JP2021521111A5 - - Google Patents
Info
- Publication number
- JP2021521111A5 JP2021521111A5 JP2020554542A JP2020554542A JP2021521111A5 JP 2021521111 A5 JP2021521111 A5 JP 2021521111A5 JP 2020554542 A JP2020554542 A JP 2020554542A JP 2020554542 A JP2020554542 A JP 2020554542A JP 2021521111 A5 JP2021521111 A5 JP 2021521111A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- gly
- camptothecin
- formula
- alkylene
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024012728A JP2024042054A (ja) | 2018-04-06 | 2024-01-31 | カンプトテシンペプチドコンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862653961P | 2018-04-06 | 2018-04-06 | |
| US62/653,961 | 2018-04-06 | ||
| PCT/US2019/025968 WO2019195665A1 (en) | 2018-04-06 | 2019-04-05 | Camptothecin peptide conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024012728A Division JP2024042054A (ja) | 2018-04-06 | 2024-01-31 | カンプトテシンペプチドコンジュゲート |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021521111A JP2021521111A (ja) | 2021-08-26 |
| JP2021521111A5 true JP2021521111A5 (https=) | 2022-04-12 |
| JPWO2019195665A5 JPWO2019195665A5 (https=) | 2022-04-12 |
| JP7430643B2 JP7430643B2 (ja) | 2024-02-13 |
Family
ID=68101237
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020554542A Active JP7430643B2 (ja) | 2018-04-06 | 2019-04-05 | カンプトテシンペプチドコンジュゲート |
| JP2024012728A Pending JP2024042054A (ja) | 2018-04-06 | 2024-01-31 | カンプトテシンペプチドコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024012728A Pending JP2024042054A (ja) | 2018-04-06 | 2024-01-31 | カンプトテシンペプチドコンジュゲート |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20190343828A1 (https=) |
| EP (1) | EP3773736A4 (https=) |
| JP (2) | JP7430643B2 (https=) |
| KR (1) | KR20210006362A (https=) |
| CN (1) | CN111936169A (https=) |
| AR (1) | AR114473A1 (https=) |
| AU (1) | AU2019247434A1 (https=) |
| BR (1) | BR112020020466A2 (https=) |
| CA (1) | CA3094313A1 (https=) |
| EA (1) | EA202092410A1 (https=) |
| IL (2) | IL310391A (https=) |
| MA (1) | MA52669A (https=) |
| MX (1) | MX2020010458A (https=) |
| SG (1) | SG11202009527PA (https=) |
| TW (1) | TW202010498A (https=) |
| WO (1) | WO2019195665A1 (https=) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250114431A (ko) | 2016-11-08 | 2025-07-29 | 리제너론 파마슈티칼스 인코포레이티드 | 스테로이드 및 이의 단백질-접합체 |
| KR20250008984A (ko) | 2017-05-18 | 2025-01-16 | 리제너론 파마슈티칼스 인코포레이티드 | 사이클로덱스트린 단백질 약물 접합체 |
| MX2020004691A (es) | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| CN112533951A (zh) | 2018-05-09 | 2021-03-19 | 里珍纳龙药品有限公司 | 抗msr1抗体及其使用方法 |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| CN110590796B (zh) * | 2018-06-12 | 2022-07-15 | 青岛海洋生物医药研究院股份有限公司 | 喜树碱衍生物及其制备方法和应用 |
| JP7561141B2 (ja) * | 2019-04-26 | 2024-10-03 | イミュノジェン・インコーポレーテッド | カンプトテシン誘導体 |
| CN112125915A (zh) * | 2019-09-18 | 2020-12-25 | 四川百利药业有限责任公司 | 一种喜树碱衍生物及其偶联物 |
| WO2021067393A1 (en) * | 2019-10-01 | 2021-04-08 | Memorial Sloan Kettering Cancer Center | SMALL MOLECULE INHIBITORS OF Id PROTEINS |
