JP2023002846A5 - - Google Patents

Download PDF

Info

Publication number
JP2023002846A5
JP2023002846A5 JP2022178009A JP2022178009A JP2023002846A5 JP 2023002846 A5 JP2023002846 A5 JP 2023002846A5 JP 2022178009 A JP2022178009 A JP 2022178009A JP 2022178009 A JP2022178009 A JP 2022178009A JP 2023002846 A5 JP2023002846 A5 JP 2023002846A5
Authority
JP
Japan
Prior art keywords
disorder
composition
compound
inclusive
peak
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022178009A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023002846A (ja
Filing date
Publication date
Priority claimed from JP2019510657A external-priority patent/JP2019524853A/ja
Application filed filed Critical
Publication of JP2023002846A publication Critical patent/JP2023002846A/ja
Priority to JP2024075299A priority Critical patent/JP2024097878A/ja
Publication of JP2023002846A5 publication Critical patent/JP2023002846A5/ja
Pending legal-status Critical Current

Links

JP2022178009A 2016-08-23 2022-11-07 結晶性19-ノルc3,3-二置換c21-n-ピラゾリルステロイド Pending JP2023002846A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024075299A JP2024097878A (ja) 2016-08-23 2024-05-07 結晶性19-ノルc3,3-二置換c21-n-ピラゾリルステロイド

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662378582P 2016-08-23 2016-08-23
US62/378,582 2016-08-23
JP2019510657A JP2019524853A (ja) 2016-08-23 2017-08-23 結晶性19−ノルc3,3−二置換c21−n−ピラゾリルステロイド
PCT/US2017/048267 WO2018039378A1 (en) 2016-08-23 2017-08-23 A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2019510657A Division JP2019524853A (ja) 2016-08-23 2017-08-23 結晶性19−ノルc3,3−二置換c21−n−ピラゾリルステロイド

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024075299A Division JP2024097878A (ja) 2016-08-23 2024-05-07 結晶性19-ノルc3,3-二置換c21-n-ピラゾリルステロイド

Publications (2)

Publication Number Publication Date
JP2023002846A JP2023002846A (ja) 2023-01-10
JP2023002846A5 true JP2023002846A5 (enExample) 2024-05-15

Family

ID=59772778

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019510657A Withdrawn JP2019524853A (ja) 2016-08-23 2017-08-23 結晶性19−ノルc3,3−二置換c21−n−ピラゾリルステロイド
JP2022178009A Pending JP2023002846A (ja) 2016-08-23 2022-11-07 結晶性19-ノルc3,3-二置換c21-n-ピラゾリルステロイド
JP2024075299A Pending JP2024097878A (ja) 2016-08-23 2024-05-07 結晶性19-ノルc3,3-二置換c21-n-ピラゾリルステロイド

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2019510657A Withdrawn JP2019524853A (ja) 2016-08-23 2017-08-23 結晶性19−ノルc3,3−二置換c21−n−ピラゾリルステロイド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024075299A Pending JP2024097878A (ja) 2016-08-23 2024-05-07 結晶性19-ノルc3,3-二置換c21-n-ピラゾリルステロイド

Country Status (25)

