JP2019524853A - 結晶性１９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイド - Google Patents

結晶性１９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイド Download PDF

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Publication number
JP2019524853A
JP2019524853A JP2019510657A JP2019510657A JP2019524853A JP 2019524853 A JP2019524853 A JP 2019524853A JP 2019510657 A JP2019510657 A JP 2019510657A JP 2019510657 A JP2019510657 A JP 2019510657A JP 2019524853 A JP2019524853 A JP 2019524853A
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Japan
Prior art keywords
crystalline compound
disorder
compound
xrpd pattern
crystalline
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Withdrawn
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JP2019510657A
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English (en)
Japanese (ja)
Inventor
ポール スティーブン ワトソン，
ポール スティーブン ワトソン，
ブレット バーナー，
ブレット バーナー，
ジョン グレゴリー リード，
ジョン グレゴリー リード，
ジアン ワン，
ジアン ワン，
ジェイムズ ジェイ． ドハーティ，
ジェイムズ ジェイ． ドハーティ，
スティーブン ジェイ． ケインズ，
スティーブン ジェイ． ケインズ，
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Sage Therapeutics, LLC
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Sage Therapeutics, LLC
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Publication of JP2019524853A publication Critical patent/JP2019524853A/ja
Priority to JP2022178009A priority Critical patent/JP2023002846A/ja
Priority to JP2024075299A priority patent/JP2024097878A/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
JP2019510657A 2016-08-23 2017-08-23 結晶性１９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイド Withdrawn JP2019524853A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022178009A JP2023002846A (ja) 2016-08-23 2022-11-07 結晶性１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド
JP2024075299A JP2024097878A (ja) 2016-08-23 2024-05-07 結晶性１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662378582P 2016-08-23 2016-08-23
US62/378,582 2016-08-23
PCT/US2017/048267 WO2018039378A1 (en) 2016-08-23 2017-08-23 A crystalline 19-nor c3, 3-disubstituted c21-n-pyrazolyl steroid

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022178009A Division JP2023002846A (ja) 2016-08-23 2022-11-07 結晶性１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド

Publications (1)

Publication Number Publication Date
JP2019524853A true JP2019524853A (ja) 2019-09-05

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JP2019510657A Withdrawn JP2019524853A (ja) 2016-08-23 2017-08-23 結晶性１９−ノルｃ３，３−二置換ｃ２１−ｎ−ピラゾリルステロイド
JP2022178009A Pending JP2023002846A (ja) 2016-08-23 2022-11-07 結晶性１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド
JP2024075299A Pending JP2024097878A (ja) 2016-08-23 2024-05-07 結晶性１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド

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JP2022178009A Pending JP2023002846A (ja) 2016-08-23 2022-11-07 結晶性１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド
JP2024075299A Pending JP2024097878A (ja) 2016-08-23 2024-05-07 結晶性１９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイド

Country Status (25)

Country Link
US (4) US11236121B2 (enExample)
EP (2) EP3981763A1 (enExample)
JP (3) JP2019524853A (enExample)
KR (2) KR20230079470A (enExample)
CN (4) CN115974956A (enExample)
AR (3) AR109393A1 (enExample)
AU (3) AU2017315682B2 (enExample)
BR (1) BR112019003637A2 (enExample)
CA (1) CA3034262A1 (enExample)
CL (2) CL2019000477A1 (enExample)
CO (1) CO2019002596A2 (enExample)
EA (1) EA201990565A1 (enExample)
EC (1) ECSP19020141A (enExample)
IL (2) IL302480A (enExample)
JO (1) JOP20190022B1 (enExample)
MA (1) MA46042A (enExample)
MX (2) MX393240B (enExample)
MY (1) MY200479A (enExample)
NZ (1) NZ791594A (enExample)
PE (2) PE20241580A1 (enExample)
PH (1) PH12019500375A1 (enExample)
SG (1) SG11201901445TA (enExample)
TW (2) TWI854445B (enExample)
WO (1) WO2018039378A1 (enExample)
ZA (1) ZA201901051B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023537240A (ja) * 2020-07-20 2023-08-31 セージ セラピューティクス， インコーポレイテッド １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドの製剤及びその使用方法

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CN117959309A (zh) * 2018-06-12 2024-05-03 萨奇治疗股份有限公司 19-去甲基c3,3-二取代的c21-n-吡唑基类固醇及其使用方法
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