JP2015506377A5 - - Google Patents
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- JP2015506377A5 JP2015506377A5 JP2014555852A JP2014555852A JP2015506377A5 JP 2015506377 A5 JP2015506377 A5 JP 2015506377A5 JP 2014555852 A JP2014555852 A JP 2014555852A JP 2014555852 A JP2014555852 A JP 2014555852A JP 2015506377 A5 JP2015506377 A5 JP 2015506377A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- oral dosage
- solid oral
- form according
- molded body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 42
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 claims description 34
- 229960004419 dimethyl fumarate Drugs 0.000 claims description 34
- 230000006835 compression Effects 0.000 claims description 13
- 238000007906 compression Methods 0.000 claims description 13
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
- 239000011248 coating agent Substances 0.000 claims description 11
- 238000000576 coating method Methods 0.000 claims description 11
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000007884 disintegrant Substances 0.000 claims description 7
- 239000000314 lubricant Substances 0.000 claims description 7
- 201000006417 multiple sclerosis Diseases 0.000 claims description 7
- 229920001577 copolymer Polymers 0.000 claims description 6
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 5
- -1 hydroxylpropyl Chemical group 0.000 claims description 5
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 5
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 5
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- OSNIIMCBVLBNGS-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino)propan-1-one Chemical compound CN(C)C(C)C(=O)C1=CC=C2OCOC2=C1 OSNIIMCBVLBNGS-UHFFFAOYSA-N 0.000 claims description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 3
- 239000004606 Fillers/Extenders Substances 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 3
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 3
- 238000011010 flushing procedure Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims description 2
- NZEXUPLJXSDMCK-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;methyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound COC(=O)C=C.CC(=C)C(O)=O.COC(=O)C(C)=C NZEXUPLJXSDMCK-UHFFFAOYSA-N 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 claims 44
- 239000007787 solid Substances 0.000 claims 43
- 239000004067 bulking agent Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 4
- 101000945318 Homo sapiens Calponin-1 Proteins 0.000 claims 2
- 101000652736 Homo sapiens Transgelin Proteins 0.000 claims 2
- 102100031013 Transgelin Human genes 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- JJAHTWIKCUJRDK-UHFFFAOYSA-N succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate Chemical compound C1CC(CN2C(C=CC2=O)=O)CCC1C(=O)ON1C(=O)CCC1=O JJAHTWIKCUJRDK-UHFFFAOYSA-N 0.000 claims 2
- 238000000748 compression moulding Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 17
- NKHAVTQWNUWKEO-UHFFFAOYSA-N fumaric acid monomethyl ester Natural products COC(=O)C=CC(O)=O NKHAVTQWNUWKEO-UHFFFAOYSA-N 0.000 description 12
- NKHAVTQWNUWKEO-NSCUHMNNSA-N monomethyl fumarate Chemical compound COC(=O)\C=C\C(O)=O NKHAVTQWNUWKEO-NSCUHMNNSA-N 0.000 description 12
- 229940005650 monomethyl fumarate Drugs 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 125000003118 aryl group Chemical group 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical group 0.000 description 2