Country Link
US (4) US11236121B2 (enExample)
EP (2) EP3981763A1 (enExample)
JP (3) JP2019524853A (enExample)
KR (2) KR20230079470A (enExample)
CN (4) CN115974956A (enExample)
AR (3) AR109393A1 (enExample)
AU (3) AU2017315682B2 (enExample)
BR (1) BR112019003637A2 (enExample)
CA (1) CA3034262A1 (enExample)
CL (2) CL2019000477A1 (enExample)
CO (1) CO2019002596A2 (enExample)
EA (1) EA201990565A1 (enExample)
EC (1) ECSP19020141A (enExample)
IL (2) IL302480A (enExample)
JO (1) JOP20190022B1 (enExample)
MA (1) MA46042A (enExample)
MX (2) MX393240B (enExample)
MY (1) MY200479A (enExample)
NZ (1) NZ791594A (enExample)
PE (2) PE20241580A1 (enExample)
PH (1) PH12019500375A1 (enExample)
SG (1) SG11201901445TA (enExample)
TW (2) TWI854445B (enExample)
WO (1) WO2018039378A1 (enExample)
ZA (1) ZA201901051B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2766380T (pt) 2011-10-14 2019-07-29 Sage Therapeutics Inc Compostos de 19-nor pregnano 3,3-dissubstituídos, composições e seus usos
EP2887944B1 (en) 2012-08-21 2021-10-06 Sage Therapeutics, Inc. Allopregnanolone for treating refractory status epilepticus
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
KR102614507B1 (ko) 2013-04-17 2023-12-19 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
PL2986624T3 (pl) 2013-04-17 2020-11-16 Sage Therapeutics, Inc. Neuroaktywne steroidy 19-NOR do stosowania w sposobach leczenia
CA3199003A1 (en) 2013-07-19 2015-01-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
HUE052308T2 (hu) 2013-08-23 2021-04-28 Sage Therapeutics Inc Neuroaktív szteroidok, készítmények és alkalmazásuk
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
EP3206493B1 (en) 2014-10-16 2020-05-06 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
CN117024502A (zh) 2014-10-16 2023-11-10 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
EP3719029A1 (en) 2014-11-27 2020-10-07 Sage Therapeutics, Inc. Compositions for inducing sedation
ES2857082T3 (es) 2015-01-26 2021-09-28 Sage Therapeutics Inc Composiciones y métodos para el tratamiento de trastornos del SNC
JP6875996B2 (ja) 2015-02-20 2021-05-26 セージ セラピューティクス, インコーポレイテッド 神経刺激性ステロイド、組成物、およびその使用
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
AU2017296295B2 (en) 2016-07-11 2022-02-24 Sage Therapeutics, Inc. C7, C12, and C16 substituted neuroactive steroids and their methods of use
KR20230079470A (ko) 2016-08-23 2023-06-07 세이지 테라퓨틱스, 인크. 결정질 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드
US20200281943A1 (en) * 2017-09-07 2020-09-10 Sage Therapeutics, Inc. Neuroactive steroids and their methods of use
IL303083A (en) * 2017-09-14 2023-07-01 Sage Therapeutics Inc 19-NOR C3,3-C21-N-pyrazolyl steroid dimer and methods of using it
KR20200096596A (ko) 2017-12-08 2020-08-12 세이지 테라퓨틱스, 인크. Cns 장애의 치료를 위한 중수소화 21 -[4-시아노-피라졸-1 -일]-19-노르-프레간-3. 알파-올-20-온 유도체
CN117959309A (zh) * 2018-06-12 2024-05-03 萨奇治疗股份有限公司 19-去甲基c3,3-二取代的c21-n-吡唑基类固醇及其使用方法
MX2021006618A (es) 2018-12-05 2021-09-23 Sage Therapeutics Inc Esteroides neuroactivos y sus metodos de uso.
CN111454318A (zh) * 2019-01-20 2020-07-28 浙江易众化工有限公司 抗抑郁药物sage-217的晶型及其制备方法
CN111770915A (zh) * 2019-01-31 2020-10-13 深圳仁泰医药科技有限公司 γ-氨基丁酸调节剂的晶型X及其制备方法和应用
US20220220149A1 (en) 2019-05-28 2022-07-14 Teva Czech Industries S.R.O Solid state forms of sage-217 and processes for preparation thereof
WO2020243488A1 (en) 2019-05-31 2020-12-03 Sage Therapeutics, Inc. Neuroactive steroids and compositions thereof
US20220275020A1 (en) * 2019-08-07 2022-09-01 Shanghai Hansoh Biomedical Co., Ltd. Salt and crystal form of steroid derivative regulator
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
EP4125921A1 (en) 2020-03-25 2023-02-08 Sage Therapeutics, Inc. Use of agents for treatment of respiratory conditions
BR112023000990A2 (pt) * 2020-07-20 2023-03-28 Sage Therapeutics Inc Formulações de esteroide c21-n-pirazolil 19-nor c3,3- dissubstituído e métodos de uso das mesmas
WO2022072620A1 (en) * 2020-10-01 2022-04-07 Eliem Therapeutics (UK) Ltd Methods of treating fibromyalgia with neuroactive steroids
JP2024507638A (ja) 2021-01-28 2024-02-21 セージ セラピューティクス, インコーポレイテッド 性機能障害処置のための神経刺激性ステロイドの使用
CA3213744A1 (en) 2021-03-17 2022-09-22 Sage Therapeutics, Inc. A 19-nor c3,3-disubstituted c21-n-pyrazolyl steroid for the treatment of major depressive disorder
WO2022232494A1 (en) 2021-04-29 2022-11-03 Sage Therapeutics, Inc. Neuroactive steroid for use in treating major depressive disorder and postpartum depression in a lactating female
IL307991A (en) 2021-04-29 2023-12-01 Sage Therapeutics Inc 19-NOR C3, 3- di-converted C21-N-pyrazolyl steroid for use in the treatment of major depressive disorder and postpartum depression
KR20240037975A (ko) 2021-07-28 2024-03-22 세이지 테라퓨틱스, 인크. 신경활성 스테로이드의 결정질 형태
KR20240148425A (ko) 2022-02-16 2024-10-11 세이지 테라퓨틱스, 인크. Cns-관련 장애의 치료를 위한 신경활성 스테로이드
TW202341996A (zh) 2022-02-28 2023-11-01 美商賽吉醫療公司 用於治療腸胃疾病或病狀之神經活性類固醇

