質。
- 前記感染性物質がウイルスであり、前記ウイルスが腫瘍溶解性ウイルスである、請求項67に記載の感染性物質。
- 請求項1~30のいずれか1項に記載のバリアントCD80ポリペプチド、請求項31~48のいずれか1項に記載の免疫調節タンパク質、請求項49~53のいずれか1項に記載のコンジュゲート、請求項61~65のいずれか1項に記載の操作された細胞、または請求項66~68のいずれか1項に記載の感染性物質を含む、薬学的組成物。
- 薬学的に許容し得る賦形剤を含む、請求項69に記載の薬学的組成物。
- 前記薬学的組成物が無菌である、請求項69または請求項70に記載の薬学的組成物。
- バイアル内に請求項69~71のいずれか1項に記載の薬学的組成物を含む製造物品。
- 前記バイアルが密封された、請求項72に記載の製造物品。
- 請求項69~71のいずれか1項に記載の薬学的組成物、または請求項72もしくは請求項73に記載の製造物品、及び使用説明書を含む、キット。
- 請求項69~71のいずれか1項に記載の薬学的組成物を投与することを含む、対象において免疫応答を調節する方法。
- 請求項31~48のいずれか1項に記載の免疫調節タンパク質を投与することを含む、対象において免疫応答を調節する方法。
- 前記免疫調節タンパク質が、Fc依存性CD28共刺激を示す請求項37に記載の免疫調節タンパク質である、請求項76に記載の方法。
- 前記免疫調節タンパク質が、PD-L1依存性CD28共刺激を示す請求項44に記載の免疫調節タンパク質であり、任意で前記免疫調節タンパク質が、請求項12~29のいずれか1項に記載のバリアントCD80ポリペプチドを含む、請求項74に記載の方法。
- 請求項61~65のいずれか1項に記載の操作された細胞を投与することを含む、対象において免疫応答を調節する方法。
- 前記操作された細胞が、前記対象に対して自家である、請求項79に記載の方法。
- 前記免疫応答を調節することにより、前記対象の疾患または状態を治療する、請求項75~80のいずれか1項に記載の方法。
- 前記免疫応答が増加される、請求項75~81のいずれか1項に記載の方法。
- バリアントCD80ポリペプチドを含む免疫調節タンパク質を投与することを含む、対象において免疫応答を増加させる方法であって、前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、前記免疫調節タンパク質が、PD-L1依存性CD28共刺激を示す、前記方法。
- 前記バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、PD-L1のエクトドメインに対して増加した結合親和性を示す、請求項83に記載の方法。
- バリアントCD80ポリペプチドを含む免疫調節タンパク質を投与することを含む、対象においてPD-L1依存性CD28共刺激によりCD28作動作用を媒介する方法であって、前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、前記バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、
PD-L1のエクトドメインに対して増加した結合親和性を示す、前記方法。 - 疾患または状態の治療に使用するためのものである、請求項83~85のいずれか1項に記載の方法。
- 前記投与の前に、表面PD-L1に陽性の細胞を含む腫瘍を有する治療対象を選択し、任意で、前記細胞が腫瘍細胞もしくは腫瘍浸潤免疫細胞である;または
前記対象がPD-L1に陽性の細胞表面を含む腫瘍を有するものとして選択され、任意で、前記細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、
請求項75~86のいずれか1項に記載の方法。 - 対象の選択が、
(a)対象由来の腫瘍組織試料を、PD-L1のエクトドメインに特異的に結合することができる結合試薬と接触させることと、
(b)前記腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で前記細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、前記検出することと、
(c)前記腫瘍組織試料が検出可能レベルのPD-L1に陽性の細胞表面を含む場合に、治療のために前記対象を選択することと
を含む、請求項87に記載の方法。 - 前記投与の前に、CD28に陽性の細胞表面を含む腫瘍を有する治療対象を選択し、任意で前記細胞が腫瘍浸潤リンパ球であり、任意で前記リンパ球がT細胞、任意でCD8+T細胞である;または
前記対象が、CD28に陽性の細胞表面を含む腫瘍を有するものとして選択され、任意で前記細胞が腫瘍浸潤リンパ球であり、任意で前記リンパ球がT細胞、任意でCD8+T細胞である、
請求項75~88のいずれか1項に記載の方法。 - 前記対象の選択が、
(a)対象由来の腫瘍組織試料を、CD28のエクトドメインに特異的に結合することができる結合試薬と接触させることと、