- 125000004404 heteroalkyl group Chemical group 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 description 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261596202P | 2012-02-07 | 2012-02-07 | |
| US61/596,202 | 2012-02-07 | ||
| US201261625621P | 2012-04-17 | 2012-04-17 | |
| US61/625,621 | 2012-04-17 | ||
| US201261723048P | 2012-11-06 | 2012-11-06 | |
| US61/723,048 | 2012-11-06 | ||
| PCT/US2013/024946 WO2013119677A1 (en) | 2012-02-07 | 2013-02-06 | Pharmaceutical compositions containing dimethyl fumarate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017149548A Division JP6430598B2 (ja) | 2012-02-07 | 2017-08-02 | フマル酸ジメチルを含有する医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506377A JP2015506377A (ja) | 2015-03-02 |
| JP2015506377A5 true JP2015506377A5 (enExample) | 2016-03-31 |
| JP6189333B2 JP6189333B2 (ja) | 2017-08-30 |
Family
ID=48947963
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555852A Expired - Fee Related JP6189333B2 (ja) | 2012-02-07 | 2013-02-06 | フマル酸ジメチルを含有する医薬組成物 |
| JP2017149548A Expired - Fee Related JP6430598B2 (ja) | 2012-02-07 | 2017-08-02 | フマル酸ジメチルを含有する医薬組成物 |
| JP2018204599A Pending JP2019059732A (ja) | 2012-02-07 | 2018-10-31 | フマル酸ジメチルを含有する医薬組成物 |
| JP2021184462A Pending JP2022024048A (ja) | 2012-02-07 | 2021-11-12 | フマル酸ジメチルを含有する医薬組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017149548A Expired - Fee Related JP6430598B2 (ja) | 2012-02-07 | 2017-08-02 | フマル酸ジメチルを含有する医薬組成物 |
| JP2018204599A Pending JP2019059732A (ja) | 2012-02-07 | 2018-10-31 | フマル酸ジメチルを含有する医薬組成物 |
| JP2021184462A Pending JP2022024048A (ja) | 2012-02-07 | 2021-11-12 | フマル酸ジメチルを含有する医薬組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (7) | US20130216615A1 (enExample) |
| EP (1) | EP2811994A4 (enExample) |
| JP (4) | JP6189333B2 (enExample) |
| KR (1) | KR102105217B1 (enExample) |
| CN (5) | CN114146079A (enExample) |
| AR (1) | AR089931A1 (enExample) |
| AU (6) | AU2013203445C1 (enExample) |
| BR (1) | BR112014019462B1 (enExample) |
| CA (1) | CA2862885C (enExample) |
| CL (1) | CL2014002077A1 (enExample) |
| CO (1) | CO7141407A2 (enExample) |
| EA (1) | EA038152B1 (enExample) |
| EC (1) | ECSP14014870A (enExample) |
| HK (1) | HK1202261A1 (enExample) |
| IL (2) | IL233833B (enExample) |
| MX (2) | MX370785B (enExample) |
| NI (1) | NI201400086A (enExample) |
| NZ (1) | NZ627980A (enExample) |
| PE (1) | PE20150092A1 (enExample) |
| PH (1) | PH12014501750A1 (enExample) |
| SG (1) | SG11201404705YA (enExample) |
| TW (4) | TWI697338B (enExample) |
| WO (1) | WO2013119677A1 (enExample) |
| ZA (1) | ZA201405511B (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2526586C (en) | 2003-09-09 | 2010-03-16 | Biogen International Gmbh | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
| EP1799196B1 (en) | 2004-10-08 | 2016-06-22 | Forward Pharma A/S | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
| EP2139467B1 (en) * | 2007-02-08 | 2016-09-21 | Biogen MA Inc. | Neuroprotection in demyelinating diseases |
| EP2334378B1 (en) | 2008-08-19 | 2014-04-09 | XenoPort, Inc. | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use |
| NZ618178A (en) | 2011-06-08 | 2016-03-31 | Biogen Ma Inc | Process for preparing high purity and crystalline dimethyl fumarate |
| CN114146079A (zh) * | 2012-02-07 | 2022-03-08 | 比奥根玛公司 | 含有富马酸二甲酯的药物组合物 |
| JP2015527372A (ja) * | 2012-08-22 | 2015-09-17 | ゼノポート，インコーポレイティド | 副作用を低減させるモノメチルフマレートおよびそのプロドラッグの投与方法 |