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120723A (en) 1987-08-25 1992-06-09 University Of Southern California Method, compositions, and compounds for modulating brain excitability
US7018406B2 (en) 1999-11-17 2006-03-28 Corevalve Sa Prosthetic valve for transluminal delivery
AU2930501A (en) * 2000-01-07 2001-07-24 Transform Pharmaceuticals, Inc. High-throughput formation, identification, and analysis of diverse solid-forms
CN1323074C (zh) 2002-02-08 2007-06-27 小野药品工业株式会社 哌啶衍生物以及包含哌啶衍生物作为活性成分的药物组合物
WO2011079047A1 (en) 2009-12-23 2011-06-30 Drugtech Corporation Methods for reducing the occurrence of preterm delivery and other pregnancy-related conditions
CA2843436A1 (en) 2011-07-29 2013-02-07 The Regents Of The University Of California Novel 17.beta.-heteroaryl-substituted steroids as modulators of gaba a receptors
WO2013043985A1 (en) 2011-09-23 2013-03-28 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
PT2766380T (pt) 2011-10-14 2019-07-29 Sage Therapeutics Inc Compostos de 19-nor pregnano 3,3-dissubstituídos, composições e seus usos
RS59734B1 (sr) 2012-01-23 2020-02-28 Sage Therapeutics Inc Formulacije neuroaktivnog steroida koje uključuju kompleks alopregnanolona i sulfobutil etar beta-ciklodekstrina
WO2013188792A2 (en) 2012-06-15 2013-12-19 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2014028398A2 (en) 2012-08-13 2014-02-20 The Regents Of The University Of California Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids
EP2887944B1 (en) 2012-08-21 2021-10-06 Sage Therapeutics, Inc. Allopregnanolone for treating refractory status epilepticus
WO2014058736A1 (en) 2012-10-08 2014-04-17 Washington University Neuroactive 19-alkoxy-17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
EP2925327B1 (en) 2012-11-30 2024-01-10 The Regents of The University of California Allopregnanolone for treating, reducing or mitigating symptoms of post-partum depression
KR102400891B1 (ko) 2012-12-18 2022-05-20 워싱톤 유니버시티 신경활성 19-알콕시-17-치환된 스테로이드, 그의 전구약물, 및 그를 사용한 치료 방법
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
KR102614507B1 (ko) 2013-04-17 2023-12-19 세이지 테라퓨틱스, 인크. 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
PL2986624T3 (pl) 2013-04-17 2020-11-16 Sage Therapeutics, Inc. Neuroaktywne steroidy 19-NOR do stosowania w sposobach leczenia
CA3199003A1 (en) 2013-07-19 2015-01-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
HUE052308T2 (hu) 2013-08-23 2021-04-28 Sage Therapeutics Inc Neuroaktív szteroidok, készítmények és alkalmazásuk
ES2927007T3 (es) 2014-05-29 2022-10-31 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
CN117024502A (zh) 2014-10-16 2023-11-10 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
EP3206493B1 (en) 2014-10-16 2020-05-06 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP3719029A1 (en) 2014-11-27 2020-10-07 Sage Therapeutics, Inc. Compositions for inducing sedation
ES2857082T3 (es) 2015-01-26 2021-09-28 Sage Therapeutics Inc Composiciones y métodos para el tratamiento de trastornos del SNC
JP6875996B2 (ja) 2015-02-20 2021-05-26 セージ セラピューティクス, インコーポレイテッド 神経刺激性ステロイド、組成物、およびその使用
US20180311258A1 (en) 2015-04-10 2018-11-01 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
MA45276A (fr) 2015-06-18 2018-04-25 Sage Therapeutics Inc Solutions de stéroïdes neuroactifs et leurs méthodes d'utilisation
UY36741A (es) 2015-06-21 2016-12-30 Prevacus Inc Compuesto de esteroide c-20, sus composiciones y usos para tratar la lesión cerebral traumática (tbi), que incluye las conmociones cerebrales
EP3347368A4 (en) 2015-09-08 2019-01-23 Viewpoint Therapeutics, Inc. COMPOUNDS AND FORMULATIONS FOR THE TREATMENT OF EYE DISEASES
EA036155B1 (ru) 2015-10-16 2020-10-06 Маринус Фармасьютикалс, Инк. Инъекционные составы нейростероида, содержащие наночастицы
WO2017087864A1 (en) 2015-11-20 2017-05-26 Sage Therapeutics, Inc. Compounds and methods of their use
AU2017229656B2 (en) 2016-03-08 2022-09-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
MA45599A (fr) 2016-07-11 2019-05-15 Sage Therapeutics Inc Stéroïdes neuroactifs substitués en c17, c20 et c21 et leurs procédés d'utilisation
