JP2017222705A5 - - Google Patents

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Publication number
JP2017222705A5
JP2017222705A5 JP2017149548A JP2017149548A JP2017222705A5 JP 2017222705 A5 JP2017222705 A5 JP 2017222705A5 JP 2017149548 A JP2017149548 A JP 2017149548A JP 2017149548 A JP2017149548 A JP 2017149548A JP 2017222705 A5 JP2017222705 A5 JP 2017222705A5
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JP
Japan
Prior art keywords
dosage form
oral dosage
solid oral
dimethyl fumarate
form according
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JP2017149548A
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English (en)
Japanese (ja)
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JP6430598B2 (ja
JP2017222705A (ja
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Publication of JP2017222705A5 publication Critical patent/JP2017222705A5/ja
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Publication of JP6430598B2 publication Critical patent/JP6430598B2/ja
Expired - Fee Related legal-status Critical Current
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JP2017149548A 2012-02-07 2017-08-02 フマル酸ジメチルを含有する医薬組成物 Expired - Fee Related JP6430598B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261596202P 2012-02-07 2012-02-07
US61/596,202 2012-02-07
US201261625621P 2012-04-17 2012-04-17
US61/625,621 2012-04-17
US201261723048P 2012-11-06 2012-11-06
US61/723,048 2012-11-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2014555852A Division JP6189333B2 (ja) 2012-02-07 2013-02-06 フマル酸ジメチルを含有する医薬組成物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018204599A Division JP2019059732A (ja) 2012-02-07 2018-10-31 フマル酸ジメチルを含有する医薬組成物

Publications (3)

Publication Number Publication Date
JP2017222705A JP2017222705A (ja) 2017-12-21
JP2017222705A5 true JP2017222705A5 (enExample) 2018-03-22
JP6430598B2 JP6430598B2 (ja) 2018-11-28

Family

ID=48947963

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2014555852A Expired - Fee Related JP6189333B2 (ja) 2012-02-07 2013-02-06 フマル酸ジメチルを含有する医薬組成物
JP2017149548A Expired - Fee Related JP6430598B2 (ja) 2012-02-07 2017-08-02 フマル酸ジメチルを含有する医薬組成物
JP2018204599A Pending JP2019059732A (ja) 2012-02-07 2018-10-31 フマル酸ジメチルを含有する医薬組成物
JP2021184462A Pending JP2022024048A (ja) 2012-02-07 2021-11-12 フマル酸ジメチルを含有する医薬組成物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2014555852A Expired - Fee Related JP6189333B2 (ja) 2012-02-07 2013-02-06 フマル酸ジメチルを含有する医薬組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018204599A Pending JP2019059732A (ja) 2012-02-07 2018-10-31 フマル酸ジメチルを含有する医薬組成物
JP2021184462A Pending JP2022024048A (ja) 2012-02-07 2021-11-12 フマル酸ジメチルを含有する医薬組成物

Country Status (24)