| WO2021067820A1 (en) * | 2019-10-04 | 2021-04-08 | Seagen Inc. | Formulation of antibody-drug conjugate |
| AU2020356955A1 (en) * | 2019-10-04 | 2022-04-14 | Seagen Inc. | Camptothecin peptide conjugates |
| AU2020358859A1 (en) * | 2019-10-04 | 2022-05-12 | Seagen Inc. | Anti-PD-L1 antibodies and antibody-drug conjugates |
| CN115052632B (zh) * | 2020-01-15 | 2025-01-14 | 北京海步医药科技有限公司 | 靶向多肽-药物缀合物及其用途 |
| CN113274507B (zh) * | 2020-02-20 | 2025-02-28 | 亚飞(上海)生物医药科技有限公司 | 靶向递送和激活的免疫刺激性偶联复合物的制备和用途 |
| MX2022010457A (es) | 2020-02-25 | 2022-11-16 | Mediboston Ltd | Derivados de camptotecina y conjugados de esta. |
| CA3183602A1 (en) * | 2020-05-13 | 2021-11-18 | Seagen Inc. | Methods of treating cancer using a combination of anti-cd30 antibody-drug conjugates |
| CN116472064A (zh) * | 2020-10-12 | 2023-07-21 | 昆山新蕴达生物科技有限公司 | 抗体-药物偶联物及其应用 |
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| AU2022207454A1 (en) * | 2021-01-15 | 2023-06-22 | R.P. Scherer Technologies, Llc | Camptothecine antibody-drug conjugates and methods of use thereof |
| KR20250120438A (ko) * | 2021-02-05 | 2025-08-08 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 캄프토테신 화합물, 그의 제조방법 및 그의 응용 |
| MX2023008895A (es) * | 2021-02-09 | 2023-08-09 | Medilink Therapeutics Suzhou Co Ltd | Conjugado de sustancia bioactiva, metodo de preparacion y uso del mismo. |
| US12521444B2 (en) | 2021-02-25 | 2026-01-13 | Fortvita Biologics Limited | Anti-HER2 antibody-drug conjugates and uses thereof |
| TW202300148A (zh) * | 2021-03-17 | 2023-01-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 喜樹鹼衍生物的製備方法 |
| AU2022238571A1 (en) | 2021-03-18 | 2023-09-14 | Seagen Inc. | Selective drug release from internalized conjugates of biologically active compounds |
| TW202547842A (zh) * | 2021-04-29 | 2025-12-16 | 愛爾蘭商艾伯維製造管理無限公司 | 抗c-Met抗體藥物結合物 |
| EP4349371A4 (en) * | 2021-06-02 | 2025-06-25 | Bio-Thera Solutions, Ltd. | DRUG CONJUGATE AND USE THEREOF |
| CN113527418B (zh) * | 2021-07-16 | 2022-05-03 | 成都普康唯新生物科技有限公司 | 一种ADC linker的制备方法 |
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| TW202320858A (zh) | 2021-07-19 | 2023-06-01 | 美商薩諾管理公司 | 免疫接合物及方法 |
| CA3228345A1 (en) * | 2021-08-19 | 2023-02-23 | Zhen Li | Camptothecin derivative, and pharmaceutical composition and use thereof |
| AU2022350588A1 (en) | 2021-09-27 | 2024-05-02 | Evopoint Biosciences Co., Ltd. | Antibody, antibody-drug conjugate thereof and use thereof |
| TW202339803A (zh) * | 2021-11-09 | 2023-10-16 | 德商圖布里斯有限公司 | 包含磷(v)及喜樹鹼分子部分的共軛物 |
| CN116199740A (zh) * | 2021-12-01 | 2023-06-02 | 上海生物制品研究所有限责任公司 | 抗体药物偶联物及其用途 |
| CN116354976B (zh) * | 2021-12-27 | 2025-01-24 | 上海复旦张江生物医药股份有限公司 | 喜树碱衍生物的纯化方法 |
| MX2024009174A (es) | 2022-01-25 | 2024-08-09 | Medilink Therapeutics Suzhou Co Ltd | Anticuerpo contra her3, conjugado y uso del mismo. |