(b)前記腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で前記細胞が腫瘍浸潤リンパ球であり、任意で前記リンパ球がT細胞、任意でCD8+T細胞である、前記検出することと、
(c)前記腫瘍組織試料が検出可能レベルのCD28に陽性の細胞表面を含む場合に、治療のために前記対象を選択することと
を含む、請求項89に記載の方法。 - (a)対象由来の腫瘍組織試料を、PD-L1に特異的に結合することができる結合試薬と接触させることと、
(b)前記腫瘍組織試料の細胞内または細胞上に結合した結合試薬の存在を検出することであって、任意で前記細胞が腫瘍細胞または腫瘍浸潤免疫細胞である、前記検出することと、
(c)前記腫瘍試料が検出可能レベルのPD-L1に陽性の細胞表面を含む場合、バリアントCD80ポリペプチドを含む免疫調節タンパク質による治療のための対象を選択することであって、前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、前記バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較して、PD-L1のエクトドメインに対して増加した結合親和性を示す、前記選択することと
を含む、治療対象を選択する方法。 - 前記腫瘍組織試料を、CD28に特異的に結合することができる結合試薬と接触させることを含み、前記腫瘍組織試料が、検出可能レベルのCD28に陽性の腫瘍浸潤リンパ球をさらに含む場合に、前記対象が選択され、任意で前記リンパ球がT細胞、任意でCD8+T細胞である、請求項91に記載の方法。
- 前記腫瘍組織試料が、腫瘍浸潤免疫細胞、腫瘍細胞、間質細胞、またはそれらの任意の組み合わせを含む、請求項88及び90~92のいずれか1項に記載の方法。
- 前記結合試薬が、抗体もしくは抗原結合断片、タンパク質リガンドもしくは結合パートナー、アプタマー、アフィマー、ペプチド、またはハプテンである、請求項88及び90~93に記載の方法。
- 前記結合試薬が、抗PD-L1抗体または抗原結合断片である、請求項88、91、93または94に記載の方法。
- 前記結合試薬が、請求項1~30のいずれか1項に記載のバリアントCD80ポリペプチドを含む、請求項88~94のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、前記IgVドメインまたはその特異的結合断片を含む、請求項96に記載の方法。
- 前記IgVドメインまたはその特異的結合断片が、前記結合試薬の唯一のCD80部分である請求項96または97に記載の方法。
- 前記バリアントCD80ポリペプチドが、前記野生型または非改変CD80ポリペプチドと比較してPD-L1への結合に対する増加した親和性を示す、請求項96~98のいずれか1項に記載の方法。
- 前記結合試薬が、検出可能部分または検出することのできる部分である部分に直接または間接的に連結される、請求項88及び90~99のいずれか1項に記載の方法。
- 前記部分がFc領域である、請求項100に記載の方法。
- 前記Fc領域が非ヒト、任意でマウスまたはウサギである、請求項101に記載の方法。
- 結合した結合試薬の存在の検出が、免疫組織化学、偽免疫組織化学、免疫蛍光、フローサイトメトリー、ELISA、または免疫ブロッティングによる、請求項88及び90~102のいずれか1項に記載の方法。
- 前記免疫調節タンパク質を前記対象に投与することをさらに含む、請求項91~103のいずれか1項に記載の方法。
- 前記免疫調節タンパク質が、第1の多量体化ドメインに連結された第1のバリアントCD80ポリペプチド及び第2の多量体化ドメインに連結された第2のバリアントCD80ポリペプチドを含む多量体であり、前記第1及び第2の多量体化ドメインが、相互作用して前記第1及び第2のバリアントCD80ポリペプチドを含む多量体を形成する、請求項83~104のいずれか1項に記載の方法。
- 前記多量体が二量体である、請求項105に記載の方法。
- 前記第1のバリアントCD80ポリペプチド及び前記第2のバリアントCD80ポリペプチドが同一である、請求項105または請求項106に記載の方法。
- 前記多量体化ドメインが、Fc領域であるか、またはそれを含む、請求項105~107のいずれか1項に記載の方法。
- 前記Fc領域が、野生型Fc領域と比較して1つまたは複数のアミノ酸置換を含むバリアントFc領域であり、前記Fc領域が、前記野生型Fc領域と比較して低下した1つまたは複数のエフェクター機能を示し、任意で前記野生型Fcが、ヒトIgG1である、請求項108に記載の方法。