Country Link
US (7) US20130216615A1 (enExample)
EP (1) EP2811994A4 (enExample)
JP (4) JP6189333B2 (enExample)
KR (1) KR102105217B1 (enExample)
CN (5) CN114146079A (enExample)
AR (1) AR089931A1 (enExample)
AU (6) AU2013203445C1 (enExample)
BR (1) BR112014019462B1 (enExample)
CA (1) CA2862885C (enExample)
CL (1) CL2014002077A1 (enExample)
CO (1) CO7141407A2 (enExample)
EA (1) EA038152B1 (enExample)
EC (1) ECSP14014870A (enExample)
HK (1) HK1202261A1 (enExample)
IL (2) IL233833B (enExample)
MX (2) MX370785B (enExample)
NI (1) NI201400086A (enExample)
NZ (1) NZ627980A (enExample)
PE (1) PE20150092A1 (enExample)
PH (1) PH12014501750A1 (enExample)
SG (1) SG11201404705YA (enExample)
TW (4) TWI697338B (enExample)
WO (1) WO2013119677A1 (enExample)
ZA (1) ZA201405511B (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2526586C (en) 2003-09-09 2010-03-16 Biogen International Gmbh The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
EP1799196B1 (en) 2004-10-08 2016-06-22 Forward Pharma A/S Controlled release pharmaceutical compositions comprising a fumaric acid ester
EP2139467B1 (en) * 2007-02-08 2016-09-21 Biogen MA Inc. Neuroprotection in demyelinating diseases
EP2334378B1 (en) 2008-08-19 2014-04-09 XenoPort, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
NZ618178A (en) 2011-06-08 2016-03-31 Biogen Ma Inc Process for preparing high purity and crystalline dimethyl fumarate
CN114146079A (zh) * 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物
JP2015527372A (ja) * 2012-08-22 2015-09-17 ゼノポート,インコーポレイティド 副作用を低減させるモノメチルフマレートおよびそのプロドラッグの投与方法
US9597292B2 (en) * 2012-08-22 2017-03-21 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
JP6506174B2 (ja) 2012-12-21 2019-04-24 バイオジェン エムエー インコーポレイテッド 重水素置換されたフマル酸誘導体
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
CA2992211C (en) 2013-03-14 2021-09-21 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
WO2014143146A1 (en) * 2013-03-15 2014-09-18 Xenoport, Inc. Methods of administering monomethyl fumarate
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
TW201516020A (zh) 2013-09-06 2015-05-01 Xenoport Inc (n,n-二乙基胺甲醯基)甲基(2e)丁-2-烯-1,4-二酸甲酯之晶形、合成方法及用途
UA120428C2 (uk) 2013-12-12 2019-12-10 Алміралл, С.А. Фармацевтичні композиції, які містять диметилфумарат
WO2015089420A1 (en) * 2013-12-13 2015-06-18 Biogen Idec Ma Inc. Controlled release dosage form for once daily administration of dimethyl fumarate
AU2015218587B2 (en) 2014-02-24 2017-04-27 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
AU2015222880B2 (en) 2014-02-28 2016-11-24 Banner Life Sciences Llc Controlled release enteric soft capsules of fumarate esters
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
CA2942690A1 (en) 2014-03-14 2015-09-17 Biogen Ma Inc. Dimethyl fumarate and vaccination regimens
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
CA2962916C (en) * 2014-10-08 2021-06-15 Banner Life Sciences Llc Controlled release enteric soft capsules of fumarate esters
EP3212626B1 (en) * 2014-10-27 2018-11-07 Cellix Bio Private Limited Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis
MA40985A (fr) 2014-11-17 2017-09-26 Biogen Ma Inc Méthodes de traitement de la sclérose en plaques
MA40990A (fr) * 2014-11-19 2017-09-26 Biogen Ma Inc Formulations de matrice pharmaceutique comprenant du fumarate de diméthyle
MA40982A (fr) * 2014-11-19 2017-09-26 Biogen Ma Inc Formulation de bille pharmaceutique comprenant du fumarate de diméthyle
CN104490849A (zh) * 2014-11-24 2015-04-08 广东东阳光药业有限公司 一种高密度的富马酸二甲酯肠溶颗粒及其制备方法
MA41139B1 (fr) 2014-12-11 2026-02-27 Laboratoires Juvise Pharmaceuticals Combinaison pharmaceutique comprenant du ponesimod et son utilisation dans le traitement de la sclérose en plaque
EA036075B1 (ru) 2014-12-11 2020-09-23 Актелион Фармасьютиклз Лтд Схема дозирования для селективного агониста рецептора s1p1