AU2017296295B2 (en) 2016-07-11 2022-02-24 Sage Therapeutics, Inc. C7, C12, and C16 substituted neuroactive steroids and their methods of use
KR20230079470A (ko) 2016-08-23 2023-06-07 세이지 테라퓨틱스, 인크. 결정질 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드
CN108727453A (zh) 2017-04-20 2018-11-02 华东理工大学 新型pd-1抑制剂及其应用
WO2019018119A1 (en) 2017-07-18 2019-01-24 Pairnomix, Llc METHODS FOR TREATING EPILEPSY AND DISORDERS ASSOCIATED WITH KCNTI
CA3073925A1 (en) 2017-08-31 2019-03-07 Takeda Pharmaceutical Company Limited Treatment of cns conditions
US20200281943A1 (en) 2017-09-07 2020-09-10 Sage Therapeutics, Inc. Neuroactive steroids and their methods of use
WO2019051477A1 (en) 2017-09-11 2019-03-14 Sage Therapeutics, Inc. METHODS OF TREATING EPILEPSY OR EPILEPTIC MALE CONDITION
IL303083A (en) 2017-09-14 2023-07-01 Sage Therapeutics Inc 19-NOR C3,3-C21-N-pyrazolyl steroid dimer and methods of using it
US20190160078A1 (en) 2017-11-10 2019-05-30 Marinus Pharmaceuticals, Inc. Ganaxolone for use in treating genetic epileptic disorders
KR20200096596A (ko) 2017-12-08 2020-08-12 세이지 테라퓨틱스, 인크. Cns 장애의 치료를 위한 중수소화 21 -[4-시아노-피라졸-1 -일]-19-노르-프레간-3. 알파-올-20-온 유도체
JP2021506904A (ja) 2017-12-22 2021-02-22 セージ セラピューティクス, インコーポレイテッド Cns障害の処置のための組成物および方法
EP3728284B1 (en) 2017-12-22 2024-08-21 Sage Therapeutics, Inc. 19-homo, 3.alpha.-hydroxy-steroid-20-one compounds for treating cns disorders
JP7538040B2 (ja) 2018-01-12 2024-08-21 セージ セラピューティクス, インコーポレイテッド CNS障害の処置における使用のためのアザ、オキサ、およびチア-プレグナン-20-オン-3α-オール化合物
CN117959309A (zh) 2018-06-12 2024-05-03 萨奇治疗股份有限公司 19-去甲基c3,3-二取代的c21-n-吡唑基类固醇及其使用方法
JP7671244B2 (ja) 2018-10-12 2025-05-01 セージ セラピューティクス, インコーポレイテッド Cns障害の処置において使用するための、10位において環式基で置換された神経刺激性ステロイド
EP3867261B1 (en) 2018-10-19 2025-04-30 Sage Therapeutics, Inc. 9(11)-unsaturated neuroactive steroids and their methods of use
MX2021006618A (es) 2018-12-05 2021-09-23 Sage Therapeutics Inc Esteroides neuroactivos y sus metodos de uso.
WO2020132504A1 (en) 2018-12-21 2020-06-25 Sage Therapeutics, Inc. 3.alpha.-hydroxy-17.beta.-amide neuroactive steroids and compositions thereof
TW202523658A (zh) 2019-05-24 2025-06-16 美商賽吉醫療公司 化合物、組合物及使用方法
WO2020243488A1 (en) 2019-05-31 2020-12-03 Sage Therapeutics, Inc. Neuroactive steroids and compositions thereof
JP7670632B2 (ja) 2019-06-27 2025-04-30 セージ セラピューティクス, インコーポレイテッド Cns障害を治療するための組成物及び方法
US20230303616A9 (en) 2019-06-27 2023-09-28 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2020264495A1 (en) 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
KR20220112803A (ko) 2019-12-05 2022-08-11 세이지 테라퓨틱스, 인크. 19-nor c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법
WO2021188778A2 (en) 2020-03-18 2021-09-23 Sage Therapeutics, Inc. Neuroactive steroids and their methods of use
EP4125921A1 (en) 2020-03-25 2023-02-08 Sage Therapeutics, Inc. Use of agents for treatment of respiratory conditions
JP2023531517A (ja) 2020-06-24 2023-07-24 セージ セラピューティクス, インコーポレイテッド 3.アルファ.-ヒドロキシ、17.ベータ.-c(o)-n-アリール置換神経活性ステロイド及びそれらの組成物
BR112023000990A2 (pt) 2020-07-20 2023-03-28 Sage Therapeutics Inc Formulações de esteroide c21-n-pirazolil 19-nor c3,3- dissubstituído e métodos de uso das mesmas
CA3202870A1 (en) 2020-11-25 2022-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
JP2024507638A (ja) 2021-01-28 2024-02-21 セージ セラピューティクス, インコーポレイテッド 性機能障害処置のための神経刺激性ステロイドの使用
WO2022177718A1 (en) 2021-02-18 2022-08-25 Sage Therapeutics, Inc. Use of neuroactive steroid for treatment of sexual dysfunction
CA3213744A1 (en) 2021-03-17 2022-09-22 Sage Therapeutics, Inc. A 19-nor c3,3-disubstituted c21-n-pyrazolyl steroid for the treatment of major depressive disorder
CA3216542A1 (en) 2021-04-12 2022-10-20 Sage Therapeutics, Inc. Treatment of essential tremor
WO2022232494A1 (en) 2021-04-29 2022-11-03 Sage Therapeutics, Inc. Neuroactive steroid for use in treating major depressive disorder and postpartum depression in a lactating female
IL307991A (en) 2021-04-29 2023-12-01 Sage Therapeutics Inc 19-NOR C3, 3- di-converted C21-N-pyrazolyl steroid for use in the treatment of major depressive disorder and postpartum depression
KR20240148425A (ko) 2022-02-16 2024-10-11 세이지 테라퓨틱스, 인크. Cns-관련 장애의 치료를 위한 신경활성 스테로이드
TW202341996A (zh) 2022-02-28 2023-11-01 美商賽吉醫療公司 用於治療腸胃疾病或病狀之神經活性類固醇