| US9597292B2 (en) * | 2012-08-22 | 2017-03-21 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| JP6506174B2 (ja) | 2012-12-21 | 2019-04-24 | バイオジェン エムエー インコーポレイテッド | 重水素置換されたフマル酸誘導体 |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| CA2992211C (en) | 2013-03-14 | 2021-09-21 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| WO2014143146A1 (en) * | 2013-03-15 | 2014-09-18 | Xenoport, Inc. | Methods of administering monomethyl fumarate |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| TW201516020A (zh) | 2013-09-06 | 2015-05-01 | Xenoport Inc | （ｎ，ｎ－二乙基胺甲醯基）甲基（２ｅ）丁－２－烯－１，４－二酸甲酯之晶形、合成方法及用途 |
| UA120428C2 (uk) | 2013-12-12 | 2019-12-10 | Алміралл, С.А. | Фармацевтичні композиції, які містять диметилфумарат |
| WO2015089420A1 (en) * | 2013-12-13 | 2015-06-18 | Biogen Idec Ma Inc. | Controlled release dosage form for once daily administration of dimethyl fumarate |
| AU2015218587B2 (en) | 2014-02-24 | 2017-04-27 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| AU2015222880B2 (en) | 2014-02-28 | 2016-11-24 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| CA2942690A1 (en) | 2014-03-14 | 2015-09-17 | Biogen Ma Inc. | Dimethyl fumarate and vaccination regimens |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| CA2962916C (en) * | 2014-10-08 | 2021-06-15 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| EP3212626B1 (en) * | 2014-10-27 | 2018-11-07 | Cellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| MA40985A (fr) | 2014-11-17 | 2017-09-26 | Biogen Ma Inc | Méthodes de traitement de la sclérose en plaques |
| MA40990A (fr) * | 2014-11-19 | 2017-09-26 | Biogen Ma Inc | Formulations de matrice pharmaceutique comprenant du fumarate de diméthyle |
| MA40982A (fr) * | 2014-11-19 | 2017-09-26 | Biogen Ma Inc | Formulation de bille pharmaceutique comprenant du fumarate de diméthyle |
| CN104490849A (zh) * | 2014-11-24 | 2015-04-08 | 广东东阳光药业有限公司 | 一种高密度的富马酸二甲酯肠溶颗粒及其制备方法 |
| MA41139B1 (fr) | 2014-12-11 | 2026-02-27 | Laboratoires Juvise Pharmaceuticals | Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque |
| EA036075B1 (ru) | 2014-12-11 | 2020-09-23 | Актелион Фармасьютиклз Лтд | Схема дозирования для селективного агониста рецептора s1p1 |
| HK1253050A1 (zh) * | 2015-02-02 | 2019-06-06 | 英仕柏集团有限责任公司 | 稳定的富马酸二烷基酯组合物 |
| SG10201907289VA (en) | 2015-02-08 | 2019-09-27 | Alkermes Pharma Ireland Ltd | Monomethylfumarate prodrug compositions |
| AU2016231883B2 (en) * | 2015-03-17 | 2019-03-07 | Hetero Labs Limited | Pharmaceutical compositions of dimethyl fumarate |
| MA41785A (fr) | 2015-03-20 | 2018-01-23 | Biogen Ma Inc | Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques |
| EP3302461A4 (en) | 2015-06-01 | 2019-02-13 | Sun Pharmaceutical Industries Ltd | PHARMACEUTICAL COMPOSITIONS OF DIMETHYLFUMARATE |
| CN107920997A (zh) | 2015-06-17 | 2018-04-17 | 比奥根Ma公司 | 富马酸二甲酯颗粒和其药物组合物 |
| WO2017056107A1 (en) | 2015-09-28 | 2017-04-06 | Natco Pharma Ltd | Pharmaceutical compositions of dimethyl fumarate |
| WO2017072699A1 (en) * | 2015-10-28 | 2017-05-04 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions of dimethyl fumarate |
| EP3397247B1 (en) | 2015-12-31 | 2023-06-07 | Zaklady Farmaceutyczne Polpharma SA | Process for preparation of an enteric coated granulate comprising dimethyl fumarate |
| WO2017129370A1 (en) * | 2016-01-28 | 2017-08-03 | Zaklady Farmaceutyczne Polpharma S.A. | Process for preparation of a granulate comprising dimethyl fumarate |
| MA44010A (fr) * | 2016-02-11 | 2018-12-19 | Biogen Ma Inc | Formulations pharmaceutiques de billes comprenant du diméthylfumarate |
| WO2017145036A1 (en) * | 2016-02-25 | 2017-08-31 | Aurobindo Pharma Ltd | Pharmaceutical compositions comprising dimethyl fumarate |