HK1253050A1 (zh) * 2015-02-02 2019-06-06 英仕柏集团有限责任公司 稳定的富马酸二烷基酯组合物
SG10201907289VA (en) 2015-02-08 2019-09-27 Alkermes Pharma Ireland Ltd Monomethylfumarate prodrug compositions
AU2016231883B2 (en) * 2015-03-17 2019-03-07 Hetero Labs Limited Pharmaceutical compositions of dimethyl fumarate
MA41785A (fr) 2015-03-20 2018-01-23 Biogen Ma Inc Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques
EP3302461A4 (en) 2015-06-01 2019-02-13 Sun Pharmaceutical Industries Ltd PHARMACEUTICAL COMPOSITIONS OF DIMETHYLFUMARATE
CN107920997A (zh) 2015-06-17 2018-04-17 比奥根Ma公司 富马酸二甲酯颗粒和其药物组合物
WO2017056107A1 (en) 2015-09-28 2017-04-06 Natco Pharma Ltd Pharmaceutical compositions of dimethyl fumarate
WO2017072699A1 (en) * 2015-10-28 2017-05-04 Sun Pharmaceutical Industries Limited Pharmaceutical compositions of dimethyl fumarate
EP3397247B1 (en) 2015-12-31 2023-06-07 Zaklady Farmaceutyczne Polpharma SA Process for preparation of an enteric coated granulate comprising dimethyl fumarate
WO2017129370A1 (en) * 2016-01-28 2017-08-03 Zaklady Farmaceutyczne Polpharma S.A. Process for preparation of a granulate comprising dimethyl fumarate
MA44010A (fr) * 2016-02-11 2018-12-19 Biogen Ma Inc Formulations pharmaceutiques de billes comprenant du diméthylfumarate
WO2017145036A1 (en) * 2016-02-25 2017-08-31 Aurobindo Pharma Ltd Pharmaceutical compositions comprising dimethyl fumarate
TR201616998A1 (en) 2016-11-23 2018-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi DELAYED RELEASE DOSING FORMS WITH DIMETHYL FUMARATE
CN110475547A (zh) * 2017-03-17 2019-11-19 维塔利斯公司 治疗多发性硬化症的组合物和方法
KR20200018458A (ko) 2017-06-23 2020-02-19 알미랄, 에스.에이. 디메틸 푸마레이트를 포함하는 약학 조성물
US20210251910A1 (en) * 2018-09-10 2021-08-19 Vitalis Llc Fumaric acid compositions with increased bioavailability and reduced side effects
US11446055B1 (en) 2018-10-18 2022-09-20 Lumoptik, Inc. Light assisted needle placement system and method
TR201818293A2 (tr) 2018-11-30 2020-06-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Di̇meti̇l fumarat i̇çeren geci̇kmeli̇ salim sağlayan kapsül
US12496287B2 (en) 2019-11-08 2025-12-16 The Children's Hospital Of Philadelphia Compositions and methods for treating macrophage activation syndrome
US11903918B2 (en) 2020-01-10 2024-02-20 Banner Life Sciences Llc Fumarate ester dosage forms with enhanced gastrointestinal tolerability
US20230099229A1 (en) * 2020-03-13 2023-03-30 Reprise Pharmaceuticals, Inc. Methods of treating multiple sclerosis
CA3182369A1 (en) 2020-05-06 2021-07-22 Imcyse Sa Combination treatment for fumarate-related diseases
BR112023025435A2 (pt) * 2021-06-04 2024-02-27 Zim Laboratories Ltd Composições de liberação retardada de fumarato de dimetila
AU2022422597A1 (en) 2021-12-23 2024-07-11 Gencaps Sàrl Drug delivery system comprising monomethyl fumarate
CN115590831A (zh) * 2022-10-26 2023-01-13 力品药业(厦门)股份有限公司(Cn) 一种富马酸二甲酯缓释微片及其制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1153927A (en) 1966-08-25 1969-06-04 Wilhelm Hoerrmann Medicinal Composition Suitable For Treating Diseases Of The Retina
US4959389A (en) * 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
US5424332A (en) 1987-10-19 1995-06-13 Speiser; Peter P. Pharmaceutical composition and process for the production thereof
US5484610A (en) 1991-01-02 1996-01-16 Macromed, Inc. pH and temperature sensitive terpolymers for oral drug delivery
DE19721099C2 (de) 1997-05-20 1999-12-02 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten
FI109088B (fi) * 1997-09-19 2002-05-31 Leiras Oy Tabletti ja menetelmä sen valmistamiseksi
DE19814358C2 (de) 1998-03-31 2002-01-17 Fumapharm Ag Muri Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn
DE19839566C2 (de) 1998-08-31 2002-01-17 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
DE19848260C2 (de) * 1998-10-20 2002-01-17 Fumapharm Ag Muri Fumarsäure-Mikrotabletten