Similar Documents

Publication Publication Date Title
JP2023002846A5 (enExample)
US10561654B2 (en) Pharmaceutical formulations of (S)-methyl(1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate
JP2017222705A5 (enExample)
JP6993502B2 (ja) Sglt-2阻害剤とアンジオテンシン受容体拮抗薬を含む医薬組成物
US20100203133A1 (en) High drug load tablet
US12016951B2 (en) Edaravone pharmaceutical composition
JP2015506377A5 (enExample)
WO2011069326A1 (zh) 包含阿替洛尔和氨氯地平的双层片剂
EP2241310A2 (en) Modified release formulations of emoxypine
WO2013100630A1 (en) Fixed dose combination formulation comprising losartan, amlodipine and hydrochlorothiazide
TR201907905A1 (tr) Alogli̇pti̇n ve metformi̇n i̇çeren bi̇r kombi̇nasyon
WO2019162800A1 (en) Pharmacutical composition comprising remogliflozin and antidiabetic agent
CN114224859A (zh) 一种复方降压药物组合物及其制备方法
EP4008315A1 (en) A process for formulations of dapagliflozin and metformin hydrochloride
EP4008316A1 (en) A film coated tablet formulation comprising dapagliflozin and metformin hydrochloride
US20250170065A1 (en) Therapeutic compounds, formulations, and use thereof
WO2024263130A1 (en) A pharmaceutical formulation comprising linagliptin, metformin and a sglt-2 inhibitor
RU2020143156A (ru) Фармацевтическая комбинация, композиция и комбинированный состав, содержащий активатор глюкокиназы и бигуанидное гипогликемическое лекарственное средство, а также способ их приготовления и их применение
NZ623628B2 (en) Solid oral pharmaceutical formulations comprising amorphous (S)-methyl (1- ((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropy1-1H-pyrazo1-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (Compound A)
HK1197024B (en) Pharmaceutical formulations