- 前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片に、SEQ ID NO:2に記載の位置の番号付けに基づいた7、12、13、15、16、18、21、20、22、23、24、25、26、27、28、29、30、31、33、34、35、36、37、38、41、42、43、44、46、47、48、51、53、54、55、57、58、61、62、63、64、65、67、68、69、70、71、72、73、74、76、77、78、79、81、82、83、84、85、86、87、88、89、90、91、92、93、94、95、及び/または97に対応する1つまたは複数のアミノ酸改変を含む、請求項83~109のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、
アミノ酸改変H18Y、
アミノ酸改変A26E、
アミノ酸改変E35D、
アミノ酸改変D46E、
アミノ酸改変D46V、
アミノ酸改変M47I、
アミノ酸改変M47L、
アミノ酸改変V68M、
アミノ酸改変A71G、
アミノ酸改変L85Q、または
アミノ酸改変D90G
を含む、請求項83~113のいずれか1項に記載の方法。 - 前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/M47I、E35D/M47L、E35D/M47V、またはE35D/V68Mを含む、請求項83~115のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/M47L/V68MまたはE35D/M47V/V68Mを含む、請求項83~116のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/M47I/L70Mを含む、請求項83~116のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/M47V/N48K/V68M/K89Nを含む、請求項83~117のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、アミノ酸改変H18Y/A26E/E35D/M47L/V68M/A71G/D90Gを含む、請求項83~117のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/D46E/M47V/V68M/D90G/K93Eを含む、請求項83~117のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、アミノ酸改変E35D/D46V/M47L/V68M/L85Q/E88Dを含む、請求項83~117のいずれか1項に記載の方法。
- 前記免疫調節タンパク質が可溶性であり、任意で、前記バリアントCD80ポリペプチドが、CD80膜貫通ドメイン及び細胞内シグナル伝達ドメインを欠く、請求項83~122のいずれか1項に記載の方法。
- 前記非改変CD80が、(i)SEQ ID NO:2に記載のアミノ酸の配列を含むか、(ii)SEQ ID NO:2に対して少なくとも95%の配列同一性を有するアミノ酸の配列を含むか、または(iii)IgVドメインもしくはその特異的結合断片を含む(i)もしくは(ii)の一部分である、請求項83~123のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、IgVドメインもしくはその特異的結合断片であるか、またはそれを含む、請求項83~124のいずれか1項に記載の方法。
- 前記IgVドメインまたはその特異的結合断片が、前記免疫調節タンパク質の唯一のCD80部分である、請求項83~125のいずれか1項に記載の方法。
- 前記バリアントCD80ポリペプチドが、最大1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19または20個のアミノ酸改変を含む、請求項83~126のいずれか1項に記載の方法。
- 前記免疫調節タンパク質がFc融合タンパク質である、請求項83~127のいずれか1項に記載の方法。
- 前記疾患または状態が、腫瘍またはがんである、請求項81、82、及び86~128のいずれか1項に記載の方法。
- 前記対象が、PD-1/PD-L1またはPD-1/PD-L2の拮抗物質による治療後、寛解後に再発したか、不応性になったか、またはノンレスポンダーである、請求項75~129のいずれか1項に記載の方法。
- 前記拮抗物質が抗PD-1抗体、任意でニボルマブまたはペンブロリズマブである、請求項130に記載の方法。
- 前記免疫応答が減少される、請求項75~81のいずれか1項に記載の方法。
- 前記疾患または状態が、炎症性または自己免疫性疾患または状態である、請求項75~81及び132のいずれか1項に記載の方法。
- 生体試料中のCD80結合パートナーを検出する方法であって、
(a)生体試料を、請求項1~30のいずれか1項に記載のバリアントCD80ポリペプチドを含む結合試薬と接触させることと、
(b)前記生体試料の細胞内または細胞上に結合した前記結合試薬の存在を検出することと
を含む、前記方法。 - 前記結合パートナーが、PD-L1、CD28、CTLA-4またはこれらの組み合わせである、請求項134に記載の方法。