| CN118434741A (zh) * | 2022-01-26 | 2024-08-02 | 苏州宜联生物医药有限公司 | 一种药物连接体偶联物的制备方法 |
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| CN119173276A (zh) * | 2022-04-13 | 2024-12-20 | 吉利德科学公司 | 用于治疗表达Trop-2的癌症的组合疗法 |
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| CN119546346A (zh) * | 2022-05-04 | 2025-02-28 | 匹诺生物股份有限公司 | 与ddx5蛋白结合的喜树碱类药物与酸敏感性接头连接的缀合物及使用该缀合物的免疫缀合物 |
| US20230357763A1 (en) * | 2022-05-06 | 2023-11-09 | James E. Summerton | Morpholinos with Increased Delivery Efficiency |
| WO2023217227A1 (zh) | 2022-05-12 | 2023-11-16 | 先声再明医药有限公司 | 喜树碱类衍生物及配体-药物偶联物 |
| CN117143177A (zh) * | 2022-05-30 | 2023-12-01 | 苏州宜联生物医药有限公司 | 一种药物连接体偶联物的制备方法及其中间体 |
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| CN117752813A (zh) | 2022-09-26 | 2024-03-26 | 成都百利多特生物药业有限责任公司 | 抗cd33抗体和抗cd33抗体-药物偶联物及其用途 |
| WO2024073610A2 (en) * | 2022-09-28 | 2024-04-04 | Solve Therapeutics, Inc. | Compositions and uses thereof |
| KR20250084919A (ko) | 2022-10-14 | 2025-06-11 | 쓰촨 케룬-바이오테크 바이오파마수티컬 컴퍼니 리미티드 | 인간 ptk7에 결합하는 항체-약물 접합체 및 그의 제조 및 사용 방법 |
| KR20250089514A (ko) * | 2022-10-18 | 2025-06-18 | 자임워크스 비씨 인코포레이티드 | 글리피칸-3을 표적화하는 항체-약물 접합체 및 사용 방법 |
| WO2024114318A1 (zh) | 2022-11-29 | 2024-06-06 | 四川科伦博泰生物医药股份有限公司 | 药物连接子化合物及其制备方法和用途 |
| WO2024129756A1 (en) | 2022-12-13 | 2024-06-20 | Seagen Inc. | Site-specific engineered cysteine antibody drug conjugates |
| CN116712561A (zh) | 2022-12-29 | 2023-09-08 | 杭州爱科瑞思生物医药有限公司 | 含n-亚甲基酰胺连接子的抗体-药物偶联物 |
| JP2026508145A (ja) * | 2023-02-09 | 2026-03-10 | ビーワン メディシンズ ワン ゲーエムベーハー | 自己安定化リンカーコンジュゲート |
| CN118666946A (zh) * | 2023-03-15 | 2024-09-20 | 上海亲合力生物医药科技股份有限公司 | 连接子及使用其的偶联药物、抗体偶联药物及其应用 |
| WO2024210687A1 (ko) * | 2023-04-06 | 2024-10-10 | 주식회사 피노바이오 | 항암 내성 극복을 위한 신규 캄토테신 유도체 및 이를 포함하는 항체-약물 접합체 |
| WO2024227440A1 (zh) * | 2023-05-04 | 2024-11-07 | 四川科伦博泰生物医药股份有限公司 | 稠环化合物及其制备方法和应用 |
| EP4719381A1 (en) * | 2023-06-05 | 2026-04-08 | Tripartite Therapeutics Inc. | Ligand-polar drug conjugates |
| WO2025040012A1 (zh) * | 2023-08-18 | 2025-02-27 | 康诺亚生物医药科技(成都)有限公司 | 五环类活性化合物及其偶联物和用途 |
| KR20250033119A (ko) * | 2023-08-31 | 2025-03-07 | 주식회사 피노바이오 | 신규 캄토테신 유도체 및 이를 포함하는 항체-약물 접합체 |
| WO2025051241A1 (zh) * | 2023-09-06 | 2025-03-13 | 劲方医药科技(上海)股份有限公司 | 大环化合物及其抗体-药物偶联物 |
| WO2025078841A2 (en) | 2023-10-11 | 2025-04-17 | Antikor Biopharma Limited | Antibodies, conjugates, and uses thereof |
| CN120053678A (zh) * | 2023-11-30 | 2025-05-30 | 上海医药集团股份有限公司 | 一种高喜树碱类抗体偶联药物、其制备方法及应用 |
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| WO2025149947A1 (en) | 2024-01-12 | 2025-07-17 | Seagen Inc. | Antibody-drug conjugates |
| TW202602929A (zh) | 2024-03-21 | 2026-01-16 | 美商思進公司 | Cd25抗體、抗體-藥物共軛體及彼等之用途 |
| WO2025221986A1 (en) * | 2024-04-18 | 2025-10-23 | Cedars-Sinai Medical Center | Targeted camptothecin derivatives for cancer treatment |
| WO2025223507A1 (zh) * | 2024-04-25 | 2025-10-30 | 江苏康宁杰瑞生物制药有限公司 | 化合物及其偶联物 |
