JP2023022326A5 - - Google Patents

Info

Publication number

JP2023022326A5

JP2023022326A5 JP2022197763A JP2022197763A JP2023022326A5 JP 2023022326 A5 JP2023022326 A5 JP 2023022326A5 JP 2022197763 A JP2022197763 A JP 2022197763A JP 2022197763 A JP2022197763 A JP 2022197763A JP 2023022326 A5 JP2023022326 A5 JP 2023022326A5

Authority

JP

Japan

Prior art keywords

polypeptide

human

seq

nucleotide sequence

encoding

Prior art date

2022-12-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000002773 nucleotide Substances 0.000 claims 44
• 125000003729 nucleotide group Chemical group 0.000 claims 44
• 108700026244 Open Reading Frames Proteins 0.000 claims 42
• 108020004999 messenger RNA Proteins 0.000 claims 36
• 125000003275 alpha amino acid group Chemical group 0.000 claims 24
• 239000000203 mixture Substances 0.000 claims 24
• 108010065637 Interleukin-23 Proteins 0.000 claims 21
• 102000013264 Interleukin-23 Human genes 0.000 claims 21
• 101000998124 Homo sapiens Interleukin-36 gamma Proteins 0.000 claims 16
• 102000055226 human IL36G Human genes 0.000 claims 16
• 101000764263 Homo sapiens Tumor necrosis factor ligand superfamily member 4 Proteins 0.000 claims 14
• 102000051450 human TNFSF4 Human genes 0.000 claims 14
• 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 claims 12
• 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 claims 12
• 150000002632 lipids Chemical class 0.000 claims 10
• 108010076561 Interleukin-23 Subunit p19 Proteins 0.000 claims 9
• 229930182558 Sterol Natural products 0.000 claims 8
• DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 8
• 150000003904 phospholipids Chemical class 0.000 claims 8
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
• 150000003432 sterols Chemical class 0.000 claims 8
• 235000003702 sterols Nutrition 0.000 claims 8
• 108091051828 miR-122 stem-loop Proteins 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 101000852980 Homo sapiens Interleukin-23 subunit alpha Proteins 0.000 claims 4
• 108091066112 miR-122-1 stem-loop Proteins 0.000 claims 4
• 108091057488 miR-122-2 stem-loop Proteins 0.000 claims 4
• 108091070501 miRNA Proteins 0.000 claims 4
• DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 3
• DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 3
• 229940045145 uridine Drugs 0.000 claims 3
• UVBYMVOUBXYSFV-XUTVFYLZSA-N 1-methylpseudouridine Chemical group O=C1NC(=O)N(C)C=C1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 UVBYMVOUBXYSFV-XUTVFYLZSA-N 0.000 claims 2
• 108020005345 3' Untranslated Regions Proteins 0.000 claims 2
• 108091007780 MiR-122 Proteins 0.000 claims 2
• LNUFLCYMSVYYNW-ZPJMAFJPSA-N [(2r,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[[(3s,5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-4,5-disulfo Chemical compound O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O LNUFLCYMSVYYNW-ZPJMAFJPSA-N 0.000 claims 2
• -1 amino lipid Chemical class 0.000 claims 2
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000002105 nanoparticle Substances 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 102000013462 Interleukin-12 Human genes 0.000 claims 1
• 108010065805 Interleukin-12 Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 102000004473 OX40 Ligand Human genes 0.000 claims 1
• 108010042215 OX40 Ligand Proteins 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1