MA44238B1 - Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r - Google Patents

Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r

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Publication number
MA44238B1
MA44238B1 MA44238A MA44238A MA44238B1 MA 44238 B1 MA44238 B1 MA 44238B1 MA 44238 A MA44238 A MA 44238A MA 44238 A MA44238 A MA 44238A MA 44238 B1 MA44238 B1 MA 44238B1
Authority
MA
Morocco
Prior art keywords
methods
antagonist
administration
vaccine
vaccine efficacy
Prior art date
Application number
MA44238A
Other languages
English (en)
Other versions
MA44238A (fr
Inventor
Andrew J. Murphy
Neil Graham
Lisa Purcell Ngambo
Robert Evans
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58192407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA44238(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of MA44238A publication Critical patent/MA44238A/fr
Publication of MA44238B1 publication Critical patent/MA44238B1/fr

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    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Abstract

La présente invention concerne des procédés d'amélioration de l'efficacité et/ou la sécurité d'un vaccin. Dans certains modes de réalisation, l'invention concerne des procédés d'augmentation ou de potentialisation de la réponse immunitaire à un vaccin chez un sujet en ayant besoin. Les procédés de la présente invention comprennent l'administration à un sujet en ayant besoin d'un antagoniste de récepteur d'interleukine 4 (IL-4R) tel qu'un anticorps anti-IL-4R en combinaison avec ledit vaccin. Dans certains modes de réalisation, les procédés de la présente invention sont utilisés pour obtenir une protection améliorée contre une maladie infectieuse telle que la coqueluche.
MA44238A 2016-02-19 2017-02-17 Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r MA44238B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662297257P 2016-02-19 2016-02-19
US201662409936P 2016-10-19 2016-10-19
PCT/US2017/018487 WO2017143270A1 (fr) 2016-02-19 2017-02-17 Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r
EP17708398.7A EP3416685B1 (fr) 2016-02-19 2017-02-17 Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r

Publications (2)

Publication Number Publication Date
MA44238A MA44238A (fr) 2018-12-26
MA44238B1 true MA44238B1 (fr) 2024-07-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
MA44238A MA44238B1 (fr) 2016-02-19 2017-02-17 Procédés d'augmentation de l'efficacité d'un vaccin par administration d'un antagoniste d'il-4r

Country Status (17)

