JP2023052458A5 - - Google Patents
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- JP2023052458A5 JP2023052458A5 JP2023005585A JP2023005585A JP2023052458A5 JP 2023052458 A5 JP2023052458 A5 JP 2023052458A5 JP 2023005585 A JP2023005585 A JP 2023005585A JP 2023005585 A JP2023005585 A JP 2023005585A JP 2023052458 A5 JP2023052458 A5 JP 2023052458A5
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- Prior art keywords
- pharmaceutical composition
- antigen
- antibody
- binding fragment
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- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 46
- 239000000427 antigen Substances 0.000 claims 37
- 102000036639 antigens Human genes 0.000 claims 37
- 108091007433 antigens Proteins 0.000 claims 37
- 239000012634 fragment Substances 0.000 claims 37
- 208000000592 Nasal Polyps Diseases 0.000 claims 21
- 238000011282 treatment Methods 0.000 claims 18
- 208000036071 Rhinorrhea Diseases 0.000 claims 14
- 206010039101 Rhinorrhoea Diseases 0.000 claims 14
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 13
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 13
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 11
- 239000003246 corticosteroid Substances 0.000 claims 10
- 229960001334 corticosteroids Drugs 0.000 claims 10
- 238000001356 surgical procedure Methods 0.000 claims 8
- 208000016366 nasal cavity polyp Diseases 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000012423 maintenance Methods 0.000 claims 6
- 230000009885 systemic effect Effects 0.000 claims 6
- 206010028735 Nasal congestion Diseases 0.000 claims 5
- 208000024891 symptom Diseases 0.000 claims 5
- 238000002591 computed tomography Methods 0.000 claims 4
- 230000008786 sensory perception of smell Effects 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 206010002653 Anosmia Diseases 0.000 claims 3
- 206010019233 Headaches Diseases 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 231100000869 headache Toxicity 0.000 claims 3
- 206010009137 Chronic sinusitis Diseases 0.000 claims 2
- 206010016059 Facial pain Diseases 0.000 claims 2
- 206010028748 Nasal obstruction Diseases 0.000 claims 2
- 235000019558 anosmia Nutrition 0.000 claims 2
- 229940090047 auto-injector Drugs 0.000 claims 2
- 229950003468 dupilumab Drugs 0.000 claims 2
- 238000011418 maintenance treatment Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940071643 prefilled syringe Drugs 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 230000002146 bilateral effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 229960002744 mometasone furoate Drugs 0.000 claims 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 1
- 239000007922 nasal spray Substances 0.000 claims 1
- 229940097496 nasal spray Drugs 0.000 claims 1
- 229940124624 oral corticosteroid Drugs 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025003986A JP2025063155A (ja) | 2014-11-14 | 2025-01-10 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080092P | 2014-11-14 | 2014-11-14 | |
| US62/080,092 | 2014-11-14 | ||
| US201462083821P | 2014-11-24 | 2014-11-24 | |
| US62/083,821 | 2014-11-24 | ||
| US201562158832P | 2015-05-08 | 2015-05-08 | |
| US62/158,832 | 2015-05-08 | ||
| US201562199305P | 2015-07-31 | 2015-07-31 | |
| US62/199,305 | 2015-07-31 | ||
| EP15306632 | 2015-10-14 | ||
| EP15306632.9 | 2015-10-14 | ||
| JP2021001858A JP7216122B2 (ja) | 2014-11-14 | 2021-01-08 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021001858A Division JP7216122B2 (ja) | 2014-11-14 | 2021-01-08 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025003986A Division JP2025063155A (ja) | 2014-11-14 | 2025-01-10 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023052458A JP2023052458A (ja) | 2023-04-11 |
| JP2023052458A5 true JP2023052458A5 (enExample) | 2023-10-12 |
Family
ID=54330704
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525897A Active JP6861630B2 (ja) | 2014-11-14 | 2015-11-13 | Ｉｌ−４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
| JP2023005585A Pending JP2023052458A (ja) | 2014-11-14 | 2023-01-18 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
| JP2025003986A Pending JP2025063155A (ja) | 2014-11-14 | 2025-01-10 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525897A Active JP6861630B2 (ja) | 2014-11-14 | 2015-11-13 | Ｉｌ−４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025003986A Pending JP2025063155A (ja) | 2014-11-14 | 2025-01-10 | Ｉｌ－４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10066017B2 (enExample) |
| EP (1) | EP3218412A1 (enExample) |
| JP (3) | JP6861630B2 (enExample) |
| KR (2) | KR20230158131A (enExample) |
| CN (1) | CN107206073A (enExample) |
| AU (3) | AU2015346150B2 (enExample) |
| CA (2) | CA3246946A1 (enExample) |
| IL (4) | IL294554B2 (enExample) |
| MX (2) | MX2017006286A (enExample) |
| RU (1) | RU2734490C2 (enExample) |
| WO (1) | WO2016077675A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