| TR201616998A1 (en) | 2016-11-23 | 2018-06-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | DELAYED RELEASE DOSING FORMS WITH DIMETHYL FUMARATE |
| CN110475547A (zh) * | 2017-03-17 | 2019-11-19 | 维塔利斯公司 | 治疗多发性硬化症的组合物和方法 |
| KR20200018458A (ko) | 2017-06-23 | 2020-02-19 | 알미랄, 에스.에이. | 디메틸 푸마레이트를 포함하는 약학 조성물 |
| US20210251910A1 (en) * | 2018-09-10 | 2021-08-19 | Vitalis Llc | Fumaric acid compositions with increased bioavailability and reduced side effects |
| US11446055B1 (en) | 2018-10-18 | 2022-09-20 | Lumoptik, Inc. | Light assisted needle placement system and method |
| TR201818293A2 (tr) | 2018-11-30 | 2020-06-22 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Di̇meti̇l fumarat i̇çeren geci̇kmeli̇ salim sağlayan kapsül |
| US12496287B2 (en) | 2019-11-08 | 2025-12-16 | The Children's Hospital Of Philadelphia | Compositions and methods for treating macrophage activation syndrome |
| US11903918B2 (en) | 2020-01-10 | 2024-02-20 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| US20230099229A1 (en) * | 2020-03-13 | 2023-03-30 | Reprise Pharmaceuticals, Inc. | Methods of treating multiple sclerosis |
| CA3182369A1 (en) | 2020-05-06 | 2021-07-22 | Imcyse Sa | Combination treatment for fumarate-related diseases |
| BR112023025435A2 (pt) * | 2021-06-04 | 2024-02-27 | Zim Laboratories Ltd | Composições de liberação retardada de fumarato de dimetila |
| AU2022422597A1 (en) | 2021-12-23 | 2024-07-11 | Gencaps Sàrl | Drug delivery system comprising monomethyl fumarate |
| CN115590831A (zh) * | 2022-10-26 | 2023-01-13 | 力品药业（厦门）股份有限公司（Cn） | 一种富马酸二甲酯缓释微片及其制备方法 |
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2013
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- 2013-02-06 WO PCT/US2013/024946 patent/WO2013119677A1/en not_active Ceased
- 2013-02-06 CA CA2862885A patent/CA2862885C/en active Active
- 2013-02-06 US US13/760,916 patent/US20130216615A1/en not_active Abandoned
- 2013-02-06 CN CN202111172018.6A patent/CN114146080A/zh active Pending
- 2013-02-06 SG SG11201404705YA patent/SG11201404705YA/en unknown
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- 2013-02-06 PE PE2014001232A patent/PE20150092A1/es not_active Application Discontinuation
- 2013-02-06 NZ NZ627980A patent/NZ627980A/en not_active IP Right Cessation
- 2013-02-06 EP EP13746306.3A patent/EP2811994A4/en not_active Withdrawn
- 2013-02-06 HK HK15102805.4A patent/HK1202261A1/xx unknown
- 2013-02-06 KR KR1020147024886A patent/KR102105217B1/ko not_active Expired - Fee Related
- 2013-02-06 CN CN202111173089.8A patent/CN114146081A/zh active Pending
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- 2013-02-06 JP JP2014555852A patent/JP6189333B2/ja not_active Expired - Fee Related
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- 2013-02-07 AR ARP130100385A patent/AR089931A1/es not_active Application Discontinuation
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2015
- 2015-04-06 US US14/679,716 patent/US20150209318A1/en not_active Abandoned
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- 2017-08-02 JP JP2017149548A patent/JP6430598B2/ja not_active Expired - Fee Related
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2018
- 2018-03-02 US US15/910,745 patent/US20180185319A1/en not_active Abandoned
- 2018-05-24 US US15/988,568 patent/US20180263946A1/en not_active Abandoned
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- 2018-11-09 AU AU2018260937A patent/AU2018260937B2/en not_active Ceased
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2019
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2020
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