JP2022550851A5 - - Google Patents
Info
- Publication number
- JP2022550851A5 JP2022550851A5 JP2022520442A JP2022520442A JP2022550851A5 JP 2022550851 A5 JP2022550851 A5 JP 2022550851A5 JP 2022520442 A JP2022520442 A JP 2022520442A JP 2022520442 A JP2022520442 A JP 2022520442A JP 2022550851 A5 JP2022550851 A5 JP 2022550851A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- ala
- pharmaceutically acceptable
- acceptable salt
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962911060P | 2019-10-04 | 2019-10-04 | |
| US62/911,060 | 2019-10-04 | ||
| PCT/US2020/054137 WO2021067861A1 (en) | 2019-10-04 | 2020-10-02 | Camptothecin peptide conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022550851A JP2022550851A (ja) | 2022-12-05 |
| JP2022550851A5 true JP2022550851A5 (https=) | 2023-10-04 |
Family
ID=73013821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022520442A Pending JP2022550851A (ja) | 2019-10-04 | 2020-10-02 | カンプトテシンペプチドコンジュゲート |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240277860A1 (https=) |
| EP (1) | EP4037717A1 (https=) |
| JP (1) | JP2022550851A (https=) |
| KR (1) | KR20220079606A (https=) |
| CN (1) | CN114929284A (https=) |
| AU (1) | AU2020356955A1 (https=) |
| CA (1) | CA3152316A1 (https=) |
| IL (1) | IL291686A (https=) |
| MX (1) | MX2022003930A (https=) |
| WO (1) | WO2021067861A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020020466A2 (pt) * | 2018-04-06 | 2021-01-12 | Seattle Genetics, Inc. | Conjugados de peptídeo de camptotecina |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CA3183602A1 (en) * | 2020-05-13 | 2021-11-18 | Seagen Inc. | Methods of treating cancer using a combination of anti-cd30 antibody-drug conjugates |
| CA3213625A1 (en) * | 2021-03-18 | 2022-09-22 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
| WO2023178289A2 (en) * | 2022-03-17 | 2023-09-21 | Seagen Inc. | Camptothecin conjugates |
| EP4523704A1 (en) * | 2022-05-12 | 2025-03-19 | Hainan Simcere Zaiming Pharmaceutical Co., Ltd. | Camptothecin derivative and ligand-drug conjugate |
| IL317271A (en) * | 2022-05-30 | 2025-01-01 | Medilink Therapeutics Suzhou Co Ltd | Preparation method for Drug Linker Conjugate and between them |
| WO2024020734A1 (en) * | 2022-07-25 | 2024-02-01 | Immunogen, Inc. | Novel processes for preparing camptothecin derivatives |
| JP2025529237A (ja) * | 2022-08-30 | 2025-09-04 | ピノットバイオ インコーポレイテッド | カンプトセシン系薬物が抗原結合親和性の低い抗体にリンカーを介して連結された抗体薬物複合体 |
| KR20240035370A (ko) * | 2022-09-08 | 2024-03-15 | 주식회사 피노바이오 | 신규 캄토테신 유도체 및 이를 포함하는 운반체-약물 접합체 |
| WO2024078449A1 (en) | 2022-10-09 | 2024-04-18 | LaNova Medicines Limited | Compounds, compositions and methods |
| WO2024114318A1 (zh) * | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
| WO2024129756A1 (en) | 2022-12-13 | 2024-06-20 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
| WO2024230301A1 (zh) * | 2023-05-09 | 2024-11-14 | 诺灵生物医药科技(北京)有限公司 | 一种抗体偶联药物及其用途 |
| WO2024230678A1 (zh) * | 2023-05-11 | 2024-11-14 | 映恩生物科技(上海)有限公司 | 喜树碱类化合物及其偶联物、其制备方法和用途 |
| WO2025149947A1 (en) | 2024-01-12 | 2025-07-17 | Seagen Inc. | Antibody-drug conjugates |
| WO2025196639A1 (en) | 2024-03-21 | 2025-09-25 | Seagen Inc. | Cd25 antibodies, antibody-drug conjugates, and uses thereof |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2036891B (en) | 1978-12-05 | 1983-05-05 | Windsor Smith C | Change speed gear |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| WO1990006952A1 (fr) | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5342947A (en) * | 1992-10-09 | 1994-08-30 | Glaxo Inc. | Preparation of water soluble camptothecin derivatives |
| JP2763020B2 (ja) | 1995-04-27 | 1998-06-11 | 日本電気株式会社 | 半導体パッケージ及び半導体装置 |
| US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| EP0964702B1 (en) | 1996-08-02 | 2006-10-04 | Ortho-McNeil Pharmaceutical, Inc. | Polypeptides having a single covalently bound n-terminal water-soluble polymer |
| US6629995B1 (en) * | 2000-03-31 | 2003-10-07 | Super Gen, Inc. | Camptothecin conjugates |