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| ATE136898T1 (de) * | 1991-10-29 | 1996-05-15 | Glaxo Wellcome Inc | Wasserlösliche camptothecinderivate |
| JPH06228141A (ja) * | 1992-01-24 | 1994-08-16 | Takeda Chem Ind Ltd | 縮合複素環誘導体、その塩、その製造法および用途 |
| US5496830A (en) * | 1994-09-14 | 1996-03-05 | Johns Hopkins University | Inhibition of hemoflagellates by camptothecin compounds |
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| DK2907824T3 (en) * | 2012-10-11 | 2018-07-23 | Daiichi Sankyo Co Ltd | ANTIBODY-drug conjugate |
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| JP7244987B2 (ja) * | 2016-12-14 | 2023-03-23 | シージェン インコーポレイテッド | 多剤抗体薬物コンジュゲート |
| TWI851577B (zh) * | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| AU2020356955A1 (en) * | 2019-10-04 | 2022-04-14 | Seagen Inc. | Camptothecin peptide conjugates |
| AU2020358859A1 (en) * | 2019-10-04 | 2022-05-12 | Seagen Inc. | Anti-PD-L1 antibodies and antibody-drug conjugates |
| CA3183602A1 (en) * | 2020-05-13 | 2021-11-18 | Seagen Inc. | Methods of treating cancer using a combination of anti-cd30 antibody-drug conjugates |
| MX2023006484A (es) * | 2020-12-03 | 2023-06-20 | Seagen Inc | Modulacion de la respuesta inmunitaria mediante conjugados anticuerpo-farmaco anti-cd30. |
| JP2025501978A (ja) * | 2022-01-05 | 2025-01-24 | アジェンシス,インコーポレイテッド | 191p4d12タンパク質に結合する抗体薬物コンジュゲート(adc)で筋層浸潤性尿路上皮癌または筋層浸潤性膀胱癌を治療するための方法 |
| IL315508A (en) * | 2022-03-17 | 2024-11-01 | Seagen Inc | Camptothecin conjugates |
-
2019
- 2019-04-05 CA CA3094313A patent/CA3094313A1/en active Pending
- 2019-04-05 US US16/376,302 patent/US20190343828A1/en not_active Abandoned
- 2019-04-05 MA MA052669A patent/MA52669A/fr unknown
- 2019-04-05 IL IL310391A patent/IL310391A/en unknown
- 2019-04-05 IL IL277748A patent/IL277748B2/en unknown
- 2019-04-05 AR ARP190100908A patent/AR114473A1/es not_active Application Discontinuation
- 2019-04-05 BR BR112020020466-8A patent/BR112020020466A2/pt unknown
- 2019-04-05 EA EA202092410A patent/EA202092410A1/ru unknown
- 2019-04-05 WO PCT/US2019/025968 patent/WO2019195665A1/en not_active Ceased
- 2019-04-05 JP JP2020554542A patent/JP7430643B2/ja active Active
- 2019-04-05 AU AU2019247434A patent/AU2019247434A1/en not_active Abandoned
- 2019-04-05 KR KR1020207031963A patent/KR20210006362A/ko not_active Withdrawn
- 2019-04-05 EP EP19781578.0A patent/EP3773736A4/en not_active Withdrawn
- 2019-04-05 SG SG11202009527PA patent/SG11202009527PA/en unknown
- 2019-04-05 CN CN201980024331.XA patent/CN111936169A/zh active Pending
- 2019-04-05 MX MX2020010458A patent/MX2020010458A/es unknown
- 2019-04-08 TW TW108112067A patent/TW202010498A/zh unknown
-
2021
- 2021-10-27 US US17/452,516 patent/US20220193069A1/en not_active Abandoned
-
2023
- 2023-10-27 US US18/496,756 patent/US20250135018A1/en active Pending
-
2024
- 2024-01-31 JP JP2024012728A patent/JP2024042054A/ja active Pending
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