Country Link
US (3) US10314904B2 (fr)
EP (2) EP3416685B1 (fr)
JP (3) JP7597500B2 (fr)
KR (1) KR102868264B1 (fr)
CN (1) CN109069625A (fr)
AU (2) AU2017220184B2 (fr)
CA (1) CA3014202A1 (fr)
ES (1) ES2983475T3 (fr)
HU (1) HUE067673T2 (fr)
IL (1) IL261025A (fr)
MA (1) MA44238B1 (fr)
MX (2) MX2018009990A (fr)
PL (1) PL3416685T3 (fr)
PT (1) PT3416685T (fr)
RU (1) RU2753869C2 (fr)
WO (1) WO2017143270A1 (fr)
ZA (1) ZA201805295B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
WO2014031610A1 (fr) 2012-08-21 2014-02-27 Sanofi Procédés permettant de traiter ou d'empêcher l'asthme par administration d'un antagoniste du récepteur à l'interleukine 4 (il-4r)
HRP20181227T1 (hr) 2012-09-07 2018-10-05 Regeneron Pharmaceuticals, Inc. Metode za liječenje atopijskog dermatitisa primjenom antagonista il-4r
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
RU2704999C2 (ru) 2014-02-28 2019-11-01 Ридженерон Фармасьютикалз, Инк. Способ лечения кожной инфекции путем введения антагониста il-4r
US10066017B2 (en) 2014-11-14 2018-09-04 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist
US12070492B2 (en) * 2016-05-10 2024-08-27 Hennepin Healthcare Research Institute Therapeutic compositions and methods with cytokine signaling immunomodulators
CN109789196B (zh) * 2016-09-01 2024-03-19 瑞泽恩制药公司 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法
WO2019028367A1 (fr) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. Méthodes de traitement de l'oesophagite à éosinophiles active
PT3515465T (pt) 2017-08-18 2024-03-04 Regeneron Pharma Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r
PL3703818T3 (pl) 2017-10-30 2024-03-25 Sanofi Biotechnology Antagonista IL-4R do zastosowania w sposobie leczenia lub zapobiegania astmie
EP3793597A1 (fr) 2018-05-13 2021-03-24 Regeneron Pharmaceuticals, Inc. Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r
WO2020092015A1 (fr) 2018-11-02 2020-05-07 University Of Rochester Atténuation thérapeutique d'une infection épithéliale
SG11202109003QA (en) * 2019-03-06 2021-09-29 Regeneron Pharma Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer
MA55372A (fr) 2019-03-21 2022-01-26 Regeneron Pharma Combinaison d'inhibiteurs de la voie il-4/il-13 et d'ablation de plasmocytes pour traiter une allergie
JP7592064B2 (ja) 2019-07-16 2024-11-29 サノフィ・バイオテクノロジー Il-4rアンタゴニストを投与することにより喘息を治療するまたは予防するための方法
CN114173819A (zh) 2019-08-05 2022-03-11 瑞泽恩制药公司 通过施用il-4r拮抗剂治疗过敏和增强过敏原特异性免疫疗法的方法
AU2020326713A1 (en) 2019-08-05 2022-02-17 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
EP3992974A1 (fr) 2020-11-02 2022-05-04 Sanofi Biotechnology Procédés pour le traitement de troubles liés à l'il-13/il-4 identifiés numériquement
EP4073810A1 (fr) 2019-12-09 2022-10-19 Sanofi Biotechnology Méthodes de traitement de troubles associés à l'il-4/il-13 identifiés numériquement
WO2021195530A1 (fr) * 2020-03-27 2021-09-30 Regeneron Pharmaceuticals, Inc. Méthodes de traitement de la dermatite atopique par administration d'un antagoniste de l'il-4r
US20240336688A1 (en) * 2021-07-22 2024-10-10 Icahn School Of Medicine At Mount Sinai Dual-blockade of il-4 signaling and immune checkpoint proteins for treating cancer
JP2024532263A (ja) * 2021-08-23 2024-09-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Il-4rアンタゴニストを投与することによってアトピー性皮膚炎を治療する方法
CN118717989A (zh) * 2024-05-27 2024-10-01 中国人民解放军军事科学院军事医学研究院 Il-4r拮抗剂在制备预防和/或治疗流感病毒感染的药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE16192152T1 (de) 2000-05-26 2020-08-06 Immunex Corporation Verwendung von interleukin-4 rezeptor (il-4r) antikörpern und zusammensetzungen davon
US20030139364A1 (en) * 2001-10-12 2003-07-24 University Of Iowa Research Foundation Methods and products for enhancing immune responses using imidazoquinoline compounds
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
GEP20104991B (en) 2003-11-07 2010-05-25 Immunex Corp Antibodies that bind interleukin-4 receptor
WO2008054606A2 (fr) 2006-10-02 2008-05-08 Regeneron Pharmaceuticals, Inc. Anticorps humains à haute affinité vis-à-vis du récepteur il-4 humain
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
RU2490278C2 (ru) 2007-12-21 2013-08-20 Медиммун Лимитед ЭЛЕМЕНТ, СВЯЗЫВАЮЩИЙСЯ С α-РЕЦЕПТОРОМ ИНТЕРЛЕЙКИНА-4 (IL-4Rα)-173
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
EP2414520A2 (fr) * 2009-03-31 2012-02-08 Altair Therapeutics, Inc. Procédés de modulation d'une réponse immunitaire à une infection virale
PL2624865T3 (pl) 2010-10-06 2018-11-30 Regeneron Pharmaceuticals, Inc. Stabilizowane preparaty zawierające przeciwciała przeciwko receptorowi interleukiny-4 (IL-4R)
SG11201408101TA (en) * 2012-06-05 2015-01-29 Univ Australian Vaccination with interleukin-4 antagonists
HRP20181227T1 (hr) 2012-09-07 2018-10-05 Regeneron Pharmaceuticals, Inc. Metode za liječenje atopijskog dermatitisa primjenom antagonista il-4r
TWI755763B (zh) * 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
PT3613432T (pt) 2014-05-07 2025-10-29 Regeneron Pharma Métodos para tratar a polipose nasal através da administração de um antagonista de il-4r
KR20190062142A (ko) * 2017-11-28 2019-06-05 (주)비티엔 면역 증강 활성을 가지는 아미노산 미네랄 복합체 및 이를 포함하는 식품, 약학 또는 사료용 조성물
US20210361700A1 (en) * 2020-05-22 2021-11-25 Trustees Of Tufts College Nutritional supplement to combat covid-19 and aid vaccination

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