- 前記バリアントCD80ポリペプチドが、非改変CD80またはその特異的結合断片のIgVドメインまたはIgCドメインまたはその特異的結合断片の1つまたは複数の位置に1つまたは複数のアミノ酸改変を含み、前記バリアントCD80ポリペプチドが、PD-L1のエクトドメインへの非改変CD80の結合親和性と比較してPD-L1のエクトドメインに対して増加した結合親和性を示す、請求項134または請求項135に記載の方法。
- 前記生体試料が、体液、細胞、もしくは組織試料であるか、またはそれを含む、請求項134~136のいずれか1項に記載の方法。
- 前記体液が、血清、血漿、または尿である、請求項137に記載の方法。
- 前記組織試料が、腫瘍組織試料である、請求項137に記載の方法。
- 前記腫瘍組織試料が、腫瘍浸潤免疫細胞、腫瘍細胞、間質細胞、またはそれらの任意の組み合わせを含む、請求項139に記載の方法。
- 前記IgVドメインまたはその特異的結合断片を含む、請求項134~140のいずれか1項に記載のバリアントCD80ポリペプチド。
- 前記IgVドメインまたはその特異的結合断片が、前記結合試薬の唯一のCD80部分である、請求項141に記載の方法。
- 前記結合試薬が、検出可能部分である標識にまたは検出することのできる部分に直接または間接的に連結される、請求項134~142のいずれか1項に記載の方法。
- 前記部分がFc領域である、請求項143に記載の方法。
- 前記Fc領域が非ヒト、任意でマウスまたはウサギである、請求項144に記載の方法。
- 結合した結合試薬の存在の検出が、免疫組織化学、偽免疫組織化学、免疫蛍光、フローサイトメトリー、ELISA、または免疫ブロッティングによる、請求項134~145のいずれか1項に記載の方法。
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JP2022501361A (ja) | 2018-09-19 | 2022-01-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | バリアントcd80融合タンパク質および関連構築物の方法および使用 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2022501361A (ja) * | 2018-09-19 | 2022-01-06 | アルパイン イミューン サイエンシズ インコーポレイテッド | バリアントcd80融合タンパク質および関連構築物の方法および使用 |
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BR112019018747A2 (pt) | 2020-05-05 |
AU2024201667A1 (en) | 2024-04-04 |
CA3054068A1 (en) | 2018-09-20 |
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JP2020511143A (ja) | 2020-04-16 |
US11117950B2 (en) | 2021-09-14 |
US11096988B2 (en) | 2021-08-24 |
NZ756395A (en) | 2024-01-26 |
US20210130436A1 (en) | 2021-05-06 |
US20210155669A1 (en) | 2021-05-27 |
US20210163571A1 (en) | 2021-06-03 |
US20210171603A1 (en) | 2021-06-10 |
US11230588B2 (en) | 2022-01-25 |
SG11201907769XA (en) | 2019-09-27 |
CN110662758A (zh) | 2020-01-07 |
US20210188942A1 (en) | 2021-06-24 |
US11639375B2 (en) | 2023-05-02 |
US20240002466A1 (en) | 2024-01-04 |
WO2018170026A2 (en) | 2018-09-20 |
EP3596114A2 (en) | 2020-01-22 |
US20210155668A1 (en) | 2021-05-27 |
WO2018170026A3 (en) | 2018-10-18 |
US11117949B2 (en) | 2021-09-14 |
JP7386083B2 (ja) | 2023-11-24 |
AU2018235838B2 (en) | 2023-12-14 |
IL268781A (en) | 2019-10-31 |
MX2019010887A (es) | 2019-10-15 |
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