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| HRP20181227T1 (hr) | 2012-09-07 | 2018-10-05 | Regeneron Pharmaceuticals, Inc. | Metode za liječenje atopijskog dermatitisa primjenom antagonista il-4r |
| TWI755763B (zh) * | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| IL315136A (en) | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| RU2704999C2 (ru) | 2014-02-28 | 2019-11-01 | Ридженерон Фармасьютикалз, Инк. | Способ лечения кожной инфекции путем введения антагониста il-4r |
| PT3613432T (pt) | 2014-05-07 | 2025-10-29 | Regeneron Pharma | Métodos para tratar a polipose nasal através da administração de um antagonista de il-4r |
| US10066017B2 (en) | 2014-11-14 | 2018-09-04 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
| CN109789196B (zh) * | 2016-09-01 | 2024-03-19 | 瑞泽恩制药公司 | 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法 |
| MX2019012171A (es) * | 2017-04-13 | 2019-11-25 | Regeneron Pharma | Tratamiento e inhibicion de enfermedades pulmonares inflamatorias en pacientes que tienen alelos de riesgo en los genes que codifican la il33 e il1rl1. |
| WO2019018441A1 (en) * | 2017-07-17 | 2019-01-24 | Massachusetts Institute Of Technology | ATLAS OF HEAVY AND ILLUMINATED HEAVY BARRIER TISSUE CELLS |
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| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| PL3703818T3 (pl) * | 2017-10-30 | 2024-03-25 | Sanofi Biotechnology | Antagonista IL-4R do zastosowania w sposobie leczenia lub zapobiegania astmie |
| RU2667819C1 (ru) * | 2017-12-20 | 2018-09-24 | Владимир Викторович Сунцов | Способ аэрозольной терапии риносинуситов |
| US20210361693A1 (en) * | 2018-02-09 | 2021-11-25 | Empirico Inc. | Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions |
| EP3793597A1 (en) | 2018-05-13 | 2021-03-24 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r inhibitor |
| IL316308A (en) | 2018-07-10 | 2024-12-01 | Regeneron Pharma | Modifying binding molecules to minimize pre-existing interactions |
| CN111494625B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
| US11116778B2 (en) | 2019-01-15 | 2021-09-14 | Empirico Inc. | Prodrugs of ALOX-15 inhibitors and methods of using the same |
| MA55372A (fr) | 2019-03-21 | 2022-01-26 | Regeneron Pharma | Combinaison d'inhibiteurs de la voie il-4/il-13 et d'ablation de plasmocytes pour traiter une allergie |
| JP7592064B2 (ja) | 2019-07-16 | 2024-11-29 | サノフィ・バイオテクノロジー | Ｉｌ－４ｒアンタゴニストを投与することにより喘息を治療するまたは予防するための方法 |
| CN114173819A (zh) | 2019-08-05 | 2022-03-11 | 瑞泽恩制药公司 | 通过施用il-4r拮抗剂治疗过敏和增强过敏原特异性免疫疗法的方法 |
| AU2020326713A1 (en) | 2019-08-05 | 2022-02-17 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| EP4073810A1 (en) | 2019-12-09 | 2022-10-19 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| EP3992974A1 (en) * | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
| KR20240038841A (ko) * | 2022-09-16 | 2024-03-26 | 연세대학교 산학협력단 | 신규한 인간 인터류킨-4 수용체 결합 나노바디 및 이의 용도 |
| CN116819076A (zh) * | 2023-05-26 | 2023-09-29 | 首都医科大学附属北京同仁医院 | 一种预测或评估抗IL-4Rα单抗在治疗慢性鼻窦炎伴鼻息肉中疗效的生物标志物、应用和方法 |
| EP4623903A1 (en) | 2024-03-28 | 2025-10-01 | Fresenius Kabi Deutschland GmbH | Pharmaceutical composition comprising dupilumab |
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| WO2013155010A1 (en) | 2012-04-09 | 2013-10-17 | Children's Hospital Medical Center | Non-invasive biomarkers for eosinophilic esophagitis |
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| HRP20181227T1 (hr) * | 2012-09-07 | 2018-10-05 | Regeneron Pharmaceuticals, Inc. | Metode za liječenje atopijskog dermatitisa primjenom antagonista il-4r |
| WO2014059178A1 (en) | 2012-10-10 | 2014-04-17 | Rhode Island Hospital | Differential expression of novel protein markers for the diagnosis and treatment of eosinophilic esophagitis |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
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| PT3515465T (pt) | 2017-08-18 | 2024-03-04 | Regeneron Pharma | Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r |
| PL3703818T3 (pl) | 2017-10-30 | 2024-03-25 | Sanofi Biotechnology | Antagonista IL-4R do zastosowania w sposobie leczenia lub zapobiegania astmie |
-
2015
- 2015-11-13 US US14/940,431 patent/US10066017B2/en active Active
- 2015-11-13 KR KR1020237038116A patent/KR20230158131A/ko not_active Ceased
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- 2015-11-13 CN CN201580073344.8A patent/CN107206073A/zh active Pending
- 2015-11-13 KR KR1020177015962A patent/KR20170081262A/ko not_active Ceased
- 2015-11-13 CA CA3246946A patent/CA3246946A1/en active Pending
- 2015-11-13 EP EP15804646.6A patent/EP3218412A1/en active Pending
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- 2015-11-13 WO PCT/US2015/060540 patent/WO2016077675A1/en not_active Ceased
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- 2015-11-13 JP JP2017525897A patent/JP6861630B2/ja active Active
- 2015-11-13 RU RU2017120437A patent/RU2734490C2/ru active
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