DE19853487A1 (de) * 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
US6537584B1 (en) 1999-11-12 2003-03-25 Macromed, Inc. Polymer blends that swell in an acidic environment and deswell in a basic environment
DE10000577A1 (de) 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
US6399101B1 (en) 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
BR0210867A (pt) 2001-07-06 2004-06-29 Lifecycle Pharma As Processo para a preparação de um material particulado, métodos para aglomeração controlada de um material sólido finamente disperso, para melhorar a biodisponibilidade de uma substância terapêutica e/ou profilaticamente ativa, e para melhorar a vida em prateleira de uma composição farmacêutica, material articulado, composição farmacêutica, uso de um veìculo, material particulado farmacêutico, e, uso de aluminossilicato de magnésio e/ou de aluminometassilicato de magnésio
KR100540035B1 (ko) * 2002-02-01 2005-12-29 주식회사 태평양 다단계 경구 약물 방출 제어 시스템
DE10214031A1 (de) 2002-03-27 2004-02-19 Pharmatech Gmbh Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation
CA2518734A1 (en) * 2003-03-14 2004-09-30 Nirmal Mulye A process for preparing sustained release tablets
DE10360869A1 (de) * 2003-09-09 2005-04-07 Fumapharm Ag Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
CA2526586C (en) * 2003-09-09 2010-03-16 Biogen International Gmbh The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma
EP1799196B1 (en) * 2004-10-08 2016-06-22 Forward Pharma A/S Controlled release pharmaceutical compositions comprising a fumaric acid ester
CN101056624A (zh) * 2004-10-08 2007-10-17 Adi技术制药股份公司 包含富马酸酯的控释药物组合物
WO2007006307A2 (en) * 2005-07-07 2007-01-18 Aditech Pharma Ab Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
WO2007042034A1 (en) 2005-10-07 2007-04-19 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester
EP1940382A2 (en) * 2005-10-07 2008-07-09 Aditech Pharma AB Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
JP2009522272A (ja) * 2005-12-30 2009-06-11 ミドルブルック ファーマスーティカルス,インコーポレイテッド 薬剤送達のための胃内放出パルスシステム
EP1985287A3 (en) * 2007-04-25 2009-04-29 Teva Pharmaceutical Industries Ltd. Pharmaceutical Excipient Complex
US8357395B2 (en) * 2007-12-21 2013-01-22 Mcneil-Ppc, Inc. Manufacture of tablet
BRPI0912842A8 (pt) * 2008-05-20 2019-01-29 Cerenis Therapeutics Holding composição farmacêutica, métodos para prevenir ou tratar o rubor induzido por niacina em um indivíduo, para reduzir pelo menos um sintoma de rubor relacionado com a terapia com niacina em um indivíduo, para diminuir os efeitos colaterais relacionados com a protaglandina em um indivíduo, para diminuir uma taxa de descontinuação do tratamento com niacina por um indivíduo, para aumentar a submissão do paciente ao tratamento com niacina, para tratar aterosclerose em um paciente, para tratar uma doença relacionada com um perfil de hdl baixo em um paciente, formulação do ácido nicotínico de dispensação modificada, uso da composição farmacêutica, e, microcápsula de aspirina
EP2334378B1 (en) * 2008-08-19 2014-04-09 XenoPort, Inc. Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use
JP2012514623A (ja) 2009-01-09 2012-06-28 フォーワード・ファルマ・アクティーゼルスカブ 1またはそれ以上のフマル酸エステルを含む医薬組成物
UA125896C2 (uk) 2009-01-09 2022-07-06 Фвп Іп Апс Фармацевтичний склад, що містить в матриці, яка піддається ерозії, один або більше ефірів фумарової кислоти
WO2010126605A1 (en) 2009-04-29 2010-11-04 Biogen Idec Ma Inc. Treatment of neurodegeneration and neuroinflammation
US20100285164A1 (en) 2009-05-11 2010-11-11 Jrs Pharma Orally Disintegrating Excipient
HUE025878T2 (en) 2010-02-12 2016-05-30 Biogen Ma Inc Neuroprotection in demyelinating diseases
CN114146079A (zh) * 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物

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