| US6825206B1 (en) * | 2000-11-16 | 2004-11-30 | Research Triangle Institute | Camptothecin compounds with a thioether group |
| US7090843B1 (en) | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
| JP5122441B2 (ja) | 2005-04-19 | 2013-01-16 | シアトル ジェネティックス， インコーポレイテッド | ヒト化抗ｃｄ７０結合剤およびその使用 |
| WO2007005644A2 (en) | 2005-07-01 | 2007-01-11 | Concert Pharmaceuticals Inc. | Novel aryloxypropanamines |
| WO2007005643A2 (en) | 2005-07-01 | 2007-01-11 | Concert Pharmaceuticals Inc. | Novel aryloxyphenylpropanamines |
| KR101380190B1 (ko) | 2005-07-29 | 2014-04-11 | 콘서트 파마슈티컬즈, 인크. | 벤조 〔ｄ〕〔１,３〕―디옥솔 유도체 |
| AU2006275702A1 (en) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| EA020696B1 (ru) * | 2007-10-12 | 2015-01-30 | Сиэтл Дженетикс, Инк. | Способ лечения лимфомы ходжкина с использованием комбинации гемцитабина и конъюгата антитела против cd30 с ауристатином |
| EP2589609A1 (en) * | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| WO2013173337A2 (en) | 2012-05-15 | 2013-11-21 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| US20160106861A1 (en) * | 2013-04-26 | 2016-04-21 | Spirogen Sarl | Axl antibody-drug conjugate and its use for the treatment of cancer |
| NZ758049A (en) | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| KR102442906B1 (ko) * | 2013-12-19 | 2022-09-14 | 씨젠 인크. | 표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커 |
| DK3270965T3 (da) | 2015-03-18 | 2020-06-08 | Seattle Genetics Inc | Cd48-antistoffer og konjugater deraf |
| SG10202005460RA (en) | 2015-06-30 | 2020-07-29 | Seattle Genetics Inc | Anti-ntb-a antibodies and related compositions and methods |
| JP2021095424A (ja) * | 2018-03-28 | 2021-06-24 | 持田製薬株式会社 | 抗癌剤結合アルギン酸誘導体 |
| BR112020020466A2 (pt) * | 2018-04-06 | 2021-01-12 | Seattle Genetics, Inc. | Conjugados de peptídeo de camptotecina |
| TWI851577B (zh) * | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CN109675050A (zh) * | 2018-12-27 | 2019-04-26 | 浙江工业大学 | 以喜树碱为母核的类似物与非甾体抗炎药物的偶联物及其制备与应用 |
-
2020
- 2020-10-02 CN CN202080080665.1A patent/CN114929284A/zh active Pending
- 2020-10-02 KR KR1020227015051A patent/KR20220079606A/ko active Pending
- 2020-10-02 WO PCT/US2020/054137 patent/WO2021067861A1/en not_active Ceased
- 2020-10-02 AU AU2020356955A patent/AU2020356955A1/en not_active Abandoned
- 2020-10-02 EP EP20796991.6A patent/EP4037717A1/en not_active Withdrawn
- 2020-10-02 CA CA3152316A patent/CA3152316A1/en active Pending
- 2020-10-02 MX MX2022003930A patent/MX2022003930A/es unknown
- 2020-10-02 US US17/766,208 patent/US20240277860A1/en active Pending
- 2020-10-02 JP JP2022520442A patent/JP2022550851A/ja active Pending
-
2022
- 2022-03-24 IL IL291686A patent/IL291686A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022550851A5 (https=) | ||
| JP2021521111A5 (https=) | ||
| JP7407973B2 (ja) | 抗体薬物複合体、その調製方法、およびその使用 | |
| RU2563830C2 (ru) | Лечение остеоартрита и боли | |
| ES2614636T3 (es) | Moléculas de anticuerpos que se unen a IL-17 humana | |
| JP2023530128A (ja) | 細胞結合分子とカンプトテシン類縁体との共役体 | |
| ES2733735T3 (es) | Anticuerpos contra CSF-1R | |
| JP2023535598A5 (https=) | ||
| JP2020509027A5 (https=) | ||
| CN111423511A (zh) | 与pd-1结合的抗原结合蛋白 | |
| ES2993153T3 (en) | Pan elr+ cxc chemokine antibodies | |
| TW202108181A (zh) | 抗trop2抗體及其生產方法、及抗trop2抗體-藥物結合物 | |
| RU2014113304A (ru) | Анти-cd40-антитела, применение и методы | |
| JP2020504112A5 (https=) | ||
| RU2009136913A (ru) | Биспецифические связывающие агенты с межвидовой специфичностью | |
| JP2024544520A5 (https=) | ||
| WO2018038684A1 (en) | Macrophage stimulating protein receptor (or ron - recepteur d' origine nantais) antibodies and uses thereof | |
| EP4155319A1 (en) | 4-1bb binding protein and application thereof | |
| WO2019050780A1 (en) | COMPOUNDS FOR REDUCING THE VISCOSITY OF BIOLOGICAL FORMULATIONS | |
| CN110022903A (zh) | Met抗体药物缀合物 | |
| JP2023515675A5 (https=) | ||
| CN111973753B (zh) | 抗肿瘤的联合用药物及其应用 | |
| IL258337B2 (en) | Antibodies that bind human cannabinoid receptor 1 | |
| JP2026001086A (ja) | 抗ｃｄ３０抗体薬物複合体療法の副作用を軽減する方法 | |
| CN115501347A (zh) | 抗her2抗体药物偶联物和parp抑制剂联合在制备治疗肿瘤的药物中的用途 |